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The map label for this gene is asd [H]

Identifier: 159900709

GI number: 159900709

Start: 5352901

End: 5353956

Strand: Reverse

Name: asd [H]

Synonym: Haur_4196

Alternate gene names: 159900709

Gene position: 5353956-5352901 (Counterclockwise)

Preceding gene: 159900711

Following gene: 159900707

Centisome position: 84.36

GC content: 53.31

Gene sequence:

>1056_bases
ATGAAGAAGATTCCTGTTGGTGTGCTAGGCGCAACAGGGATGGTTGGACAACGCTTTTTGAGTTTGTTGATCGATCACCC
CTATTTTGAAGTAACGGTAGTTGCCGCTTCGGAGCGTTCGGCTGGTAAGACCTTGGCCGAAGCTGGCCGCTGGATGATCG
GCGGCGAAATGCCTAGCCAATTTGCCAAGATGACCGTCCAGCCCGTTGATCAGGTTGGCGATGTTGGCTTAGTGTTCAGT
GCCTTGCCCAGTGATGCTGCTGGCCCGACCGAAATTGCTTGGGCCAAATCAGGCGCGTTGGTTTTCTCAAATGCTGGTGC
ACATCGCCGCGATCCACTTGTGCCGCTGTTAGTGCCCGAAGTCAACCCTGACCATGTTAATTTGTTGGAATTACAACGCC
AACAGTATGGCTGGAGCGGCGGCATTTTGACCAACCCCAACTGCACAACCACCCATGCTGTGTTGCCAATGCGAGCTTTG
CACGATGCCTTTGGCCTCACCAAGGTTTTGTTGGTGAGCATGCAAGCAATTTCGGGCGCAGGCTATCCAGGTGTGCCAAG
CCTCGACATTATTGACAATGTTGTGCCGTTGATCAAAGGCGAAGAAGAAAAAGTTGAGTGGGAGCCACGCAAGCTTTTGG
GTACGCTTGGCGCTCAGGGCGTGGAAGAAGCCCAAATCACAATTAGCGCTCATTGTAATCGGGTGGCGGTTATTGATGGC
CATACCGAGTGTTTATCATTGGCGTTCGAGCGTCCGCCCGCCGATGAAGCTGAATTGATCGCGGTCTTGCGTGAATTTAA
GGCTGAACCACAAGCGCTCAATTTGCCAAGTGCGCCAGCCCACCCAATTTTGGTAACTGAATTGGCCGATGGCCCGCAGC
CACGCCGTGATCGCGATGCTGAGCGTGGTATGGCGACGACCGTTGGGCGCGTTCGCCGTTGCCCAATTCTTGATTACAAA
TTAGTTTTGTTGGGGCACAATACCTTGCGCGGAGCCGCTGGGGGTTCGTTGCTCAACGCTGAATTAATGGTTGCCAAAGG
CTTGATCAAAGCCTAA

Upstream 100 bases:

>100_bases
ACGTTGCAGGGTCGTGTGGAGTTGCTATAATGCCCGCAGCAACGACGCTGATGAGCAATGGTGCTAATTCACATACATTC
CCACTGCGGAGGCTTTTGGT

Downstream 100 bases:

>100_bases
AATGCGCTGCGCACAGAACCGATGGTGAGGAATTCTGTGCGCAGTGACTTTTAAATAGTATTGATCACCACGATGATCAG
GCCAACAACCATAAATGCGC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKKIPVGVLGATGMVGQRFLSLLIDHPYFEVTVVAASERSAGKTLAEAGRWMIGGEMPSQFAKMTVQPVDQVGDVGLVFS
ALPSDAAGPTEIAWAKSGALVFSNAGAHRRDPLVPLLVPEVNPDHVNLLELQRQQYGWSGGILTNPNCTTTHAVLPMRAL
HDAFGLTKVLLVSMQAISGAGYPGVPSLDIIDNVVPLIKGEEEKVEWEPRKLLGTLGAQGVEEAQITISAHCNRVAVIDG
HTECLSLAFERPPADEAELIAVLREFKAEPQALNLPSAPAHPILVTELADGPQPRRDRDAERGMATTVGRVRRCPILDYK
LVLLGHNTLRGAAGGSLLNAELMVAKGLIKA

Sequences:

>Translated_351_residues
MKKIPVGVLGATGMVGQRFLSLLIDHPYFEVTVVAASERSAGKTLAEAGRWMIGGEMPSQFAKMTVQPVDQVGDVGLVFS
ALPSDAAGPTEIAWAKSGALVFSNAGAHRRDPLVPLLVPEVNPDHVNLLELQRQQYGWSGGILTNPNCTTTHAVLPMRAL
HDAFGLTKVLLVSMQAISGAGYPGVPSLDIIDNVVPLIKGEEEKVEWEPRKLLGTLGAQGVEEAQITISAHCNRVAVIDG
HTECLSLAFERPPADEAELIAVLREFKAEPQALNLPSAPAHPILVTELADGPQPRRDRDAERGMATTVGRVRRCPILDYK
LVLLGHNTLRGAAGGSLLNAELMVAKGLIKA
>Mature_351_residues
MKKIPVGVLGATGMVGQRFLSLLIDHPYFEVTVVAASERSAGKTLAEAGRWMIGGEMPSQFAKMTVQPVDQVGDVGLVFS
ALPSDAAGPTEIAWAKSGALVFSNAGAHRRDPLVPLLVPEVNPDHVNLLELQRQQYGWSGGILTNPNCTTTHAVLPMRAL
HDAFGLTKVLLVSMQAISGAGYPGVPSLDIIDNVVPLIKGEEEKVEWEPRKLLGTLGAQGVEEAQITISAHCNRVAVIDG
HTECLSLAFERPPADEAELIAVLREFKAEPQALNLPSAPAHPILVTELADGPQPRRDRDAERGMATTVGRVRRCPILDYK
LVLLGHNTLRGAAGGSLLNAELMVAKGLIKA

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320362, Length=363, Percent_Identity=42.6997245179063, Blast_Score=277, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 37431; Mature: 37431

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIPVGVLGATGMVGQRFLSLLIDHPYFEVTVVAASERSAGKTLAEAGRWMIGGEMPSQ
CCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCCEEECCCCHHH
FAKMTVQPVDQVGDVGLVFSALPSDAAGPTEIAWAKSGALVFSNAGAHRRDPLVPLLVPE
HHHHHHCHHHHCCCHHHEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCEEEECC
VNPDHVNLLELQRQQYGWSGGILTNPNCTTTHAVLPMRALHDAFGLTKVLLVSMQAISGA
CCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYPGVPSLDIIDNVVPLIKGEEEKVEWEPRKLLGTLGAQGVEEAQITISAHCNRVAVIDG
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCEEEEECC
HTECLSLAFERPPADEAELIAVLREFKAEPQALNLPSAPAHPILVTELADGPQPRRDRDA
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCHH
ERGMATTVGRVRRCPILDYKLVLLGHNTLRGAAGGSLLNAELMVAKGLIKA
HCCHHHHHHHHHCCCCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIPVGVLGATGMVGQRFLSLLIDHPYFEVTVVAASERSAGKTLAEAGRWMIGGEMPSQ
CCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCCEEECCCCHHH
FAKMTVQPVDQVGDVGLVFSALPSDAAGPTEIAWAKSGALVFSNAGAHRRDPLVPLLVPE
HHHHHHCHHHHCCCHHHEEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCEEEECC
VNPDHVNLLELQRQQYGWSGGILTNPNCTTTHAVLPMRALHDAFGLTKVLLVSMQAISGA
CCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYPGVPSLDIIDNVVPLIKGEEEKVEWEPRKLLGTLGAQGVEEAQITISAHCNRVAVIDG
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCEEEEECC
HTECLSLAFERPPADEAELIAVLREFKAEPQALNLPSAPAHPILVTELADGPQPRRDRDA
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCHH
ERGMATTVGRVRRCPILDYKLVLLGHNTLRGAAGGSLLNAELMVAKGLIKA
HCCHHHHHHHHHCCCCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]