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The map label for this gene is maeA [H]

Identifier: 160876861

GI number: 160876861

Start: 4425645

End: 4427333

Strand: Direct

Name: maeA [H]

Synonym: Sbal195_3757

Alternate gene names: 160876861

Gene position: 4425645-4427333 (Clockwise)

Preceding gene: 160876860

Following gene: 160876864

Centisome position: 82.76

GC content: 47.78

Gene sequence:

>1689_bases
ATGGACGATAATAAACGCCCCCTCTATCTTCCGTTTGCAGGACCTGCCATTCTTGAAGCCCCACTGATTAACAAGGGCAG
TGCATTTTCTGAAGAAGAGCGTATTTTCTTTAACCTCGAAGGCTTAGTTCCCTATGCCATTGAAACGATTGAGGAGCAGG
CTTCCCGCGCCTACGATCAATTTAGAAGTTTCAACAACGACTTAGACAAGCATATTTACCTACGTAATATCCAAGACACT
AACGAGACCTTATTTTATCGTTTAGTGCAAAATAACATCAGCGAGATGATGCCCATCATCTATACGCCGACGGTAGGTTT
GGCTTGTGAACGTTTCTCAAAAAACTATCGCCGCAACCGTGGTTTATTTATCTCCTATCCGAACAAAGATAGGATCGATG
ACATTCTCAATAACTCGACTCGCCAAAAAGTCAAAATCATCGTTGTTACCGACGGTGAACGTATTTTAGGCCTTGGCGAT
CAAGGTATTGGCGGCATGGGGATCCCTATCGGTAAGTTATCACTCTACACTAGCTGTGGTGGCATCAGTCCGGCTTATAC
TCTGCCTATCACTTTAGACGTAGGCACAGATAATCCGCAGTTGTTAGAAGATCCTATGTATATGGGCTGGCGCCATCCGC
GCATCGGTGGCGAAGAGTACGCCGAGTTTATAGAAGCCTTTATGCAAGCTGTACATGTGCGTTGGCCAGACACTTTGATC
CAATTCGAAGACTTTGCCCAAAAGAATGCCATGCCGATCTTAGAGCGTTATAAAGATCGCTATTGCTGCTTTAACGATGA
TATTCAAGGTACCGCAGCCGTTGCCGTCGGTTCATTGCTGGCCGCTTGTAAAGCTGCAGGTACTGAATTAAATCAACAAC
GTATTGCCTTCCTTGGTGCGGGTAGCGCGGGTTGCGGTATCGCCGAAGCTATCGTGGCGCAAATGGTGTCCGAAGGGATC
AGCGACGAGCAAGCTCGTACGCAAGTATGTATGGTTGACCGTTGGGGCTTATTGCTAGACAACATGCCTAACCTGTTGCC
ATTCCAGCAAAAATTGGCGCAGAAATGCACCAATATCCAAAACTGGAGTAATTTCAGCGACAATATTTCGTTATTGGATG
TAGTTAACAACGCTAAGCCAACCGTGCTGATTGGCGTGTCCGGTGTACCGGGTCTGTTCACCGAAGAAATTATTCGCGCT
ATGCACAGCCATTGTGCCCGCCCGATTATTTTCCCACTGTCGAACCCAACCAGCCGTGTTGAAGCGACGCCAAAGGACAT
TTTGCATTGGACCTCAGGTCAAGCACTCGTCGCCACGGGTAGTCCGTTCGAGCCCGTTGTGGTCGATGGTGAAACCTATG
AGATTGCCCAGTGTAACAACAGCTTTATCTTCCCAGGTATTGGCTTAGGCGTTTTAGCCTCTGGTGCCCGCCACGTTTCC
GATGCCATGTTAATGGCATCAAGCCGCGCACTTGCAGAATGCTCGCCACTGGCAATCGACGGTAGCGGCCCATTATTACC
TAAACTGGAAGATATCCACGCGGTCAGTAAACACATCGCTTTCGCCGTAGGTAAAGTCGCAGTTGAACAAGGTTTAACGC
TGCCAATGAGCGATGAAATCTTACAACAATCAATTGAAGGCAATTTCTGGAGTCCAGAATATCGCCGCTACAAACGCACT
TCGTTCTAA

Upstream 100 bases:

>100_bases
AATACCTCGTTCCACGGACAACAAAGATCACATTTCATGATAACCTTACGTGACTTACAGCACGTATTGACCACTTAAAC
AATAACTCAAAAGGTTACCC

Downstream 100 bases:

>100_bases
GCATAACGTTGCCGCGACTTAAGTCGTGGCAACGCAGCTTTAGCTAAGGGTTTGTGCCAGCAAAAAGCCCGTCACTGCAA
AGTGACGGGCTTTTTAATTT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQNWSNFSDNISLLDVVNNAKPTVLIGVSGVPGLFTEEIIRA
MHSHCARPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEILQQSIEGNFWSPEYRRYKRT
SF

Sequences:

>Translated_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQNWSNFSDNISLLDVVNNAKPTVLIGVSGVPGLFTEEIIRA
MHSHCARPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEILQQSIEGNFWSPEYRRYKRT
SF
>Mature_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDT
NETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGAGSAGCGIAEAIVAQMVSEGI
SDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQNWSNFSDNISLLDVVNNAKPTVLIGVSGVPGLFTEEIIRA
MHSHCARPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
DAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEILQQSIEGNFWSPEYRRYKRT
SF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=519, Percent_Identity=43.5452793834297, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI62420882, Length=563, Percent_Identity=41.2078152753108, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI62420880, Length=563, Percent_Identity=41.2078152753108, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI239049447, Length=563, Percent_Identity=41.2078152753108, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI4505145, Length=553, Percent_Identity=42.1338155515371, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI270265879, Length=468, Percent_Identity=45.0854700854701, Blast_Score=393, Evalue=1e-109,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=67.5627240143369, Blast_Score=781, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=546, Percent_Identity=43.956043956044, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322823, Length=566, Percent_Identity=43.4628975265018, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI281362672, Length=521, Percent_Identity=43.9539347408829, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21356279, Length=521, Percent_Identity=43.9539347408829, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281362674, Length=521, Percent_Identity=43.9539347408829, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24646388, Length=511, Percent_Identity=42.6614481409002, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646386, Length=511, Percent_Identity=42.6614481409002, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363505, Length=535, Percent_Identity=37.3831775700935, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707236, Length=535, Percent_Identity=37.3831775700935, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=38.3104125736739, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363503, Length=543, Percent_Identity=36.8324125230203, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707242, Length=537, Percent_Identity=38.7337057728119, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707238, Length=537, Percent_Identity=38.7337057728119, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707240, Length=518, Percent_Identity=39.3822393822394, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19922384, Length=543, Percent_Identity=30.0184162062615, Blast_Score=251, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62103; Mature: 62103

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQ
CCCCCHHHHHHHHHHHHCCCCCHHHHHHEEEEHHHHHHHHCCCCCCHHHHHHHHHHCCCC
NWSNFSDNISLLDVVNNAKPTVLIGVSGVPGLFTEEIIRAMHSHCARPIIFPLSNPTSRV
CCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHCCHHHHH
DAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEI
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LQQSIEGNFWSPEYRRYKRTSF
HHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
FRSFNNDLDKHIYLRNIQDTNETLFYRLVQNNISEMMPIIYTPTVGLACERFSKNYRRNR
HHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHCC
GLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLI
CCCCCEEEEEEEEECCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
QFEDFAQKNAMPILERYKDRYCCFNDDIQGTAAVAVGSLLAACKAAGTELNQQRIAFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIVAQMVSEGISDEQARTQVCMVDRWGLLLDNMPNLLPFQQKLAQKCTNIQ
CCCCCHHHHHHHHHHHHCCCCCHHHHHHEEEEHHHHHHHHCCCCCCHHHHHHHHHHCCCC
NWSNFSDNISLLDVVNNAKPTVLIGVSGVPGLFTEEIIRAMHSHCARPIIFPLSNPTSRV
CCCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVS
CCCHHHHHEECCCCEEEECCCCCCCEEECCCEEEEEECCCCEECCCCCHHHHHCCHHHHH
DAMLMASSRALAECSPLAIDGSGPLLPKLEDIHAVSKHIAFAVGKVAVEQGLTLPMSDEI
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LQQSIEGNFWSPEYRRYKRTSF
HHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA