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The map label for this gene is nuoM [H]

Identifier: 159901501

GI number: 159901501

Start: 6326977

End: 6328491

Strand: Direct

Name: nuoM [H]

Synonym: Haur_4990

Alternate gene names: 159901501

Gene position: 6326977-6328491 (Clockwise)

Preceding gene: 159901500

Following gene: 159901502

Centisome position: 99.69

GC content: 51.42

Gene sequence:

>1515_bases
ATGCATTTGATCGAAAGTTTGCCAGCGGGCATTCCGTACCTGAGCCTTATCTGGTTGATTCCCTTACTTGGGGCTTTGGT
GATTATGTTTTTGCCCAAAGAGCAAAAACAAGCCATGCGGATTATCTCGGCAGTGGTTGCGACAATCTCGTTTGGCATCG
CCTTGCTGGTCTTTTTTGCCTATGATCCCAACGCAACGGGCTATATGGGCACCAAGATGCAGTTTGTCGAAAAGCTAGAT
TGGGTTCCGCAGCTCGGCATGTCGTATTTGGTCGGCGCTGATGGGATCAGCTTGCCCTTGATTGTTTTGAATGGTTTGGT
GATTTTCACTGGCACATTCATCTCATGGAATATCGAAGATCGGGTCAAGGAATATTTCGTCCTGCTGCTCTTGTTGGTGG
TCGGCGTGTACGGCGTGTTTATGGCGCTCGACTTGTTCCTGATGTTCGTGTTCTATGAATTGGCTGTGTTGCCAATGTAC
CTGCTGATCGGGATTTGGGGTTCGACGCGCAAAGAATATGGCGCGATGAAACTTACCATTTACTTGATGGTTGGTTCGGC
AGCCTTGATGATTGGGATGGTGGCGATTTACGTTGTGGGCGGTACCTTTAATATGGTCGAGCTTTCACAACGGGTATTCA
GCCTCGAATTCCAAAAAATCTTCTTCTTGCCAGTGTTTGTTGGGTTTGCCGTGTTGGCGGGGATGTTCCCCTTCCATACT
TGGTCGCCAACTGGTCACGTGGCTGCTCCGACAGCGGTTTCGATGCTCCACGCTGGGGTGTTGATGAAGCTGGGAGCTTA
TGGTGCATTACGGGCAGCGTTGTGGTTGATGCCAAACGGCGCACAATTCTGGTTGCCAGGCATTGCCGTCATGACCTTGA
TGAACGTCGTGTACGGGGCATCGATTGCGATGGTTCAGAAAGACTTCAAGTATGTGATCGGCTACTCATCAGTGAGCCAC
ATGGGCTTGGTGATGTTGGCGCTGGCCTCGATGAACGAAACCGCGCTCAACGGCGCAGTGATGCAAATGTTTGCCCACGG
CGTAATGACCGCCTTGTTCTTTGCGGTGGTTGGTCGGATGGTCTATGAACGGACGCACACCCGCCAATTGCCTGAACTCG
GTGGCTTGATGAAAGTTATGCCATTTGCCTTTGTCGTCTTCATCATCGCGAGTCTCTCGTCGATGGGGATGCCAGGCACG
GCAGGCTTTATGGCCGAGTTCACGATCTTCACTGGCGTGATGAACCAATATCCCTTGGTGGCGGCAGTCGCAGCTTTGTC
GATTCCAATTACTGCGGCCTATGTTTTGCGGGTTGGCTATATGGCGTTTATGGGCGAGGTCAAAGACCCGCACTACCATG
ATTTGCCACCGCTGACTTGGCAAGAAAAATTCTCAGGCACAGTCTTGGCGATTGTGGTGATTGGGGTTGGTTTATTCCCC
AGCATCATCATGGACTACATTGCGACCGGTGTCCAGCCCATTGCCCAGCGCATGATTGATCTAGCAGGACGTTAG

Upstream 100 bases:

>100_bases
GTTTGGGATTTTCCCCAAGCCACTGATGGATTTATCAAACTACGCAGCCACGGTGATGGCTCAGGTGTTTACAAACCTGT
AACGTGGACGGAGTTAAACG

Downstream 100 bases:

>100_bases
GGAGGAATGACGTGAATTTTCAAATAGCTGATTTTACGCGGCTCATCCCTGAGTTTTTGCTACTGGCGATTGCGGCCATG
GTGCTGCTTGGCGATGTCCT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MHLIESLPAGIPYLSLIWLIPLLGALVIMFLPKEQKQAMRIISAVVATISFGIALLVFFAYDPNATGYMGTKMQFVEKLD
WVPQLGMSYLVGADGISLPLIVLNGLVIFTGTFISWNIEDRVKEYFVLLLLLVVGVYGVFMALDLFLMFVFYELAVLPMY
LLIGIWGSTRKEYGAMKLTIYLMVGSAALMIGMVAIYVVGGTFNMVELSQRVFSLEFQKIFFLPVFVGFAVLAGMFPFHT
WSPTGHVAAPTAVSMLHAGVLMKLGAYGALRAALWLMPNGAQFWLPGIAVMTLMNVVYGASIAMVQKDFKYVIGYSSVSH
MGLVMLALASMNETALNGAVMQMFAHGVMTALFFAVVGRMVYERTHTRQLPELGGLMKVMPFAFVVFIIASLSSMGMPGT
AGFMAEFTIFTGVMNQYPLVAAVAALSIPITAAYVLRVGYMAFMGEVKDPHYHDLPPLTWQEKFSGTVLAIVVIGVGLFP
SIIMDYIATGVQPIAQRMIDLAGR

Sequences:

>Translated_504_residues
MHLIESLPAGIPYLSLIWLIPLLGALVIMFLPKEQKQAMRIISAVVATISFGIALLVFFAYDPNATGYMGTKMQFVEKLD
WVPQLGMSYLVGADGISLPLIVLNGLVIFTGTFISWNIEDRVKEYFVLLLLLVVGVYGVFMALDLFLMFVFYELAVLPMY
LLIGIWGSTRKEYGAMKLTIYLMVGSAALMIGMVAIYVVGGTFNMVELSQRVFSLEFQKIFFLPVFVGFAVLAGMFPFHT
WSPTGHVAAPTAVSMLHAGVLMKLGAYGALRAALWLMPNGAQFWLPGIAVMTLMNVVYGASIAMVQKDFKYVIGYSSVSH
MGLVMLALASMNETALNGAVMQMFAHGVMTALFFAVVGRMVYERTHTRQLPELGGLMKVMPFAFVVFIIASLSSMGMPGT
AGFMAEFTIFTGVMNQYPLVAAVAALSIPITAAYVLRVGYMAFMGEVKDPHYHDLPPLTWQEKFSGTVLAIVVIGVGLFP
SIIMDYIATGVQPIAQRMIDLAGR
>Mature_504_residues
MHLIESLPAGIPYLSLIWLIPLLGALVIMFLPKEQKQAMRIISAVVATISFGIALLVFFAYDPNATGYMGTKMQFVEKLD
WVPQLGMSYLVGADGISLPLIVLNGLVIFTGTFISWNIEDRVKEYFVLLLLLVVGVYGVFMALDLFLMFVFYELAVLPMY
LLIGIWGSTRKEYGAMKLTIYLMVGSAALMIGMVAIYVVGGTFNMVELSQRVFSLEFQKIFFLPVFVGFAVLAGMFPFHT
WSPTGHVAAPTAVSMLHAGVLMKLGAYGALRAALWLMPNGAQFWLPGIAVMTLMNVVYGASIAMVQKDFKYVIGYSSVSH
MGLVMLALASMNETALNGAVMQMFAHGVMTALFFAVVGRMVYERTHTRQLPELGGLMKVMPFAFVVFIIASLSSMGMPGT
AGFMAEFTIFTGVMNQYPLVAAVAALSIPITAAYVLRVGYMAFMGEVKDPHYHDLPPLTWQEKFSGTVLAIVVIGVGLFP
SIIMDYIATGVQPIAQRMIDLAGR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=342, Percent_Identity=29.2397660818713, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI251831117, Length=342, Percent_Identity=21.9298245614035, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788613, Length=497, Percent_Identity=31.3883299798793, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1788827, Length=325, Percent_Identity=26.7692307692308, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788614, Length=461, Percent_Identity=27.3318872017354, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=25.4854368932039, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=26.8011527377522, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693160, Length=396, Percent_Identity=28.030303030303, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI2367154, Length=347, Percent_Identity=25.3602305475504, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55151; Mature: 55151

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.5 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLIESLPAGIPYLSLIWLIPLLGALVIMFLPKEQKQAMRIISAVVATISFGIALLVFFA
CCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDPNATGYMGTKMQFVEKLDWVPQLGMSYLVGADGISLPLIVLNGLVIFTGTFISWNIED
CCCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHCCHHHEEECEEEECHHH
RVKEYFVLLLLLVVGVYGVFMALDLFLMFVFYELAVLPMYLLIGIWGSTRKEYGAMKLTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEE
YLMVGSAALMIGMVAIYVVGGTFNMVELSQRVFSLEFQKIFFLPVFVGFAVLAGMFPFHT
EEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WSPTGHVAAPTAVSMLHAGVLMKLGAYGALRAALWLMPNGAQFWLPGIAVMTLMNVVYGA
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
SIAMVQKDFKYVIGYSSVSHMGLVMLALASMNETALNGAVMQMFAHGVMTALFFAVVGRM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYERTHTRQLPELGGLMKVMPFAFVVFIIASLSSMGMPGTAGFMAEFTIFTGVMNQYPLV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AAVAALSIPITAAYVLRVGYMAFMGEVKDPHYHDLPPLTWQEKFSGTVLAIVVIGVGLFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
SIIMDYIATGVQPIAQRMIDLAGR
HHHHHHHHHCHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA