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The map label for this gene is ilvC

Identifier: 159900960

GI number: 159900960

Start: 5689114

End: 5690127

Strand: Reverse

Name: ilvC

Synonym: Haur_4447

Alternate gene names: 159900960

Gene position: 5690127-5689114 (Counterclockwise)

Preceding gene: 159900961

Following gene: 159900959

Centisome position: 89.66

GC content: 51.68

Gene sequence:

>1014_bases
ATGGCAAAGCTTTATTACGATAACGATGCAGATCTTGGACGCTTGGCTGGCAAAACTGTGGCGATCATCGGTTATGGCTC
ACAAGGCCACGCCCACGCCTTGAACTTGAAGGATAGCGGCGTGCAGGTGGTGGTTGGTTTGCACGAAGGTAGCAAATCAA
AGGCCAAAGCCGAAGCTGCGGGCTTGCAAGTGTTGAGCGTTGGCGAGGCCACCAAGGCTGCTGATGTTGTCATGGTCTTG
GTGCCAGATACCACCCAAGCCCAACTCTACAGCGATGAAATTGCCCCGAACTTAAAGCCCAATGCAACCTTGATGTTTGC
CCACGGCTTCAACATTCGCTATGGTCAAATCGTGCCACCTGCTGGCGTTGATGTTTCGTTGATCGCGCCAAAATCACCTG
GACATCGCGTCCGTGAAGTATTCGAACATGGCGGCGGCGTACCAGGTTTGGTCGCAGTTTATCAAGATGCCAGCGGCGAA
GCCTTGCAAAACGCCTTGGCCTATGGCAAAGGCATCGGTTGTGCTCGCGCTGGTGTGCTCGAAACTACCTTTGCCGAAGA
AACCGAAACCGACTTGTTCGGCGAGCAAGCCATCTTGTGTGGCGGGGTTTCGGCCTTGGTCAAAGCAGGTTTTGAAACCT
TGGTCGAAGCTGGCTATCAACCAGAAGTTGCCTACTTTGAATGTATGCACGAACTCAAGTTGATCGTCGATTTGTTCTAT
CAAGGTGGCTTGAGCTACATGCGCTACTCGGTCAGTGATACTGCTGAATGGGGCGATTATATTGCTGGGCCACGGGTCGT
AACCAGCGAAACCAAAGCTGCCATGAAACTGTTGTTGGAAGAGATTCAAAATGGCGCATTCGCCGAAGATTGGATCGAAG
AAAACCACACTGGCCGCGCTCGTTTCAACAAGTATCGCTCAACCGATGTTGGCCACCAAATCGAGCAAGTTGGCCGCGAA
TTGCGCTCAATGATGCCATTCGTCAATCCAAAAGAAATTAACCCAGGCAGTTAA

Upstream 100 bases:

>100_bases
TTGGGATACATGGTGGGGCGATTACGGCGAGACCATGGAATAAACACGGGTAGCAATTGTTCATCGTTCAGCCCATTAGT
TATATTGAGGAACTCATTCA

Downstream 100 bases:

>100_bases
TTAGGGAACGAGGGCTTGGTGTCTTATGTTCCCTCACCCCCTAGCCCCCTCTCCCGCCCAGCGAGGCGAGGGGGAATTGC
TTAGGCTAACTCCCCTCTCC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKLYYDNDADLGRLAGKTVAIIGYGSQGHAHALNLKDSGVQVVVGLHEGSKSKAKAEAAGLQVLSVGEATKAADVVMVL
VPDTTQAQLYSDEIAPNLKPNATLMFAHGFNIRYGQIVPPAGVDVSLIAPKSPGHRVREVFEHGGGVPGLVAVYQDASGE
ALQNALAYGKGIGCARAGVLETTFAEETETDLFGEQAILCGGVSALVKAGFETLVEAGYQPEVAYFECMHELKLIVDLFY
QGGLSYMRYSVSDTAEWGDYIAGPRVVTSETKAAMKLLLEEIQNGAFAEDWIEENHTGRARFNKYRSTDVGHQIEQVGRE
LRSMMPFVNPKEINPGS

Sequences:

>Translated_337_residues
MAKLYYDNDADLGRLAGKTVAIIGYGSQGHAHALNLKDSGVQVVVGLHEGSKSKAKAEAAGLQVLSVGEATKAADVVMVL
VPDTTQAQLYSDEIAPNLKPNATLMFAHGFNIRYGQIVPPAGVDVSLIAPKSPGHRVREVFEHGGGVPGLVAVYQDASGE
ALQNALAYGKGIGCARAGVLETTFAEETETDLFGEQAILCGGVSALVKAGFETLVEAGYQPEVAYFECMHELKLIVDLFY
QGGLSYMRYSVSDTAEWGDYIAGPRVVTSETKAAMKLLLEEIQNGAFAEDWIEENHTGRARFNKYRSTDVGHQIEQVGRE
LRSMMPFVNPKEINPGS
>Mature_336_residues
AKLYYDNDADLGRLAGKTVAIIGYGSQGHAHALNLKDSGVQVVVGLHEGSKSKAKAEAAGLQVLSVGEATKAADVVMVLV
PDTTQAQLYSDEIAPNLKPNATLMFAHGFNIRYGQIVPPAGVDVSLIAPKSPGHRVREVFEHGGGVPGLVAVYQDASGEA
LQNALAYGKGIGCARAGVLETTFAEETETDLFGEQAILCGGVSALVKAGFETLVEAGYQPEVAYFECMHELKLIVDLFYQ
GGLSYMRYSVSDTAEWGDYIAGPRVVTSETKAAMKLLLEEIQNGAFAEDWIEENHTGRARFNKYRSTDVGHQIEQVGREL
RSMMPFVNPKEINPGS

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=297, Percent_Identity=34.006734006734, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=332, Percent_Identity=32.8313253012048, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HERA2 (A9AZM5)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547207.1
- ProteinModelPortal:   A9AZM5
- SMR:   A9AZM5
- GeneID:   5736298
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4447
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   HAUR316274:HAUR_4447-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36155; Mature: 36024

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLYYDNDADLGRLAGKTVAIIGYGSQGHAHALNLKDSGVQVVVGLHEGSKSKAKAEAA
CCEEEECCCCCHHHHCCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHH
GLQVLSVGEATKAADVVMVLVPDTTQAQLYSDEIAPNLKPNATLMFAHGFNIRYGQIVPP
CEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCEEECCCCCC
AGVDVSLIAPKSPGHRVREVFEHGGGVPGLVAVYQDASGEALQNALAYGKGIGCARAGVL
CCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHCCHH
ETTFAEETETDLFGEQAILCGGVSALVKAGFETLVEAGYQPEVAYFECMHELKLIVDLFY
HHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QGGLSYMRYSVSDTAEWGDYIAGPRVVTSETKAAMKLLLEEIQNGAFAEDWIEENHTGRA
HCCHHHEEECCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
RFNKYRSTDVGHQIEQVGRELRSMMPFVNPKEINPGS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AKLYYDNDADLGRLAGKTVAIIGYGSQGHAHALNLKDSGVQVVVGLHEGSKSKAKAEAA
CEEEECCCCCHHHHCCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHH
GLQVLSVGEATKAADVVMVLVPDTTQAQLYSDEIAPNLKPNATLMFAHGFNIRYGQIVPP
CEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCEEECCCCCC
AGVDVSLIAPKSPGHRVREVFEHGGGVPGLVAVYQDASGEALQNALAYGKGIGCARAGVL
CCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHCCHH
ETTFAEETETDLFGEQAILCGGVSALVKAGFETLVEAGYQPEVAYFECMHELKLIVDLFY
HHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QGGLSYMRYSVSDTAEWGDYIAGPRVVTSETKAAMKLLLEEIQNGAFAEDWIEENHTGRA
HCCHHHEEECCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
RFNKYRSTDVGHQIEQVGRELRSMMPFVNPKEINPGS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA