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The map label for this gene is fumC [H]

Identifier: 159901274

GI number: 159901274

Start: 6068381

End: 6069802

Strand: Direct

Name: fumC [H]

Synonym: Haur_4762

Alternate gene names: 159901274

Gene position: 6068381-6069802 (Clockwise)

Preceding gene: 159901273

Following gene: 159901275

Centisome position: 95.62

GC content: 51.83

Gene sequence:

>1422_bases
ATGTCGGCTGAGTTTCGTGTGGAGAAAGATTCGCTCGGTGAGGTACAGGTGCCAGCGTGGGCATTGTATGGGGCACAAAC
TCAACGAGCAGTGCAGAATTTCCCCATCAGCGGGCTGAAACAGTACCCTGCATTCATTTGGTCAATGGCGACGATCAAAA
AGGCCGCCGCTCTTGTCCACCAAGATTTAGCGTTGCTCGATGCCAAAATGGCCGCTGCGATTGTGCAAGCAGCCGATGAA
GTGATCGACGGTAAATTGAACGATCACTTTGTGGTTGACCCATTCCAAGCTGGCGCTGGCACTTCGCACAACATGAATAT
CAACGAAGTGATCTCAAATCGGGCTAACCAAATTTTGGGCTACGAGATTGACGATCCCAAAAAGCCCGTCAACCCCAACG
ATCACGTTAATATGGCTCAAAGCACCAACGACACGATTCCAACCGCGTTGCGTTTGGGCGCATTGTGGCGCTTAGATGAG
TTGGTCAACACAGTTTTGGGCTTGGCCGAAACATTCGCCACCAAAGGTCAAGAATTCGACCATGTGCTCAAATCAGGCCG
TACCCACTTGCAAGACGCTGTGCCAGTGCGCTTGGGCCAAGAATTCAATGCCTATGCCAAAGCTGTGCGGCTTGATGCCA
AACGCATCCAAGCTGCTGGCGATCGTTTGCGCGAACTGGGCATCGGTGGCACGGCCACTGGCTCAGGCTTGAACGCTCAC
CCTGAGTACCACCATCGGATGGTCACGAAGTTGATGGGCTTGACCGGAATTGAGTTGCGTACATCAGACGATTTGTTTGA
ACGCATGCAAAGCATGGGCGACCAAGCCGATTTCTCTGGCTCAATGCGGGCTTTGTGTGTCACCTTGATTCGGATTGCCA
ACGACCTGCGTTTGTTGGCTTCTGGCCCAGCAACTGGCTTGGACGAAATTCGCTTGCCAGCAGTGCAGCCAGGTTCGTCA
ATTATGCCTGGTAAAGTCAATCCAGTGCTGGCTGAAATGCTCAACCAAGCCTGTTTTCATGTGATGGGCAATGATCATGC
AGTAACTTTGGCTGCTCAAGCTGGCCAGTTGGAACTAAACGTGATGATGCCAATTATCGGCTATAACATTTTCCAAATGA
TGGATGTCTTGATTGGCGCAGTCAAGGCCTTTACCGAAAAGTGTGTCTTGGGTATTCAAGCCAACGAAGAAAAAGCCACA
GGTTGGTTGGCCAAGAACGCCATTTTGGTAACCGCGCTCAATCCAACGATTGGCTATCTCAAAGGCGCTGAAGTGGCCAA
GGAAGCCATGGCGACCAACCGCACGATTCGCGAAGTAGTGGTCGAAAAAGGCTATTTGACTGCTGAAGAAGCCGATAGCT
TACTCGACGTTCGCGCAATGACCGAAGGTGGCATCTTTGGTGGCGGCGGCGCTGGCGGCTAA

Upstream 100 bases:

>100_bases
TTAAACCTGCCACTTTTGCTTGGCAAGTATCGACCTGCATGATTAAAAGCATCGCGTATAATAGGCCATATATTGATTCG
ACCTTTCATGTGGAGGTTTT

Downstream 100 bases:

>100_bases
ACATTAAGCCAAATTCAACTATTTCAACCCCTTGCTCAGTTTGAGCAGGGGGTTTTTGATTACTGGCCGCAACGCCAAAA
CTGTGACTTTGTTTGACACA

Product: fumarate lyase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSAEFRVEKDSLGEVQVPAWALYGAQTQRAVQNFPISGLKQYPAFIWSMATIKKAAALVHQDLALLDAKMAAAIVQAADE
VIDGKLNDHFVVDPFQAGAGTSHNMNINEVISNRANQILGYEIDDPKKPVNPNDHVNMAQSTNDTIPTALRLGALWRLDE
LVNTVLGLAETFATKGQEFDHVLKSGRTHLQDAVPVRLGQEFNAYAKAVRLDAKRIQAAGDRLRELGIGGTATGSGLNAH
PEYHHRMVTKLMGLTGIELRTSDDLFERMQSMGDQADFSGSMRALCVTLIRIANDLRLLASGPATGLDEIRLPAVQPGSS
IMPGKVNPVLAEMLNQACFHVMGNDHAVTLAAQAGQLELNVMMPIIGYNIFQMMDVLIGAVKAFTEKCVLGIQANEEKAT
GWLAKNAILVTALNPTIGYLKGAEVAKEAMATNRTIREVVVEKGYLTAEEADSLLDVRAMTEGGIFGGGGAGG

Sequences:

>Translated_473_residues
MSAEFRVEKDSLGEVQVPAWALYGAQTQRAVQNFPISGLKQYPAFIWSMATIKKAAALVHQDLALLDAKMAAAIVQAADE
VIDGKLNDHFVVDPFQAGAGTSHNMNINEVISNRANQILGYEIDDPKKPVNPNDHVNMAQSTNDTIPTALRLGALWRLDE
LVNTVLGLAETFATKGQEFDHVLKSGRTHLQDAVPVRLGQEFNAYAKAVRLDAKRIQAAGDRLRELGIGGTATGSGLNAH
PEYHHRMVTKLMGLTGIELRTSDDLFERMQSMGDQADFSGSMRALCVTLIRIANDLRLLASGPATGLDEIRLPAVQPGSS
IMPGKVNPVLAEMLNQACFHVMGNDHAVTLAAQAGQLELNVMMPIIGYNIFQMMDVLIGAVKAFTEKCVLGIQANEEKAT
GWLAKNAILVTALNPTIGYLKGAEVAKEAMATNRTIREVVVEKGYLTAEEADSLLDVRAMTEGGIFGGGGAGG
>Mature_472_residues
SAEFRVEKDSLGEVQVPAWALYGAQTQRAVQNFPISGLKQYPAFIWSMATIKKAAALVHQDLALLDAKMAAAIVQAADEV
IDGKLNDHFVVDPFQAGAGTSHNMNINEVISNRANQILGYEIDDPKKPVNPNDHVNMAQSTNDTIPTALRLGALWRLDEL
VNTVLGLAETFATKGQEFDHVLKSGRTHLQDAVPVRLGQEFNAYAKAVRLDAKRIQAAGDRLRELGIGGTATGSGLNAHP
EYHHRMVTKLMGLTGIELRTSDDLFERMQSMGDQADFSGSMRALCVTLIRIANDLRLLASGPATGLDEIRLPAVQPGSSI
MPGKVNPVLAEMLNQACFHVMGNDHAVTLAAQAGQLELNVMMPIIGYNIFQMMDVLIGAVKAFTEKCVLGIQANEEKATG
WLAKNAILVTALNPTIGYLKGAEVAKEAMATNRTIREVVVEKGYLTAEEADSLLDVRAMTEGGIFGGGGAGG

Specific function: Unknown

COG id: COG1027

COG function: function code E; Aspartate ammonia-lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=45.7516339869281, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=45.1403887688985, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=42.1052631578947, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17553882, Length=451, Percent_Identity=43.2372505543237, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI32565146, Length=314, Percent_Identity=38.5350318471338, Blast_Score=227, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324993, Length=455, Percent_Identity=44.1758241758242, Blast_Score=382, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24640179, Length=453, Percent_Identity=44.3708609271523, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24640177, Length=453, Percent_Identity=44.3708609271523, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=42.2993492407809, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI24662684, Length=439, Percent_Identity=42.1412300683371, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24583245, Length=444, Percent_Identity=37.6126126126126, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50840; Mature: 50709

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEFRVEKDSLGEVQVPAWALYGAQTQRAVQNFPISGLKQYPAFIWSMATIKKAAALVH
CCCCCCCCCCCCCCEECCHHEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
QDLALLDAKMAAAIVQAADEVIDGKLNDHFVVDPFQAGAGTSHNMNINEVISNRANQILG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCCHHHHHHHHHHHEEC
YEIDDPKKPVNPNDHVNMAQSTNDTIPTALRLGALWRLDELVNTVLGLAETFATKGQEFD
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
HVLKSGRTHLQDAVPVRLGQEFNAYAKAVRLDAKRIQAAGDRLRELGIGGTATGSGLNAH
HHHHCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PEYHHRMVTKLMGLTGIELRTSDDLFERMQSMGDQADFSGSMRALCVTLIRIANDLRLLA
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
SGPATGLDEIRLPAVQPGSSIMPGKVNPVLAEMLNQACFHVMGNDHAVTLAAQAGQLELN
CCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEE
VMMPIIGYNIFQMMDVLIGAVKAFTEKCVLGIQANEEKATGWLAKNAILVTALNPTIGYL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHEECCEEEEEECCCHHHHH
KGAEVAKEAMATNRTIREVVVEKGYLTAEEADSLLDVRAMTEGGIFGGGGAGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SAEFRVEKDSLGEVQVPAWALYGAQTQRAVQNFPISGLKQYPAFIWSMATIKKAAALVH
CCCCCCCCCCCCCEECCHHEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
QDLALLDAKMAAAIVQAADEVIDGKLNDHFVVDPFQAGAGTSHNMNINEVISNRANQILG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCCHHHHHHHHHHHEEC
YEIDDPKKPVNPNDHVNMAQSTNDTIPTALRLGALWRLDELVNTVLGLAETFATKGQEFD
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
HVLKSGRTHLQDAVPVRLGQEFNAYAKAVRLDAKRIQAAGDRLRELGIGGTATGSGLNAH
HHHHCCCHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PEYHHRMVTKLMGLTGIELRTSDDLFERMQSMGDQADFSGSMRALCVTLIRIANDLRLLA
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
SGPATGLDEIRLPAVQPGSSIMPGKVNPVLAEMLNQACFHVMGNDHAVTLAAQAGQLELN
CCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEE
VMMPIIGYNIFQMMDVLIGAVKAFTEKCVLGIQANEEKATGWLAKNAILVTALNPTIGYL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHEECCEEEEEECCCHHHHH
KGAEVAKEAMATNRTIREVVVEKGYLTAEEADSLLDVRAMTEGGIFGGGGAGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]