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The map label for this gene is fmt

Identifier: 159901343

GI number: 159901343

Start: 6160994

End: 6161914

Strand: Direct

Name: fmt

Synonym: Haur_4832

Alternate gene names: 159901343

Gene position: 6160994-6161914 (Clockwise)

Preceding gene: 159901342

Following gene: 159901344

Centisome position: 97.08

GC content: 52.88

Gene sequence:

>921_bases
ATGCGAATTTTATATTTAGGTACGCCTGAGATTGCGGTTGCGCCGCTTGAGTTGCTGCATGCCAGCGGTCATGAGATCGT
GGGCGTGGTAACGCAGCCCGATCGTCCGGCTGGGCGTAAAAATGTGCTCACGGCTCCGCCCGTTAAGCTTGCTGCTGAAC
GGCTTGGGATTCCTGTTTTTCAACCGGAAACTCTCAAAGATCCGGCGGCAGTGGCGCGTTTGCGGGCGTTTGAGCCTGAA
GTTGGAGTGGTGGCAGCCTATGGCGAAATTTTACGGAAACAGGTTTTAGCAATTCCGGCCTTAGGCTATTTGAATATTCA
TCCATCCATTTTGCCACTGTATCGTGGGCCAGCCCCAGTGACTGGCGCAATTTTGGCTGGCGACGATTTGGTCGGGGTTT
CAATCATCAAACTAACAGCTAAAATGGATGCGGGGCCGATTCTTGGCCAAATGGTAATGCCGTTGGCTAATGATGCCCGT
GCTGGTGAATGGACAGCTCAATTGATGCGTCAGGGTGGCGAGTTGCTTGCCCAGGTCTTGCCGGCCTATGCTGCGGGCCA
AATTCAAGCGCAGATTCAGGATGATAGCCAAGCCAGCTATACCCAAATGATTAGCAAAAACGATGGCTTGATCAATTGGA
ATTTGCCCGCCTTGGTGATCGAACGCATGACTCGTGCTTACGATCCATGGCCTGGGACTGCGGTTAAACTCAATGATCAG
CCGTTTAAGATTTTGCGAGCCAAGGCGCATACAAGCTGGAGTGGTACGATCCAGCCTGGTACGTTGTTCGAGCAGCAAGG
CCAGATTTTGGTAGCAACTGGTAGCGGGGCATTGGAACTGCTTGAAGTTCAACCAGCTGGTAAGCGGCCAATGGCTGCCA
ACGATTGGCGGCGTGGTGCGAAGGATATCGAGCAGCTGTAG

Upstream 100 bases:

>100_bases
TATTTTTGTTGCGGTTTGCCTGCAACGTTGATTAATACTTTTGTTTTTGCTCAAGCACGGTATCATGCTGGTTAGCACTC
TTCAGTATGAGGTATCAGCG

Downstream 100 bases:

>100_bases
CTTGATCGGCTAGCTATTGGCTACGTGTAATGGTTCATTGGGTTTGTAACCATTTTTTATTCCCTTATCCCCAACCTCTC
TCCTGCCAAGCGAGGCGCGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRILYLGTPEIAVAPLELLHASGHEIVGVVTQPDRPAGRKNVLTAPPVKLAAERLGIPVFQPETLKDPAAVARLRAFEPE
VGVVAAYGEILRKQVLAIPALGYLNIHPSILPLYRGPAPVTGAILAGDDLVGVSIIKLTAKMDAGPILGQMVMPLANDAR
AGEWTAQLMRQGGELLAQVLPAYAAGQIQAQIQDDSQASYTQMISKNDGLINWNLPALVIERMTRAYDPWPGTAVKLNDQ
PFKILRAKAHTSWSGTIQPGTLFEQQGQILVATGSGALELLEVQPAGKRPMAANDWRRGAKDIEQL

Sequences:

>Translated_306_residues
MRILYLGTPEIAVAPLELLHASGHEIVGVVTQPDRPAGRKNVLTAPPVKLAAERLGIPVFQPETLKDPAAVARLRAFEPE
VGVVAAYGEILRKQVLAIPALGYLNIHPSILPLYRGPAPVTGAILAGDDLVGVSIIKLTAKMDAGPILGQMVMPLANDAR
AGEWTAQLMRQGGELLAQVLPAYAAGQIQAQIQDDSQASYTQMISKNDGLINWNLPALVIERMTRAYDPWPGTAVKLNDQ
PFKILRAKAHTSWSGTIQPGTLFEQQGQILVATGSGALELLEVQPAGKRPMAANDWRRGAKDIEQL
>Mature_306_residues
MRILYLGTPEIAVAPLELLHASGHEIVGVVTQPDRPAGRKNVLTAPPVKLAAERLGIPVFQPETLKDPAAVARLRAFEPE
VGVVAAYGEILRKQVLAIPALGYLNIHPSILPLYRGPAPVTGAILAGDDLVGVSIIKLTAKMDAGPILGQMVMPLANDAR
AGEWTAQLMRQGGELLAQVLPAYAAGQIQAQIQDDSQASYTQMISKNDGLINWNLPALVIERMTRAYDPWPGTAVKLNDQ
PFKILRAKAHTSWSGTIQPGTLFEQQGQILVATGSGALELLEVQPAGKRPMAANDWRRGAKDIEQL

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=223, Percent_Identity=33.1838565022422, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI21614513, Length=323, Percent_Identity=26.0061919504644, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI238814322, Length=257, Percent_Identity=27.2373540856031, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789683, Length=296, Percent_Identity=39.8648648648649, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1788589, Length=285, Percent_Identity=30.8771929824561, Blast_Score=144, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI133930964, Length=332, Percent_Identity=24.3975903614458, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550868, Length=303, Percent_Identity=27.0627062706271, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571984, Length=278, Percent_Identity=26.978417266187, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24585660, Length=323, Percent_Identity=24.7678018575851, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_HERA2 (A9B2Z9)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547590.1
- ProteinModelPortal:   A9B2Z9
- SMR:   A9B2Z9
- GeneID:   5736677
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4832
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   CLSK975056
- BioCyc:   HAUR316274:HAUR_4832-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32838; Mature: 32838

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILYLGTPEIAVAPLELLHASGHEIVGVVTQPDRPAGRKNVLTAPPVKLAAERLGIPVF
CEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCC
QPETLKDPAAVARLRAFEPEVGVVAAYGEILRKQVLAIPALGYLNIHPSILPLYRGPAPV
CCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCC
TGAILAGDDLVGVSIIKLTAKMDAGPILGQMVMPLANDARAGEWTAQLMRQGGELLAQVL
CEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
PAYAAGQIQAQIQDDSQASYTQMISKNDGLINWNLPALVIERMTRAYDPWPGTAVKLNDQ
HHHHCCEEEEEECCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCEEEECCC
PFKILRAKAHTSWSGTIQPGTLFEQQGQILVATGSGALELLEVQPAGKRPMAANDWRRGA
CCEEEEECCCCCCCCCCCCCCCHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHH
KDIEQL
HHHHCC
>Mature Secondary Structure
MRILYLGTPEIAVAPLELLHASGHEIVGVVTQPDRPAGRKNVLTAPPVKLAAERLGIPVF
CEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCC
QPETLKDPAAVARLRAFEPEVGVVAAYGEILRKQVLAIPALGYLNIHPSILPLYRGPAPV
CCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCC
TGAILAGDDLVGVSIIKLTAKMDAGPILGQMVMPLANDARAGEWTAQLMRQGGELLAQVL
CEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
PAYAAGQIQAQIQDDSQASYTQMISKNDGLINWNLPALVIERMTRAYDPWPGTAVKLNDQ
HHHHCCEEEEEECCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCEEEECCC
PFKILRAKAHTSWSGTIQPGTLFEQQGQILVATGSGALELLEVQPAGKRPMAANDWRRGA
CCEEEEECCCCCCCCCCCCCCCHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHH
KDIEQL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA