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The map label for this gene is hisN [H]

Identifier: 159900832

GI number: 159900832

Start: 5515061

End: 5515837

Strand: Direct

Name: hisN [H]

Synonym: Haur_4319

Alternate gene names: 159900832

Gene position: 5515061-5515837 (Clockwise)

Preceding gene: 159900831

Following gene: 159900833

Centisome position: 86.9

GC content: 52.64

Gene sequence:

>777_bases
ATGCCAAGTTTGCGTGAACTGTTGGATGTTGCGACCGAAGCGGCCTATTTAGGTGGTCGCCGAACCCTGGCTTATTTTGG
AGCCGATGTTCAAGTTGAAACCAAAGGCGATGCCACTCCCGTCACCCGTGCCGATCGCGAGGCCGAAACGATTATTCGCG
ACTATATTGGGCGCTATTTTCCAAGCCATACGATTATTGGCGAGGAGCACGGCGAGCAAAAGGGCGATGCCGATTATCGC
TGGATTATCGACCCAATTGATGGCACCAAAACCTTTATTCATGGTGTGCCGTTTTATGGCGTGCTGATTGGGCTAGAAAT
TAAGGGCGAGGCCAGTGTTGGCGCGGTCTATTTGCCTGCTTTCGATGAAATGTTGGCGGCTGCCAATGGCTTAGGATGTA
GCTGGAATGGCCGCCCGGCTCAGGTTAGCAAGGTTGATAATCTGGCTGATGCCACCTTGCTGACCACCTCAGTCACTTCG
GCCATGAAGCGCTCTAATGCCTATGAAACGCTTGTCAGCAAAACCAAACTTCAACGAACATGGGGAGATTGCTACGGCTA
TGTGTTGGTGGCGACTGGTCGGGCCGAAATTATGCTTGATCCAGCTATGAATCCATGGGATTGTGCGCCAATGCTGCCAA
TTTTGCGCGAGGCTGGCGGCCATTTCACCACATGGGCAGGCGAGGCGACAATTTGGGGTGCTGATGGAATGGCGACCAAC
GCGGCATTGCATCAAGAAGTGCTAGCAATTTTAGCCACCGAGCAACGCCATATCTAG

Upstream 100 bases:

>100_bases
CTCCAGCATTGTTGAGCGTTTTGTGCACGAACTTGCTCGTTTGGATGCTGCCAACTACCATGGCCCACGCTAATTGTGTT
GCCATGGAAGGATTCAAGCC

Downstream 100 bases:

>100_bases
CCACCTTTTAGGCTGACTTACGTAGACGTTTATTATAAATTAAAAGCCTTTGATTTTGAGATCATTCTATGCAATGTGCT
GCTTGTGGCGCGACCACCAC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPSLRELLDVATEAAYLGGRRTLAYFGADVQVETKGDATPVTRADREAETIIRDYIGRYFPSHTIIGEEHGEQKGDADYR
WIIDPIDGTKTFIHGVPFYGVLIGLEIKGEASVGAVYLPAFDEMLAAANGLGCSWNGRPAQVSKVDNLADATLLTTSVTS
AMKRSNAYETLVSKTKLQRTWGDCYGYVLVATGRAEIMLDPAMNPWDCAPMLPILREAGGHFTTWAGEATIWGADGMATN
AALHQEVLAILATEQRHI

Sequences:

>Translated_258_residues
MPSLRELLDVATEAAYLGGRRTLAYFGADVQVETKGDATPVTRADREAETIIRDYIGRYFPSHTIIGEEHGEQKGDADYR
WIIDPIDGTKTFIHGVPFYGVLIGLEIKGEASVGAVYLPAFDEMLAAANGLGCSWNGRPAQVSKVDNLADATLLTTSVTS
AMKRSNAYETLVSKTKLQRTWGDCYGYVLVATGRAEIMLDPAMNPWDCAPMLPILREAGGHFTTWAGEATIWGADGMATN
AALHQEVLAILATEQRHI
>Mature_257_residues
PSLRELLDVATEAAYLGGRRTLAYFGADVQVETKGDATPVTRADREAETIIRDYIGRYFPSHTIIGEEHGEQKGDADYRW
IIDPIDGTKTFIHGVPFYGVLIGLEIKGEASVGAVYLPAFDEMLAAANGLGCSWNGRPAQVSKVDNLADATLLTTSVTSA
MKRSNAYETLVSKTKLQRTWGDCYGYVLVATGRAEIMLDPAMNPWDCAPMLPILREAGGHFTTWAGEATIWGADGMATNA
ALHQEVLAILATEQRHI

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=228, Percent_Identity=32.0175438596491, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI221625487, Length=228, Percent_Identity=32.0175438596491, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7657236, Length=227, Percent_Identity=29.5154185022026, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI221625507, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788882, Length=233, Percent_Identity=33.9055793991416, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790659, Length=210, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=217, Percent_Identity=31.3364055299539, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193202570, Length=220, Percent_Identity=30, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=30.8457711442786, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321836, Length=202, Percent_Identity=29.2079207920792, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357329, Length=203, Percent_Identity=32.512315270936, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664922, Length=238, Percent_Identity=32.3529411764706, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664918, Length=234, Percent_Identity=31.1965811965812, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664926, Length=215, Percent_Identity=31.6279069767442, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357957, Length=212, Percent_Identity=30.6603773584906, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357303, Length=192, Percent_Identity=31.25, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28038; Mature: 27907

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLRELLDVATEAAYLGGRRTLAYFGADVQVETKGDATPVTRADREAETIIRDYIGRYF
CCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
PSHTIIGEEHGEQKGDADYRWIIDPIDGTKTFIHGVPFYGVLIGLEIKGEASVGAVYLPA
CCCCEECCCCCCCCCCCCEEEEEECCCCCHHHHHCCCHHHEEEEEEECCCCCCCEEECCH
FDEMLAAANGLGCSWNGRPAQVSKVDNLADATLLTTSVTSAMKRSNAYETLVSKTKLQRT
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
WGDCYGYVLVATGRAEIMLDPAMNPWDCAPMLPILREAGGHFTTWAGEATIWGADGMATN
HHHHCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEECCCCCHHH
AALHQEVLAILATEQRHI
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSLRELLDVATEAAYLGGRRTLAYFGADVQVETKGDATPVTRADREAETIIRDYIGRYF
CCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
PSHTIIGEEHGEQKGDADYRWIIDPIDGTKTFIHGVPFYGVLIGLEIKGEASVGAVYLPA
CCCCEECCCCCCCCCCCCEEEEEECCCCCHHHHHCCCHHHEEEEEEECCCCCCCEEECCH
FDEMLAAANGLGCSWNGRPAQVSKVDNLADATLLTTSVTSAMKRSNAYETLVSKTKLQRT
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
WGDCYGYVLVATGRAEIMLDPAMNPWDCAPMLPILREAGGHFTTWAGEATIWGADGMATN
HHHHCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCEEEECCCCCHHH
AALHQEVLAILATEQRHI
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]