Click here to switch to the map view.

The map label for this gene is adhE [H]

Identifier: 160875070

GI number: 160875070

Start: 2337011

End: 2339614

Strand: Reverse

Name: adhE [H]

Synonym: Sbal195_1955

Alternate gene names: 160875070

Gene position: 2339614-2337011 (Counterclockwise)

Preceding gene: 160875073

Following gene: 160875065

Centisome position: 43.75

GC content: 49.31

Gene sequence:

>2604_bases
ATGACAGTGACCAATGCACAAGAACTGGATCTCATGGTCGAGCGTGTTGCGAAAGCACAAGCCGAATATGCGACATTCAG
CCAAGCGCAAGTCGATAAAATTTTCCGCGCAGCGGCCCTTGCCGCTGCCGATGCGCGTATCTCGCTGGCAAAAATGGCCG
CCGCAGAAACCCGCATGGGTGTCGTTGAAGACAAAGTGATCAAAAACCACTTTGCCTCTGAGTATATTTATAACAAATAC
AAAGATGAAAAAACCTGCGGGATTTTATCTGAAGACGTCACCTTCGGCACTATCACCATTGCCGAACCTGTGGGCATCAT
TTGTGGCATAGTACCGACCACGAACCCCACATCGACCGCGATATTTAAGGCCTTAATCAGCCTTAAAACCCGTAACGCAA
TTATCTTCTCGCCCCACCCAAGGGCCAAAGTTTCCACCACAACTGCGGCAAAATTAGTGCTTGATGCAGCCATTGCTGCT
GGCGCGCCCAAAGACATTATTGGCTGGATTGATGAACCCAGCGTCGCACTGTCAAATCAATTGATGACACACCCAAGGAT
CAATTTAATTCTCGCAACAGGTGGCCCAGGCATGGTGAAAGCCGCCTACTCTTCCGGTAAACCCGCGATTGGCGTAGGTG
CGGGTAACACGCCTATTGTTATCGATGAAACCGCCGACATCAAACGCGCGGTCAGTTCGATTCTCATGTCGAAAACCTTC
GATAACGGCGTCGTTTGTGCGTCAGAACAAGCTGTGATTGTGGTTGACAGTATTTATGAGCAAGTAAAAGAGCGCTTTAT
CTCCCACGGTGGCTACATGCTATCGAAGAATGAAACCGCGGCGATGCAACAGGTCATTTTAAAAAATGGCGGTTTGAATG
CCGATATCGTTGGCCAAAGCGCCGCCAGTATCGCGCAAATGGCGGGCTTTGAAGTGCCGCACTGGACTAAGGTTCTGATT
GGTGAGGTCACCGACATTTGCGACAGCGAAGCCTTCGCCCATGAAAAATTATCGCCACTGCTTGGCATGTACCGCGCCAT
CGACTTTAACGATGCCATGGATAAAGCCGAAGCTTTAGTCGCACTTGGCGGCATTGGTCACACTTCAGGGCTTTATACCG
ACCAAGATACCCAAACTGAACGTGTGCATGCCTTTGGTTTTAGAATGAAAACAGCACGTATCTTGATCAACACTCCTGCC
TCACAGGGTGGTATTGGCGATCTGTACAACTTCAAACTAGCACCTTCACTCACTTTGGGTTGTGGTTCTTGGGGCGGCAA
CTCGATTTCAGAAAACGTTGGCCCAAGTCATCTGATCAACAAAAAAACCGTCGCTAAGAGGGCCGAAAACATGTTGTGGC
ATAAACTTCCTGCATCCATCTATTTCCGCCGCGGCAGTTTACCCATCGCGCTCGAAGAACTGAGCGATAAAAAACGCGCC
TTAATCATCACAGACAGATTTTTGTTCAATCACGGTTATTGCGACGAAACTATGCGGATTTTAAAGGCCCAAGGCCTTGA
AACCGAAATCTTTTACGATGTTGAAGCCGACCCAACCTTAGCCATAGTCCGTCAAGGCGCTAAGGTGGCCCAAAGCTTTA
AACCCGATGTAATTATTGCACTCGGCGGCGGCTCACCAATGGATGCGGCTAAGATTATTTGGGTGATGTACGAGCATCCC
GATGTGGATTTTGCCGATTTGGCGCTGCGCTTTATGGACATTCGTAAACGTATCTACAAATTCCCTAAAATGGGCACCAA
GGCCATGATGGTGGCTATTCCAACCACTTCAGGCACAGGCTCAGAAGTCACCCCTTTTGCGGTAGTGACAGACGAAATTA
CCGGTAAAAAATACCCGATTGCCGATTATCAACTCACGCCCAACATGGCGATTGTTGATCCTAATCTAGTGATGGACATG
CCTAAATCTCTGACCGCCTTTGGTGGCATAGATGCGGTGACCCATGCTCTTGAAGCCTATGTCAGCGTGATGGCGAACGA
ATACAGCGACGGCCAAGCACTGCAAGCCCTCGACTTACTGTGCAAATATTTACCCGATGCGTACAACTTGGGCTCACAGT
CACCCGTCGCCCGTGAAAAAGTCCACAATGGCGCCACCATCGCAGGTATCGCCTTTGCTAACGCTTTCCTCGGGATTTGC
CACTCAATGGCGCACAAACTGGGCGCAGAATTCCATCTCGCCCACGGTTTAGCCAATGCGCTGCTGATCAATAACGTAAT
ACGCTTTAACGCAACAGATCTGCCCACTAAGCAAGCGGCCTTTAGCCAATACGACAGGCCAAAAGCCCTGTGCCGTTATG
CTGCCATCGCAGATCACTTGAAACTAGGCGGAAAAACGGATGAAGAAAAAGTCGAAAAATTGCTTGAGAAAATCACACAC
CTCAAGAAGACGATTGGCATTCCTGCTTCTATCCAAGAAGCCGGCGTCAACGAAGCCGACTTCCTCGCCAAGTTAGATGA
ATTAGCCGAAGATGCGTTCGATGATCAATGTACCGGTGCCAACCCACGTTACCCCTTGATTAACGAGCTGAAACAACTGT
TCCTCGATAGCTATTATGGCCGTGACTATAGCGACAACAACTAG

Upstream 100 bases:

>100_bases
GTGGCGTCACACTTTAAATGCGGCTTTAGGTGTAATTTTCTACCATAAAGAGGATTTAGTGAATGCCTTGATTCACTAAA
TCTTTTTAGGAGTATTAATC

Downstream 100 bases:

>100_bases
GCAATCGCCTAACTATGCTAAGCGCGTGCTAAATAAATGCAGCGCGACATAAATGAAAAAGCTCTCGAATGAGGGCTTTT
TACTGCGTGATGTTCCGTGG

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]

Number of amino acids: Translated: 867; Mature: 866

Protein sequence:

>867_residues
MTVTNAQELDLMVERVAKAQAEYATFSQAQVDKIFRAAALAAADARISLAKMAAAETRMGVVEDKVIKNHFASEYIYNKY
KDEKTCGILSEDVTFGTITIAEPVGIICGIVPTTNPTSTAIFKALISLKTRNAIIFSPHPRAKVSTTTAAKLVLDAAIAA
GAPKDIIGWIDEPSVALSNQLMTHPRINLILATGGPGMVKAAYSSGKPAIGVGAGNTPIVIDETADIKRAVSSILMSKTF
DNGVVCASEQAVIVVDSIYEQVKERFISHGGYMLSKNETAAMQQVILKNGGLNADIVGQSAASIAQMAGFEVPHWTKVLI
GEVTDICDSEAFAHEKLSPLLGMYRAIDFNDAMDKAEALVALGGIGHTSGLYTDQDTQTERVHAFGFRMKTARILINTPA
SQGGIGDLYNFKLAPSLTLGCGSWGGNSISENVGPSHLINKKTVAKRAENMLWHKLPASIYFRRGSLPIALEELSDKKRA
LIITDRFLFNHGYCDETMRILKAQGLETEIFYDVEADPTLAIVRQGAKVAQSFKPDVIIALGGGSPMDAAKIIWVMYEHP
DVDFADLALRFMDIRKRIYKFPKMGTKAMMVAIPTTSGTGSEVTPFAVVTDEITGKKYPIADYQLTPNMAIVDPNLVMDM
PKSLTAFGGIDAVTHALEAYVSVMANEYSDGQALQALDLLCKYLPDAYNLGSQSPVAREKVHNGATIAGIAFANAFLGIC
HSMAHKLGAEFHLAHGLANALLINNVIRFNATDLPTKQAAFSQYDRPKALCRYAAIADHLKLGGKTDEEKVEKLLEKITH
LKKTIGIPASIQEAGVNEADFLAKLDELAEDAFDDQCTGANPRYPLINELKQLFLDSYYGRDYSDNN

Sequences:

>Translated_867_residues
MTVTNAQELDLMVERVAKAQAEYATFSQAQVDKIFRAAALAAADARISLAKMAAAETRMGVVEDKVIKNHFASEYIYNKY
KDEKTCGILSEDVTFGTITIAEPVGIICGIVPTTNPTSTAIFKALISLKTRNAIIFSPHPRAKVSTTTAAKLVLDAAIAA
GAPKDIIGWIDEPSVALSNQLMTHPRINLILATGGPGMVKAAYSSGKPAIGVGAGNTPIVIDETADIKRAVSSILMSKTF
DNGVVCASEQAVIVVDSIYEQVKERFISHGGYMLSKNETAAMQQVILKNGGLNADIVGQSAASIAQMAGFEVPHWTKVLI
GEVTDICDSEAFAHEKLSPLLGMYRAIDFNDAMDKAEALVALGGIGHTSGLYTDQDTQTERVHAFGFRMKTARILINTPA
SQGGIGDLYNFKLAPSLTLGCGSWGGNSISENVGPSHLINKKTVAKRAENMLWHKLPASIYFRRGSLPIALEELSDKKRA
LIITDRFLFNHGYCDETMRILKAQGLETEIFYDVEADPTLAIVRQGAKVAQSFKPDVIIALGGGSPMDAAKIIWVMYEHP
DVDFADLALRFMDIRKRIYKFPKMGTKAMMVAIPTTSGTGSEVTPFAVVTDEITGKKYPIADYQLTPNMAIVDPNLVMDM
PKSLTAFGGIDAVTHALEAYVSVMANEYSDGQALQALDLLCKYLPDAYNLGSQSPVAREKVHNGATIAGIAFANAFLGIC
HSMAHKLGAEFHLAHGLANALLINNVIRFNATDLPTKQAAFSQYDRPKALCRYAAIADHLKLGGKTDEEKVEKLLEKITH
LKKTIGIPASIQEAGVNEADFLAKLDELAEDAFDDQCTGANPRYPLINELKQLFLDSYYGRDYSDNN
>Mature_866_residues
TVTNAQELDLMVERVAKAQAEYATFSQAQVDKIFRAAALAAADARISLAKMAAAETRMGVVEDKVIKNHFASEYIYNKYK
DEKTCGILSEDVTFGTITIAEPVGIICGIVPTTNPTSTAIFKALISLKTRNAIIFSPHPRAKVSTTTAAKLVLDAAIAAG
APKDIIGWIDEPSVALSNQLMTHPRINLILATGGPGMVKAAYSSGKPAIGVGAGNTPIVIDETADIKRAVSSILMSKTFD
NGVVCASEQAVIVVDSIYEQVKERFISHGGYMLSKNETAAMQQVILKNGGLNADIVGQSAASIAQMAGFEVPHWTKVLIG
EVTDICDSEAFAHEKLSPLLGMYRAIDFNDAMDKAEALVALGGIGHTSGLYTDQDTQTERVHAFGFRMKTARILINTPAS
QGGIGDLYNFKLAPSLTLGCGSWGGNSISENVGPSHLINKKTVAKRAENMLWHKLPASIYFRRGSLPIALEELSDKKRAL
IITDRFLFNHGYCDETMRILKAQGLETEIFYDVEADPTLAIVRQGAKVAQSFKPDVIIALGGGSPMDAAKIIWVMYEHPD
VDFADLALRFMDIRKRIYKFPKMGTKAMMVAIPTTSGTGSEVTPFAVVTDEITGKKYPIADYQLTPNMAIVDPNLVMDMP
KSLTAFGGIDAVTHALEAYVSVMANEYSDGQALQALDLLCKYLPDAYNLGSQSPVAREKVHNGATIAGIAFANAFLGICH
SMAHKLGAEFHLAHGLANALLINNVIRFNATDLPTKQAAFSQYDRPKALCRYAAIADHLKLGGKTDEEKVEKLLEKITHL
KKTIGIPASIQEAGVNEADFLAKLDELAEDAFDDQCTGANPRYPLINELKQLFLDSYYGRDYSDNN

Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=313, Percent_Identity=27.1565495207668, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1787493, Length=867, Percent_Identity=77.8546712802768, Blast_Score=1367, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=405, Percent_Identity=31.358024691358, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=36.745406824147, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI87082107, Length=379, Percent_Identity=30.8707124010554, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788797, Length=371, Percent_Identity=33.1536388140162, Blast_Score=176, Evalue=8e-45,
Organism=Escherichia coli, GI1789386, Length=388, Percent_Identity=24.2268041237113, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1789015, Length=174, Percent_Identity=25.8620689655172, Blast_Score=63, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17537053, Length=280, Percent_Identity=28.2142857142857, Blast_Score=106, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=392, Percent_Identity=33.4183673469388, Blast_Score=180, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6320917, Length=174, Percent_Identity=25.2873563218391, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24657991, Length=420, Percent_Identity=24.047619047619, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 93791; Mature: 93659

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTNAQELDLMVERVAKAQAEYATFSQAQVDKIFRAAALAAADARISLAKMAAAETRMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVEDKVIKNHFASEYIYNKYKDEKTCGILSEDVTFGTITIAEPVGIICGIVPTTNPTSTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCCCCEEECCCCCCCHHHH
IFKALISLKTRNAIIFSPHPRAKVSTTTAAKLVLDAAIAAGAPKDIIGWIDEPSVALSNQ
HHHHHHHHHCCCEEEECCCCCCEECHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
LMTHPRINLILATGGPGMVKAAYSSGKPAIGVGAGNTPIVIDETADIKRAVSSILMSKTF
HHCCCCEEEEEEECCCCEEEEECCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHCC
DNGVVCASEQAVIVVDSIYEQVKERFISHGGYMLSKNETAAMQQVILKNGGLNADIVGQS
CCCEEEECCCCEEEHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCEECCCH
AASIAQMAGFEVPHWTKVLIGEVTDICDSEAFAHEKLSPLLGMYRAIDFNDAMDKAEALV
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALGGIGHTSGLYTDQDTQTERVHAFGFRMKTARILINTPASQGGIGDLYNFKLAPSLTLG
HCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCEEEECCCEEEE
CGSWGGNSISENVGPSHLINKKTVAKRAENMLWHKLPASIYFRRGSLPIALEELSDKKRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHCCCCCCE
LIITDRFLFNHGYCDETMRILKAQGLETEIFYDVEADPTLAIVRQGAKVAQSFKPDVIIA
EEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHCCCCCEEEE
LGGGSPMDAAKIIWVMYEHPDVDFADLALRFMDIRKRIYKFPKMGTKAMMVAIPTTSGTG
ECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
SEVTPFAVVTDEITGKKYPIADYQLTPNMAIVDPNLVMDMPKSLTAFGGIDAVTHALEAY
CCCCCEEEEEECCCCCCCCCCCEEECCCEEEECCHHHHHCCHHHHHHCCHHHHHHHHHHH
VSVMANEYSDGQALQALDLLCKYLPDAYNLGSQSPVAREKVHNGATIAGIAFANAFLGIC
HHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHH
HSMAHKLGAEFHLAHGLANALLINNVIRFNATDLPTKQAAFSQYDRPKALCRYAAIADHL
HHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
KLGGKTDEEKVEKLLEKITHLKKTIGIPASIQEAGVNEADFLAKLDELAEDAFDDQCTGA
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
NPRYPLINELKQLFLDSYYGRDYSDNN
CCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVTNAQELDLMVERVAKAQAEYATFSQAQVDKIFRAAALAAADARISLAKMAAAETRMG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVEDKVIKNHFASEYIYNKYKDEKTCGILSEDVTFGTITIAEPVGIICGIVPTTNPTSTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCCCCEEECCCCCCCHHHH
IFKALISLKTRNAIIFSPHPRAKVSTTTAAKLVLDAAIAAGAPKDIIGWIDEPSVALSNQ
HHHHHHHHHCCCEEEECCCCCCEECHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
LMTHPRINLILATGGPGMVKAAYSSGKPAIGVGAGNTPIVIDETADIKRAVSSILMSKTF
HHCCCCEEEEEEECCCCEEEEECCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHCC
DNGVVCASEQAVIVVDSIYEQVKERFISHGGYMLSKNETAAMQQVILKNGGLNADIVGQS
CCCEEEECCCCEEEHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCCCEECCCH
AASIAQMAGFEVPHWTKVLIGEVTDICDSEAFAHEKLSPLLGMYRAIDFNDAMDKAEALV
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ALGGIGHTSGLYTDQDTQTERVHAFGFRMKTARILINTPASQGGIGDLYNFKLAPSLTLG
HCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCEEEECCCEEEE
CGSWGGNSISENVGPSHLINKKTVAKRAENMLWHKLPASIYFRRGSLPIALEELSDKKRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHCCCCCCE
LIITDRFLFNHGYCDETMRILKAQGLETEIFYDVEADPTLAIVRQGAKVAQSFKPDVIIA
EEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHCCCCCEEEE
LGGGSPMDAAKIIWVMYEHPDVDFADLALRFMDIRKRIYKFPKMGTKAMMVAIPTTSGTG
ECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
SEVTPFAVVTDEITGKKYPIADYQLTPNMAIVDPNLVMDMPKSLTAFGGIDAVTHALEAY
CCCCCEEEEEECCCCCCCCCCCEEECCCEEEECCHHHHHCCHHHHHHCCHHHHHHHHHHH
VSVMANEYSDGQALQALDLLCKYLPDAYNLGSQSPVAREKVHNGATIAGIAFANAFLGIC
HHHHHCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHH
HSMAHKLGAEFHLAHGLANALLINNVIRFNATDLPTKQAAFSQYDRPKALCRYAAIADHL
HHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
KLGGKTDEEKVEKLLEKITHLKKTIGIPASIQEAGVNEADFLAKLDELAEDAFDDQCTGA
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
NPRYPLINELKQLFLDSYYGRDYSDNN
CCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]