Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 159901139

GI number: 159901139

Start: 5911619

End: 5914102

Strand: Direct

Name: gyrA [H]

Synonym: Haur_4627

Alternate gene names: 159901139

Gene position: 5911619-5914102 (Clockwise)

Preceding gene: 159901136

Following gene: 159901140

Centisome position: 93.15

GC content: 51.49

Gene sequence:

>2484_bases
ATGGAAATAGGGATTGTCAAGCCTGTTGCGATTGTTGACGAGATGCGTACCGCCTATCTCGATTATGCAATGAGTGTGAT
TGTATCGCGGGCCTTACCTGATGCTCGCGATGGTCTCAAACCTGTGCAGCGGCGGATTTTATATGCAATGTTCCGCGAAG
GGCTATTGCACAACGTGCGCTATTCCAAATGCGCTGGGGTTGTCGGCGAAGTGCTCAAGAAGTATCACCCTCACGGCGAT
GCTTCGGTTTATGATGCCCTCGTGCGCCTCGCCCAACCATGGAATATGCGCTATCCGCTCGTCGATGGCCAAGGGAATTT
TGGCAGTGTTGACGGCGACGCAGCGGCGGCCTACAGATACACTGAAGCGCGGCTCAAAGAAATTGCCGAGGAATTGTTGC
GCGATATCGACCGCGATACGGTGAATTTCGGCCCCAACTTCGATGGCGGCTATCAAGAGCCATTGGTGTTGCCAGCGCGT
TTGCCCAACTTGCTGCTCAACGGCTCAGCTGGGATTGCGGTTGGTATGGCCACCAACATTCCGCCACATAACCTTGGCGA
GCTGTGCGATGGCATCGGCTACTTGGTTGATAATCCCGATGCAACCGTTGAAGATTTGATCAAATTTATCCCTGGCCCCG
ACTTCCCAACGGGCGGCTCGATTCTGGGTACTGAAGGGATTATCAGCGCTTATTCGAGTGGTCGTGGCCGGATTTTGATT
CGCGCTAAAGCCCACATCGAAGAAGCTGCTCGCGGTGCGTTCCATATCGTCGTGACCGAATTGCCCTATCAAGTTAACAA
AGCCCGTTTGATTGAACGGATTGCCGAGTTAGTCAAAGATAAACGGATCGAAGGGATTCGCGATGTGCGCGATGAATCCG
ACCGTTCAGGGATTCGCATGGTGATTATCTTGAAGCAAGATGCCCAGCCCAAGAAAGTGCTGAATCATCTATTCAAATAC
ACCAGCATGCAAACCACCTTTGGCGCAAATATGTTGGCCTTGGTCGAAGATGGCAAGCAGCCACGCACGCTTTCGCTTAA
AAAAGCCTTGCAAGAATATATCGAGCATCGCCAAATTGTCATTCGGCGGCGTACCGAGCATGATCTGGCCAAAGCCAAAG
CACGGGCGCATATTCTCGAAGGCTTGAAAATTGCGCTCGATCAGCTTGATGAAGTGATTGCCACGATTCGCGCTAGCCGC
ACCGCTGAAACTGCCCGCAGCAATTTGATGAAAAACTTCAAGCTCAGCGAATTGCAATCGCAAGCGATCTTGGAAATGCA
ATTGCGGCGCTTGGCCGGCCTCGAACGCAAAAAGATCGAGGATGAATATAAAGAAGTCTTGGGGACGATTGCCGACCTTG
AAGATATTTTGTCCAAGCCCGAACGGGTTTTCAAAATTATCAAGGACGATGTGGCTGAACTCAAAGAAAAATATGGTGAT
GTGCGGCGCTCACGGATCATTGCCGATGCCACTGGCGATATCAGCACCGAAGATCTGATTCCCGACATGAATGTGTTGGT
GACGGTGACCGATCGTGGCTACATCAAGAAATTGCCTGGCGATACCTATCGCGTGCAAAATCGCGGTGGCCGTGGTATTA
AGGGCATGACCACCAAAGAAGATGATGTGGTGGCACATCTCTTGATGTGTAATACCCTGAACGATCTTTTGTTCTTTACC
AACCGTGGCAAAGTCTATCAACTCAAAGTTCATGAAGTTCCCGATGCGAGCCGTACCGCCAAAGGTCTGCCGCTGGTCAA
CCTGATCTCGCTCGAACCAGGCGAATTGGTCACATCATTGATCGCTGTGCCCGATTTCGACGATGGCGAATATTTGGTGA
TGACCACGGTCAAAGGCCGAATCAAACGCACCAAGTTGAGCGAATATAGCTCAGTGCGCTCGAATGGCTTGATCGCGATC
GGGCTTGATACTGGCGACGAACTGCGCTGGGTCAAAACTAGCAATGGCGACGAAGATATTTTGATGACTACCCAACATGG
CCAAACCATCCGCTTCAGTCAAGCCGAAGTGCGTCCGATGGGTCGGCCAGCTAGTGGGGTGATTGGCATCAAAATGTCAG
CCAAAGATCAAGTGGTCGGCATGGATTTGGTGCGGCCAGATTCACAACTGCTCGTGATTACCTCTCACGGCATGGGCAAG
CGCACCGACCTCGAAGACTATCCGGTCAAGGGGCGGGCAACCCAAGGCGTGATTACCATGCGGCTCAAGCCAGGCGATAT
TATTGCCGCCGCATTGGTGTTGACTGATAGTGATATTGTGACCACAATTACCCGCAATGGTGTCGTGATGCGTACTCGTG
CCGACAAGATTTCTAAGTATGGGCGAACAACTCAAGGCGTAACCGTAATCAATCTTGATAAGAAAGATTTGGTCGCAGCA
GTTTCGGCTGAACCACCAGTCGATGACAAGAGCGATGATTCGGATGCCAACGATAGCCCCGGCACAGTAACCCTGACAGC
TTAA

Upstream 100 bases:

>100_bases
GCATATTTGTGCTAAAAATATTCGACATTATGGCTATTTCGCGGTATAATACAGGAAGCTTAACTTTAGGGATTTAGCGC
TTACGCAAGGGATAAAATTC

Downstream 100 bases:

>100_bases
GCTTTTTAAGCAAATTAATGCTAAAAACCCGTTGCATATCCGATATGCAACGGGTTTTTAGCGGTTAAACTAAGTTCACC
TATATACCTATATCCGCTCT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MEIGIVKPVAIVDEMRTAYLDYAMSVIVSRALPDARDGLKPVQRRILYAMFREGLLHNVRYSKCAGVVGEVLKKYHPHGD
ASVYDALVRLAQPWNMRYPLVDGQGNFGSVDGDAAAAYRYTEARLKEIAEELLRDIDRDTVNFGPNFDGGYQEPLVLPAR
LPNLLLNGSAGIAVGMATNIPPHNLGELCDGIGYLVDNPDATVEDLIKFIPGPDFPTGGSILGTEGIISAYSSGRGRILI
RAKAHIEEAARGAFHIVVTELPYQVNKARLIERIAELVKDKRIEGIRDVRDESDRSGIRMVIILKQDAQPKKVLNHLFKY
TSMQTTFGANMLALVEDGKQPRTLSLKKALQEYIEHRQIVIRRRTEHDLAKAKARAHILEGLKIALDQLDEVIATIRASR
TAETARSNLMKNFKLSELQSQAILEMQLRRLAGLERKKIEDEYKEVLGTIADLEDILSKPERVFKIIKDDVAELKEKYGD
VRRSRIIADATGDISTEDLIPDMNVLVTVTDRGYIKKLPGDTYRVQNRGGRGIKGMTTKEDDVVAHLLMCNTLNDLLFFT
NRGKVYQLKVHEVPDASRTAKGLPLVNLISLEPGELVTSLIAVPDFDDGEYLVMTTVKGRIKRTKLSEYSSVRSNGLIAI
GLDTGDELRWVKTSNGDEDILMTTQHGQTIRFSQAEVRPMGRPASGVIGIKMSAKDQVVGMDLVRPDSQLLVITSHGMGK
RTDLEDYPVKGRATQGVITMRLKPGDIIAAALVLTDSDIVTTITRNGVVMRTRADKISKYGRTTQGVTVINLDKKDLVAA
VSAEPPVDDKSDDSDANDSPGTVTLTA

Sequences:

>Translated_827_residues
MEIGIVKPVAIVDEMRTAYLDYAMSVIVSRALPDARDGLKPVQRRILYAMFREGLLHNVRYSKCAGVVGEVLKKYHPHGD
ASVYDALVRLAQPWNMRYPLVDGQGNFGSVDGDAAAAYRYTEARLKEIAEELLRDIDRDTVNFGPNFDGGYQEPLVLPAR
LPNLLLNGSAGIAVGMATNIPPHNLGELCDGIGYLVDNPDATVEDLIKFIPGPDFPTGGSILGTEGIISAYSSGRGRILI
RAKAHIEEAARGAFHIVVTELPYQVNKARLIERIAELVKDKRIEGIRDVRDESDRSGIRMVIILKQDAQPKKVLNHLFKY
TSMQTTFGANMLALVEDGKQPRTLSLKKALQEYIEHRQIVIRRRTEHDLAKAKARAHILEGLKIALDQLDEVIATIRASR
TAETARSNLMKNFKLSELQSQAILEMQLRRLAGLERKKIEDEYKEVLGTIADLEDILSKPERVFKIIKDDVAELKEKYGD
VRRSRIIADATGDISTEDLIPDMNVLVTVTDRGYIKKLPGDTYRVQNRGGRGIKGMTTKEDDVVAHLLMCNTLNDLLFFT
NRGKVYQLKVHEVPDASRTAKGLPLVNLISLEPGELVTSLIAVPDFDDGEYLVMTTVKGRIKRTKLSEYSSVRSNGLIAI
GLDTGDELRWVKTSNGDEDILMTTQHGQTIRFSQAEVRPMGRPASGVIGIKMSAKDQVVGMDLVRPDSQLLVITSHGMGK
RTDLEDYPVKGRATQGVITMRLKPGDIIAAALVLTDSDIVTTITRNGVVMRTRADKISKYGRTTQGVTVINLDKKDLVAA
VSAEPPVDDKSDDSDANDSPGTVTLTA
>Mature_827_residues
MEIGIVKPVAIVDEMRTAYLDYAMSVIVSRALPDARDGLKPVQRRILYAMFREGLLHNVRYSKCAGVVGEVLKKYHPHGD
ASVYDALVRLAQPWNMRYPLVDGQGNFGSVDGDAAAAYRYTEARLKEIAEELLRDIDRDTVNFGPNFDGGYQEPLVLPAR
LPNLLLNGSAGIAVGMATNIPPHNLGELCDGIGYLVDNPDATVEDLIKFIPGPDFPTGGSILGTEGIISAYSSGRGRILI
RAKAHIEEAARGAFHIVVTELPYQVNKARLIERIAELVKDKRIEGIRDVRDESDRSGIRMVIILKQDAQPKKVLNHLFKY
TSMQTTFGANMLALVEDGKQPRTLSLKKALQEYIEHRQIVIRRRTEHDLAKAKARAHILEGLKIALDQLDEVIATIRASR
TAETARSNLMKNFKLSELQSQAILEMQLRRLAGLERKKIEDEYKEVLGTIADLEDILSKPERVFKIIKDDVAELKEKYGD
VRRSRIIADATGDISTEDLIPDMNVLVTVTDRGYIKKLPGDTYRVQNRGGRGIKGMTTKEDDVVAHLLMCNTLNDLLFFT
NRGKVYQLKVHEVPDASRTAKGLPLVNLISLEPGELVTSLIAVPDFDDGEYLVMTTVKGRIKRTKLSEYSSVRSNGLIAI
GLDTGDELRWVKTSNGDEDILMTTQHGQTIRFSQAEVRPMGRPASGVIGIKMSAKDQVVGMDLVRPDSQLLVITSHGMGK
RTDLEDYPVKGRATQGVITMRLKPGDIIAAALVLTDSDIVTTITRNGVVMRTRADKISKYGRTTQGVTVINLDKKDLVAA
VSAEPPVDDKSDDSDANDSPGTVTLTA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=342, Percent_Identity=24.8538011695906, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI19913406, Length=322, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=846, Percent_Identity=45.0354609929078, Blast_Score=738, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=609, Percent_Identity=37.7668308702791, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=371, Percent_Identity=25.6064690026954, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=387, Percent_Identity=24.8062015503876, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=450, Percent_Identity=24, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=348, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136538, Length=359, Percent_Identity=23.3983286908078, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91321; Mature: 91321

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIGIVKPVAIVDEMRTAYLDYAMSVIVSRALPDARDGLKPVQRRILYAMFREGLLHNVR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHCH
YSKCAGVVGEVLKKYHPHGDASVYDALVRLAQPWNMRYPLVDGQGNFGSVDGDAAAAYRY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHH
TEARLKEIAEELLRDIDRDTVNFGPNFDGGYQEPLVLPARLPNLLLNGSAGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHCCCEEECCCCCEEEEEECCC
PPHNLGELCDGIGYLVDNPDATVEDLIKFIPGPDFPTGGSILGTEGIISAYSSGRGRILI
CCCCHHHHHCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHCCCCCEEEE
RAKAHIEEAARGAFHIVVTELPYQVNKARLIERIAELVKDKRIEGIRDVRDESDRSGIRM
EEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VIILKQDAQPKKVLNHLFKYTSMQTTFGANMLALVEDGKQPRTLSLKKALQEYIEHRQIV
EEEECCCCCHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
IRRRTEHDLAKAKARAHILEGLKIALDQLDEVIATIRASRTAETARSNLMKNFKLSELQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QAILEMQLRRLAGLERKKIEDEYKEVLGTIADLEDILSKPERVFKIIKDDVAELKEKYGD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VRRSRIIADATGDISTEDLIPDMNVLVTVTDRGYIKKLPGDTYRVQNRGGRGIKGMTTKE
HHHHEEEEECCCCCCHHHCCCCCEEEEEEECCCEEECCCCCCEEEECCCCCCCCCCCCCC
DDVVAHLLMCNTLNDLLFFTNRGKVYQLKVHEVPDASRTAKGLPLVNLISLEPGELVTSL
HHHHHHHHHHHHHHHHEEEECCCEEEEEEEECCCCCHHHCCCCCEEEEEECCHHHHHHHH
IAVPDFDDGEYLVMTTVKGRIKRTKLSEYSSVRSNGLIAIGLDTGDELRWVKTSNGDEDI
HHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCE
LMTTQHGQTIRFSQAEVRPMGRPASGVIGIKMSAKDQVVGMDLVRPDSQLLVITSHGMGK
EEEECCCCEEEECCHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCC
RTDLEDYPVKGRATQGVITMRLKPGDIIAAALVLTDSDIVTTITRNGVVMRTRADKISKY
CCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCEEEEECCCEEEEECHHHHHHH
GRTTQGVTVINLDKKDLVAAVSAEPPVDDKSDDSDANDSPGTVTLTA
CCCCCCEEEEEECHHHHEEEECCCCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MEIGIVKPVAIVDEMRTAYLDYAMSVIVSRALPDARDGLKPVQRRILYAMFREGLLHNVR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHCH
YSKCAGVVGEVLKKYHPHGDASVYDALVRLAQPWNMRYPLVDGQGNFGSVDGDAAAAYRY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHH
TEARLKEIAEELLRDIDRDTVNFGPNFDGGYQEPLVLPARLPNLLLNGSAGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHCCCEEECCCCCEEEEEECCC
PPHNLGELCDGIGYLVDNPDATVEDLIKFIPGPDFPTGGSILGTEGIISAYSSGRGRILI
CCCCHHHHHCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHCCCCCEEEE
RAKAHIEEAARGAFHIVVTELPYQVNKARLIERIAELVKDKRIEGIRDVRDESDRSGIRM
EEHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VIILKQDAQPKKVLNHLFKYTSMQTTFGANMLALVEDGKQPRTLSLKKALQEYIEHRQIV
EEEECCCCCHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
IRRRTEHDLAKAKARAHILEGLKIALDQLDEVIATIRASRTAETARSNLMKNFKLSELQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QAILEMQLRRLAGLERKKIEDEYKEVLGTIADLEDILSKPERVFKIIKDDVAELKEKYGD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
VRRSRIIADATGDISTEDLIPDMNVLVTVTDRGYIKKLPGDTYRVQNRGGRGIKGMTTKE
HHHHEEEEECCCCCCHHHCCCCCEEEEEEECCCEEECCCCCCEEEECCCCCCCCCCCCCC
DDVVAHLLMCNTLNDLLFFTNRGKVYQLKVHEVPDASRTAKGLPLVNLISLEPGELVTSL
HHHHHHHHHHHHHHHHEEEECCCEEEEEEEECCCCCHHHCCCCCEEEEEECCHHHHHHHH
IAVPDFDDGEYLVMTTVKGRIKRTKLSEYSSVRSNGLIAIGLDTGDELRWVKTSNGDEDI
HHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCE
LMTTQHGQTIRFSQAEVRPMGRPASGVIGIKMSAKDQVVGMDLVRPDSQLLVITSHGMGK
EEEECCCCEEEECCHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCC
RTDLEDYPVKGRATQGVITMRLKPGDIIAAALVLTDSDIVTTITRNGVVMRTRADKISKY
CCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCEEEEECCCEEEEECHHHHHHH
GRTTQGVTVINLDKKDLVAAVSAEPPVDDKSDDSDANDSPGTVTLTA
CCCCCCEEEEEECHHHHEEEECCCCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]