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The map label for this gene is uvrB

Identifier: 159901478

GI number: 159901478

Start: 6300864

End: 6302960

Strand: Reverse

Name: uvrB

Synonym: Haur_4967

Alternate gene names: 159901478

Gene position: 6302960-6300864 (Counterclockwise)

Preceding gene: 159901482

Following gene: 159901472

Centisome position: 99.31

GC content: 49.36

Gene sequence:

>2097_bases
ATGCCACCATTAAAAGTCCATGCACCCTACGAACCGCGTGGCGATCAACCACAGGCGATTGCCCAATTAGTCAATGGATT
AAACAGCGGGCTTGTCCACCAAACCTTATTGGGGGCAACAGGGACTGGCAAAACTCATACAATTGCGCGGGTTATTGAGC
AAGTTCAACGGCCTACCTTGGTGATGGCACATAATAAAACCCTCGCCGCACAGTTGTATGCTGAGTTTAAAGAATTTTTT
CCTGAGAATGCCGTAGGCTATTTCGTTTCCTACTACGATGCCTATACCCCCGAAGCCTACGTGCCATCAAAGGATTTGTA
TATTGAAAAAGAAGCGCAAATCAATGAAGAAATTGATCGTTTGCGCCACGAAGCAACCCAAGCGCTGTTTACCCGCAGCG
ATGTCATTATCGTGGCCTCGGTCTCGGCGATCTACGGGCTTGGCTCGCCCACGGATTACGGTCAAGTGGCACTCAAGCTT
AAAACTGGTGAGATTCGCAACCGCGATAAAGTGCTGCGAACGCTGATCGATCTACAATTTGAGCGCAACGATCTTGATTT
TCACCGTGGCACCTTCCGTGTGCGTGGCGATACACTCGAAATCTTTCCAGCTAATGCCGAAAGCGCCTTTCGGATCGAGA
TGTGGGGCGATGAAATTGAGCGCATGGTCGAGGTTGATCCCTTGACAGGTGAGATTTTGACCCAAAAAGATCACATCGAA
GTCTTTCCGGCCAAGCACTTTATTCCCAACGCCGACAAAATGCAGGCAGCAATTGGCGATATTCGGCTTGAGCTTGAACA
GCAATTAGCCCATCTCGAAGGCGAAGGCAAAGTGCTTGAAGCAGCGCGGCTCAAACAGCGCACACTCTACGATCTCGAAA
TTATGGAAGAATTGGGCTACTGCTCAGGAATTGAAAATTATAGTCGGCATATGGATCGGCGTAGCGAAGGCCAAACACCG
TGGACATTGCTCGATTACTTTCCTGATGATTTTCTTTTGGTGATCGACGAATCGCATATTTCAGTGCCGCAAATTCGTGG
GATGTTCAATGGCGACCGTTCGCGCAAGCAAACCTTGGTCGATTTTGGCTTCCGTTTGCCCTCGGCGCTCGATAACCGAC
CCTTGATGTTTGACGAATTTTCCAAGCATGTGCATCAAGCAATTTATGTTTCAGCTACGCCTGGGGTCTACGAATATCAA
CATCATGAACAGGTAGTTGAGCAAATTATTCGGCCAACTGGCTTGCTCGACCCTATGGTTGAAGTGCGACGCACCCGTGG
CCAAATCGATGATTTACTTGGTGAAATCAAACGGCGGGTTGATACTGGCTCGCGGGTATTGGTCACAACCCTCACCAAGC
GCATGGCCGAAGATCTGACCGATTATCTCAAAGAAATGGGCGTGCGCACTCAATATCTCCACTCCGATGTTGATACGATT
GAGCGCATCGACATTCTGCGTGATTTACGTTTAGGGGTTTTTGATGTGCTGGTGGGGATCAACCTCTTGCGCGAAGGCTT
AGACTTGCCTGAAGTATCGTTGGTGGCAATTCTTGATGCTGATAAAGCGGGCTTCTTACGCTCCGAATCGTCGTTGGTGC
AAATTATTGGGCGGGCTGCCCGCCACATCGATGGTACGGTGCTGATGTATGCCGATACGATTACCCCAGCCATGGATTAT
GCGATCAGCGAAACCCGTCGCCGTCGCCAAATTCAAGAGCGTTATAATCAACAACATGGCATTGAACCCAAAGGGATCGT
CAAAGCAGTACGCGATTTGACCGAAGGTATGAAAAAAGTTGCTGAAAAACCAGCAGCCTACCAAACCGCCGCCAACCCCG
ACAGCATGACCAAAGAAGAACTCTTCAAAGTGATCAACGCGCTTGAAAAACAGATGAAACAAGCCGCCAAAGACCTAGAG
TTTGAAAAAGCGGCCTTGCTGCGTGACCAACTGACCGAAATGCGCCAAACCCTAGCCTTGATCGACAACACGGCCTTGCT
TGAGAGCGTCAATCGCAAACCACGAGCCAAAGCAGCTATGGTGGTTGAAGATACTGGTAAACGCAAAGTCAAAGGCCGTT
CACGCGGCAAACTTTAA

