Click here to switch to the map view.

The map label for this gene is 159901275

Identifier: 159901275

GI number: 159901275

Start: 6069995

End: 6071239

Strand: Direct

Name: 159901275

Synonym: Haur_4763

Alternate gene names: NA

Gene position: 6069995-6071239 (Clockwise)

Preceding gene: 159901274

Following gene: 159901276

Centisome position: 95.64

GC content: 51.16

Gene sequence:

>1245_bases
GTGGGTACGGCAAGCGATGCGCCGCAAGGCGAACCAACCCAGCGCCGCAAGTTCCAGCTGACCAACTTAGATGGTAATAA
CAACAAATACTATCTAGTTGAGATCTGGCAGCTTGCAGCAAACGATGTTTATTTTCGCGCTACCTATGGTCGGGTTGGCT
CTGCCGCCCAAATCGATGAGAAAGTGACGACGCAGGAATGGATCGAGCGCAAAATTCGTGAAAAGCTCAAAAAGGGCTAT
CACGAGGTGGCGTTACATCGCCCAACGGTGGTCGCTACCGCGTCAGCGCCAGTTGTAACGCTGGCCGAGCCAATTCGCAA
CGTGATTGATTATATTTTCGATGAGGCTGGCGAGGGCATTGCTTCGTATTTGGCAGTTGGCCTTGATGCAATTTCGGCTG
AACAAATTGAGCATGGCCGTAAGTTATTGGCCTTGGCCCAGCTCCAACATAGCACATGGCAAAAAAGCCAAACGCCCGCC
AATTTGGCCTTGCTCAGCAGCACAATTCAACATTTTTACAATACCGTGCCAACCAAATTGCCCAGCCGAATCAAGCGTGA
AACCGTCGTCGAGAATTTTTGTAACGACTTCGACCAACAAGAAACGCGCTTGCATCAGCTTGAGGCCGCGATTGCCACCA
TGACTGCTCAGCAGCAAAATCCGCAGGTTTCACGCTACGAAACCTTGGGCGCTGAACTGGATATGTTGCCACAGAACGAT
GATCGTTATCGCCAAATTTGCGATTATGTTGATCGAACCAGCGTGCATGGCTATAAAGTGCGGGTCAACAGCATTTTCAC
AATCAATATTGCCGCCGAACGCCGTACCTTTGAGCAAAGCCAGCTTGGCCGTAGCAATACTCAATTGTTATTCCACGGCA
CGGCGGGGCAAAATGTGCGCCACATCTTGCGTAGCGGCCTCGTTTGCCCGCGCACTCCCTCGAATGGGCGCATGTTTGGC
CACGGCATTTATTTCGCCAATAAGGCCACCAAATCAACCAATTATTGCTCGGTGCGGCGGCGTAATCGCCCGATGTTTCT
CTTTTTGGCCGATGTGGCTTTGGGCAATCCATATGTTGCGCCAACTGCCCAGAGCGATTTTCGGGCTGCGCCCAAGGGCT
TCGATTCGGTTTGGGGTAAGGCTCAACATACTGTCGCTTGGGCCGGCAAACTGCAATACGATGAATTTATTGTCTATCAA
TCAGCCCAACAAACCTTACGCTATTTGGTGCTTTTCGATCGCTAA

Upstream 100 bases:

>100_bases
TTGACACAGCAGTTTGTTAGAGTAAGGCCAGCAAAACCAAGTGACCCAATGCACAGGTTTGAGCGTTAGACAATGGTTTG
AGTATATGCGAGGTGCAATT

Downstream 100 bases:

>100_bases
AAACGACACTATTAACTTTGGAGGCTTCTATGCAACTCGGTGATTGGGTTGAATTTCAAATTATTGTCAGCAAACAATCA
AAAGGCCCAGGCAGTACGCC

Product: Poly(ADP-ribose) polymerase catalytic subunit

Products: NA

Alternate protein names: PARP Catalytic Domain Protein; Poly(ADP-Ribose) Polymerase Catalytic Region

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MGTASDAPQGEPTQRRKFQLTNLDGNNNKYYLVEIWQLAANDVYFRATYGRVGSAAQIDEKVTTQEWIERKIREKLKKGY
HEVALHRPTVVATASAPVVTLAEPIRNVIDYIFDEAGEGIASYLAVGLDAISAEQIEHGRKLLALAQLQHSTWQKSQTPA
NLALLSSTIQHFYNTVPTKLPSRIKRETVVENFCNDFDQQETRLHQLEAAIATMTAQQQNPQVSRYETLGAELDMLPQND
DRYRQICDYVDRTSVHGYKVRVNSIFTINIAAERRTFEQSQLGRSNTQLLFHGTAGQNVRHILRSGLVCPRTPSNGRMFG
HGIYFANKATKSTNYCSVRRRNRPMFLFLADVALGNPYVAPTAQSDFRAAPKGFDSVWGKAQHTVAWAGKLQYDEFIVYQ
SAQQTLRYLVLFDR

Sequences:

>Translated_414_residues
MGTASDAPQGEPTQRRKFQLTNLDGNNNKYYLVEIWQLAANDVYFRATYGRVGSAAQIDEKVTTQEWIERKIREKLKKGY
HEVALHRPTVVATASAPVVTLAEPIRNVIDYIFDEAGEGIASYLAVGLDAISAEQIEHGRKLLALAQLQHSTWQKSQTPA
NLALLSSTIQHFYNTVPTKLPSRIKRETVVENFCNDFDQQETRLHQLEAAIATMTAQQQNPQVSRYETLGAELDMLPQND
DRYRQICDYVDRTSVHGYKVRVNSIFTINIAAERRTFEQSQLGRSNTQLLFHGTAGQNVRHILRSGLVCPRTPSNGRMFG
HGIYFANKATKSTNYCSVRRRNRPMFLFLADVALGNPYVAPTAQSDFRAAPKGFDSVWGKAQHTVAWAGKLQYDEFIVYQ
SAQQTLRYLVLFDR
>Mature_413_residues
GTASDAPQGEPTQRRKFQLTNLDGNNNKYYLVEIWQLAANDVYFRATYGRVGSAAQIDEKVTTQEWIERKIREKLKKGYH
EVALHRPTVVATASAPVVTLAEPIRNVIDYIFDEAGEGIASYLAVGLDAISAEQIEHGRKLLALAQLQHSTWQKSQTPAN
LALLSSTIQHFYNTVPTKLPSRIKRETVVENFCNDFDQQETRLHQLEAAIATMTAQQQNPQVSRYETLGAELDMLPQNDD
RYRQICDYVDRTSVHGYKVRVNSIFTINIAAERRTFEQSQLGRSNTQLLFHGTAGQNVRHILRSGLVCPRTPSNGRMFGH
GIYFANKATKSTNYCSVRRRNRPMFLFLADVALGNPYVAPTAQSDFRAAPKGFDSVWGKAQHTVAWAGKLQYDEFIVYQS
AQQTLRYLVLFDR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156523968, Length=462, Percent_Identity=25.5411255411255, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI112789550, Length=324, Percent_Identity=22.8395061728395, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI110825963, Length=467, Percent_Identity=23.982869379015, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI110825961, Length=467, Percent_Identity=23.982869379015, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI158634482, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI158634478, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510487, Length=468, Percent_Identity=24.5726495726496, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71985054, Length=147, Percent_Identity=30.6122448979592, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 46868; Mature: 46737

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS51059 PARP_CATALYTIC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTASDAPQGEPTQRRKFQLTNLDGNNNKYYLVEIWQLAANDVYFRATYGRVGSAAQIDE
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEHHCCCEEEEEECCCCCCCHHHHH
KVTTQEWIERKIREKLKKGYHEVALHRPTVVATASAPVVTLAEPIRNVIDYIFDEAGEGI
HHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHH
ASYLAVGLDAISAEQIEHGRKLLALAQLQHSTWQKSQTPANLALLSSTIQHFYNTVPTKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
PSRIKRETVVENFCNDFDQQETRLHQLEAAIATMTAQQQNPQVSRYETLGAELDMLPQND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCC
DRYRQICDYVDRTSVHGYKVRVNSIFTINIAAERRTFEQSQLGRSNTQLLFHGTAGQNVR
HHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHH
HILRSGLVCPRTPSNGRMFGHGIYFANKATKSTNYCSVRRRNRPMFLFLADVALGNPYVA
HHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEHHHCCCCEEEEEEEECCCCCCCC
PTAQSDFRAAPKGFDSVWGKAQHTVAWAGKLQYDEFIVYQSAQQTLRYLVLFDR
CCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHHEEHHHHHHHHHEEEEECC
>Mature Secondary Structure 
GTASDAPQGEPTQRRKFQLTNLDGNNNKYYLVEIWQLAANDVYFRATYGRVGSAAQIDE
CCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEHHCCCEEEEEECCCCCCCHHHHH
KVTTQEWIERKIREKLKKGYHEVALHRPTVVATASAPVVTLAEPIRNVIDYIFDEAGEGI
HHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHH
ASYLAVGLDAISAEQIEHGRKLLALAQLQHSTWQKSQTPANLALLSSTIQHFYNTVPTKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
PSRIKRETVVENFCNDFDQQETRLHQLEAAIATMTAQQQNPQVSRYETLGAELDMLPQND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCC
DRYRQICDYVDRTSVHGYKVRVNSIFTINIAAERRTFEQSQLGRSNTQLLFHGTAGQNVR
HHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEHHHHHHHHHHCCCCCCEEEEECCCCHHHH
HILRSGLVCPRTPSNGRMFGHGIYFANKATKSTNYCSVRRRNRPMFLFLADVALGNPYVA
HHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEHHHCCCCEEEEEEEECCCCCCCC
PTAQSDFRAAPKGFDSVWGKAQHTVAWAGKLQYDEFIVYQSAQQTLRYLVLFDR
CCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCHHHHEEHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA