Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 160875655

GI number: 160875655

Start: 3006305

End: 3006946

Strand: Direct

Name: hisI [H]

Synonym: Sbal195_2543

Alternate gene names: 160875655

Gene position: 3006305-3006946 (Clockwise)

Preceding gene: 160875654

Following gene: 160875656

Centisome position: 56.22

GC content: 47.51

Gene sequence:

>642_bases
ATGTCAACGCAAACACACACTAAATCGGATTTTAGCGAGCTGGATTGGGACAAACAGGATGGACTTATTCCTGCCGTGAT
CCAAAATCACTTATCGGGCAAGGTATTAATGCTCGGTTATATGGATAAAGCCGCGCTGGAAAAAACCTTAAGCACAGGTG
ATGTGACCTTTTTCAGCCGCTCAAAACAGCGTTTGTGGACTAAGGGGGAAACCTCAGGCAATACGCTAAAATTGGTGGCT
ATCGATAAAGACTGCGATAACGACAGCCTGTTATTGCAAGTGATCCCCAACGGCCCAACCTGCCACAAAGGCACCGAAAG
TTGCTGGTTAGATGACAATGCGCACCCCTTTTTGAACAACCTCGCCAGCTTAATCACCTCGCGTAAAGGGCAAAATGCCG
ATTCCAGCTATACAGCGTCTTTATTTGCGCGCGGCACTAAACGTATCGCCCAAAAGGTCGGGGAAGAAGGTCTCGAAACC
GCCCTTGCCGCTGCGACCCACGATAAGGAAGAGTTAGTTAACGAAGCCTCAGATCTTATCTATCACTTGCTGGTATTGCT
TGAAGATCAAAACTTAAGCCTCAGTGACATCACAGCAAACTTGCTGGCAAGACATCAAAAGGCACTGCAGAGCAAAGCAT
AA

Upstream 100 bases:

>100_bases
TAGCGAGCTAATGGCGCCTACAGCTACAGTAAAAGCATGAGTAAGAGCTAGCAACCACAATACGTCGCTAAAAAGCATCA
ACAAATTAAGAGTGAACACT

Downstream 100 bases:

>100_bases
ACGTCTCACTGTCTCTGATTTCAAGCTAATCGCTTACATCAAGAAATGCCGCACACTTAAGCCAAGTCTGCGGCATTTTT
TATCACGCGATAAACGTGGC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSTQTHTKSDFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVA
IDKDCDNDSLLLQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQNADSSYTASLFARGTKRIAQKVGEEGLET
ALAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHQKALQSKA

Sequences:

>Translated_213_residues
MSTQTHTKSDFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVA
IDKDCDNDSLLLQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQNADSSYTASLFARGTKRIAQKVGEEGLET
ALAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHQKALQSKA
>Mature_212_residues
STQTHTKSDFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSRSKQRLWTKGETSGNTLKLVAI
DKDCDNDSLLLQVIPNGPTCHKGTESCWLDDNAHPFLNNLASLITSRKGQNADSSYTASLFARGTKRIAQKVGEEGLETA
LAAATHDKEELVNEASDLIYHLLVLLEDQNLSLSDITANLLARHQKALQSKA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=202, Percent_Identity=62.3762376237624, Blast_Score=258, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319819, Length=214, Percent_Identity=34.1121495327103, Blast_Score=95, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23370; Mature: 23238

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQTHTKSDFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSR
CCCCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCHHHHC
SKQRLWTKGETSGNTLKLVAIDKDCDNDSLLLQVIPNGPTCHKGTESCWLDDNAHPFLNN
CHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHH
LASLITSRKGQNADSSYTASLFARGTKRIAQKVGEEGLETALAAATHDKEELVNEASDLI
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YHLLVLLEDQNLSLSDITANLLARHQKALQSKA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STQTHTKSDFSELDWDKQDGLIPAVIQNHLSGKVLMLGYMDKAALEKTLSTGDVTFFSR
CCCCCCCCCHHHCCCCCCCCEEHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCHHHHC
SKQRLWTKGETSGNTLKLVAIDKDCDNDSLLLQVIPNGPTCHKGTESCWLDDNAHPFLNN
CHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHH
LASLITSRKGQNADSSYTASLFARGTKRIAQKVGEEGLETALAAATHDKEELVNEASDLI
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
YHLLVLLEDQNLSLSDITANLLARHQKALQSKA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]