Click here to switch to the map view.

The map label for this gene is rcsC [H]

Identifier: 159901028

GI number: 159901028

Start: 5782874

End: 5784034

Strand: Reverse

Name: rcsC [H]

Synonym: Haur_4515

Alternate gene names: 159901028

Gene position: 5784034-5782874 (Counterclockwise)

Preceding gene: 159901029

Following gene: 159901027

Centisome position: 91.14

GC content: 48.15

Gene sequence:

>1161_bases
ATGCCCAAACAAGCGCTTGAACAATCAATCCAGCAGTTACGCCATATCATGATTATTGGGATGGCTTTCGTTGGCTACAG
CCTCGGTTTTATGTGGTTCTACGATCAGGTGGGGGCCGTGATTGGTTCGCTATTACTGCTCCCTGTTGGTTTAGCTGCAT
GGCTTTTGGGTTGGCGCGGTGGTTTGCTCGCGGCCTTGATTGGGATTTGCCTCAACATCGGTTTATTTTTGTTGAATGGG
TCATCATTTGCTGAGATTCTGGCGCTCGGGCCTGGCTTGATGATGGCATTTGTGGTCGGCGGAGCAATTGGCTGGTTGCG
ATCGCTGATCGATAAAATTCAAACTCAAACTACCGAGCTTCAGCGCGAGCGCGAATTGTTGGCCAACGAAATTAGCCAGC
GCAAACAGATTGAGCAATCGTTACTGGCTGCCAAAGAAGAGGCTGAGTTGGCCAATCGCTCCAAAAGCCAATTTCTGGCC
ATGATGAGCCATGAGTTGCGCACGCCACTGAATGCAATTATCGGCTATAGCGAGCTGCTGCAAGAAGATGCCGAGGCTGA
TCAATTACCCAATTATGTGCAAGATCTCAGTACCATTCGCAACGCTGGCGTGCATCTGTTGGGTTTAATCAACGATGTGC
TGGATCTTTCGAAAATTGAGGCTGGCCGCATGGAATTGTTCGGCCAAGATTTTCGTGCGATTGAGTTGATCAACGATCTG
GAATTGTATATTCAGCCGCAAATTGCCAAGAACAACAATCGCCTTGTGTTGGATGTAGCTAAGGATTTGGGTGTGATGCA
CAGTGATTTGCAAAAGTTACGCCAAATCTTACTTAATTTATTAACTAATGCTAGCAAATTTACCCAACAAGGCACAATTA
CCTTACGAGCCAAACGTGATGGCGATTGGCTGCATTTTGAAGTGGTTGATACTGGGATTGGCATGAGCAGCGAACACGTT
GCCAACCTGTTTCAGCCCTTTGTCCAAGCCGAACAATCGACAGCGGCACGCTTTGGCGGCACTGGTTTAGGCTTGGCAAT
TAGTCGTTCGCTGGCGCGGCTTTTAGGCGGCGATATTATGGTTGAGAGCGTGCTGGGGCAGGGTTCGAATTTTCAATTAA
TTGTGCCAGCGTTTCAATTAGCGCCTGTTACAGCTATGTAA

Upstream 100 bases:

>100_bases
TACTTTTGACCTCGTTGGGCTTATCATTGCGTGAAATTCAGGTTTCAATCGATGCTCTTAGCCTTGAAATTGCCGATCTC
GATGAGTAATTGGATTTGTT

Downstream 100 bases:

>100_bases
CCCGATTTAGACCTTTGTGATGGGCTGAATTGCTGCGAGTATCCCCCATGGTTTTGCCACTAAATTCATACGAATTGCTT
ATTTGACAAGCACCAAAATT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPKQALEQSIQQLRHIMIIGMAFVGYSLGFMWFYDQVGAVIGSLLLLPVGLAAWLLGWRGGLLAALIGICLNIGLFLLNG
SSFAEILALGPGLMMAFVVGGAIGWLRSLIDKIQTQTTELQRERELLANEISQRKQIEQSLLAAKEEAELANRSKSQFLA
MMSHELRTPLNAIIGYSELLQEDAEADQLPNYVQDLSTIRNAGVHLLGLINDVLDLSKIEAGRMELFGQDFRAIELINDL
ELYIQPQIAKNNNRLVLDVAKDLGVMHSDLQKLRQILLNLLTNASKFTQQGTITLRAKRDGDWLHFEVVDTGIGMSSEHV
ANLFQPFVQAEQSTAARFGGTGLGLAISRSLARLLGGDIMVESVLGQGSNFQLIVPAFQLAPVTAM

Sequences:

>Translated_386_residues
MPKQALEQSIQQLRHIMIIGMAFVGYSLGFMWFYDQVGAVIGSLLLLPVGLAAWLLGWRGGLLAALIGICLNIGLFLLNG
SSFAEILALGPGLMMAFVVGGAIGWLRSLIDKIQTQTTELQRERELLANEISQRKQIEQSLLAAKEEAELANRSKSQFLA
MMSHELRTPLNAIIGYSELLQEDAEADQLPNYVQDLSTIRNAGVHLLGLINDVLDLSKIEAGRMELFGQDFRAIELINDL
ELYIQPQIAKNNNRLVLDVAKDLGVMHSDLQKLRQILLNLLTNASKFTQQGTITLRAKRDGDWLHFEVVDTGIGMSSEHV
ANLFQPFVQAEQSTAARFGGTGLGLAISRSLARLLGGDIMVESVLGQGSNFQLIVPAFQLAPVTAM
>Mature_385_residues
PKQALEQSIQQLRHIMIIGMAFVGYSLGFMWFYDQVGAVIGSLLLLPVGLAAWLLGWRGGLLAALIGICLNIGLFLLNGS
SFAEILALGPGLMMAFVVGGAIGWLRSLIDKIQTQTTELQRERELLANEISQRKQIEQSLLAAKEEAELANRSKSQFLAM
MSHELRTPLNAIIGYSELLQEDAEADQLPNYVQDLSTIRNAGVHLLGLINDVLDLSKIEAGRMELFGQDFRAIELINDLE
LYIQPQIAKNNNRLVLDVAKDLGVMHSDLQKLRQILLNLLTNASKFTQQGTITLRAKRDGDWLHFEVVDTGIGMSSEHVA
NLFQPFVQAEQSTAARFGGTGLGLAISRSLARLLGGDIMVESVLGQGSNFQLIVPAFQLAPVTAM

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=39.8406374501992, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87081816, Length=283, Percent_Identity=37.4558303886926, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=38.5214007782101, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789149, Length=345, Percent_Identity=32.463768115942, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=31.2252964426877, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=30.9734513274336, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=29.1497975708502, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082128, Length=259, Percent_Identity=25.4826254826255, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=271, Percent_Identity=26.9372693726937, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790861, Length=276, Percent_Identity=25.3623188405797, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=25.6, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790346, Length=198, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI1788393, Length=207, Percent_Identity=27.536231884058, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=81, Percent_Identity=39.5061728395062, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42322; Mature: 42191

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQALEQSIQQLRHIMIIGMAFVGYSLGFMWFYDQVGAVIGSLLLLPVGLAAWLLGWRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
GLLAALIGICLNIGLFLLNGSSFAEILALGPGLMMAFVVGGAIGWLRSLIDKIQTQTTEL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRERELLANEISQRKQIEQSLLAAKEEAELANRSKSQFLAMMSHELRTPLNAIIGYSELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCHHHHH
QEDAEADQLPNYVQDLSTIRNAGVHLLGLINDVLDLSKIEAGRMELFGQDFRAIELINDL
HCCCCHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHH
ELYIQPQIAKNNNRLVLDVAKDLGVMHSDLQKLRQILLNLLTNASKFTQQGTITLRAKRD
HHHCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEECC
GDWLHFEVVDTGIGMSSEHVANLFQPFVQAEQSTAARFGGTGLGLAISRSLARLLGGDIM
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHH
VESVLGQGSNFQLIVPAFQLAPVTAM
HHHHHCCCCCCEEEEEHHHHCCCCCC
>Mature Secondary Structure 
PKQALEQSIQQLRHIMIIGMAFVGYSLGFMWFYDQVGAVIGSLLLLPVGLAAWLLGWRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
GLLAALIGICLNIGLFLLNGSSFAEILALGPGLMMAFVVGGAIGWLRSLIDKIQTQTTEL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRERELLANEISQRKQIEQSLLAAKEEAELANRSKSQFLAMMSHELRTPLNAIIGYSELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCHHHHH
QEDAEADQLPNYVQDLSTIRNAGVHLLGLINDVLDLSKIEAGRMELFGQDFRAIELINDL
HCCCCHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHH
ELYIQPQIAKNNNRLVLDVAKDLGVMHSDLQKLRQILLNLLTNASKFTQQGTITLRAKRD
HHHCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEECC
GDWLHFEVVDTGIGMSSEHVANLFQPFVQAEQSTAARFGGTGLGLAISRSLARLLGGDIM
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHH
VESVLGQGSNFQLIVPAFQLAPVTAM
HHHHHCCCCCCEEEEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]