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The map label for this gene is mutS2 [H]

Identifier: 159901402

GI number: 159901402

Start: 6226670

End: 6229090

Strand: Direct

Name: mutS2 [H]

Synonym: Haur_4891

Alternate gene names: 159901402

Gene position: 6226670-6229090 (Clockwise)

Preceding gene: 159901401

Following gene: 159901403

Centisome position: 98.11

GC content: 52.25

Gene sequence:

>2421_bases
ATGATATCAGAAGTTGTACTCCAAACCCTTGAGTTCGATAAAGTTCGTGATCAGCTTGCACGTCATGCTGCGTTTAGCGC
AAGCCGTGAGTTGGTTGCGCAACTCCATCCATCAACCGATGGGCAGTGGATTCTGCAGGCGCAAATTCGTACTAGTGCCG
CCCGTGCTTTAATTGAATCGTTTGCCGATGTCTCAATTGGCGGTGCTCGTGATGTTCGCCCTGCGGTGGAACATGCTCGT
CGTGGTGGGATTCTTGAGGCGAGTCGGGTACAAGAAATTGCCGCTACCTTGGGGGCGATGCGGCGGTTGCGTGGCCAAGT
TTTGCGCAATCATCCCGATTTTGTGCCATTACACCCTTTAGCCGAGCAACTGCCAAATTTGGCCACGCTGGAACATGAAA
TTGAACGCACAATCGGCCCTGATGGCGAGGTATTAGATAGTGCTTCGGCTGAATTGGGCCGCTTACGTAGCGCCATTCGG
GTGGCGTTTAATCGGTTGCAAGAGCGTTTGCAAGCAATTATCAATTCGTCGCAATATGCCGATGTGCTGCAAGAGCCAAT
TATCACGGTGCGCGATGGCCGCTATGTCGTGCCAGTCAAAGCCCCACAACGACGGGCCTTGCGCGGGATTGTCCACGATC
AATCATCGTCGGGCGCAACCCTGTATATCGAGCCATTGGCTACGGTTGAGTTAAATAACCAGTGGCGCGAGCTGCAATTG
GCCGAACGCGAAGAAATCCAGCGCATTTTGGCGGCGCTCTCGGGCAAAATTGCCAACGAAGGTATGCCAATTATTGTTGG
GGTTGAGGCTACCGCTGAATTAGATTTAGCCTTTGCCAAAGCCAAATATAGCATTAGCTTGCGTGCTAGCCAACCTGCGA
TCAATACGCCAGTTCCTGCCGATGATTTGCACCCCGAATCAACTTTGTCATTGCTCAAAGCCCGCCATCCCTTGCTCAAC
CAAGATCTGGTTGTGCCAACCGATGTCTGGCTGGGCGGCCCAACGCAGATGATTATTATCACTGGCCCGAATACTGGTGG
TAAAACGGTGGCGCTCAAAACCGTTGGTTTGATGGCATTAATGGCCCAGGCGGGTCTGCATATTCCGGCCCATCAAGGCT
CGCGCTTACCTATTTTTGGTAAAATTTTTGCTGATATCGGCGATGAACAAAGTATCGAACAAAGCCTCTCGACCTTCTCC
TCCCACATGACCAACATTATCCAAATCTTGGATCGGGTAACCCCCGATTCGTTGGTGTTGTTTGATGAATTGGGCGCTGG
TACTGATCCAGTCGAGGGTGCTGCTTTGGCGCGAGCAATTATCGAACGCTTGTTGAATGTGGGATGTTTGGCGATGGCAA
CCAGCCACTATGCTGAACTCAAGGCTTTTGCCTACAGCACTGATGGGGTTGAAAATGCCTCGGTTGAGTTTGATGTTGAA
ACCTTATCGCCAACCTATCGACTTTCAATCGGCTTGCCAGGCCGCTCGAATGCTTTGGCAATTGCTGAACGCTTGGGGCT
TAAACGCGACTTAATCGAACGTGCTCGGGCAACGATTAGCCGCGATAACGTCCAAGTTGAAGATTTGCTGGCCGCGATTC
ATCGCGAACGCACAACCGCCGAAAGTGAGGCTGCCCGCGCCTTGGAATTGCGCGAAGATGCCGAATTGGTGCGCGATCGG
CTGAGCCGCGAATTGTATGAGTTTGAACAGGATCGCGAACAGCAATTAGCCAGTTACCAACGCCAACTTGATGATGAATT
GCGTGAAGTACGAGCTGAATTGCGCCGCCTACGTGATGAATTTCGCTCAGTTTCGGTTAGCCGCCAATGGATGGAACAAG
CCGAACAACGCCTCAGCCGAGTTGCCGAACGGGTTCCCCAAACTCCAACTCCCCCCAAAGCCAAAGTTCCAGTTGTACCC
AAAGTTGCGCTTGCCCCACTTCCTCGCACAATTCAAGTTGGCGATCAGGTGTTTGTGAGCAGCGTGAAGCTTTCGGGCGT
GGTGCTCGATTTGGATGAAGAAGCCAACGAGGCCGAGGTTCAATTGGGTGGCTTCCGCTTGCGGGTTGATTTACGCGAGT
TGCGGCTGGAAAAAGCGGGCACTAGTCCAACCCAAGCGGTACAAAAATATGTACCTGTTCAGCGCATGATCAATACTCCT
CCACCGCCGAATGTTTCGATGCAGCTTGATATGCGTGGTTGGCGAGCCTCGGATGTGGAAAGTCAGCTCGATCATTATCT
CAACGATGCGTACCTCGCCAATCTTTCAGAAGTGCGTTTGGTTCATGGCAAGGGTACAGGGGCGCTGCGCCAAGTTGTAC
GAACATTGCTCAAACGCCATCCCTTGGTCGAATCGTACAATAGCGGTAGCCAAGGTGATGGCGGCGATGGCGTAACAATC
GCCAAAATGGTTGCTCGTTGA

