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The map label for this gene is rsbRA [H]

Identifier: 159900705

GI number: 159900705

Start: 5348311

End: 5349453

Strand: Direct

Name: rsbRA [H]

Synonym: Haur_4192

Alternate gene names: 159900705

Gene position: 5348311-5349453 (Clockwise)

Preceding gene: 159900704

Following gene: 159900708

Centisome position: 84.27

GC content: 42.17

Gene sequence:

>1143_bases
ATGCTGAGCCGCTGGCGCGTATGGTTTGATCAATTACCACAGACAAGTCTGATTGAACGTCGTCAAGCACGGGCATTTCA
AGCAATTGTGCTCGGGTTAGTTGGAATTGCAATTGTTGGAGTGCTCAGTTCGGCGCTTATTTTCGTAACGTTTCCTTCTA
CATCCGATACGTTCAAACAGCTACTTATGGCGATGGGAACTTATTCAACCATGGGCATTGGTGCAGCGATTGCGCTCCAG
CAGCTACGCCGCAATCACTTGCAACGAGCAGCAATGATTGTAAGTGCCAGCATTCAATTGATGTTGCTGATAGGCTATGC
GGTCGTTGGGATTTTACGTGAAAATAGTACCTATGGTTTTATCTTTTTCGCGATTCCTTTAATTATTAGTGCATTGCTAA
ATAACCGTAATGTCTTGATTTTGAATGTATGTATCTCAATTTTAATCGTAACATCAATTGGGATACTTGAATCGACTGAA
ATTTTACAGCCAATCGACATGATCGAAAATTTTTGGGTTATCTTCGTAACGATGACAATTGCCATTGTCAGCCAAGCTTT
ATTAGTTGAGCGATTTGGTAGCAGCTTGCATATGGAGATTTATAATTTAATCCAGCGTGAAGATGAATCACAACATTTGC
AGCATTTATTAGAGCAAAAATTTGACGAACGCAACCAAAGTCTACAAAATGCTCTAAATGAGCTAGCACAACGCGAAAAA
GTTCTGCAACAAGCCCTCAGTGAATTACAAACGAGTCAAACAATTGTCGCTCAATTAAATATCCCAGTCATTCCAGTTTT
GCCACGCGTGTTGATCGCGCCCTTGATTGGCGAAATGACCGCCGAACATGCACAAGGTCTGAAGCATGATATTTTTACAG
CAATCGAACGTTCGAGTGCGCATACGATCATTTTAGATATTACAGGTGTGTCATTGATCGATCGAGTCGTGGCTGAAACA
ATTATTCAAATTGCCAAGGCCGCTCAATTGCTTGGCACCAAAACCATTTTGGTTGGCTTGCGCCCTGAAGTTGCCACCGC
CTTAGTTTCGCTTGATATGCAGGCAAATTTGGTGAAAAATTATCTGACGCTCGAAAAAGCCATCCAATCATTGCTCCAAA
CCCATATACGGCGAGCAGCTTAA

Upstream 100 bases:

>100_bases
AATTTTCCAGCGATTGAAACCTTTGCCAATCTTGAACAAGCAGTTTTATCGCTGATCAATCAACGACGAGAATTGAACTA
GCACCAAAGAGGAACAGGCT

Downstream 100 bases:

>100_bases
TCAATGTCGTCCGCTTCGGTTTCATCAGCTTCGCCATTTGATTGCAGCTCTTGCCAAAGTTGATCAAGCACAGGTTTGAT
TGTGTCAAAGCCAAAACCAC

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MLSRWRVWFDQLPQTSLIERRQARAFQAIVLGLVGIAIVGVLSSALIFVTFPSTSDTFKQLLMAMGTYSTMGIGAAIALQ
QLRRNHLQRAAMIVSASIQLMLLIGYAVVGILRENSTYGFIFFAIPLIISALLNNRNVLILNVCISILIVTSIGILESTE
ILQPIDMIENFWVIFVTMTIAIVSQALLVERFGSSLHMEIYNLIQREDESQHLQHLLEQKFDERNQSLQNALNELAQREK
VLQQALSELQTSQTIVAQLNIPVIPVLPRVLIAPLIGEMTAEHAQGLKHDIFTAIERSSAHTIILDITGVSLIDRVVAET
IIQIAKAAQLLGTKTILVGLRPEVATALVSLDMQANLVKNYLTLEKAIQSLLQTHIRRAA

Sequences:

>Translated_380_residues
MLSRWRVWFDQLPQTSLIERRQARAFQAIVLGLVGIAIVGVLSSALIFVTFPSTSDTFKQLLMAMGTYSTMGIGAAIALQ
QLRRNHLQRAAMIVSASIQLMLLIGYAVVGILRENSTYGFIFFAIPLIISALLNNRNVLILNVCISILIVTSIGILESTE
ILQPIDMIENFWVIFVTMTIAIVSQALLVERFGSSLHMEIYNLIQREDESQHLQHLLEQKFDERNQSLQNALNELAQREK
VLQQALSELQTSQTIVAQLNIPVIPVLPRVLIAPLIGEMTAEHAQGLKHDIFTAIERSSAHTIILDITGVSLIDRVVAET
IIQIAKAAQLLGTKTILVGLRPEVATALVSLDMQANLVKNYLTLEKAIQSLLQTHIRRAA
>Mature_380_residues
MLSRWRVWFDQLPQTSLIERRQARAFQAIVLGLVGIAIVGVLSSALIFVTFPSTSDTFKQLLMAMGTYSTMGIGAAIALQ
QLRRNHLQRAAMIVSASIQLMLLIGYAVVGILRENSTYGFIFFAIPLIISALLNNRNVLILNVCISILIVTSIGILESTE
ILQPIDMIENFWVIFVTMTIAIVSQALLVERFGSSLHMEIYNLIQREDESQHLQHLLEQKFDERNQSLQNALNELAQREK
VLQQALSELQTSQTIVAQLNIPVIPVLPRVLIAPLIGEMTAEHAQGLKHDIFTAIERSSAHTIILDITGVSLIDRVVAET
IIQIAKAAQLLGTKTILVGLRPEVATALVSLDMQANLVKNYLTLEKAIQSLLQTHIRRAA

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 42171; Mature: 42171

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRWRVWFDQLPQTSLIERRQARAFQAIVLGLVGIAIVGVLSSALIFVTFPSTSDTFKQ
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
LLMAMGTYSTMGIGAAIALQQLRRNHLQRAAMIVSASIQLMLLIGYAVVGILRENSTYGF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IFFAIPLIISALLNNRNVLILNVCISILIVTSIGILESTEILQPIDMIENFWVIFVTMTI
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVSQALLVERFGSSLHMEIYNLIQREDESQHLQHLLEQKFDERNQSLQNALNELAQREK
HHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQQALSELQTSQTIVAQLNIPVIPVLPRVLIAPLIGEMTAEHAQGLKHDIFTAIERSSA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
HTIILDITGVSLIDRVVAETIIQIAKAAQLLGTKTILVGLRPEVATALVSLDMQANLVKN
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHH
YLTLEKAIQSLLQTHIRRAA
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSRWRVWFDQLPQTSLIERRQARAFQAIVLGLVGIAIVGVLSSALIFVTFPSTSDTFKQ
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
LLMAMGTYSTMGIGAAIALQQLRRNHLQRAAMIVSASIQLMLLIGYAVVGILRENSTYGF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IFFAIPLIISALLNNRNVLILNVCISILIVTSIGILESTEILQPIDMIENFWVIFVTMTI
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIVSQALLVERFGSSLHMEIYNLIQREDESQHLQHLLEQKFDERNQSLQNALNELAQREK
HHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLQQALSELQTSQTIVAQLNIPVIPVLPRVLIAPLIGEMTAEHAQGLKHDIFTAIERSSA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
HTIILDITGVSLIDRVVAETIIQIAKAAQLLGTKTILVGLRPEVATALVSLDMQANLVKN
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHH
YLTLEKAIQSLLQTHIRRAA
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]