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The map label for this gene is fadE [H]

Identifier: 160875181

GI number: 160875181

Start: 2459248

End: 2461695

Strand: Reverse

Name: fadE [H]

Synonym: Sbal195_2067

Alternate gene names: 160875181

Gene position: 2461695-2459248 (Counterclockwise)

Preceding gene: 160875183

Following gene: 160875176

Centisome position: 46.04

GC content: 49.1

Gene sequence:

>2448_bases
GTGACTACCCTACTTTGGATCATCGCTATGATCTTAGTGCTAGGAGCCCTAGCTTACCTTCGGGTATCTTTGCTCACTGC
CACTATTGCAGCCGCTGTTGTGATGACAGCAGGATGGACACTCGATGTTGTCGGCCCTATCTCTTGGATCGTTTTCCTTG
TGGTAGCCTTGCCGTTAAATATCAGTGCATTTAGACAAAATGTGATCAGTCGTCCACTGATGAAAGTATATCGCGGCATC
ATGCCGGAAATGTCTTCAACAGAGAAAGAAGCGATTGAAGCCGGCACCACTTGGTGGGAAGCCGATCTGTTTGCGGGTAA
CCCTAACTGGAAAAAACTACATAACTACCCAGTTGCGCGTTTAAGTGCAGACGAACAGGCCTTCCTTGATGGCCCTGTTG
AAGAAGTGTGCCGCATGGTGAATCAACACCAAGTGTCACATCAACTTGCCGATCTGCCAGCCGACGTATGGCAATATCTG
AAAGATAATGGCTTCTTCGCCATGATCATTAAGAAAAAATACGGCGGTTTAGAGTATTCAGCTTATGCCCAATCGCGCGT
GTTACAAAAACTAGCAGGTTTGAGCAGTGAGCTGGCATCCACTGTTGGTGTGCCTAACTCTTTAGGCCCTGGAGAGCTGC
TGCAACATTACGGCACGCCAGAGCAACAAAACCATTATTTACCGCGTTTAGCTAAAGGATTAGAAGTACCTTGTTTCGCA
CTGACCAGCCCAGAAGCCGGTAGCGATGCAGGCTCTATTCCTGACTTTGGTATCGTGTGTAAAGGCCAATGGGAAGGTGA
AGAAGTTCTGGGTATGAAACTGACCTGGAACAAGCGTTACATCACTTTAGCCCCTGTCGCGACAGTATTAGGCTTAGCCT
TTAAACTGCGCGATCCAGAACATCTACTTGGCGATAAAGAAGAACTCGGCATTACTTGTGCTTTGATCCCTACCGATATG
GAAGGAGTTGAAACCGGTCGTCGTCACTTCCCGCTCAACTGTATGTTCCAAAACGGTCCAACTCACGGCAACGAAGTGTT
CGTGCCATTAAGCTTCATCATTGGCGGCCCGAAAATGGCAGGTCAAGGCTGGCGCATGCTGGTGGAATGTTTATCTGTGG
GTCGTGGTATCACACTGCCATCAAACTCAGCTGGCGGCGTGAAAACCGCGGCACTGGCAACGGGTGCTTATGCTCGCATT
CGTCGTCAGTTCAAATTGCCTATCGGCAAGCTTGAAGGTATCGAAGAGCCAATGGCACGCATCGGCGGTAACGCTTATCT
GATGGATGCGGTAACCACGTTGACCACTACAGGTATCGACCTAGGTGAAAAACCGTCGGTTATCTCTGCGATTGTGAAAT
ATCACCTGACAGACAGAATGCAGAAATGCGTTATCGATGCCATGGATATTCACGGTGGTAAAGGCGTGTGCCTTGGCCCC
AATAACTACTTAGGCCGTGGCTACCAAGCTGCGCCTATCGCAATTACCGTTGAAGGCGCAAACATCCTGACCCGTTCTAT
GATCATCTACGGCCAAGGCGCAATTCGCTGCCATCCGTACGTGCTTGCAGAAATGGAATCAGCGTTTGATACCGAATCGG
GTCAAGGTTTAGCTAACTTTGATGCGGCCATCTTTGGTCACATTGGTTTTGCGACCAGTAACTTCATCCGTAGCTTCTGG
TTAGGTCTGACATCAAGCCGTTTCTCTAACGCGCCTTATTCAGATAAAACCAAGCGTTATTATCAACAGATGAACCGTTT
CAGTGCCAACCTTGCCCTGCTTTCTGACTTAGCCATGGCAACCTTGGGCGGCAACCTTAAACGTAAAGAGCGTATTTCTG
CCCGTTTAGGTGACTTACTGAGCCAACTGTATCTGGCATCTGCCACGCTGAAGCGGTATGAAGATGAAGGCCGTCAAACC
GACGACTTACCATTAGTGCAATGGGCGGTTGAAGATGCGCTGTACAAGTTACAAGCCTCGTTAGACGATTTGCTGGATAA
CTTCCCTATGGGTCTTGGCGGCGCATTACGCGTGGTGATGTTCCCATTCGGTCGTCCACTGAAACGCCCAAGCGATGTGT
TAGATCATAAAGTCGCTAAGATCATGCAAACACCGTGTGAAAGCCGTGACCGTCTAGGTAAAGGCCAGTTCTGGACCAAC
TCTGAGCACAATGCTGTGGGTATCCAAGAACAAACGCTACTGGACATCATTGCATCTGAGCCTCTGCATGACAAAGTCTG
TAAGGCGAGCGGTAAACGTCTACCCTTCATGTGGTTAGATAAAGTAGCCGCTGAAGGTAAAGCACTAGGCGTGCTGAGCG
ACGATGAAGTTAACTTGCTAGAAAGAGCGGAAATCGGTCGTATGAAGTCAATCAACGTTGATGACTTTGACCCAGCTGAA
CTGCGTCCAGAAGTGGTTTCTACCACTTCACAGGAACGCGCAGCGTAA

Upstream 100 bases:

>100_bases
ATGCGACACAGGTCTGACCACAAACTATAATTGTGATCGCAATCAACAAAACACTCTATGACCTGTGGTTGGCACTCGGT
CATATTTAAGGAGAATTACA

Downstream 100 bases:

>100_bases
TCCACTCAGTAAGATTTAAACCAACAAAAAGGAGGCTAATTAGCCTCCTTTTTTAATGCCTATTGTACCGTCCTGAAATA
CGTTGACATAAAGAGGACTT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MTTLLWIIAMILVLGALAYLRVSLLTATIAAAVVMTAGWTLDVVGPISWIVFLVVALPLNISAFRQNVISRPLMKVYRGI
MPEMSSTEKEAIEAGTTWWEADLFAGNPNWKKLHNYPVARLSADEQAFLDGPVEEVCRMVNQHQVSHQLADLPADVWQYL
KDNGFFAMIIKKKYGGLEYSAYAQSRVLQKLAGLSSELASTVGVPNSLGPGELLQHYGTPEQQNHYLPRLAKGLEVPCFA
LTSPEAGSDAGSIPDFGIVCKGQWEGEEVLGMKLTWNKRYITLAPVATVLGLAFKLRDPEHLLGDKEELGITCALIPTDM
EGVETGRRHFPLNCMFQNGPTHGNEVFVPLSFIIGGPKMAGQGWRMLVECLSVGRGITLPSNSAGGVKTAALATGAYARI
RRQFKLPIGKLEGIEEPMARIGGNAYLMDAVTTLTTTGIDLGEKPSVISAIVKYHLTDRMQKCVIDAMDIHGGKGVCLGP
NNYLGRGYQAAPIAITVEGANILTRSMIIYGQGAIRCHPYVLAEMESAFDTESGQGLANFDAAIFGHIGFATSNFIRSFW
LGLTSSRFSNAPYSDKTKRYYQQMNRFSANLALLSDLAMATLGGNLKRKERISARLGDLLSQLYLASATLKRYEDEGRQT
DDLPLVQWAVEDALYKLQASLDDLLDNFPMGLGGALRVVMFPFGRPLKRPSDVLDHKVAKIMQTPCESRDRLGKGQFWTN
SEHNAVGIQEQTLLDIIASEPLHDKVCKASGKRLPFMWLDKVAAEGKALGVLSDDEVNLLERAEIGRMKSINVDDFDPAE
LRPEVVSTTSQERAA

Sequences:

>Translated_815_residues
MTTLLWIIAMILVLGALAYLRVSLLTATIAAAVVMTAGWTLDVVGPISWIVFLVVALPLNISAFRQNVISRPLMKVYRGI
MPEMSSTEKEAIEAGTTWWEADLFAGNPNWKKLHNYPVARLSADEQAFLDGPVEEVCRMVNQHQVSHQLADLPADVWQYL
KDNGFFAMIIKKKYGGLEYSAYAQSRVLQKLAGLSSELASTVGVPNSLGPGELLQHYGTPEQQNHYLPRLAKGLEVPCFA
LTSPEAGSDAGSIPDFGIVCKGQWEGEEVLGMKLTWNKRYITLAPVATVLGLAFKLRDPEHLLGDKEELGITCALIPTDM
EGVETGRRHFPLNCMFQNGPTHGNEVFVPLSFIIGGPKMAGQGWRMLVECLSVGRGITLPSNSAGGVKTAALATGAYARI
RRQFKLPIGKLEGIEEPMARIGGNAYLMDAVTTLTTTGIDLGEKPSVISAIVKYHLTDRMQKCVIDAMDIHGGKGVCLGP
NNYLGRGYQAAPIAITVEGANILTRSMIIYGQGAIRCHPYVLAEMESAFDTESGQGLANFDAAIFGHIGFATSNFIRSFW
LGLTSSRFSNAPYSDKTKRYYQQMNRFSANLALLSDLAMATLGGNLKRKERISARLGDLLSQLYLASATLKRYEDEGRQT
DDLPLVQWAVEDALYKLQASLDDLLDNFPMGLGGALRVVMFPFGRPLKRPSDVLDHKVAKIMQTPCESRDRLGKGQFWTN
SEHNAVGIQEQTLLDIIASEPLHDKVCKASGKRLPFMWLDKVAAEGKALGVLSDDEVNLLERAEIGRMKSINVDDFDPAE
LRPEVVSTTSQERAA
>Mature_814_residues
TTLLWIIAMILVLGALAYLRVSLLTATIAAAVVMTAGWTLDVVGPISWIVFLVVALPLNISAFRQNVISRPLMKVYRGIM
PEMSSTEKEAIEAGTTWWEADLFAGNPNWKKLHNYPVARLSADEQAFLDGPVEEVCRMVNQHQVSHQLADLPADVWQYLK
DNGFFAMIIKKKYGGLEYSAYAQSRVLQKLAGLSSELASTVGVPNSLGPGELLQHYGTPEQQNHYLPRLAKGLEVPCFAL
TSPEAGSDAGSIPDFGIVCKGQWEGEEVLGMKLTWNKRYITLAPVATVLGLAFKLRDPEHLLGDKEELGITCALIPTDME
GVETGRRHFPLNCMFQNGPTHGNEVFVPLSFIIGGPKMAGQGWRMLVECLSVGRGITLPSNSAGGVKTAALATGAYARIR
RQFKLPIGKLEGIEEPMARIGGNAYLMDAVTTLTTTGIDLGEKPSVISAIVKYHLTDRMQKCVIDAMDIHGGKGVCLGPN
NYLGRGYQAAPIAITVEGANILTRSMIIYGQGAIRCHPYVLAEMESAFDTESGQGLANFDAAIFGHIGFATSNFIRSFWL
GLTSSRFSNAPYSDKTKRYYQQMNRFSANLALLSDLAMATLGGNLKRKERISARLGDLLSQLYLASATLKRYEDEGRQTD
DLPLVQWAVEDALYKLQASLDDLLDNFPMGLGGALRVVMFPFGRPLKRPSDVLDHKVAKIMQTPCESRDRLGKGQFWTNS
EHNAVGIQEQTLLDIIASEPLHDKVCKASGKRLPFMWLDKVAAEGKALGVLSDDEVNLLERAEIGRMKSINVDDFDPAEL
RPEVVSTTSQERAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=553, Percent_Identity=26.4014466546112, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4557235, Length=410, Percent_Identity=24.8780487804878, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI4557233, Length=414, Percent_Identity=26.5700483091787, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=25.1928020565553, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI87081702, Length=816, Percent_Identity=64.828431372549, Blast_Score=1098, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506239, Length=307, Percent_Identity=26.0586319218241, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=323, Percent_Identity=23.5294117647059, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363737, Length=444, Percent_Identity=24.3243243243243, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355753, Length=323, Percent_Identity=24.1486068111455, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89260; Mature: 89129

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLWIIAMILVLGALAYLRVSLLTATIAAAVVMTAGWTLDVVGPISWIVFLVVALPLN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCC
ISAFRQNVISRPLMKVYRGIMPEMSSTEKEAIEAGTTWWEADLFAGNPNWKKLHNYPVAR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECEEECCCCCHHHHCCCCCEE
LSADEQAFLDGPVEEVCRMVNQHQVSHQLADLPADVWQYLKDNGFFAMIIKKKYGGLEYS
ECCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCCCHH
AYAQSRVLQKLAGLSSELASTVGVPNSLGPGELLQHYGTPEQQNHYLPRLAKGLEVPCFA
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEE
LTSPEAGSDAGSIPDFGIVCKGQWEGEEVLGMKLTWNKRYITLAPVATVLGLAFKLRDPE
ECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCH
HLLGDKEELGITCALIPTDMEGVETGRRHFPLNCMFQNGPTHGNEVFVPLSFIIGGPKMA
HHHCCCHHCCEEEEEECCCCHHHHCCCCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCC
GQGWRMLVECLSVGRGITLPSNSAGGVKTAALATGAYARIRRQFKLPIGKLEGIEEPMAR
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
IGGNAYLMDAVTTLTTTGIDLGEKPSVISAIVKYHLTDRMQKCVIDAMDIHGGKGVCLGP
HCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
NNYLGRGYQAAPIAITVEGANILTRSMIIYGQGAIRCHPYVLAEMESAFDTESGQGLANF
CCCCCCCCCCCCEEEEECCCHHHHHEEEEECCCCEEECHHHHHHHHHHCCCCCCCCCHHH
DAAIFGHIGFATSNFIRSFWLGLTSSRFSNAPYSDKTKRYYQQMNRFSANLALLSDLAMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGGNLKRKERISARLGDLLSQLYLASATLKRYEDEGRQTDDLPLVQWAVEDALYKLQAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LDDLLDNFPMGLGGALRVVMFPFGRPLKRPSDVLDHKVAKIMQTPCESRDRLGKGQFWTN
HHHHHHHCCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
SEHNAVGIQEQTLLDIIASEPLHDKVCKASGKRLPFMWLDKVAAEGKALGVLSDDEVNLL
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCHHHH
ERAEIGRMKSINVDDFDPAELRPEVVSTTSQERAA
HHHHCCCCCCCCCCCCCHHHCCHHHHCCCCHHCCC
>Mature Secondary Structure 
TTLLWIIAMILVLGALAYLRVSLLTATIAAAVVMTAGWTLDVVGPISWIVFLVVALPLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCC
ISAFRQNVISRPLMKVYRGIMPEMSSTEKEAIEAGTTWWEADLFAGNPNWKKLHNYPVAR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECEEECCCCCHHHHCCCCCEE
LSADEQAFLDGPVEEVCRMVNQHQVSHQLADLPADVWQYLKDNGFFAMIIKKKYGGLEYS
ECCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCCCHH
AYAQSRVLQKLAGLSSELASTVGVPNSLGPGELLQHYGTPEQQNHYLPRLAKGLEVPCFA
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCEEE
LTSPEAGSDAGSIPDFGIVCKGQWEGEEVLGMKLTWNKRYITLAPVATVLGLAFKLRDPE
ECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCH
HLLGDKEELGITCALIPTDMEGVETGRRHFPLNCMFQNGPTHGNEVFVPLSFIIGGPKMA
HHHCCCHHCCEEEEEECCCCHHHHCCCCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCC
GQGWRMLVECLSVGRGITLPSNSAGGVKTAALATGAYARIRRQFKLPIGKLEGIEEPMAR
CHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
IGGNAYLMDAVTTLTTTGIDLGEKPSVISAIVKYHLTDRMQKCVIDAMDIHGGKGVCLGP
HCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
NNYLGRGYQAAPIAITVEGANILTRSMIIYGQGAIRCHPYVLAEMESAFDTESGQGLANF
CCCCCCCCCCCCEEEEECCCHHHHHEEEEECCCCEEECHHHHHHHHHHCCCCCCCCCHHH
DAAIFGHIGFATSNFIRSFWLGLTSSRFSNAPYSDKTKRYYQQMNRFSANLALLSDLAMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGGNLKRKERISARLGDLLSQLYLASATLKRYEDEGRQTDDLPLVQWAVEDALYKLQAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LDDLLDNFPMGLGGALRVVMFPFGRPLKRPSDVLDHKVAKIMQTPCESRDRLGKGQFWTN
HHHHHHHCCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
SEHNAVGIQEQTLLDIIASEPLHDKVCKASGKRLPFMWLDKVAAEGKALGVLSDDEVNLL
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCHHHH
ERAEIGRMKSINVDDFDPAELRPEVVSTTSQERAA
HHHHCCCCCCCCCCCCCHHHCCHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]