Upstream 100 bases:

>100_bases
CAATTCGCCCAATTATGCCTGAAAGTGCTGATGCATTATTCCGTAGTATTCAACGGTAATCGGGCGGTGCTGGCGCACTT
GCAATAGAAGAAGTTTCGTG

Downstream 100 bases:

>100_bases
GTCAGCACAGGGTTGAGTTTGCTCAGCCCTGTTGCTATTTTAGAGATCGATTATGTATGTTGTGCCGCACGATCAAGATA
GTTATCAAAGCATCAATCAA

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MISEVVLQTLEFDKVRDQLARHAAFSASRELVAQLHPSTDGQWILQAQIRTSAARALIESFADVSIGGARDVRPAVEHAR
RGGILEASRVQEIAATLGAMRRLRGQVLRNHPDFVPLHPLAEQLPNLATLEHEIERTIGPDGEVLDSASAELGRLRSAIR
VAFNRLQERLQAIINSSQYADVLQEPIITVRDGRYVVPVKAPQRRALRGIVHDQSSSGATLYIEPLATVELNNQWRELQL
AEREEIQRILAALSGKIANEGMPIIVGVEATAELDLAFAKAKYSISLRASQPAINTPVPADDLHPESTLSLLKARHPLLN
QDLVVPTDVWLGGPTQMIIITGPNTGGKTVALKTVGLMALMAQAGLHIPAHQGSRLPIFGKIFADIGDEQSIEQSLSTFS
SHMTNIIQILDRVTPDSLVLFDELGAGTDPVEGAALARAIIERLLNVGCLAMATSHYAELKAFAYSTDGVENASVEFDVE
TLSPTYRLSIGLPGRSNALAIAERLGLKRDLIERARATISRDNVQVEDLLAAIHRERTTAESEAARALELREDAELVRDR
LSRELYEFEQDREQQLASYQRQLDDELREVRAELRRLRDEFRSVSVSRQWMEQAEQRLSRVAERVPQTPTPPKAKVPVVP
KVALAPLPRTIQVGDQVFVSSVKLSGVVLDLDEEANEAEVQLGGFRLRVDLRELRLEKAGTSPTQAVQKYVPVQRMINTP
PPPNVSMQLDMRGWRASDVESQLDHYLNDAYLANLSEVRLVHGKGTGALRQVVRTLLKRHPLVESYNSGSQGDGGDGVTI
AKMVAR

Sequences:

>Translated_806_residues
MISEVVLQTLEFDKVRDQLARHAAFSASRELVAQLHPSTDGQWILQAQIRTSAARALIESFADVSIGGARDVRPAVEHAR
RGGILEASRVQEIAATLGAMRRLRGQVLRNHPDFVPLHPLAEQLPNLATLEHEIERTIGPDGEVLDSASAELGRLRSAIR
VAFNRLQERLQAIINSSQYADVLQEPIITVRDGRYVVPVKAPQRRALRGIVHDQSSSGATLYIEPLATVELNNQWRELQL
AEREEIQRILAALSGKIANEGMPIIVGVEATAELDLAFAKAKYSISLRASQPAINTPVPADDLHPESTLSLLKARHPLLN
QDLVVPTDVWLGGPTQMIIITGPNTGGKTVALKTVGLMALMAQAGLHIPAHQGSRLPIFGKIFADIGDEQSIEQSLSTFS
SHMTNIIQILDRVTPDSLVLFDELGAGTDPVEGAALARAIIERLLNVGCLAMATSHYAELKAFAYSTDGVENASVEFDVE
TLSPTYRLSIGLPGRSNALAIAERLGLKRDLIERARATISRDNVQVEDLLAAIHRERTTAESEAARALELREDAELVRDR
LSRELYEFEQDREQQLASYQRQLDDELREVRAELRRLRDEFRSVSVSRQWMEQAEQRLSRVAERVPQTPTPPKAKVPVVP
KVALAPLPRTIQVGDQVFVSSVKLSGVVLDLDEEANEAEVQLGGFRLRVDLRELRLEKAGTSPTQAVQKYVPVQRMINTP
PPPNVSMQLDMRGWRASDVESQLDHYLNDAYLANLSEVRLVHGKGTGALRQVVRTLLKRHPLVESYNSGSQGDGGDGVTI
AKMVAR
>Mature_806_residues
MISEVVLQTLEFDKVRDQLARHAAFSASRELVAQLHPSTDGQWILQAQIRTSAARALIESFADVSIGGARDVRPAVEHAR
RGGILEASRVQEIAATLGAMRRLRGQVLRNHPDFVPLHPLAEQLPNLATLEHEIERTIGPDGEVLDSASAELGRLRSAIR
VAFNRLQERLQAIINSSQYADVLQEPIITVRDGRYVVPVKAPQRRALRGIVHDQSSSGATLYIEPLATVELNNQWRELQL
AEREEIQRILAALSGKIANEGMPIIVGVEATAELDLAFAKAKYSISLRASQPAINTPVPADDLHPESTLSLLKARHPLLN
QDLVVPTDVWLGGPTQMIIITGPNTGGKTVALKTVGLMALMAQAGLHIPAHQGSRLPIFGKIFADIGDEQSIEQSLSTFS
SHMTNIIQILDRVTPDSLVLFDELGAGTDPVEGAALARAIIERLLNVGCLAMATSHYAELKAFAYSTDGVENASVEFDVE
TLSPTYRLSIGLPGRSNALAIAERLGLKRDLIERARATISRDNVQVEDLLAAIHRERTTAESEAARALELREDAELVRDR
LSRELYEFEQDREQQLASYQRQLDDELREVRAELRRLRDEFRSVSVSRQWMEQAEQRLSRVAERVPQTPTPPKAKVPVVP
KVALAPLPRTIQVGDQVFVSSVKLSGVVLDLDEEANEAEVQLGGFRLRVDLRELRLEKAGTSPTQAVQKYVPVQRMINTP
PPPNVSMQLDMRGWRASDVESQLDHYLNDAYLANLSEVRLVHGKGTGALRQVVRTLLKRHPLVESYNSGSQGDGGDGVTI
AKMVAR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=311, Percent_Identity=28.9389067524116, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI36949366, Length=263, Percent_Identity=30.7984790874525, Blast_Score=111, Evalue=4e-24,
Organism=Homo sapiens, GI4557761, Length=214, Percent_Identity=34.5794392523364, Blast_Score=107, Evalue=5e-23,
Organism=Homo sapiens, GI284813531, Length=287, Percent_Identity=27.8745644599303, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI26638666, Length=214, Percent_Identity=31.3084112149533, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI4505253, Length=214, Percent_Identity=31.3084112149533, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI26638664, Length=215, Percent_Identity=31.1627906976744, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI262231786, Length=140, Percent_Identity=37.1428571428571, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1789089, Length=256, Percent_Identity=33.203125, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17508445, Length=315, Percent_Identity=27.6190476190476, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=168, Percent_Identity=33.9285714285714, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508447, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=277, Percent_Identity=26.7148014440433, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=241, Percent_Identity=30.7053941908714, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319935, Length=298, Percent_Identity=29.8657718120805, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321109, Length=228, Percent_Identity=30.2631578947368, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321912, Length=192, Percent_Identity=26.5625, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=310, Percent_Identity=26.1290322580645, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664545, Length=303, Percent_Identity=30.3630363036304, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24584320, Length=215, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88809; Mature: 88809

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEVVLQTLEFDKVRDQLARHAAFSASRELVAQLHPSTDGQWILQAQIRTSAARALIES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
FADVSIGGARDVRPAVEHARRGGILEASRVQEIAATLGAMRRLRGQVLRNHPDFVPLHPL
HHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AEQLPNLATLEHEIERTIGPDGEVLDSASAELGRLRSAIRVAFNRLQERLQAIINSSQYA
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DVLQEPIITVRDGRYVVPVKAPQRRALRGIVHDQSSSGATLYIEPLATVELNNQWRELQL
HHHHCCCEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECEEEEEECCCHHHHHH
AEREEIQRILAALSGKIANEGMPIIVGVEATAELDLAFAKAKYSISLRASQPAINTPVPA
HHHHHHHHHHHHHCCHHHCCCCCEEEEECCCHHHHHHEEEEEEEEEEEECCCCCCCCCCC
DDLHPESTLSLLKARHPLLNQDLVVPTDVWLGGPTQMIIITGPNTGGKTVALKTVGLMAL
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCEEEHHHHHHHHH
MAQAGLHIPAHQGSRLPIFGKIFADIGDEQSIEQSLSTFSSHMTNIIQILDRVTPDSLVL
HHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
FDELGAGTDPVEGAALARAIIERLLNVGCLAMATSHYAELKAFAYSTDGVENASVEFDVE
EHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEE
TLSPTYRLSIGLPGRSNALAIAERLGLKRDLIERARATISRDNVQVEDLLAAIHRERTTA
ECCCEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
ESEAARALELREDAELVRDRLSRELYEFEQDREQQLASYQRQLDDELREVRAELRRLRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSVSVSRQWMEQAEQRLSRVAERVPQTPTPPKAKVPVVPKVALAPLPRTIQVGDQVFVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCCHHHHH
SVKLSGVVLDLDEEANEAEVQLGGFRLRVDLRELRLEKAGTSPTQAVQKYVPVQRMINTP
HEEECEEEEECCCCCCCCEEEECCEEEEEEHHHHHHHHCCCCHHHHHHHHHCHHHHHCCC
PPPNVSMQLDMRGWRASDVESQLDHYLNDAYLANLSEVRLVHGKGTGALRQVVRTLLKRH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHHC
PLVESYNSGSQGDGGDGVTIAKMVAR
CCHHCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MISEVVLQTLEFDKVRDQLARHAAFSASRELVAQLHPSTDGQWILQAQIRTSAARALIES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
FADVSIGGARDVRPAVEHARRGGILEASRVQEIAATLGAMRRLRGQVLRNHPDFVPLHPL
HHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AEQLPNLATLEHEIERTIGPDGEVLDSASAELGRLRSAIRVAFNRLQERLQAIINSSQYA
HHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DVLQEPIITVRDGRYVVPVKAPQRRALRGIVHDQSSSGATLYIEPLATVELNNQWRELQL
HHHHCCCEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEECEEEEEECCCHHHHHH
AEREEIQRILAALSGKIANEGMPIIVGVEATAELDLAFAKAKYSISLRASQPAINTPVPA
HHHHHHHHHHHHHCCHHHCCCCCEEEEECCCHHHHHHEEEEEEEEEEEECCCCCCCCCCC
DDLHPESTLSLLKARHPLLNQDLVVPTDVWLGGPTQMIIITGPNTGGKTVALKTVGLMAL
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCCEEEHHHHHHHHH
MAQAGLHIPAHQGSRLPIFGKIFADIGDEQSIEQSLSTFSSHMTNIIQILDRVTPDSLVL
HHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
FDELGAGTDPVEGAALARAIIERLLNVGCLAMATSHYAELKAFAYSTDGVENASVEFDVE
EHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEE
TLSPTYRLSIGLPGRSNALAIAERLGLKRDLIERARATISRDNVQVEDLLAAIHRERTTA
ECCCEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
ESEAARALELREDAELVRDRLSRELYEFEQDREQQLASYQRQLDDELREVRAELRRLRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRSVSVSRQWMEQAEQRLSRVAERVPQTPTPPKAKVPVVPKVALAPLPRTIQVGDQVFVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCHHHHCCHHHHH
SVKLSGVVLDLDEEANEAEVQLGGFRLRVDLRELRLEKAGTSPTQAVQKYVPVQRMINTP
HEEECEEEEECCCCCCCCEEEECCEEEEEEHHHHHHHHCCCCHHHHHHHHHCHHHHHCCC
PPPNVSMQLDMRGWRASDVESQLDHYLNDAYLANLSEVRLVHGKGTGALRQVVRTLLKRH
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHHC
PLVESYNSGSQGDGGDGVTIAKMVAR
CCHHCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]