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The map label for this gene is hldE [H]

Identifier: 160874066

GI number: 160874066

Start: 1119865

End: 1121295

Strand: Direct

Name: hldE [H]

Synonym: Sbal195_0946

Alternate gene names: 160874066

Gene position: 1119865-1121295 (Clockwise)

Preceding gene: 160874064

Following gene: 160874067

Centisome position: 20.94

GC content: 51.92

Gene sequence:

>1431_bases
ATGAAGGTTTCTCTGCCAGCATTTGAAAAAGCCAGAGTGTTAGTCGTCGGCGATGTGATGTTAGACCGCTATTGGGTTGG
CCCAACGGGACGTATCTCCCCCGAAGCTCCCGTACCTGTGGTGAAGATTAATCAAGTCGAAGACAGACCCGGCGGCGCGG
CCAACGTGGCGCTCAATATCGCGACCTTAGGTGGTCAAGTCCAACTTGCTGGGCTCGTCGGTCAAGACGATACCGCCCAT
GCCTTAACGCTTGGCGTGCAAACCTTAGGGGTTGAACCACAATGGTTAACCATTGCAGACAAGCCAACCATCACTAAGTT
ACGGGTGTTATCACGTAACCAGCAGTTGATCCGCCTCGATTTCGAAGAAGCTTTTGACAAGGCCGATAGTGTGCGTTTGC
TCAAGCAATCTGAGGCGTTACTCGATTCCGTCGATGTGGTGGTGTTGTCAGATTATGCTAAGGGCGCTATCGATCAGCCG
CGAGATTTTATTGCGCTTGCCCGCGCAAAAGGTGTGATGGTGTTAGTCGATCCTAAGGGCAGTGACTTTGGCCGTTATCA
GGGCGCGTCATTGATTACCCCGAATATGAGCGAGTTTGAAGCCGTTGTTGGCACTGTGACCTCAGAAGCGGATCTGCTGG
AAAAAGCCCGTGGCTTACTTAAGCAACATCATTTTGATGCCATCTTAGTTACCCGCTCTGAAAAGGGCATGACCTTAGTG
ACTGCCAATGCGCCCGAGCTGCACATTCCTACCGTTGCCCGTGAAGTCTATGACGTGACGGGTGCTGGCGATACTGTAAT
TTCTGCCTTAGCAACCTCATTAGCCGCGGGCGCCGATTTACCGCAAGCTTGTGCGATTGCGAACACTGCCGCTGGCGTAG
TGGTTGGTAAACTTGGCACTTCTACCGTGAGCCGCATTGAGCTTATTGAAGCTTTGGCTTTGCATCATGGAGAATCGGGT
TTTGGGGTGGTGAGTGAAGATCAGCTCGCCTATGCCTTAGAGCAGGCCAAACTGCGCGGTGAGCGTGTGGTAATGACCAA
TGGTTGCTTTGATATTTTGCATGCGGGCCACGTGAGTTACCTCAAACAAGCCAAAGCCTTAGGCGATCGTTTGATTGTTG
CAGTAAACGATGATGCCTCGGTTAAACGCCTTAAGGGTGATGGTCGTCCGGTCAATCAGGTTGATCGCCGTATGGCCGTG
CTCGCTGGCTTAGCCTCTGTCGATTGGGTGGTGCCTTTTAGTGAAGATACGCCGCAGCGCATTATCACTCGACTGCTGCC
AAATCTACTGGTTAAAGGCGGCGACTATAAGCTTGAAGATATCGCGGGCGGCGCTGAAGTGATTGCCGCCGGTGGTCAAG
TACAAGTGCTGGGCTTTGAGGATGGTATTTCAACCACGGCGATTATTCAAAATATCATGGCGAATCAGTGA

Upstream 100 bases:

>100_bases
AATACTCACTACTTTTGAAAATTACTGCTTATTCTAACTCAATTTTTACTGAAAATTAGGTACAATCACGGTTTAATTTC
TGCATAAAGATAAGAGCACT

Downstream 100 bases:

>100_bases
GCTTAGTTGCTCTGGTATTCGCATCTAGCTTGTCTTGGACGCCCATTGCCGATAAGCAGGCTTTGATTTGCCCTTTACCA
GAGCTGGGCACTTGCTTGGC

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNIATLGGQVQLAGLVGQDDTAH
ALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLDFEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQP
RDFIALARAKGVMVLVDPKGSDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLV
TANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGTSTVSRIELIEALALHHGESG
FGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSYLKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAV
LAGLASVDWVVPFSEDTPQRIITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ

Sequences:

>Translated_476_residues
MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNIATLGGQVQLAGLVGQDDTAH
ALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLDFEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQP
RDFIALARAKGVMVLVDPKGSDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLV
TANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGTSTVSRIELIEALALHHGESG
FGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSYLKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAV
LAGLASVDWVVPFSEDTPQRIITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ
>Mature_476_residues
MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNIATLGGQVQLAGLVGQDDTAH
ALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLDFEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQP
RDFIALARAKGVMVLVDPKGSDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLV
TANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGTSTVSRIELIEALALHHGESG
FGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSYLKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAV
LAGLASVDWVVPFSEDTPQRIITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=476, Percent_Identity=61.3445378151261, Blast_Score=579, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 50494; Mature: 50494

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNI
CCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEE
ATLGGQVQLAGLVGQDDTAHALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLD
EEECCEEEEEEEECCCCCCCEEEEEHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEEEEE
FEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQPRDFIALARAKGVMVLVDPKG
HHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCC
SDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLV
CCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
TANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGT
ECCCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCC
STVSRIELIEALALHHGESGFGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSY
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
LKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAVLAGLASVDWVVPFSEDTPQR
HHHHHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHH
IITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ
HHHHHHHHHHCCCCCEEEHHHCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNI
CCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEE
ATLGGQVQLAGLVGQDDTAHALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLD
EEECCEEEEEEEECCCCCCCEEEEEHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEEEEE
FEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQPRDFIALARAKGVMVLVDPKG
HHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCC
SDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLV
CCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
TANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGT
ECCCCCEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCC
STVSRIELIEALALHHGESGFGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSY
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
LKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAVLAGLASVDWVVPFSEDTPQR
HHHHHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHH
IITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ
HHHHHHHHHHCCCCCEEEHHHCCCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA