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The map label for this gene is dnaA

Identifier: 160873127

GI number: 160873127

Start: 382

End: 1770

Strand: Direct

Name: dnaA

Synonym: Sbal195_0001

Alternate gene names: 160873127

Gene position: 382-1770 (Clockwise)

Preceding gene: NA

Following gene: 160873128

Centisome position: 0.01

GC content: 44.56

Gene sequence:

>1389_bases
GTGGCTGTTTCACTTTGGCAACAATGTATCGGACGATTGCAAGATGAGCTTTCTGCTCAGCAGTTCAGTATGTGGATCAG
ACCGTTACAAGCCGAAATGGATGGAGATACTCTGGTGCTTTATGCGCCCAACCGCTTCGTGCTTGATTGGGTCAGAGATA
AGTACATCAATATCATTAATCAGTTCTTTACTGAGCAGATGGGCAGCGATGCACCTAAATTGCGTTTCGATATTGGTAGT
CGTCCTTCGGCGAAAAAGCCAAGTGTGCCAGCACCTATAGCGCCAACTCGTGTAGCGAATACCCAAACTAAAGCGACGGT
AGGCACGACGTTTAACGTCCAAGCCGAGCCGATGGCGAACGCGAATCACCGCAGTAACATTAATCCTAGCTACCAGTTTG
ATAACTTCGTAGAAGGTAAGTCAAACCAATTAGGTAAGGCTGCAGCGTTGCAAGTGGCTGAAAATCCAGGTGGTGCTTAT
AACCCATTATTCTTATATGGCGGAACAGGTCTAGGTAAGACTCACTTGTTGCACGCTGTCGGTAACGGGATCATTAAAAA
TAATCCGAATGCCAAAGTGGTTTACATGCATTCCGAGCGTTTTGTCCAAGACATGGTTAAAGCGCTGCAAAACAATGCGA
TCGAAGAATTTAAACGTTACTACCGTAGCGTCGATGCTTTGTTTATCGATGATATTCAATTTTTTGCCAATAAAGACAGA
TCCCAAGAAGAATTCTTCCATACCTTCAACGCCTTGCTTGAGGGTAATCACCAAATTATTTTGACTTCAGATCGTTATCC
AAAAGAGATCGACGGTGTTGAAGACAGATTGAAATCGCGTTTTGGTTGGGGTTTAACTGTGGCGATTGAGCCACCAGAGT
TAGAAACCCGCGTCGCGATTTTGATGCGTAAAGCCCAAGAGAGTGGCATTAACTTGCCCGATGAAGTGGCCTTCTTTATT
GCTAAACGTTTACGTTCAAACGTGCGTGAGCTAGAAGGGGCGTTAAACCGCGTTATTGCGAATGCTAACTTCACTGGCCG
CCCAATTACCATTGATTTTGTTCGTGAAGCTTTACGTGACCTCTTGGCACTTCAAGAAAAATTAGTCACTATAGACAATA
TTCAGAAAACCGTAGCTGAATACTACAAGATCAAGATGGCTGATATGTTGTCTAAGCGCCGTTCACGCAGTGTCGCGCGG
CCTAGACAAGTGGCAATGGCGTTATCCAAAGAATTAACTAACCAAAGCTTGCCGGAAATTGGTGATGCTTTTGGTGGTCG
AGATCACACCACAGTGTTGCATGCCTGTCGTAAGATTGCTCAGCTACGGGAAGAGAGCCACGACATTAAAGAAGATTATG
CTAATTTGATTAGAACCTTATCTTCTTAA

Upstream 100 bases:

>100_bases
GAATGATCTCGCTGGGGATAAATATTTTTTAAGGATAGCGATCCTTGAGATCTCGCTATAGAATACACCTCTTTTTTGAT
GATCTTTTGGGGATAACTAA

Downstream 100 bases:

>100_bases
AACAAGGAATTTGGACACTATGAAATTCTCAATTGATAGGGATGCCCTATTAAAGCCGTTGCAATTGGTGTGTGGTGCGG
TAGAAAGACGCCATAATTTG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGSDAPKLRFDIGS
RPSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMANANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAY
NPLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDR
SQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFI
AKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVAR
PRQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS

Sequences:

>Translated_462_residues
MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGSDAPKLRFDIGS
RPSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMANANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAY
NPLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDR
SQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFI
AKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVAR
PRQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
>Mature_461_residues
AVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGSDAPKLRFDIGSR
PSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMANANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAYN
PLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRS
QEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIA
KRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARP
RQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=469, Percent_Identity=79.9573560767591, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_SHEB2 (B8E3P4)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002355968.1
- ProteinModelPortal:   B8E3P4
- GeneID:   7089134
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_0001
- HOGENOM:   HBG695666
- OMA:   DEVAFLI
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52176; Mature: 52045

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIIN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
QFFTEQMGSDAPKLRFDIGSRPSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMAN
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEEECCCCCC
ANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAYNPLFLYGGTGLGKTHLLHAV
CCCCCCCCCCCCCCCHHCCCCCCCCHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHH
GNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDR
CCCCEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAI
CHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHH
LMRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
LLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHH
GDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
QFFTEQMGSDAPKLRFDIGSRPSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMAN
HHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEEECCCCCC
ANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAYNPLFLYGGTGLGKTHLLHAV
CCCCCCCCCCCCCCCHHCCCCCCCCHHHHHEEECCCCCCCCCEEEECCCCCCHHHHHHHH
GNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDR
CCCCEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAI
CHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHH
LMRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
LLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHH
GDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA