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The map label for this gene is pdhA [H]

Identifier: 159901146

GI number: 159901146

Start: 5922400

End: 5923377

Strand: Direct

Name: pdhA [H]

Synonym: Haur_4634

Alternate gene names: 159901146

Gene position: 5922400-5923377 (Clockwise)

Preceding gene: 159901144

Following gene: 159901147

Centisome position: 93.32

GC content: 50.31

Gene sequence:

>978_bases
ATGGAAAAGCAAGATTTACTTGCCGATTACCGCACGATGGTGCTGATTCGCTCATTTGAAGAACATTGCCAGCAACAGTA
CACCCGTGCTCGGATCGGCGGCTTCTTGCACTTATATGTTGGGCAAGAAGCAGTCGCGGTTGGTGCGATTGGTGCCTTGA
AAGCACAAGATCATTTAGTCACTCACTATCGCGACCATGGCCACGCCCTTGCTCGTGGCTTGGAACCCAAACCTCTGATG
GCTGAATTGTTTGGCCGCAGCACTGGCACCGGTAAAGGCAAAGGCGGCTCAATGCACTTTGCTGATAAAAATAAAAATTT
CTGGGGCGGTTACGCCATCGTTGGTGCCCACTTGCTGTTGGCCATGGGGATTGCCTACTCGATCAAATACAAGCGCGAAG
TGCTTGGCCAAGCTGATCAAGATGGTGTTGTCATGTGTTTCTTTGGCGATGGCGCAACCAATGGCGGCGAATTCTACGAA
GCCGTCAGTATGGCCGCATTATATAAATTGCCAATCGTTTTCCTATGCGAAAACAACGAATTTGCCATGGGTACGCCGCT
CAGCGTGCACACCTCGGTCACCGAAATTCACAAAAAAGCTTCGCCATTTATGCCTGGCGAACGGGTGAATGGCAACGACG
TTGAAGAAATGCGTGCTCGCGCCCTTTACGCCGTCAACCATGCCCGCACCGAAGGCCCATATTTCTTAGAAGCGATGACC
TATCGTCTCCGTGGTCACTCGGCTGCCGACCCTCAAATGTATCGAACTCGCGACGATATTAATGCTCGGCGTTCCGGCGA
CCCAATTGCTTTGCTCAAGCAAAAACTGATCGATCAAAACTTGTTGACTGAAAAACAAGCCAAGCAAATCGATAAAGAAG
TTGAAAAGGAAATGGATGTAGTGGTGCAATTTGCCGAAGAAAGCCCTGCCCCAGACCTGAGCGAAGCATGGACCGAAATC
TATTCGAAGCCGCTCTAA

Upstream 100 bases:

>100_bases
TCACCTTAAACTACTTAATTTATAGAGGCGTTCTATCCCCGTTGATAGGACGGCCAGGTATGGCTTTTCTTCTTCTGCAA
CCCTCGATAAAGGAGCCTTG

Downstream 100 bases:

>100_bases
GGAGATATCAATGCCCGTTATAACCTACTCGGAAGCCTTGCGCCAAGCATTGCGCGAAGCAATGACCAACGATCCACGGG
TGTTTATCATTGGTGAAGAT

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MEKQDLLADYRTMVLIRSFEEHCQQQYTRARIGGFLHLYVGQEAVAVGAIGALKAQDHLVTHYRDHGHALARGLEPKPLM
AELFGRSTGTGKGKGGSMHFADKNKNFWGGYAIVGAHLLLAMGIAYSIKYKREVLGQADQDGVVMCFFGDGATNGGEFYE
AVSMAALYKLPIVFLCENNEFAMGTPLSVHTSVTEIHKKASPFMPGERVNGNDVEEMRARALYAVNHARTEGPYFLEAMT
YRLRGHSAADPQMYRTRDDINARRSGDPIALLKQKLIDQNLLTEKQAKQIDKEVEKEMDVVVQFAEESPAPDLSEAWTEI
YSKPL

Sequences:

>Translated_325_residues
MEKQDLLADYRTMVLIRSFEEHCQQQYTRARIGGFLHLYVGQEAVAVGAIGALKAQDHLVTHYRDHGHALARGLEPKPLM
AELFGRSTGTGKGKGGSMHFADKNKNFWGGYAIVGAHLLLAMGIAYSIKYKREVLGQADQDGVVMCFFGDGATNGGEFYE
AVSMAALYKLPIVFLCENNEFAMGTPLSVHTSVTEIHKKASPFMPGERVNGNDVEEMRARALYAVNHARTEGPYFLEAMT
YRLRGHSAADPQMYRTRDDINARRSGDPIALLKQKLIDQNLLTEKQAKQIDKEVEKEMDVVVQFAEESPAPDLSEAWTEI
YSKPL
>Mature_325_residues
MEKQDLLADYRTMVLIRSFEEHCQQQYTRARIGGFLHLYVGQEAVAVGAIGALKAQDHLVTHYRDHGHALARGLEPKPLM
AELFGRSTGTGKGKGGSMHFADKNKNFWGGYAIVGAHLLLAMGIAYSIKYKREVLGQADQDGVVMCFFGDGATNGGEFYE
AVSMAALYKLPIVFLCENNEFAMGTPLSVHTSVTEIHKKASPFMPGERVNGNDVEEMRARALYAVNHARTEGPYFLEAMT
YRLRGHSAADPQMYRTRDDINARRSGDPIALLKQKLIDQNLLTEKQAKQIDKEVEKEMDVVVQFAEESPAPDLSEAWTEI
YSKPL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=325, Percent_Identity=42.1538461538462, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4505685, Length=325, Percent_Identity=43.0769230769231, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI291084742, Length=325, Percent_Identity=43.0769230769231, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI291084744, Length=332, Percent_Identity=42.1686746987952, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI291084757, Length=325, Percent_Identity=39.0769230769231, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI258645172, Length=332, Percent_Identity=28.9156626506024, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI11386135, Length=333, Percent_Identity=28.8288288288288, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=308, Percent_Identity=40.5844155844156, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17536047, Length=308, Percent_Identity=40.5844155844156, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI86563355, Length=308, Percent_Identity=31.1688311688312, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI86563357, Length=308, Percent_Identity=31.1688311688312, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=42.0245398773006, Blast_Score=238, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=38.8379204892966, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=38.8379204892966, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=38.8379204892966, Blast_Score=230, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24639746, Length=315, Percent_Identity=39.3650793650794, Blast_Score=227, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24639748, Length=326, Percent_Identity=38.3435582822086, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21355903, Length=323, Percent_Identity=25.6965944272446, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36206; Mature: 36206

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQDLLADYRTMVLIRSFEEHCQQQYTRARIGGFLHLYVGQEAVAVGAIGALKAQDHLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHH
THYRDHGHALARGLEPKPLMAELFGRSTGTGKGKGGSMHFADKNKNFWGGYAIVGAHLLL
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
AMGIAYSIKYKREVLGQADQDGVVMCFFGDGATNGGEFYEAVSMAALYKLPIVFLCENNE
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCC
FAMGTPLSVHTSVTEIHKKASPFMPGERVNGNDVEEMRARALYAVNHARTEGPYFLEAMT
EECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
YRLRGHSAADPQMYRTRDDINARRSGDPIALLKQKLIDQNLLTEKQAKQIDKEVEKEMDV
HHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVQFAEESPAPDLSEAWTEIYSKPL
HHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MEKQDLLADYRTMVLIRSFEEHCQQQYTRARIGGFLHLYVGQEAVAVGAIGALKAQDHLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHH
THYRDHGHALARGLEPKPLMAELFGRSTGTGKGKGGSMHFADKNKNFWGGYAIVGAHLLL
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
AMGIAYSIKYKREVLGQADQDGVVMCFFGDGATNGGEFYEAVSMAALYKLPIVFLCENNE
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCC
FAMGTPLSVHTSVTEIHKKASPFMPGERVNGNDVEEMRARALYAVNHARTEGPYFLEAMT
EECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
YRLRGHSAADPQMYRTRDDINARRSGDPIALLKQKLIDQNLLTEKQAKQIDKEVEKEMDV
HHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVQFAEESPAPDLSEAWTEIYSKPL
HHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]