Upstream 100 bases:

>100_bases
AAAATCGCTATAATAACACAATTGTTCGATAATCAGTCGCAAGAACGACCATAAATAAGCATAAGCACAGTATAATTAAT
GACGTGATTTAGGAGGTCGT

Downstream 100 bases:

>100_bases
TCGCAATGCGCGGCTGGTTGAGCACAGCTAGCCGCGCACCACCACCCAAACTGCCACCGCCAAAAATAGCTGGATCACTG
AGCTACCAATTAAGAGTGCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MPPLKVHAPYEPRGDQPQAIAQLVNGLNSGLVHQTLLGATGTGKTHTIARVIEQVQRPTLVMAHNKTLAAQLYAEFKEFF
PENAVGYFVSYYDAYTPEAYVPSKDLYIEKEAQINEEIDRLRHEATQALFTRSDVIIVASVSAIYGLGSPTDYGQVALKL
KTGEIRNRDKVLRTLIDLQFERNDLDFHRGTFRVRGDTLEIFPANAESAFRIEMWGDEIERMVEVDPLTGEILTQKDHIE
VFPAKHFIPNADKMQAAIGDIRLELEQQLAHLEGEGKVLEAARLKQRTLYDLEIMEELGYCSGIENYSRHMDRRSEGQTP
WTLLDYFPDDFLLVIDESHISVPQIRGMFNGDRSRKQTLVDFGFRLPSALDNRPLMFDEFSKHVHQAIYVSATPGVYEYQ
HHEQVVEQIIRPTGLLDPMVEVRRTRGQIDDLLGEIKRRVDTGSRVLVTTLTKRMAEDLTDYLKEMGVRTQYLHSDVDTI
ERIDILRDLRLGVFDVLVGINLLREGLDLPEVSLVAILDADKAGFLRSESSLVQIIGRAARHIDGTVLMYADTITPAMDY
AISETRRRRQIQERYNQQHGIEPKGIVKAVRDLTEGMKKVAEKPAAYQTAANPDSMTKEELFKVINALEKQMKQAAKDLE
FEKAALLRDQLTEMRQTLALIDNTALLESVNRKPRAKAAMVVEDTGKRKVKGRSRGKL

Sequences:

>Translated_698_residues
MPPLKVHAPYEPRGDQPQAIAQLVNGLNSGLVHQTLLGATGTGKTHTIARVIEQVQRPTLVMAHNKTLAAQLYAEFKEFF
PENAVGYFVSYYDAYTPEAYVPSKDLYIEKEAQINEEIDRLRHEATQALFTRSDVIIVASVSAIYGLGSPTDYGQVALKL
KTGEIRNRDKVLRTLIDLQFERNDLDFHRGTFRVRGDTLEIFPANAESAFRIEMWGDEIERMVEVDPLTGEILTQKDHIE
VFPAKHFIPNADKMQAAIGDIRLELEQQLAHLEGEGKVLEAARLKQRTLYDLEIMEELGYCSGIENYSRHMDRRSEGQTP
WTLLDYFPDDFLLVIDESHISVPQIRGMFNGDRSRKQTLVDFGFRLPSALDNRPLMFDEFSKHVHQAIYVSATPGVYEYQ
HHEQVVEQIIRPTGLLDPMVEVRRTRGQIDDLLGEIKRRVDTGSRVLVTTLTKRMAEDLTDYLKEMGVRTQYLHSDVDTI
ERIDILRDLRLGVFDVLVGINLLREGLDLPEVSLVAILDADKAGFLRSESSLVQIIGRAARHIDGTVLMYADTITPAMDY
AISETRRRRQIQERYNQQHGIEPKGIVKAVRDLTEGMKKVAEKPAAYQTAANPDSMTKEELFKVINALEKQMKQAAKDLE
FEKAALLRDQLTEMRQTLALIDNTALLESVNRKPRAKAAMVVEDTGKRKVKGRSRGKL
>Mature_697_residues
PPLKVHAPYEPRGDQPQAIAQLVNGLNSGLVHQTLLGATGTGKTHTIARVIEQVQRPTLVMAHNKTLAAQLYAEFKEFFP
ENAVGYFVSYYDAYTPEAYVPSKDLYIEKEAQINEEIDRLRHEATQALFTRSDVIIVASVSAIYGLGSPTDYGQVALKLK
TGEIRNRDKVLRTLIDLQFERNDLDFHRGTFRVRGDTLEIFPANAESAFRIEMWGDEIERMVEVDPLTGEILTQKDHIEV
FPAKHFIPNADKMQAAIGDIRLELEQQLAHLEGEGKVLEAARLKQRTLYDLEIMEELGYCSGIENYSRHMDRRSEGQTPW
TLLDYFPDDFLLVIDESHISVPQIRGMFNGDRSRKQTLVDFGFRLPSALDNRPLMFDEFSKHVHQAIYVSATPGVYEYQH
HEQVVEQIIRPTGLLDPMVEVRRTRGQIDDLLGEIKRRVDTGSRVLVTTLTKRMAEDLTDYLKEMGVRTQYLHSDVDTIE
RIDILRDLRLGVFDVLVGINLLREGLDLPEVSLVAILDADKAGFLRSESSLVQIIGRAARHIDGTVLMYADTITPAMDYA
ISETRRRRQIQERYNQQHGIEPKGIVKAVRDLTEGMKKVAEKPAAYQTAANPDSMTKEELFKVINALEKQMKQAAKDLEF
EKAALLRDQLTEMRQTLALIDNTALLESVNRKPRAKAAMVVEDTGKRKVKGRSRGKL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=56.1746987951807, Blast_Score=731, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_HERA2 (A9B464)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547725.1
- ProteinModelPortal:   A9B464
- SMR:   A9B464
- GeneID:   5736803
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4967
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   HAUR316274:HAUR_4967-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 79255; Mature: 79124

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLKVHAPYEPRGDQPQAIAQLVNGLNSGLVHQTLLGATGTGKTHTIARVIEQVQRPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCEE
VMAHNKTLAAQLYAEFKEFFPENAVGYFVSYYDAYTPEAYVPSKDLYIEKEAQINEEIDR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHH
LRHEATQALFTRSDVIIVASVSAIYGLGSPTDYGQVALKLKTGEIRNRDKVLRTLIDLQF
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
ERNDLDFHRGTFRVRGDTLEIFPANAESAFRIEMWGDEIERMVEVDPLTGEILTQKDHIE
CCCCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCHHHCCCCCEE
VFPAKHFIPNADKMQAAIGDIRLELEQQLAHLEGEGKVLEAARLKQRTLYDLEIMEELGY
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CSGIENYSRHMDRRSEGQTPWTLLDYFPDDFLLVIDESHISVPQIRGMFNGDRSRKQTLV
HCCHHHHHHHHHHHCCCCCCEEEHCCCCCCEEEEEECCCCCCHHHHCCCCCCHHHHHHHH
DFGFRLPSALDNRPLMFDEFSKHVHQAIYVSATPGVYEYQHHEQVVEQIIRPTGLLDPMV
HHHHHCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
EVRRTRGQIDDLLGEIKRRVDTGSRVLVTTLTKRMAEDLTDYLKEMGVRTQYLHSDVDTI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERIDILRDLRLGVFDVLVGINLLREGLDLPEVSLVAILDADKAGFLRSESSLVQIIGRAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
RHIDGTVLMYADTITPAMDYAISETRRRRQIQERYNQQHGIEPKGIVKAVRDLTEGMKKV
HHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AEKPAAYQTAANPDSMTKEELFKVINALEKQMKQAAKDLEFEKAALLRDQLTEMRQTLAL
HHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IDNTALLESVNRKPRAKAAMVVEDTGKRKVKGRSRGKL
HHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCCCCCC
>Mature Secondary Structure 
PPLKVHAPYEPRGDQPQAIAQLVNGLNSGLVHQTLLGATGTGKTHTIARVIEQVQRPTL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCEE
VMAHNKTLAAQLYAEFKEFFPENAVGYFVSYYDAYTPEAYVPSKDLYIEKEAQINEEIDR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHH
LRHEATQALFTRSDVIIVASVSAIYGLGSPTDYGQVALKLKTGEIRNRDKVLRTLIDLQF
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
ERNDLDFHRGTFRVRGDTLEIFPANAESAFRIEMWGDEIERMVEVDPLTGEILTQKDHIE
CCCCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCCHHHCCCCCEE
VFPAKHFIPNADKMQAAIGDIRLELEQQLAHLEGEGKVLEAARLKQRTLYDLEIMEELGY
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
CSGIENYSRHMDRRSEGQTPWTLLDYFPDDFLLVIDESHISVPQIRGMFNGDRSRKQTLV
HCCHHHHHHHHHHHCCCCCCEEEHCCCCCCEEEEEECCCCCCHHHHCCCCCCHHHHHHHH
DFGFRLPSALDNRPLMFDEFSKHVHQAIYVSATPGVYEYQHHEQVVEQIIRPTGLLDPMV
HHHHHCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
EVRRTRGQIDDLLGEIKRRVDTGSRVLVTTLTKRMAEDLTDYLKEMGVRTQYLHSDVDTI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERIDILRDLRLGVFDVLVGINLLREGLDLPEVSLVAILDADKAGFLRSESSLVQIIGRAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHH
RHIDGTVLMYADTITPAMDYAISETRRRRQIQERYNQQHGIEPKGIVKAVRDLTEGMKKV
HHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
AEKPAAYQTAANPDSMTKEELFKVINALEKQMKQAAKDLEFEKAALLRDQLTEMRQTLAL
HHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IDNTALLESVNRKPRAKAAMVVEDTGKRKVKGRSRGKL
HHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA