Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 160875656

GI number: 160875656

Start: 3007490

End: 3008677

Strand: Direct

Name: tyrP [H]

Synonym: Sbal195_2544

Alternate gene names: 160875656

Gene position: 3007490-3008677 (Clockwise)

Preceding gene: 160875655

Following gene: 160875657

Centisome position: 56.24

GC content: 51.77

Gene sequence:

>1188_bases
ATGACACAGAATAAAATTTTCGGCAGTCTGCTGCTTATCGCAGGCACCACAATCGGCGCGGGTATGCTGGCTTTGCCTAT
CGCTTCGGCGGGACTTGGTTTTGGTACGTCCTCCGCCATCATGTTGATCCTATGGGCGCTAATGGCCTACACGGCACTGC
TAATGGTGGAAATCCATCAATTCGCCCCCAGCGATGCCAGCCTTAATCACTTGGCGCAACGCTTATTGGGCCGTAAGGGC
CAGTTGATCGCCAATAGCGCCTTGATGTTTTTACTGTACGCCCTTTGCGCCGCCTACATTGCCGGTGGCGGTGAGCAAGT
GAACCAAAAGCTGAGCACTTGGCTAGGGCTAAGTTTGCCACCACAGGCGGGCGCGATCCTGTTTACCCTGCTGATTGGGG
CGATTGTGGGCATGGGAACCCACTGTGTGGACCTTATCAATCGCGGTTTATTTGCCCTTAAGCTATTGGCATTATTGCTT
ATGTTGGCCTTGTTACTGCCGCAGGTAGAAAGCCCACATTTGCTTGAACTTCCGCTCAACCAAGGTTTAATTATCACGGC
TATTCCGGTGATTTTTACTTCCTTTGGTTTCCACGGTTCGATTCCATCAGTGGTGCGCTACTTAGGCGTTGAGGTCAAAG
CCCTGCGCAGGATCATGCTGCTCGGCTCGGCCTTACCTCTGGTCATTTATCTTTTGTGGCAAGTAGGTAGCCAAGGCGTA
TTGAGCCAAAGCCAATTGCTCGAAAACCAAAGTTTATCGAGCTTTATCAGTCAACTAGCAAGCGTACTACACAGCGAATA
CTTAAGCAGCGCGATCAGTCTATTTGCCGATCTCGCCCTTGCGACTTCGTTTTTAGGGGTGAGTTTAGGTTTGTTCGATT
TTATGGCCTCGACCTTAAGGCGTGAGGATGATTTTTCTGGTCGTAGCCTAACCGCTGCCATCACCTTTTTACCGCCCTTA
GGTTTTGCCCTCTTCTACCCCCAAGGTTTTATCACTGCCCTAGGTTACGCAGCGATTGCGCTGGTGATCCTCGCCATCTT
TTTACCTGTGGCCATGGTGTGGACACAGCGCCAGACGCGAGATGCGGCCAATATGCCGACGGGATATCGGGTCGCGGGCG
GTAAGTTTGCCTTAATGCTCGCCACACTTTGCGGAATCGTGGTTATCGCCGCGCAGATGTTTAGCTAG

Upstream 100 bases:

>100_bases
AATCATTTTGTGCTTAAAGCGCATCAAAATCCTTTAAGACAGTTGCTTTAGGATCAAATCTTTAGCTCATTTTCTTGCAA
CACGCTTTTGAGATCATGTT

Downstream 100 bases:

>100_bases
CTCCAATTCACTCACCAAGAGTGAGTTAACTAAAAGTTAGCTAGCTCGAATAAAAGATTAGGTACAAGAGCCTGTAAAGC
TTCAACTATTGACAGCAGGC

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKG
QLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLL
MLALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
LSQSQLLENQSLSSFISQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDDFSGRSLTAAITFLPPL
GFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFALMLATLCGIVVIAAQMFS

Sequences:

>Translated_395_residues
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKG
QLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLL
MLALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
LSQSQLLENQSLSSFISQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDDFSGRSLTAAITFLPPL
GFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFALMLATLCGIVVIAAQMFS
>Mature_394_residues
TQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQFAPSDASLNHLAQRLLGRKGQ
LIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLPPQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLM
LALLLPQVESPHLLELPLNQGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGVL
SQSQLLENQSLSSFISQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLRREDDFSGRSLTAAITFLPPLG
FALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTRDAANMPTGYRVAGGKFALMLATLCGIVVIAAQMFS

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=394, Percent_Identity=50.253807106599, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1790145, Length=398, Percent_Identity=28.894472361809, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1789552, Length=362, Percent_Identity=28.1767955801105, Blast_Score=166, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 41989; Mature: 41858

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNHLAQRLLGRKGQLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLP
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
PQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLMLALLLPQVESPHLLELPLN
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
QGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSQSQLLENQSLSSFISQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDDFSGRSLTAAITFLPPLGFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTR
CCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAANMPTGYRVAGGKFALMLATLCGIVVIAAQMFS
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNKIFGSLLLIAGTTIGAGMLALPIASAGLGFGTSSAIMLILWALMAYTALLMVEIHQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNHLAQRLLGRKGQLIANSALMFLLYALCAAYIAGGGEQVNQKLSTWLGLSLP
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
PQAGAILFTLLIGAIVGMGTHCVDLINRGLFALKLLALLLMLALLLPQVESPHLLELPLN
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
QGLIITAIPVIFTSFGFHGSIPSVVRYLGVEVKALRRIMLLGSALPLVIYLLWQVGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSQSQLLENQSLSSFISQLASVLHSEYLSSAISLFADLALATSFLGVSLGLFDFMASTLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDDFSGRSLTAAITFLPPLGFALFYPQGFITALGYAAIALVILAIFLPVAMVWTQRQTR
CCCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAANMPTGYRVAGGKFALMLATLCGIVVIAAQMFS
HHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]