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The map label for this gene is prrB [H]

Identifier: 159901482

GI number: 159901482

Start: 6307614

End: 6308909

Strand: Reverse

Name: prrB [H]

Synonym: Haur_4971

Alternate gene names: 159901482

Gene position: 6308909-6307614 (Counterclockwise)

Preceding gene: 159901484

Following gene: 159901478

Centisome position: 99.41

GC content: 50.85

Gene sequence:

>1296_bases
ATGCCAGAGCAACCAATCGTCCCATGGAAAGTGCGTGCTTGGCGCTGGATCAAGCAATGGTGGCAGGATATTGTCCATGG
CGCTGATCCATTTGCAACGCTCACGGCGATTTTGGCCTTGTTTACGGCATTAATTGGGATTATGGGCGCAGTCAATTTAG
ATTATGGTGATGTGCCAACCGCCGTTATTTTGCTCGATTTTGGGGTTACATTGTGTTTGGGCGGCTTAGCATGGTGGATG
TTCCGCCAACCTAATGCACTTTGGCCACGCTGGATTGTGGTTGCTGTGCTCACGATCGCCTGTTTTTATGTGCTGGCGAC
GATTCCCTCGGATGCGGCGGTGGTTGTCTTGACGATGTTGCCAATTTTGATGGCAATGTTGGCTAGTCGGCGGTGGTGGC
CAATTGCCTTTTACCCGCTCTCAGTCACGATTGTTGCTTCGATTCATGCTGGTGGTTGGCGCGTTTTTACGCCAGCTATC
ATCGCATTCAACATTTTAGAGTTTTTGATGCTCTGGGGGGTCACGTCGCAGGCGGTGCAATTTGCCAAAGCACGGATCAA
AACTGAAGCTCAACTGAGCAAAGAGCAGCAAGTCCGCCAATTTATGCGCTTCTTCCAGCACGAATTGCGCTCCTACAGTA
ATAGCCTTGATGTGCTGTTGCCAATGCTCAATCAACATCTTGCCAAACAATCAGTGATCGACCACGATGCGATTCATCCG
CAGGAGTTGGTGCGTGTATTGCAAACCACCGCCGATTCAATTCGCCAACTCACCACCGAATTGCTGGTGCTGACCCGCGA
AGGCCAATTGCTGCCTCAACAACGCATTCCCATCCAATTATTGCCACTGCTGCAAACTGAACAAGCTGAATGCCAAACCG
AAATGCAGCGCCATGGCCTTAATTCGACGATTCAGATCGATTGCCCGGCTGATTGTATTGTGGTTGGCGATGCACTTTTT
TTGCGCTTGGCGATTCATACGATTTTGCAAAACGCGATCGAGGCGCTGTTACGCCACCCTGGCGAAGGCCAAATCTTCAT
TCAGGTTGAACAAACGCCTCAATCGACGCAGATTGAGATCTACGACACGGGCAAGGGCTTTCCTGCCGATTTGCTTGATC
ATTTAAATCAGGCTCAATCGTTGAACCAAGCCTTGGGCTGGACGACCAAAATGGGTGGCAGCGGCTTAGGTATGCCCTTG
ATTCGCCATGTGGCACTCTTGCATGGTGGCACTGCCCAGTTTAGCAATCGGCCAGAAGGCGGTGCACAAATTAGGCTCAA
TTTGCCGCAGGTTTAG

Upstream 100 bases:

>100_bases
CTAGATCGAATTAGGCTAAATGAACCCTTAAAAAGTGTTAGAAAGCCACGTTGACCAAACCCTTAGCAACCACTCAAGCC
CATTTCAAGAAAGCAAGCCT

Downstream 100 bases:

>100_bases
CAATCGTCAAACGAAATAGCAATGGTGCACCAAAGGTCGTCCACACGCCAATGATCAAATAACGGATACCATCAGCAATC
AGCGTTTCGGGCAAAATACT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPEQPIVPWKVRAWRWIKQWWQDIVHGADPFATLTAILALFTALIGIMGAVNLDYGDVPTAVILLDFGVTLCLGGLAWWM
FRQPNALWPRWIVVAVLTIACFYVLATIPSDAAVVVLTMLPILMAMLASRRWWPIAFYPLSVTIVASIHAGGWRVFTPAI
IAFNILEFLMLWGVTSQAVQFAKARIKTEAQLSKEQQVRQFMRFFQHELRSYSNSLDVLLPMLNQHLAKQSVIDHDAIHP
QELVRVLQTTADSIRQLTTELLVLTREGQLLPQQRIPIQLLPLLQTEQAECQTEMQRHGLNSTIQIDCPADCIVVGDALF
LRLAIHTILQNAIEALLRHPGEGQIFIQVEQTPQSTQIEIYDTGKGFPADLLDHLNQAQSLNQALGWTTKMGGSGLGMPL
IRHVALLHGGTAQFSNRPEGGAQIRLNLPQV

Sequences:

>Translated_431_residues
MPEQPIVPWKVRAWRWIKQWWQDIVHGADPFATLTAILALFTALIGIMGAVNLDYGDVPTAVILLDFGVTLCLGGLAWWM
FRQPNALWPRWIVVAVLTIACFYVLATIPSDAAVVVLTMLPILMAMLASRRWWPIAFYPLSVTIVASIHAGGWRVFTPAI
IAFNILEFLMLWGVTSQAVQFAKARIKTEAQLSKEQQVRQFMRFFQHELRSYSNSLDVLLPMLNQHLAKQSVIDHDAIHP
QELVRVLQTTADSIRQLTTELLVLTREGQLLPQQRIPIQLLPLLQTEQAECQTEMQRHGLNSTIQIDCPADCIVVGDALF
LRLAIHTILQNAIEALLRHPGEGQIFIQVEQTPQSTQIEIYDTGKGFPADLLDHLNQAQSLNQALGWTTKMGGSGLGMPL
IRHVALLHGGTAQFSNRPEGGAQIRLNLPQV
>Mature_430_residues
PEQPIVPWKVRAWRWIKQWWQDIVHGADPFATLTAILALFTALIGIMGAVNLDYGDVPTAVILLDFGVTLCLGGLAWWMF
RQPNALWPRWIVVAVLTIACFYVLATIPSDAAVVVLTMLPILMAMLASRRWWPIAFYPLSVTIVASIHAGGWRVFTPAII
AFNILEFLMLWGVTSQAVQFAKARIKTEAQLSKEQQVRQFMRFFQHELRSYSNSLDVLLPMLNQHLAKQSVIDHDAIHPQ
ELVRVLQTTADSIRQLTTELLVLTREGQLLPQQRIPIQLLPLLQTEQAECQTEMQRHGLNSTIQIDCPADCIVVGDALFL
RLAIHTILQNAIEALLRHPGEGQIFIQVEQTPQSTQIEIYDTGKGFPADLLDHLNQAQSLNQALGWTTKMGGSGLGMPLI
RHVALLHGGTAQFSNRPEGGAQIRLNLPQV

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48237; Mature: 48106

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQPIVPWKVRAWRWIKQWWQDIVHGADPFATLTAILALFTALIGIMGAVNLDYGDVPT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
AVILLDFGVTLCLGGLAWWMFRQPNALWPRWIVVAVLTIACFYVLATIPSDAAVVVLTML
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PILMAMLASRRWWPIAFYPLSVTIVASIHAGGWRVFTPAIIAFNILEFLMLWGVTSQAVQ
HHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHH
FAKARIKTEAQLSKEQQVRQFMRFFQHELRSYSNSLDVLLPMLNQHLAKQSVIDHDAIHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCH
QELVRVLQTTADSIRQLTTELLVLTREGQLLPQQRIPIQLLPLLQTEQAECQTEMQRHGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCC
NSTIQIDCPADCIVVGDALFLRLAIHTILQNAIEALLRHPGEGQIFIQVEQTPQSTQIEI
CCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEE
YDTGKGFPADLLDHLNQAQSLNQALGWTTKMGGSGLGMPLIRHVALLHGGTAQFSNRPEG
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
GAQIRLNLPQV
CCEEEEECCCC
>Mature Secondary Structure 
PEQPIVPWKVRAWRWIKQWWQDIVHGADPFATLTAILALFTALIGIMGAVNLDYGDVPT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
AVILLDFGVTLCLGGLAWWMFRQPNALWPRWIVVAVLTIACFYVLATIPSDAAVVVLTML
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
PILMAMLASRRWWPIAFYPLSVTIVASIHAGGWRVFTPAIIAFNILEFLMLWGVTSQAVQ
HHHHHHHHCCCCCEEEEEEEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHH
FAKARIKTEAQLSKEQQVRQFMRFFQHELRSYSNSLDVLLPMLNQHLAKQSVIDHDAIHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCH
QELVRVLQTTADSIRQLTTELLVLTREGQLLPQQRIPIQLLPLLQTEQAECQTEMQRHGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCC
NSTIQIDCPADCIVVGDALFLRLAIHTILQNAIEALLRHPGEGQIFIQVEQTPQSTQIEI
CCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEE
YDTGKGFPADLLDHLNQAQSLNQALGWTTKMGGSGLGMPLIRHVALLHGGTAQFSNRPEG
EECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
GAQIRLNLPQV
CCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]