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The map label for this gene is nuoM [H]

Identifier: 159901500

GI number: 159901500

Start: 6325261

End: 6326958

Strand: Direct

Name: nuoM [H]

Synonym: Haur_4989

Alternate gene names: 159901500

Gene position: 6325261-6326958 (Clockwise)

Preceding gene: 159901499

Following gene: 159901501

Centisome position: 99.66

GC content: 51.24

Gene sequence:

>1698_bases
ATGCTGAACGAATTTATCAAATTCAGTGATTGGAGCATCACCACGCTAATTGCCCTTTCGCCATTGGTGGGGATGTTGCT
GGCCTTGGTATTCCCCAAGCCAGCCGAAAACAGCCGCACGATTGCTTGGGGGGTGTTTGCGTGGAGCTTGGTGCCACTCG
GACTCACGCTCTTCTTGTGGCTTAGCGGTGGGTTTAATCCAGCCCTCGCTTCTGTCGCTGGCGATCAAGCCATGATCCAG
CAAGTGGATCGGGTGCGCTGGGTTCCATTTTTCAACGCTGACTATTTTGTTGGCCTTGATGGCCTGAACTTCCCGCTGGT
GTTTTTGACCACAGCGTTAACGCCAGTCTGTATCTTGGCAGCCTTCCGCATCAAACATCGCCAAAACGTCTATTTGGCCT
TGATGTTGTTGTTGGAATCGGCGATGTTGGGCTATTTCGTATCGCTCAACTTCTTGCTGTTGTTCCTGTTCTGGGAATTC
AGCTTGGTGCCAATGTTCTTTATTATCAACAACTGGGGTGGTGAAAACCGCCGCTACGCTGCCTTCAAGTTCTTCGTGTA
TACGATGGCTGGCTCGGTGGCGATGTTGTTGATTTTCGAATTTATCTATTTGGCGACTGGTACCTTCGATTTGGTGGTGC
TCTCACGCTTGGGTCAGGGCTTGCCCGTTGATCCAGCCTTGCTTGCGCCAAAATTGGGTGCAGGCTACACCAGCGGCGCA
ACCTTGCAATCAATGTTGTTCAGCGCCGTCGAAGATATTGGCTTGACCAGCATTTTGGGTACAAGCAATGGCACCCCAGC
AGCAATTGTCTTCTGGAGTATCTTTGTGGCCTTTGCGGTGAAATTGGCAGTTTGGCCGTTGCACACCTGGCAGCCCGACA
CTTACGAAAATGCCCCAACCAGTGGCTCGATGATTGTCTCAGCCGTGATGTCGAAGATGGGTGCGTATGGCATGATCCGC
ATTATGATTATGCTCTTCCCCCAACAAACCAAATTCTTCGCACCAGCGTTAGCAATCTTGGCCTTGGCAAGCATTTTGTT
TGGTGCCTACGCTGGTTTGGCCCAAATCAACCTTAAGCGTTTGATCGCCTATGCTTCGATTAACCACATGGGCTATGTTT
TGCTTGGCTTGGCGGCAGTAGCTTCGGCAGCGCCCGAAAGCCTTGGCGACTTAGCCGTGAATATCCGCGCCTCAGCAATG
AATGGGGTGCAAGCACAGATGGTTGCCCACGGTTTCAGCACCGCCGCATTGTTCTTCCTCGCGGGTGAACTCTACGAACG
GACTGGCACGTACCAGCTTGATCAATTTGGCGGCTTGCGTAAAGTTATGCCAATTTTTGCTGGGATTATGGGCGTGGCGA
TGTTTGCCAACCTTGGGTTACCTGGTTTGGCTGGCTTCGTCGGCGAATTCTTTATTTTCCGTGGCGCGTGGGGCACGCAG
CCAGTGATCACCACAATTGCTGTGTTGGGCTTGATTGTGACTGCCTTGGTGCTGATCCGAATGTATCAAAAGATCTTCTA
CGGGCCAGTTAACCACAAGCTGACCAACCTGCCAGACATCAAAGTTGGTGATTGGGCCTTCAACGTAACCCTACCGTTGA
TTATTGTACTGTTGGTGTTTGGGATTTTCCCCAAGCCACTGATGGATTTATCAAACTACGCAGCCACGGTGATGGCTCAG
GTGTTTACAAACCTGTAA

Upstream 100 bases:

>100_bases
ATCGGCCACGGGCAAGATTCAAGACTACGGTGCCTACATCTTTGGTGGCGTGGTGCTGTTGGCCTTGATTTATATGTATG
CCTTCTAGGAGCGTGAGCGA

Downstream 100 bases:

>100_bases
CGTGGACGGAGTTAAACGATGCATTTGATCGAAAGTTTGCCAGCGGGCATTCCGTACCTGAGCCTTATCTGGTTGATTCC
CTTACTTGGGGCTTTGGTGA

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MLNEFIKFSDWSITTLIALSPLVGMLLALVFPKPAENSRTIAWGVFAWSLVPLGLTLFLWLSGGFNPALASVAGDQAMIQ
QVDRVRWVPFFNADYFVGLDGLNFPLVFLTTALTPVCILAAFRIKHRQNVYLALMLLLESAMLGYFVSLNFLLLFLFWEF
SLVPMFFIINNWGGENRRYAAFKFFVYTMAGSVAMLLIFEFIYLATGTFDLVVLSRLGQGLPVDPALLAPKLGAGYTSGA
TLQSMLFSAVEDIGLTSILGTSNGTPAAIVFWSIFVAFAVKLAVWPLHTWQPDTYENAPTSGSMIVSAVMSKMGAYGMIR
IMIMLFPQQTKFFAPALAILALASILFGAYAGLAQINLKRLIAYASINHMGYVLLGLAAVASAAPESLGDLAVNIRASAM
NGVQAQMVAHGFSTAALFFLAGELYERTGTYQLDQFGGLRKVMPIFAGIMGVAMFANLGLPGLAGFVGEFFIFRGAWGTQ
PVITTIAVLGLIVTALVLIRMYQKIFYGPVNHKLTNLPDIKVGDWAFNVTLPLIIVLLVFGIFPKPLMDLSNYAATVMAQ
VFTNL

Sequences:

>Translated_565_residues
MLNEFIKFSDWSITTLIALSPLVGMLLALVFPKPAENSRTIAWGVFAWSLVPLGLTLFLWLSGGFNPALASVAGDQAMIQ
QVDRVRWVPFFNADYFVGLDGLNFPLVFLTTALTPVCILAAFRIKHRQNVYLALMLLLESAMLGYFVSLNFLLLFLFWEF
SLVPMFFIINNWGGENRRYAAFKFFVYTMAGSVAMLLIFEFIYLATGTFDLVVLSRLGQGLPVDPALLAPKLGAGYTSGA
TLQSMLFSAVEDIGLTSILGTSNGTPAAIVFWSIFVAFAVKLAVWPLHTWQPDTYENAPTSGSMIVSAVMSKMGAYGMIR
IMIMLFPQQTKFFAPALAILALASILFGAYAGLAQINLKRLIAYASINHMGYVLLGLAAVASAAPESLGDLAVNIRASAM
NGVQAQMVAHGFSTAALFFLAGELYERTGTYQLDQFGGLRKVMPIFAGIMGVAMFANLGLPGLAGFVGEFFIFRGAWGTQ
PVITTIAVLGLIVTALVLIRMYQKIFYGPVNHKLTNLPDIKVGDWAFNVTLPLIIVLLVFGIFPKPLMDLSNYAATVMAQ
VFTNL
>Mature_565_residues
MLNEFIKFSDWSITTLIALSPLVGMLLALVFPKPAENSRTIAWGVFAWSLVPLGLTLFLWLSGGFNPALASVAGDQAMIQ
QVDRVRWVPFFNADYFVGLDGLNFPLVFLTTALTPVCILAAFRIKHRQNVYLALMLLLESAMLGYFVSLNFLLLFLFWEF
SLVPMFFIINNWGGENRRYAAFKFFVYTMAGSVAMLLIFEFIYLATGTFDLVVLSRLGQGLPVDPALLAPKLGAGYTSGA
TLQSMLFSAVEDIGLTSILGTSNGTPAAIVFWSIFVAFAVKLAVWPLHTWQPDTYENAPTSGSMIVSAVMSKMGAYGMIR
IMIMLFPQQTKFFAPALAILALASILFGAYAGLAQINLKRLIAYASINHMGYVLLGLAAVASAAPESLGDLAVNIRASAM
NGVQAQMVAHGFSTAALFFLAGELYERTGTYQLDQFGGLRKVMPIFAGIMGVAMFANLGLPGLAGFVGEFFIFRGAWGTQ
PVITTIAVLGLIVTALVLIRMYQKIFYGPVNHKLTNLPDIKVGDWAFNVTLPLIIVLLVFGIFPKPLMDLSNYAATVMAQ
VFTNL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=392, Percent_Identity=26.7857142857143, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1788613, Length=525, Percent_Identity=32.5714285714286, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI145693160, Length=415, Percent_Identity=25.5421686746988, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788827, Length=257, Percent_Identity=26.8482490272374, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788829, Length=355, Percent_Identity=24.5070422535211, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788831, Length=291, Percent_Identity=26.1168384879725, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI2367154, Length=200, Percent_Identity=29.5, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 61567; Mature: 61567

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNEFIKFSDWSITTLIALSPLVGMLLALVFPKPAENSRTIAWGVFAWSLVPLGLTLFLW
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
LSGGFNPALASVAGDQAMIQQVDRVRWVPFFNADYFVGLDGLNFPLVFLTTALTPVCILA
HCCCCCHHHHHHCCCHHHHHHHHHHEECEEECCCEEEECCCCCCHHHHHHHHHHHHHHHH
AFRIKHRQNVYLALMLLLESAMLGYFVSLNFLLLFLFWEFSLVPMFFIINNWGGENRRYA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEH
AFKFFVYTMAGSVAMLLIFEFIYLATGTFDLVVLSRLGQGLPVDPALLAPKLGAGYTSGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCH
TLQSMLFSAVEDIGLTSILGTSNGTPAAIVFWSIFVAFAVKLAVWPLHTWQPDTYENAPT
HHHHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SGSMIVSAVMSKMGAYGMIRIMIMLFPQQTKFFAPALAILALASILFGAYAGLAQINLKR
CHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAYASINHMGYVLLGLAAVASAAPESLGDLAVNIRASAMNGVQAQMVAHGFSTAALFFL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHH
AGELYERTGTYQLDQFGGLRKVMPIFAGIMGVAMFANLGLPGLAGFVGEFFIFRGAWGTQ
HHHHHHHCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
PVITTIAVLGLIVTALVLIRMYQKIFYGPVNHKLTNLPDIKVGDWAFNVTLPLIIVLLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEEHHHHHHHHHHHHH
GIFPKPLMDLSNYAATVMAQVFTNL
HCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLNEFIKFSDWSITTLIALSPLVGMLLALVFPKPAENSRTIAWGVFAWSLVPLGLTLFLW
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
LSGGFNPALASVAGDQAMIQQVDRVRWVPFFNADYFVGLDGLNFPLVFLTTALTPVCILA
HCCCCCHHHHHHCCCHHHHHHHHHHEECEEECCCEEEECCCCCCHHHHHHHHHHHHHHHH
AFRIKHRQNVYLALMLLLESAMLGYFVSLNFLLLFLFWEFSLVPMFFIINNWGGENRRYA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEH
AFKFFVYTMAGSVAMLLIFEFIYLATGTFDLVVLSRLGQGLPVDPALLAPKLGAGYTSGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCH
TLQSMLFSAVEDIGLTSILGTSNGTPAAIVFWSIFVAFAVKLAVWPLHTWQPDTYENAPT
HHHHHHHHHHHHCCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SGSMIVSAVMSKMGAYGMIRIMIMLFPQQTKFFAPALAILALASILFGAYAGLAQINLKR
CHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAYASINHMGYVLLGLAAVASAAPESLGDLAVNIRASAMNGVQAQMVAHGFSTAALFFL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHH
AGELYERTGTYQLDQFGGLRKVMPIFAGIMGVAMFANLGLPGLAGFVGEFFIFRGAWGTQ
HHHHHHHCCCEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
PVITTIAVLGLIVTALVLIRMYQKIFYGPVNHKLTNLPDIKVGDWAFNVTLPLIIVLLVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEEHHHHHHHHHHHHH
GIFPKPLMDLSNYAATVMAQVFTNL
HCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA