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The map label for this gene is purC

Identifier: 159901346

GI number: 159901346

Start: 6165009

End: 6165752

Strand: Reverse

Name: purC

Synonym: Haur_4835

Alternate gene names: 159901346

Gene position: 6165752-6165009 (Counterclockwise)

Preceding gene: 159901347

Following gene: 159901338

Centisome position: 97.15

GC content: 50.13

Gene sequence:

>744_bases
ATGCAATACGGCACAAAATTAGCCGAAGGCAAAACCAAGATTATCTATGCTCACCCTGAAGACCAAAGCTTGGCCTATAT
GGTCCAAAAGGATTCGATTAGCGCTGGCGATGGGGCACGACGCAATGAAATCGACGGAAAAGGCGCGATCAGCGGTCGCA
CCTCGGCTAATGTCTTTGCCTTGCTCAACCGCAGTGGCGTGCGCACCCACTATCAATCCGACCCTGAACCTGGGGTGATG
CTGGTTGAACGTTGTGAAATGTTGCCCTTAGAAGTAGTCATGCGCCGTTTGGCAACTGGCTCATATTGCCGCCGCCACCC
TGAAACGCCCGAAGGCACCCGTTTTAGCCCACCATTGGTTGAATTTTTTTATAAAGACGATGCCAACCACGATCCTCAAA
TTTACTTGGAAGGGATTGTTGAAAAAGGCTTGGCGACTGCCGAGGAAGTCAGTTTTATCGAGCAAGAAGGCACGCGGGTG
TTTGAGTTGCTTGAACAAACTTGGGCTGAGCGCGGTGTACAATTGGTTGATCTCAAGATCGAATTTGGCCGCACTGCCGA
TGGGAGCCTGATCGTTGCCGATATGATCGACAATGATTCATGGCGTTTGTGGCCCGACGGCGATAAGAGCAAAATGCTTG
ATAAGCAAATTTATCGCAATTTGCAAACTGTCACCGAGGAAGCGCTGCAAAACCTCAAAGCCAAATACGAGGAAGTGCGC
GATATTACCGAGAGCTTCCGCTAA

Upstream 100 bases:

>100_bases
AGTGAAAACGCATAAGCATGTATAATGGGGCGGGCAGACTCCATTTGCTGAGTTTGCCGTTGAATTTGCTTGCTCAACAA
CGCATGAAGGAGCGTTTTCA

Downstream 100 bases:

>100_bases
ATTAGTGCTGATTACTGCGCCGCGTTCCATTCGGTGGAGCGCGGTTTTGCTTTAAGAGAGAAACTGCAAGGGTCGGCGGG
CGGCGGCAATTCCAGCTTGC

Product: phosphoribosylaminoimidazolesuccinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MQYGTKLAEGKTKIIYAHPEDQSLAYMVQKDSISAGDGARRNEIDGKGAISGRTSANVFALLNRSGVRTHYQSDPEPGVM
LVERCEMLPLEVVMRRLATGSYCRRHPETPEGTRFSPPLVEFFYKDDANHDPQIYLEGIVEKGLATAEEVSFIEQEGTRV
FELLEQTWAERGVQLVDLKIEFGRTADGSLIVADMIDNDSWRLWPDGDKSKMLDKQIYRNLQTVTEEALQNLKAKYEEVR
DITESFR

Sequences:

>Translated_247_residues
MQYGTKLAEGKTKIIYAHPEDQSLAYMVQKDSISAGDGARRNEIDGKGAISGRTSANVFALLNRSGVRTHYQSDPEPGVM
LVERCEMLPLEVVMRRLATGSYCRRHPETPEGTRFSPPLVEFFYKDDANHDPQIYLEGIVEKGLATAEEVSFIEQEGTRV
FELLEQTWAERGVQLVDLKIEFGRTADGSLIVADMIDNDSWRLWPDGDKSKMLDKQIYRNLQTVTEEALQNLKAKYEEVR
DITESFR
>Mature_247_residues
MQYGTKLAEGKTKIIYAHPEDQSLAYMVQKDSISAGDGARRNEIDGKGAISGRTSANVFALLNRSGVRTHYQSDPEPGVM
LVERCEMLPLEVVMRRLATGSYCRRHPETPEGTRFSPPLVEFFYKDDANHDPQIYLEGIVEKGLATAEEVSFIEQEGTRV
FELLEQTWAERGVQLVDLKIEFGRTADGSLIVADMIDNDSWRLWPDGDKSKMLDKQIYRNLQTVTEEALQNLKAKYEEVR
DITESFR

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=251, Percent_Identity=41.4342629482072, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI5453539, Length=251, Percent_Identity=41.4342629482072, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI119220559, Length=258, Percent_Identity=39.922480620155, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI1788820, Length=239, Percent_Identity=29.7071129707113, Blast_Score=104, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531275, Length=246, Percent_Identity=42.6829268292683, Blast_Score=210, Evalue=5e-55,
Organism=Drosophila melanogaster, GI18860083, Length=252, Percent_Identity=44.8412698412698, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24583917, Length=244, Percent_Identity=43.8524590163934, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI160714955, Length=100, Percent_Identity=42, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_HERA2 (A9B302)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547593.1
- ProteinModelPortal:   A9B302
- SMR:   A9B302
- GeneID:   5736680
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4835
- HOGENOM:   HBG306070
- OMA:   SWRIWPG
- ProtClustDB:   CLSK974244
- BioCyc:   HAUR316274:HAUR_4835-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28041; Mature: 28041

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYGTKLAEGKTKIIYAHPEDQSLAYMVQKDSISAGDGARRNEIDGKGAISGRTSANVFA
CCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHEE
LLNRSGVRTHYQSDPEPGVMLVERCEMLPLEVVMRRLATGSYCRRHPETPEGTRFSPPLV
EECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHH
EFFYKDDANHDPQIYLEGIVEKGLATAEEVSFIEQEGTRVFELLEQTWAERGVQLVDLKI
HHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEE
EFGRTADGSLIVADMIDNDSWRLWPDGDKSKMLDKQIYRNLQTVTEEALQNLKAKYEEVR
EECCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DITESFR
HHHHHCC
>Mature Secondary Structure
MQYGTKLAEGKTKIIYAHPEDQSLAYMVQKDSISAGDGARRNEIDGKGAISGRTSANVFA
CCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHEE
LLNRSGVRTHYQSDPEPGVMLVERCEMLPLEVVMRRLATGSYCRRHPETPEGTRFSPPLV
EECCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHH
EFFYKDDANHDPQIYLEGIVEKGLATAEEVSFIEQEGTRVFELLEQTWAERGVQLVDLKI
HHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEE
EFGRTADGSLIVADMIDNDSWRLWPDGDKSKMLDKQIYRNLQTVTEEALQNLKAKYEEVR
EECCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DITESFR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA