Click here to switch to the map view.

The map label for this gene is ada [H]

Identifier: 159901119

GI number: 159901119

Start: 5892841

End: 5893377

Strand: Direct

Name: ada [H]

Synonym: Haur_4607

Alternate gene names: 159901119

Gene position: 5892841-5893377 (Clockwise)

Preceding gene: 159901118

Following gene: 159901120

Centisome position: 92.85

GC content: 48.98

Gene sequence:

>537_bases
ATGCCCGTAGAGTATTGTATTCAAACCAGCCCGTTTGGGCGTTTGCTGCTGGCGGCTGCGTCCGAGGGGTTGTTGTTGGC
CAGTTTTGCCGATGATGATAGTGAGTTGTTGGCTGAATTAACCGAAGCCTACCCCGAACGCTTGTTGCTCTATCGCTCAA
ATACATTGCTTGACCAAGCATTTTATCAATATCAGGCCTATTTTTCGGGCCAACGCCAGCAATTTGCATTACCAATTGCC
TGGCATGGCTCGGCGCAGCAGCAAGCAATTTGGCAACAAATAATCCAAATTCCCTTTGGTCAGCAATGGTCATATCAACA
GCTTGCCCAAACGTTGCCAACGCCGTATCAAGCTGCTCATGCGATCAATCAAGCCTTGCGCCATAATCCTTTAGCATTAA
TTATTCCCTGCCATCGTTTATCCAATTCGCCGCAAGGGCTTGGCTACTACCGCTGGGGGCGGGTTCGCCAACAACAACTT
TGCGATCGTGAAGCAAGTCCGGTTATCGCCACATATTCAATGGAGATGATGTCATGA

Upstream 100 bases:

>100_bases
GTTAATGGTGATGGTGTTGCTTCACGCACCGTTCAAGTAAGCCTGCGGGTGGTTGATCAGCTTCAGCCCATCTATTTGCC
GCTGACTAGAAAATAGCATT

Downstream 100 bases:

>100_bases
TTGTTGGACGCTTGCCTGATGTGCCACTCGATGCCGATTTGCCAATAAGCGCGAGCCTGATCTCTCAAGGATTAGAACAT
TATCAAGCAGTAGCCCGCTG

Product: methylated-DNA--protein-cysteine methyltransferase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MPVEYCIQTSPFGRLLLAAASEGLLLASFADDDSELLAELTEAYPERLLLYRSNTLLDQAFYQYQAYFSGQRQQFALPIA
WHGSAQQQAIWQQIIQIPFGQQWSYQQLAQTLPTPYQAAHAINQALRHNPLALIIPCHRLSNSPQGLGYYRWGRVRQQQL
CDREASPVIATYSMEMMS

Sequences:

>Translated_178_residues
MPVEYCIQTSPFGRLLLAAASEGLLLASFADDDSELLAELTEAYPERLLLYRSNTLLDQAFYQYQAYFSGQRQQFALPIA
WHGSAQQQAIWQQIIQIPFGQQWSYQQLAQTLPTPYQAAHAINQALRHNPLALIIPCHRLSNSPQGLGYYRWGRVRQQQL
CDREASPVIATYSMEMMS
>Mature_177_residues
PVEYCIQTSPFGRLLLAAASEGLLLASFADDDSELLAELTEAYPERLLLYRSNTLLDQAFYQYQAYFSGQRQQFALPIAW
HGSAQQQAIWQQIIQIPFGQQWSYQQLAQTLPTPYQAAHAINQALRHNPLALIIPCHRLSNSPQGLGYYRWGRVRQQQLC
DREASPVIATYSMEMMS

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=166, Percent_Identity=28.9156626506024, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788542, Length=169, Percent_Identity=35.5029585798817, Blast_Score=99, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 20313; Mature: 20182

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVEYCIQTSPFGRLLLAAASEGLLLASFADDDSELLAELTEAYPERLLLYRSNTLLDQA
CCCCCEECCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHEEHHHCCHHHHHH
FYQYQAYFSGQRQQFALPIAWHGSAQQQAIWQQIIQIPFGQQWSYQQLAQTLPTPYQAAH
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHH
AINQALRHNPLALIIPCHRLSNSPQGLGYYRWGRVRQQQLCDREASPVIATYSMEMMS
HHHHHHHCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCC
>Mature Secondary Structure 
PVEYCIQTSPFGRLLLAAASEGLLLASFADDDSELLAELTEAYPERLLLYRSNTLLDQA
CCCCEECCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHEEHHHCCHHHHHH
FYQYQAYFSGQRQQFALPIAWHGSAQQQAIWQQIIQIPFGQQWSYQQLAQTLPTPYQAAH
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHH
AINQALRHNPLALIIPCHRLSNSPQGLGYYRWGRVRQQQLCDREASPVIATYSMEMMS
HHHHHHHCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]