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The map label for this gene is napA [H]

Identifier: 159900761

GI number: 159900761

Start: 5420279

End: 5421517

Strand: Reverse

Name: napA [H]

Synonym: Haur_4248

Alternate gene names: 159900761

Gene position: 5421517-5420279 (Counterclockwise)

Preceding gene: 159900762

Following gene: 159900760

Centisome position: 85.42

GC content: 50.85

Gene sequence:

>1239_bases
ATGAGTTCAACTGTGCAACTGATCTTATTGCTGTTGGTGTTAATCGGTGTTGCTAAAATTGGGGGCGCACTTAGTGCCGC
GCTTGGCCAACCAACCGTGTTGGGTAAGCTGTTGGCGGGCGTGCTGCTTGGCCCAAGTTTAATTAATGTCATGCACTGGG
AAACCTTTCAAAGCAGCGATCTGAAATCGACCATCCACTACCTCTCGGAGCTTGGGGTCATTTTCCTCATGTTTATCGCA
GGCCTGCGCATCGAAGCCCATGAGTTGCGCGAAGCTGGCAAGGCCGCAACTTGGACAGCGATTTTGGGTGTGATCATTCC
ATTTTTTGGTGGGCTGCTCAGCGCGTTGGCTTTTGGCTATGGCCTTATTCCAGCGATTTTTGTGGGCCTATTGTTGACCG
CAACCAGCGTTAGCATTTCGGCTCAAACCTTGGTTGAGTTGGGGCGGCTCAAAAGTCGAGTTGGTACAACGTTGCTAGGC
GCGGCGGTGCTCGACGATATTATTGGGCTGCTGTTACTCTCAATTTTTATGGCCACTCAAACCAGCGATGGCAACTTCAT
GACGATTGTTTGGACGATTGTACGCTTGGTGGGCTTTTTGGTGGTGGCTTGGTTCTTGGGCCAGCGCTTTTTGCCGCGCA
TCCTTGAACGGGTCAAAAAAATGCGCACCAACGAGCCAGTGCTCACCTTTGCGGTGTTGGTGGTGCTTGGCTTAGCCTTC
ACGGCTGAAACGGTGGGGCATTTGGCCGCAATTACCGGGGCATTTATGGCCGGTATTCTCCTGAGCCATACCGATGTGCG
CGATGAAATTGACCGCTCAATTTCGAGCTTTACCTATGCCGTACTTGTGCCAATTTTCTTTATTGGAATTGGATTGAACA
CCGATTTGAGCAGCCTCAGCGGTGCAGCCATCCCAATGGCCATTATGTTGTGTATCGTAGCGATTGGTACCAAAATTGTG
GGCTGTGGCCTAGGAGCCAAAATTGCTGGCCTCAACCAACGTGAGGCAATTCAGGTTGGCTGTGGCATGATCTCGCGCGG
CGAGGTCGGGTTAATTGTCGCCTCGCTGGGTGTCCAAAATCAAATTGTTGATACTAATGTATTTTCATTGACCGTAGCAG
TAGTCTTGGTAACCACTCTCGTCACGCCAATTCTGCTGAAATGGTCATTCAAAACCGAGCCATTGCCAAGCCTCCACTTG
GCGCTTGAGCCTGAAGATGAAGTGTTGGCAATTGGCTAA

Upstream 100 bases:

>100_bases
ACGATCAGCTACTATAAATTCAATCGCCCAACTTAGGCAAAATCCACAAATAAGCGACCTCTCAACCTTTATAAAAACCC
AAGCTGTGAGGTATCCGACG

Downstream 100 bases:

>100_bases
GGCACTCTATTCTTGAGGATTGATTGATTGAAGAAGCGTTGGAATCCCCTCTTGCATTCCAGCCGTCAGTGTTGACGTGA
GCCGCGTTGCAGCGACATGC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSSTVQLILLLLVLIGVAKIGGALSAALGQPTVLGKLLAGVLLGPSLINVMHWETFQSSDLKSTIHYLSELGVIFLMFIA
GLRIEAHELREAGKAATWTAILGVIIPFFGGLLSALAFGYGLIPAIFVGLLLTATSVSISAQTLVELGRLKSRVGTTLLG
AAVLDDIIGLLLLSIFMATQTSDGNFMTIVWTIVRLVGFLVVAWFLGQRFLPRILERVKKMRTNEPVLTFAVLVVLGLAF
TAETVGHLAAITGAFMAGILLSHTDVRDEIDRSISSFTYAVLVPIFFIGIGLNTDLSSLSGAAIPMAIMLCIVAIGTKIV
GCGLGAKIAGLNQREAIQVGCGMISRGEVGLIVASLGVQNQIVDTNVFSLTVAVVLVTTLVTPILLKWSFKTEPLPSLHL
ALEPEDEVLAIG

Sequences:

>Translated_412_residues
MSSTVQLILLLLVLIGVAKIGGALSAALGQPTVLGKLLAGVLLGPSLINVMHWETFQSSDLKSTIHYLSELGVIFLMFIA
GLRIEAHELREAGKAATWTAILGVIIPFFGGLLSALAFGYGLIPAIFVGLLLTATSVSISAQTLVELGRLKSRVGTTLLG
AAVLDDIIGLLLLSIFMATQTSDGNFMTIVWTIVRLVGFLVVAWFLGQRFLPRILERVKKMRTNEPVLTFAVLVVLGLAF
TAETVGHLAAITGAFMAGILLSHTDVRDEIDRSISSFTYAVLVPIFFIGIGLNTDLSSLSGAAIPMAIMLCIVAIGTKIV
GCGLGAKIAGLNQREAIQVGCGMISRGEVGLIVASLGVQNQIVDTNVFSLTVAVVLVTTLVTPILLKWSFKTEPLPSLHL
ALEPEDEVLAIG
>Mature_411_residues
SSTVQLILLLLVLIGVAKIGGALSAALGQPTVLGKLLAGVLLGPSLINVMHWETFQSSDLKSTIHYLSELGVIFLMFIAG
LRIEAHELREAGKAATWTAILGVIIPFFGGLLSALAFGYGLIPAIFVGLLLTATSVSISAQTLVELGRLKSRVGTTLLGA
AVLDDIIGLLLLSIFMATQTSDGNFMTIVWTIVRLVGFLVVAWFLGQRFLPRILERVKKMRTNEPVLTFAVLVVLGLAFT
AETVGHLAAITGAFMAGILLSHTDVRDEIDRSISSFTYAVLVPIFFIGIGLNTDLSSLSGAAIPMAIMLCIVAIGTKIVG
CGLGAKIAGLNQREAIQVGCGMISRGEVGLIVASLGVQNQIVDTNVFSLTVAVVLVTTLVTPILLKWSFKTEPLPSLHLA
LEPEDEVLAIG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1789749, Length=368, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786232, Length=303, Percent_Identity=27.0627062706271, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786685, Length=373, Percent_Identity=26.0053619302949, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322367, Length=402, Percent_Identity=28.1094527363184, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43511; Mature: 43380

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTVQLILLLLVLIGVAKIGGALSAALGQPTVLGKLLAGVLLGPSLINVMHWETFQSSD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LKSTIHYLSELGVIFLMFIAGLRIEAHELREAGKAATWTAILGVIIPFFGGLLSALAFGY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIPAIFVGLLLTATSVSISAQTLVELGRLKSRVGTTLLGAAVLDDIIGLLLLSIFMATQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TSDGNFMTIVWTIVRLVGFLVVAWFLGQRFLPRILERVKKMRTNEPVLTFAVLVVLGLAF
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAETVGHLAAITGAFMAGILLSHTDVRDEIDRSISSFTYAVLVPIFFIGIGLNTDLSSLS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
GAAIPMAIMLCIVAIGTKIVGCGLGAKIAGLNQREAIQVGCGMISRGEVGLIVASLGVQN
CHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCC
QIVDTNVFSLTVAVVLVTTLVTPILLKWSFKTEPLPSLHLALEPEDEVLAIG
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECC
>Mature Secondary Structure 
SSTVQLILLLLVLIGVAKIGGALSAALGQPTVLGKLLAGVLLGPSLINVMHWETFQSSD
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LKSTIHYLSELGVIFLMFIAGLRIEAHELREAGKAATWTAILGVIIPFFGGLLSALAFGY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIPAIFVGLLLTATSVSISAQTLVELGRLKSRVGTTLLGAAVLDDIIGLLLLSIFMATQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TSDGNFMTIVWTIVRLVGFLVVAWFLGQRFLPRILERVKKMRTNEPVLTFAVLVVLGLAF
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
TAETVGHLAAITGAFMAGILLSHTDVRDEIDRSISSFTYAVLVPIFFIGIGLNTDLSSLS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
GAAIPMAIMLCIVAIGTKIVGCGLGAKIAGLNQREAIQVGCGMISRGEVGLIVASLGVQN
CHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCC
QIVDTNVFSLTVAVVLVTTLVTPILLKWSFKTEPLPSLHLALEPEDEVLAIG
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]