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The map label for this gene is tlpA [H]

Identifier: 160873400

GI number: 160873400

Start: 312569

End: 314524

Strand: Direct

Name: tlpA [H]

Synonym: Sbal195_0274

Alternate gene names: 160873400

Gene position: 312569-314524 (Clockwise)

Preceding gene: 160873391

Following gene: 160873402

Centisome position: 5.85

GC content: 49.59

Gene sequence:

>1956_bases
ATGGGTTTTACTCGTAAAATTCAGCTGATCAGTTTATTGATTGTCCTACTACCCCTCATATTTGCTACCGCGATAGTGAC
TTACATTGCTCGGGATGAGTTATTTGCCGAGGCTCAGTCTCGTTTAGTGGCGGTGCGCGAGATCAAGCAGCGACAGATTG
TCGGTATGTTTCAGGACTTTTCAGATAACCTGCAGGCCGTCAGTGCGGTGATCGCCAGCCAAAAAAGCCTCGATACTATC
TCCGACCTTGATGAGACCTTAAAGTCGTTAAATAAGTCTTTAGGTTTCTATGATCTGTTCATCATTCGGGATGACGGCAC
TGTGTTTTACACCGCCGCGAAGGAGTCGGATTTCGGCACAAATCTTCGCACTGGGCCCTACCATGATTCGGGGTTAGCGC
AGTTATTCAACAAGGCATTGGGGTCGACTGGTACTGTATTGCTGCAAGACTTCTCCGCATACGCTCCTTCAAATGGTCAA
CCGGCAGCATTTATTGGTCAGTCGATTCAATTCAACCAGCAAAGATTAGTGGTGGCGGCTCAAGTATCAATCGACCGCAT
CAACCGAGTTATGCAGATCCGCGAAGGTATGGGACAAAGTGGCGAGACCTATTTAATTGGCCCCAATAATCGCATGCGTT
CCGATTCTTTTCTTGACCCGAACAATCGCACTGTGACCGCCTCCTTCGCTGGAACGGTTGCCCAGAATGGTGTTGACACA
CTTGCGGTGAAAGAGGCGCTGGCGGGTAAGACTGGTGTGATGCAAGTGAATGACTACAATCATAATCCGGTGTTATCTGC
CTATTCTCCCGTTGTTGAACTTGGCTTACGTTGGGGCTTGATGGCTGAAATTGATGTGAGCGAAATCGCTGCGCCAGCCT
ATCGAATGCTATTTATCGGCTTATTTGTTTGTGTGGCGGCCTTAGTGTTGGCATTCGCTGCCGCTAAGTTAGTCACAGGA
TTTGTGTTGAAGCCACTCGGCGGTGAGCCTGAGGATATGTGTAACTTGACCAGCATGATCGCTTCTGGCGATCTCACCCA
TAATCTGCCCCATGTTCAAACGGATAATCATCTGATGAGCTGGTTGGCCCGGATGCAAACAAAGCTCAAAGAAATCATTA
GTCAGCTGGTGGGCGTTGGACATGAACTCGAATCCGCCGCTGAACAAAACTCGGCCGCTATGACCCAAGCCGATTGCAGT
ATTCAGATGCAGGCGAAAGAGACCGATATGTTAGCAACCGCAGTCGAAGAAATGAGTTATGCCGCCGCGGAAATCAGCAC
TAATACGCTTAAATCCTCCGATGAAGTGTCAGCCTGTACCCATTCGAGTGAAATTCTTTCGCAAAATTTAGCCAGTACAC
GTAAAAGCTTGAAAGTGACCTTGAGCAGTTTTGCGACCATTCATCAACAGGTGGGCAGCCTTGAGGCCGACAGTCAGAAA
ATCGGTTCGGTATTGGCTGTGATTAATGCGATAGCCGAACAAACGAATCTGCTGTCACTTAATGCGGCGATTGAAGCGGC
GAGAGCTGGTGAACATGGTCGTGGCTTTGCCGTAGTTGCCGATGAGGTGCGCCAGTTAGCAGTTAAGGTTCAGTTGGCGA
CTCAGGATATTGGCCAAGTGTTAAAAGGCATTCAGCAGCAGTCTGGCGTGTTGGCACTGCATAGCGTGACTTGTACTACA
GAAGCCTCTAAAACCGCAGAAGATGCCGATGGCATGCAAGCCGCAGTGGATGACATCGCTTTACGTTTGGAAACCTTAAA
GGCATTAATGATCCAAACCGCCACCGCCGCGGAGGAGCAAACAACGGTTTCGGCAACGATTGCACAGGGGATTGCGGGCT
TGAGCGTGGCGGCGGAAGAAAATAGCGCGGCGATCAGCCAAGTGGCAGCGAGTACTCGCAGTTTGTTAGGGTTAGCGAAT
CAGCTTGGTTTAACAACGGCACAGTTTAAGGTGTAG

Upstream 100 bases:

>100_bases
CGCTTTGTTTAGCTGAGATTCTTCTCCTATAGTTTTAGGGCAGATTTAATTTTGCAAAAAGTGAATGAATGGAATTCGAA
GCGCGACAAGGAGTCTCACC

Downstream 100 bases:

>100_bases
GTATTTGCGCTGTATTTGCCGTGTTCAACTTTAGTTGATGCTGCAAAGATGACTGAGCTGGATGTTACACATCCGCCAGA
AATGGATTTCTGGCGGATAT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVGMFQDFSDNLQAVSAVIASQKSLDTI
SDLDETLKSLNKSLGFYDLFIIRDDGTVFYTAAKESDFGTNLRTGPYHDSGLAQLFNKALGSTGTVLLQDFSAYAPSNGQ
PAAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPNNRTVTASFAGTVAQNGVDT
LAVKEALAGKTGVMQVNDYNHNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLFVCVAALVLAFAAAKLVTG
FVLKPLGGEPEDMCNLTSMIASGDLTHNLPHVQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMTQADCS
IQMQAKETDMLATAVEEMSYAAAEISTNTLKSSDEVSACTHSSEILSQNLASTRKSLKVTLSSFATIHQQVGSLEADSQK
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCTT
EASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLAN
QLGLTTAQFKV

Sequences:

>Translated_651_residues
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVGMFQDFSDNLQAVSAVIASQKSLDTI
SDLDETLKSLNKSLGFYDLFIIRDDGTVFYTAAKESDFGTNLRTGPYHDSGLAQLFNKALGSTGTVLLQDFSAYAPSNGQ
PAAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPNNRTVTASFAGTVAQNGVDT
LAVKEALAGKTGVMQVNDYNHNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLFVCVAALVLAFAAAKLVTG
FVLKPLGGEPEDMCNLTSMIASGDLTHNLPHVQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMTQADCS
IQMQAKETDMLATAVEEMSYAAAEISTNTLKSSDEVSACTHSSEILSQNLASTRKSLKVTLSSFATIHQQVGSLEADSQK
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCTT
EASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLAN
QLGLTTAQFKV
>Mature_650_residues
GFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVGMFQDFSDNLQAVSAVIASQKSLDTIS
DLDETLKSLNKSLGFYDLFIIRDDGTVFYTAAKESDFGTNLRTGPYHDSGLAQLFNKALGSTGTVLLQDFSAYAPSNGQP
AAFIGQSIQFNQQRLVVAAQVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPNNRTVTASFAGTVAQNGVDTL
AVKEALAGKTGVMQVNDYNHNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIGLFVCVAALVLAFAAAKLVTGF
VLKPLGGEPEDMCNLTSMIASGDLTHNLPHVQTDNHLMSWLARMQTKLKEIISQLVGVGHELESAAEQNSAAMTQADCSI
QMQAKETDMLATAVEEMSYAAAEISTNTLKSSDEVSACTHSSEILSQNLASTRKSLKVTLSSFATIHQQVGSLEADSQKI
GSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQVLKGIQQQSGVLALHSVTCTTE
ASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQTTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQ
LGLTTAQFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=277, Percent_Identity=30.3249097472924, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787690, Length=378, Percent_Identity=28.8359788359788, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1789453, Length=154, Percent_Identity=39.6103896103896, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI2367378, Length=265, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788195, Length=139, Percent_Identity=36.6906474820144, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 69402; Mature: 69271

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVGMFQDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNLQAVSAVIASQKSLDTISDLDETLKSLNKSLGFYDLFIIRDDGTVFYTAAKESDFGT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCC
NLRTGPYHDSGLAQLFNKALGSTGTVLLQDFSAYAPSNGQPAAFIGQSIQFNQQRLVVAA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEE
QVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPNNRTVTASFAGTVAQNGVDT
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCHH
LAVKEALAGKTGVMQVNDYNHNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIG
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
LFVCVAALVLAFAAAKLVTGFVLKPLGGEPEDMCNLTSMIASGDLTHNLPHVQTDNHLMS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
WLARMQTKLKEIISQLVGVGHELESAAEQNSAAMTQADCSIQMQAKETDMLATAVEEMSY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHEECCCCEEEECHHHHHHHHHHHHHHH
AAAEISTNTLKSSDEVSACTHSSEILSQNLASTRKSLKVTLSSFATIHQQVGSLEADSQK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQV
HHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LKGIQQQSGVLALHSVTCTTEASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQ
HHHHHHHCCEEEEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQLGLTTAQFKV
HHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
GFTRKIQLISLLIVLLPLIFATAIVTYIARDELFAEAQSRLVAVREIKQRQIVGMFQDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDNLQAVSAVIASQKSLDTISDLDETLKSLNKSLGFYDLFIIRDDGTVFYTAAKESDFGT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCCC
NLRTGPYHDSGLAQLFNKALGSTGTVLLQDFSAYAPSNGQPAAFIGQSIQFNQQRLVVAA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEE
QVSIDRINRVMQIREGMGQSGETYLIGPNNRMRSDSFLDPNNRTVTASFAGTVAQNGVDT
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCHH
LAVKEALAGKTGVMQVNDYNHNPVLSAYSPVVELGLRWGLMAEIDVSEIAAPAYRMLFIG
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHH
LFVCVAALVLAFAAAKLVTGFVLKPLGGEPEDMCNLTSMIASGDLTHNLPHVQTDNHLMS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
WLARMQTKLKEIISQLVGVGHELESAAEQNSAAMTQADCSIQMQAKETDMLATAVEEMSY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHEECCCCEEEECHHHHHHHHHHHHHHH
AAAEISTNTLKSSDEVSACTHSSEILSQNLASTRKSLKVTLSSFATIHQQVGSLEADSQK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IGSVLAVINAIAEQTNLLSLNAAIEAARAGEHGRGFAVVADEVRQLAVKVQLATQDIGQV
HHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LKGIQQQSGVLALHSVTCTTEASKTAEDADGMQAAVDDIALRLETLKALMIQTATAAEEQ
HHHHHHHCCEEEEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
TTVSATIAQGIAGLSVAAEENSAAISQVAASTRSLLGLANQLGLTTAQFKV
HHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]