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The map label for this gene is dmsA [H]

Identifier: 160875341

GI number: 160875341

Start: 2643783

End: 2646326

Strand: Reverse

Name: dmsA [H]

Synonym: Sbal195_2228

Alternate gene names: 160875341

Gene position: 2646326-2643783 (Counterclockwise)

Preceding gene: 160875342

Following gene: 160875340

Centisome position: 49.49

GC content: 43.95

Gene sequence:

>2544_bases
ATGGAACGTAGAAGTTTTTTAAAGATGAGTGCCGCAGTGACCGCTGTTGCAACAGTTTCTGGATGCAATAAAAGTGCTAG
TGAAGCTAATGTTGTACCACCGACGACAATACCCACGGATGAAGTAATTAATTGGTCCGCTTGTTTGGTTAACTGTGGCT
CGAACTGTCCTATAAAAGTCTTCAGTAAAGATGGGATTATCACCCGTATAGAAACAGACCATGAAACAACAGATGAATAT
GGCGTTAATCATCAAGCAAGAGCCTGTCCCAGAGGTCGCTCATTAAGGCAACGAACGTATGCTACCGATAGATTACGCTC
ACCAATGAAGCGTGTTGGTAAACGTGGCGATGCCCAATTTATTCCCATTACTTGGGAACAAGCTTACTCAGACATAGCCA
CAAAATTACAAGCCATTAAAGATACTTATGGTGCTGAATCTATATATCTGCATTATGGTACAGGGGCATACTATGGCTTT
TCGTCCAATACAGCTACTTGGGGACGCCTATTAAATTTAAATGGGGGCTTTCTCGATCACCACTGGGACTATTCTTGGGC
TGGCGTCTATGCGGCATGTATAGCAACATATGGGGATCAATGGGACAGTATTAGTGGAACCTCTCTAAGCGAAATAGAAA
ACTCCGACCTGTTTATCGGTTTTGGCTTTAACCCAAATGAAATTCGCATGAGTGGTAGTGGCGAAGGTTACGACTTTATC
AAAGCACTTGAGAATAACGCAAAAGGCATCAAAGTGTGGATGATTGAGCCTCGTTACACTGATTCTATGCGTGGTAATGA
AGATGAATGGCTTGCCATTCGCCCTGGAACAGATGCCGCATTAGTTGAAGCTATTATTTATCAGATGATTAACTCAGGTT
GGGTAGACACAAATGCGAAGTCATTTTTAGATAAGTATGTTCTAGGTTACGACCGGAATTCTCTAGTTAATGCTAAAGCT
TCCATAGCATTACATTCAGATCCATTCATCGCATCACATGCACAATATGTAGACCCAGATCAAAACTATTTTGATTACAT
CATGGGACAAGGTATTTACTCCGCTAGCGGAGCTAAAACACCTAGTTGGGCTGCCGCGATCTGTGGTATTTCAGAAAATA
AGATCAAACAATTAGCTAACGCTATTATGGCTGCCGAAGCGCCTTACATCTCTGCAGGCGCAGGTATCAGTCGACATGCT
AACGGTGACCAAGCAACCCGTGCTGTTTATACGCTGGCCATCATGACAGGTAAGATTGGCCGTTCAGGTGTGAACAGTGG
TGCAATGCCTACCAGTTATAGCTTTGGCGTATCAGGTATGCCGGCAGGCACAAACCCTGTAGAAATAACAATCCCAGTAT
TTACATGGTCTGATGCTATTGTTCGAGGCAAAGAGTTTACAGGAACCACAGACGGAGTTCGTTACAAGACGAGTGGCAGC
CAAGAACGAATCGATAACAACCCTGCGAAATTAACTACCAATATCAAAGCCGTTATTAACTGTGCAGGTAATGCACTGGT
AAATCAACACTCTGATAGCAACGGTACCGCTGAGATCTTACGAGACGAGACACAGTGTGAGTTAGTGATAGTCAGTGATT
GTTGGATGACACCTTCAGCCAAATTTGCCGACTATCTGCTACCTGATAGCACTTGGCTTGAATCTGTTGACTATGCCAAT
GATTCCTATGCGTCAGGGCAAATGGCTTACGCAACCTTTATGAGCACATCACTCACTCCTCTTGGCAAAGCACAATCAAT
GTATGAAATATGCTCAGGCATAGCCAAGGCGATGGGTAAAGAGTCTGAATATACCAATGGGCTAACAGGCCAACAATGGT
GTCAAAAACTCTACAGCGAAACTAAGGCGATGAATCCCGACGTTGCGATGCCTAATTCTTATGAAGAAGCTCAAAAAGTC
GGAGTGTTTCGCAAATACATGCCTGCATCAACAATAGCCTATGAATTATTTATTCAAAACCCAACAGCAAATCCACGCCC
AACGGTCTCTGGAAAGTTTGAAATTTTCTCAATTTCTCTTGCTCGCAAAGCGGCAACTTGGATATTACCTGCTGGTGACA
AGATCACTGCGCTTCCACAATATGTTGTAACCTGGGACGGCTATGAAGATTCTACCGCGATCAATGCTGGCTACCCACTA
CAGCTCTGTGGCTATCACACCAAAGGTCGAACCCATTCCAGTTATCATAATGTCCCTTGGTTACGTGAAGCGGTTGAAGA
TGCTGTGTGGATGAATCCAATTGATGCAGTTCAGCGTGGCTTAGCCGATGGTGATAAAGTCCATATTTTCAATGATAGAG
GTACGATAGAAATCCCAGTCAGATTGACACCTAGAGTAACACCGGGAGTGTGCTCCTTAGGGCAAGGCGCATGGTACAAA
CCAGATAGTAATGGTCGAATTGGTCCATCCGGACATGTGATTGATGTTGGTGGTTGTATTAACGCATTGACCAAATACCA
TCCGTCACCCATTACAAAGGGGAATCCACAACATACCAATCGTGTTCAGGTTGTAAAAGCTTAG

Upstream 100 bases:

>100_bases
GGATTAGTGACCTTGGGTGAGCTTAATCATAACTACAACGCGCATCTGCTGATGTTGACCTTCAGCTACATGCTGCCTTG
ATTTAACAGAGGTGAAGAGA

Downstream 100 bases:

>100_bases
GGGTAATCAAAAATGACAGAAAAAACTCAATTAGGATTCTATTTCGATAGTAGTAAATGTACAGGTTGTAAGACTTGTCA
CATTGCTTGTAAAGACCGAA

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 847; Mature: 847

Protein sequence:

>847_residues
MERRSFLKMSAAVTAVATVSGCNKSASEANVVPPTTIPTDEVINWSACLVNCGSNCPIKVFSKDGIITRIETDHETTDEY
GVNHQARACPRGRSLRQRTYATDRLRSPMKRVGKRGDAQFIPITWEQAYSDIATKLQAIKDTYGAESIYLHYGTGAYYGF
SSNTATWGRLLNLNGGFLDHHWDYSWAGVYAACIATYGDQWDSISGTSLSEIENSDLFIGFGFNPNEIRMSGSGEGYDFI
KALENNAKGIKVWMIEPRYTDSMRGNEDEWLAIRPGTDAALVEAIIYQMINSGWVDTNAKSFLDKYVLGYDRNSLVNAKA
SIALHSDPFIASHAQYVDPDQNYFDYIMGQGIYSASGAKTPSWAAAICGISENKIKQLANAIMAAEAPYISAGAGISRHA
NGDQATRAVYTLAIMTGKIGRSGVNSGAMPTSYSFGVSGMPAGTNPVEITIPVFTWSDAIVRGKEFTGTTDGVRYKTSGS
QERIDNNPAKLTTNIKAVINCAGNALVNQHSDSNGTAEILRDETQCELVIVSDCWMTPSAKFADYLLPDSTWLESVDYAN
DSYASGQMAYATFMSTSLTPLGKAQSMYEICSGIAKAMGKESEYTNGLTGQQWCQKLYSETKAMNPDVAMPNSYEEAQKV
GVFRKYMPASTIAYELFIQNPTANPRPTVSGKFEIFSISLARKAATWILPAGDKITALPQYVVTWDGYEDSTAINAGYPL
QLCGYHTKGRTHSSYHNVPWLREAVEDAVWMNPIDAVQRGLADGDKVHIFNDRGTIEIPVRLTPRVTPGVCSLGQGAWYK
PDSNGRIGPSGHVIDVGGCINALTKYHPSPITKGNPQHTNRVQVVKA

Sequences:

>Translated_847_residues
MERRSFLKMSAAVTAVATVSGCNKSASEANVVPPTTIPTDEVINWSACLVNCGSNCPIKVFSKDGIITRIETDHETTDEY
GVNHQARACPRGRSLRQRTYATDRLRSPMKRVGKRGDAQFIPITWEQAYSDIATKLQAIKDTYGAESIYLHYGTGAYYGF
SSNTATWGRLLNLNGGFLDHHWDYSWAGVYAACIATYGDQWDSISGTSLSEIENSDLFIGFGFNPNEIRMSGSGEGYDFI
KALENNAKGIKVWMIEPRYTDSMRGNEDEWLAIRPGTDAALVEAIIYQMINSGWVDTNAKSFLDKYVLGYDRNSLVNAKA
SIALHSDPFIASHAQYVDPDQNYFDYIMGQGIYSASGAKTPSWAAAICGISENKIKQLANAIMAAEAPYISAGAGISRHA
NGDQATRAVYTLAIMTGKIGRSGVNSGAMPTSYSFGVSGMPAGTNPVEITIPVFTWSDAIVRGKEFTGTTDGVRYKTSGS
QERIDNNPAKLTTNIKAVINCAGNALVNQHSDSNGTAEILRDETQCELVIVSDCWMTPSAKFADYLLPDSTWLESVDYAN
DSYASGQMAYATFMSTSLTPLGKAQSMYEICSGIAKAMGKESEYTNGLTGQQWCQKLYSETKAMNPDVAMPNSYEEAQKV
GVFRKYMPASTIAYELFIQNPTANPRPTVSGKFEIFSISLARKAATWILPAGDKITALPQYVVTWDGYEDSTAINAGYPL
QLCGYHTKGRTHSSYHNVPWLREAVEDAVWMNPIDAVQRGLADGDKVHIFNDRGTIEIPVRLTPRVTPGVCSLGQGAWYK
PDSNGRIGPSGHVIDVGGCINALTKYHPSPITKGNPQHTNRVQVVKA
>Mature_847_residues
MERRSFLKMSAAVTAVATVSGCNKSASEANVVPPTTIPTDEVINWSACLVNCGSNCPIKVFSKDGIITRIETDHETTDEY
GVNHQARACPRGRSLRQRTYATDRLRSPMKRVGKRGDAQFIPITWEQAYSDIATKLQAIKDTYGAESIYLHYGTGAYYGF
SSNTATWGRLLNLNGGFLDHHWDYSWAGVYAACIATYGDQWDSISGTSLSEIENSDLFIGFGFNPNEIRMSGSGEGYDFI
KALENNAKGIKVWMIEPRYTDSMRGNEDEWLAIRPGTDAALVEAIIYQMINSGWVDTNAKSFLDKYVLGYDRNSLVNAKA
SIALHSDPFIASHAQYVDPDQNYFDYIMGQGIYSASGAKTPSWAAAICGISENKIKQLANAIMAAEAPYISAGAGISRHA
NGDQATRAVYTLAIMTGKIGRSGVNSGAMPTSYSFGVSGMPAGTNPVEITIPVFTWSDAIVRGKEFTGTTDGVRYKTSGS
QERIDNNPAKLTTNIKAVINCAGNALVNQHSDSNGTAEILRDETQCELVIVSDCWMTPSAKFADYLLPDSTWLESVDYAN
DSYASGQMAYATFMSTSLTPLGKAQSMYEICSGIAKAMGKESEYTNGLTGQQWCQKLYSETKAMNPDVAMPNSYEEAQKV
GVFRKYMPASTIAYELFIQNPTANPRPTVSGKFEIFSISLARKAATWILPAGDKITALPQYVVTWDGYEDSTAINAGYPL
QLCGYHTKGRTHSSYHNVPWLREAVEDAVWMNPIDAVQRGLADGDKVHIFNDRGTIEIPVRLTPRVTPGVCSLGQGAWYK
PDSNGRIGPSGHVIDVGGCINALTKYHPSPITKGNPQHTNRVQVVKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=855, Percent_Identity=44.5614035087719, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=854, Percent_Identity=42.3887587822014, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=850, Percent_Identity=41.1764705882353, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI145693196, Length=791, Percent_Identity=26.8015170670038, Blast_Score=196, Evalue=7e-51,
Organism=Escherichia coli, GI87081994, Length=740, Percent_Identity=25.9459459459459, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1787231, Length=803, Percent_Identity=23.5367372353674, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI3868721, Length=607, Percent_Identity=22.4052718286656, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1788534, Length=581, Percent_Identity=22.2030981067126, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787477, Length=295, Percent_Identity=27.4576271186441, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 92432; Mature: 92432

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRSFLKMSAAVTAVATVSGCNKSASEANVVPPTTIPTDEVINWSACLVNCGSNCPIKV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHHHHEEECCCCCCEEE
FSKDGIITRIETDHETTDEYGVNHQARACPRGRSLRQRTYATDRLRSPMKRVGKRGDAQF
EECCCEEEEEECCCCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
IPITWEQAYSDIATKLQAIKDTYGAESIYLHYGTGAYYGFSSNTATWGRLLNLNGGFLDH
EEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCCCC
HWDYSWAGVYAACIATYGDQWDSISGTSLSEIENSDLFIGFGFNPNEIRMSGSGEGYDFI
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCCCCHHHH
KALENNAKGIKVWMIEPRYTDSMRGNEDEWLAIRPGTDAALVEAIIYQMINSGWVDTNAK
HHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHH
SFLDKYVLGYDRNSLVNAKASIALHSDPFIASHAQYVDPDQNYFDYIMGQGIYSASGAKT
HHHHHHHHCCCCCCEECCEEEEEEECCCCEECCCCCCCCCCCHHHHHHCCCEECCCCCCC
PSWAAAICGISENKIKQLANAIMAAEAPYISAGAGISRHANGDQATRAVYTLAIMTGKIG
CCHHHHEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHEEEEEHCCCCC
RSGVNSGAMPTSYSFGVSGMPAGTNPVEITIPVFTWSDAIVRGKEFTGTTDGVRYKTSGS
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCCCCCCCCCEEEECCCC
QERIDNNPAKLTTNIKAVINCAGNALVNQHSDSNGTAEILRDETQCELVIVSDCWMTPSA
HHHCCCCCCEEEECCEEEEEECCCCEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCCCC
KFADYLLPDSTWLESVDYANDSYASGQMAYATFMSTSLTPLGKAQSMYEICSGIAKAMGK
CHHHHCCCCHHHHHHHCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
ESEYTNGLTGQQWCQKLYSETKAMNPDVAMPNSYEEAQKVGVFRKYMPASTIAYELFIQN
CCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEC
PTANPRPTVSGKFEIFSISLARKAATWILPAGDKITALPQYVVTWDGYEDSTAINAGYPL
CCCCCCCCCCCCEEEEEEEEHHCCEEEEEECCCCEEECCCEEEEECCCCCCCEECCCCCE
QLCGYHTKGRTHSSYHNVPWLREAVEDAVWMNPIDAVQRGLADGDKVHIFNDRGTIEIPV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCEEEEEE
RLTPRVTPGVCSLGQGAWYKPDSNGRIGPSGHVIDVGGCINALTKYHPSPITKGNPQHTN
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCC
RVQVVKA
EEEEEEC
>Mature Secondary Structure
MERRSFLKMSAAVTAVATVSGCNKSASEANVVPPTTIPTDEVINWSACLVNCGSNCPIKV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHHHHEEECCCCCCEEE
FSKDGIITRIETDHETTDEYGVNHQARACPRGRSLRQRTYATDRLRSPMKRVGKRGDAQF
EECCCEEEEEECCCCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
IPITWEQAYSDIATKLQAIKDTYGAESIYLHYGTGAYYGFSSNTATWGRLLNLNGGFLDH
EEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCCCC
HWDYSWAGVYAACIATYGDQWDSISGTSLSEIENSDLFIGFGFNPNEIRMSGSGEGYDFI
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCCCCHHHH
KALENNAKGIKVWMIEPRYTDSMRGNEDEWLAIRPGTDAALVEAIIYQMINSGWVDTNAK
HHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHH
SFLDKYVLGYDRNSLVNAKASIALHSDPFIASHAQYVDPDQNYFDYIMGQGIYSASGAKT
HHHHHHHHCCCCCCEECCEEEEEEECCCCEECCCCCCCCCCCHHHHHHCCCEECCCCCCC
PSWAAAICGISENKIKQLANAIMAAEAPYISAGAGISRHANGDQATRAVYTLAIMTGKIG
CCHHHHEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHEEEEEHCCCCC
RSGVNSGAMPTSYSFGVSGMPAGTNPVEITIPVFTWSDAIVRGKEFTGTTDGVRYKTSGS
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCCCCCCCCCEEEECCCC
QERIDNNPAKLTTNIKAVINCAGNALVNQHSDSNGTAEILRDETQCELVIVSDCWMTPSA
HHHCCCCCCEEEECCEEEEEECCCCEEECCCCCCCHHHHHCCCCCEEEEEEECCCCCCCC
KFADYLLPDSTWLESVDYANDSYASGQMAYATFMSTSLTPLGKAQSMYEICSGIAKAMGK
CHHHHCCCCHHHHHHHCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
ESEYTNGLTGQQWCQKLYSETKAMNPDVAMPNSYEEAQKVGVFRKYMPASTIAYELFIQN
CCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEC
PTANPRPTVSGKFEIFSISLARKAATWILPAGDKITALPQYVVTWDGYEDSTAINAGYPL
CCCCCCCCCCCCEEEEEEEEHHCCEEEEEECCCCEEECCCEEEEECCCCCCCEECCCCCE
QLCGYHTKGRTHSSYHNVPWLREAVEDAVWMNPIDAVQRGLADGDKVHIFNDRGTIEIPV
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCEEEEEE
RLTPRVTPGVCSLGQGAWYKPDSNGRIGPSGHVIDVGGCINALTKYHPSPITKGNPQHTN
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCC
RVQVVKA
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]