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The map label for this gene is aarA [H]

Identifier: 160874113

GI number: 160874113

Start: 1176795

End: 1178420

Strand: Direct

Name: aarA [H]

Synonym: Sbal195_0993

Alternate gene names: 160874113

Gene position: 1176795-1178420 (Clockwise)

Preceding gene: 160874112

Following gene: 160874120

Centisome position: 22.01

GC content: 43.97

Gene sequence:

>1626_bases
GTGGATGTACTGCTAAAAAAACTTCAACTGATCTATTTTCCCTTCTTATTCACGAGCCTGTTATTTATCTCTGGCTATAG
CTTAATCCATTGGCTGTTGTTGATTAAATTTGAGTTTTTTAGCATAGATGAAGATCTGGTCAATTTTGGATTACCGCTGA
TACTGTCATGGCTCTTGTTGCTTGTTTTTCTGAGGCCAAGGCTAAAACTGCTGAAGTTTGTTAAGGATAATTCACGCTTT
TACTATCTACTTTTCGCCGTGCAGCTCGTGGCTGTGCCTTGTATTATTGCGCAGGAATATCTTAAAACAGCAACGGGTCA
GTTAACCCAATTAGCATCGATCCAAGAATTGTATCTGCATAAAAAGACACAGTATTACCAGTTACAGCAAGCTTATATTG
ATAAGACGCAAATTGGTGTGCAGCGAAAGATTGAGGTGACAGGAAAAAGTAACAGTCACTTGAATATGACGCTCTATATT
GCGATGCCGATTTTTGCGAGTGGCGCCGATCGTCGCCGAACTTCTGTCTTAGCCTGGTATGGCAAAACTTATCAGCAGGA
GATCAGTAATAGACTCGAACCCGATGAAAAAGAACAAGCATACAAGGCGTTTTTGACTCAATCCCAACGTGAGTTTGATA
AGTTTGACCCGCAAACGTTTGTTTACCTTGAACGGTTAGCCCCTTCGTCTCTTAAGAGAGACTTACTTAGCGCAGCGGAA
AAAAGTCCGCTTTATCAAGCTGAATACCCAACGATTTTTATGCCGAAGTTTGAGCCATTTGAAGCCCGTAATGGCCATAA
ACTCGCTTGGATGCTGATTTGGTTTGTTGCAGGTGCGTTAGTCTGGTTTGTGCTCTTGCTGCGGGTGAAACTGGATGAAG
AGGTTCTTAAGGCTGAAACAGTTACAAAGCGTTTGAACCATGCGGGCACAATCGCCGAGCTTAACGATTTTTTTGAAATG
ATACGGCCCAAGCCGGGTTTTATTGCAACTCCTATTCTGATGTATTTCAATGTATTAGTGTTTATCCTTATGGCATGGTC
AAGCCAACATTTTATTAACTTACAGGGTAGTTTTCTGCTCGAATGGGGGGCTAACTTTCGGCCTAAAGTGCTTGCTGGTG
AGTGGTGGCGCTTAATTACGAGTACCTTTATCCATGGCGGTTTAGCCCACTTAGCGCTGAATCTTTACGGCTTGTTTTTT
GTCGGCAGCTTTCTTGAACCTGTACTCGGTAAGTGGCGACTATTTTTGGCGTATTTGATCACTGGGATATTAGCCAGTAT
CGCCAGTATCTGTTGGTATGATGCCACTGTGAGTGTCGGTGCATCGGGCGCCATTATGGGGCTATTAGGTATACTCGTGA
TTTGGGCTTGGAAAAAGATTTTCCCTGAGGATATCAACTGGATATTGAGTATTAATTTGGCATTTTTTGTGACCATAAGT
CTGGTCGCCGGATTATTGGGTGGAGTGGACAATGCTGCCCATGTTGGCGGATTGCTGAGTGGGTTAGTGGTTGGTTACCT
TTCGCTGCGCTATGCTCAGCGGGCTCAGGGGGATCGAGGTGCTCAGAGAGCTCGGAAGATTGAGGGCCATAGTCCAGCTA
AAAAACGTAAGCCGAGACGCAAATAA

Upstream 100 bases:

>100_bases
GGCCTTTGGCTTTTTAATACTGTAAGTCCTTGATGATTTTTGGTAAATTCCCCGTGGTATTACTACCATAGTGATTGATG
TACTCAAGGAAGAAATACGT

Downstream 100 bases:

>100_bases
GCCGCGCTCGGCTTTGGATTTAAGAAGATTTAGGCGTGTTCAAACATTAAGAACAAGTAAACGATAAACAGCACTATATG
CGTCGCGCCGTGCAGGGCAT

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MDVLLKKLQLIYFPFLFTSLLFISGYSLIHWLLLIKFEFFSIDEDLVNFGLPLILSWLLLLVFLRPRLKLLKFVKDNSRF
YYLLFAVQLVAVPCIIAQEYLKTATGQLTQLASIQELYLHKKTQYYQLQQAYIDKTQIGVQRKIEVTGKSNSHLNMTLYI
AMPIFASGADRRRTSVLAWYGKTYQQEISNRLEPDEKEQAYKAFLTQSQREFDKFDPQTFVYLERLAPSSLKRDLLSAAE
KSPLYQAEYPTIFMPKFEPFEARNGHKLAWMLIWFVAGALVWFVLLLRVKLDEEVLKAETVTKRLNHAGTIAELNDFFEM
IRPKPGFIATPILMYFNVLVFILMAWSSQHFINLQGSFLLEWGANFRPKVLAGEWWRLITSTFIHGGLAHLALNLYGLFF
VGSFLEPVLGKWRLFLAYLITGILASIASICWYDATVSVGASGAIMGLLGILVIWAWKKIFPEDINWILSINLAFFVTIS
LVAGLLGGVDNAAHVGGLLSGLVVGYLSLRYAQRAQGDRGAQRARKIEGHSPAKKRKPRRK

Sequences:

>Translated_541_residues
MDVLLKKLQLIYFPFLFTSLLFISGYSLIHWLLLIKFEFFSIDEDLVNFGLPLILSWLLLLVFLRPRLKLLKFVKDNSRF
YYLLFAVQLVAVPCIIAQEYLKTATGQLTQLASIQELYLHKKTQYYQLQQAYIDKTQIGVQRKIEVTGKSNSHLNMTLYI
AMPIFASGADRRRTSVLAWYGKTYQQEISNRLEPDEKEQAYKAFLTQSQREFDKFDPQTFVYLERLAPSSLKRDLLSAAE
KSPLYQAEYPTIFMPKFEPFEARNGHKLAWMLIWFVAGALVWFVLLLRVKLDEEVLKAETVTKRLNHAGTIAELNDFFEM
IRPKPGFIATPILMYFNVLVFILMAWSSQHFINLQGSFLLEWGANFRPKVLAGEWWRLITSTFIHGGLAHLALNLYGLFF
VGSFLEPVLGKWRLFLAYLITGILASIASICWYDATVSVGASGAIMGLLGILVIWAWKKIFPEDINWILSINLAFFVTIS
LVAGLLGGVDNAAHVGGLLSGLVVGYLSLRYAQRAQGDRGAQRARKIEGHSPAKKRKPRRK
>Mature_541_residues
MDVLLKKLQLIYFPFLFTSLLFISGYSLIHWLLLIKFEFFSIDEDLVNFGLPLILSWLLLLVFLRPRLKLLKFVKDNSRF
YYLLFAVQLVAVPCIIAQEYLKTATGQLTQLASIQELYLHKKTQYYQLQQAYIDKTQIGVQRKIEVTGKSNSHLNMTLYI
AMPIFASGADRRRTSVLAWYGKTYQQEISNRLEPDEKEQAYKAFLTQSQREFDKFDPQTFVYLERLAPSSLKRDLLSAAE
KSPLYQAEYPTIFMPKFEPFEARNGHKLAWMLIWFVAGALVWFVLLLRVKLDEEVLKAETVTKRLNHAGTIAELNDFFEM
IRPKPGFIATPILMYFNVLVFILMAWSSQHFINLQGSFLLEWGANFRPKVLAGEWWRLITSTFIHGGLAHLALNLYGLFF
VGSFLEPVLGKWRLFLAYLITGILASIASICWYDATVSVGASGAIMGLLGILVIWAWKKIFPEDINWILSINLAFFVTIS
LVAGLLGGVDNAAHVGGLLSGLVVGYLSLRYAQRAQGDRGAQRARKIEGHSPAKKRKPRRK

Specific function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of tatA by removal of its N- ter

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 61896; Mature: 61896

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8051030 [H]