Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 160873367

GI number: 160873367

Start: 280866

End: 282182

Strand: Reverse

Name: phoQ [H]

Synonym: Sbal195_0241

Alternate gene names: 160873367

Gene position: 282182-280866 (Counterclockwise)

Preceding gene: 160873368

Following gene: 160873366

Centisome position: 5.28

GC content: 49.66

Gene sequence:

>1317_bases
GTGTATTCACTCAAGGGTTATCTGACGCGCAATCTGCTGATCACGCTCACCTTTGCCATGGTGCTGCTACTGTATTTTCT
GTACCAAGGTATTCAAATATTAACCCAAGATTTTGTTGCTTCGCGATTGCAGCACGATGCCGACAGCCTGATCTCCGCCC
TGAATAACCATCCCGATGGCACCTGGGCGCTCACCACTGACCGCTTACCCAATGTGTACCACAGGGTTAATTCTGGGCAT
TATTTTGCGATTCTAATCGGCGAGCAAACCCTGCGCTCACGCTCCCTATTCGACCATAACGTGAACATGCCAAAACTGAT
CGCCGGTGAGCACCACCAAGCCACTGAGTTTGTCGGCAAAGAACATTGGCTGATGTTCAGTCAGGCCGTAATCAAAGATG
ATCAATTAGTTACCCTGTGGGTGACAGAAGACATCAGCGAGCTCGAACAAACTCAAGTACAGTTTTTAGCCTTTGCTAGC
GCGGCCGTGTTGCTCACGATTGTTATTCTATTACTAGCGCAGTATCAGCTACTGAAACGCGGCTTTAAACCCTTAGAGCA
GATGCCTGAAGCCATACGGCAGATGCGCACCCAAGGGCAAGAAATTAATCCAGACCAAATGCCGAGCGAAATCATCCCGC
TGATTGAGGAGATAGATCGTTTAGTCAATCAATTGGGCCAACGAGTACAACGCTCCCGTAATGCCTTGGGTAACTTAGCC
CACGAAATGAAACGTCCGCTACAAGGGCTGCAGTCCTACCTAGAAAGCCTTCCACCGGAACAGAGGAGTGAGGGCAGCAA
GGTGCTCGCAAACCTGCACCACATCATTGAGAGAGAGCTTAAGCGCACTAAGATTGTCGGCCTGTCTACTCCGGGGCGTT
ATACCGTACTCGATGACGATCTCGCGCCGCTAATCAAAGTAATGCAGCGTATTTACCCAGACCGCATTATTCATAGCCAT
TACGCGAGTGGCTTAGTGATGCCATTTGACCGCGATGACTTACTCGAACTCTTAGGCAATTTACTGGATAACGCCTGCAA
GCATAGCCGCAAGAACATTGAGATCCGTATAGTGCATCAAACGGCTGCCACCGCAGGTTATGGGATCATAGTCAGCGATG
ATGGCGAAGGCGTCTCCGATGCCGCATTGTCGATTATCATCGAGCGCGGCATTCGGTTAGATGAAAGCATCCAAGGCCAT
GGCTTAGGATTATCAATCTGCAAAGATATCGTTGACAGTTATCAGGGCGAACTTAGCTTTAGCCACGCGAAACAAGGTGG
ACTCGAAGCCAGCGTATTTCTGCCGATCCCAAGTTAA

Upstream 100 bases:

>100_bases
ATGTCATCGAAGTGTACGTCAACCGCCTGCGCCAACGCTTAGGCAAGGATTATATCGAAACCCGTCGCGGCCAAGGTTAT
CGACTCAAGGAGTAAAAGGC

Downstream 100 bases:

>100_bases
GCGGTATACTCAGCCAAACCGTGCTCAATCAAACCTGCCACCACATCATTCAGACCAGCGAACGGACTTAAGTATTCGTG
CCACTATGTCGCACCATTAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MYSLKGYLTRNLLITLTFAMVLLLYFLYQGIQILTQDFVASRLQHDADSLISALNNHPDGTWALTTDRLPNVYHRVNSGH
YFAILIGEQTLRSRSLFDHNVNMPKLIAGEHHQATEFVGKEHWLMFSQAVIKDDQLVTLWVTEDISELEQTQVQFLAFAS
AAVLLTIVILLLAQYQLLKRGFKPLEQMPEAIRQMRTQGQEINPDQMPSEIIPLIEEIDRLVNQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLPPEQRSEGSKVLANLHHIIERELKRTKIVGLSTPGRYTVLDDDLAPLIKVMQRIYPDRIIHSH
YASGLVMPFDRDDLLELLGNLLDNACKHSRKNIEIRIVHQTAATAGYGIIVSDDGEGVSDAALSIIIERGIRLDESIQGH
GLGLSICKDIVDSYQGELSFSHAKQGGLEASVFLPIPS

Sequences:

>Translated_438_residues
MYSLKGYLTRNLLITLTFAMVLLLYFLYQGIQILTQDFVASRLQHDADSLISALNNHPDGTWALTTDRLPNVYHRVNSGH
YFAILIGEQTLRSRSLFDHNVNMPKLIAGEHHQATEFVGKEHWLMFSQAVIKDDQLVTLWVTEDISELEQTQVQFLAFAS
AAVLLTIVILLLAQYQLLKRGFKPLEQMPEAIRQMRTQGQEINPDQMPSEIIPLIEEIDRLVNQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLPPEQRSEGSKVLANLHHIIERELKRTKIVGLSTPGRYTVLDDDLAPLIKVMQRIYPDRIIHSH
YASGLVMPFDRDDLLELLGNLLDNACKHSRKNIEIRIVHQTAATAGYGIIVSDDGEGVSDAALSIIIERGIRLDESIQGH
GLGLSICKDIVDSYQGELSFSHAKQGGLEASVFLPIPS
>Mature_438_residues
MYSLKGYLTRNLLITLTFAMVLLLYFLYQGIQILTQDFVASRLQHDADSLISALNNHPDGTWALTTDRLPNVYHRVNSGH
YFAILIGEQTLRSRSLFDHNVNMPKLIAGEHHQATEFVGKEHWLMFSQAVIKDDQLVTLWVTEDISELEQTQVQFLAFAS
AAVLLTIVILLLAQYQLLKRGFKPLEQMPEAIRQMRTQGQEINPDQMPSEIIPLIEEIDRLVNQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLPPEQRSEGSKVLANLHHIIERELKRTKIVGLSTPGRYTVLDDDLAPLIKVMQRIYPDRIIHSH
YASGLVMPFDRDDLLELLGNLLDNACKHSRKNIEIRIVHQTAATAGYGIIVSDDGEGVSDAALSIIIERGIRLDESIQGH
GLGLSICKDIVDSYQGELSFSHAKQGGLEASVFLPIPS

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=28.5223367697594, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789403, Length=398, Percent_Identity=28.1407035175879, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=27.2357723577236, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=25.531914893617, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=25.3623188405797, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49304; Mature: 49304

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLKGYLTRNLLITLTFAMVLLLYFLYQGIQILTQDFVASRLQHDADSLISALNNHPDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TWALTTDRLPNVYHRVNSGHYFAILIGEQTLRSRSLFDHNVNMPKLIAGEHHQATEFVGK
CEEEECCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCC
EHWLMFSQAVIKDDQLVTLWVTEDISELEQTQVQFLAFASAAVLLTIVILLLAQYQLLKR
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFKPLEQMPEAIRQMRTQGQEINPDQMPSEIIPLIEEIDRLVNQLGQRVQRSRNALGNLA
CCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEMKRPLQGLQSYLESLPPEQRSEGSKVLANLHHIIERELKRTKIVGLSTPGRYTVLDDD
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCC
LAPLIKVMQRIYPDRIIHSHYASGLVMPFDRDDLLELLGNLLDNACKHSRKNIEIRIVHQ
HHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
TAATAGYGIIVSDDGEGVSDAALSIIIERGIRLDESIQGHGLGLSICKDIVDSYQGELSF
ECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
SHAKQGGLEASVFLPIPS
HHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MYSLKGYLTRNLLITLTFAMVLLLYFLYQGIQILTQDFVASRLQHDADSLISALNNHPDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TWALTTDRLPNVYHRVNSGHYFAILIGEQTLRSRSLFDHNVNMPKLIAGEHHQATEFVGK
CEEEECCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHCC
EHWLMFSQAVIKDDQLVTLWVTEDISELEQTQVQFLAFASAAVLLTIVILLLAQYQLLKR
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFKPLEQMPEAIRQMRTQGQEINPDQMPSEIIPLIEEIDRLVNQLGQRVQRSRNALGNLA
CCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEMKRPLQGLQSYLESLPPEQRSEGSKVLANLHHIIERELKRTKIVGLSTPGRYTVLDDD
HHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCC
LAPLIKVMQRIYPDRIIHSHYASGLVMPFDRDDLLELLGNLLDNACKHSRKNIEIRIVHQ
HHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
TAATAGYGIIVSDDGEGVSDAALSIIIERGIRLDESIQGHGLGLSICKDIVDSYQGELSF
ECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCH
SHAKQGGLEASVFLPIPS
HHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]