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The map label for this gene is srrA [H]

Identifier: 159900626

GI number: 159900626

Start: 5250982

End: 5251362

Strand: Reverse

Name: srrA [H]

Synonym: Haur_4113

Alternate gene names: 159900626

Gene position: 5251362-5250982 (Counterclockwise)

Preceding gene: 159900627

Following gene: 159900625

Centisome position: 82.74

GC content: 49.87

Gene sequence:

>381_bases
ATGGGCATGATCAAAATTCTCGTTGCAGACGATGAGCCAGATGTGCTGTTTATGACCAGCTTTAGCCTGCGGAGCCTTGG
CGGGTTTGAGGTGATCGAAGCACATAATGGAGCAGAAGCGGTTGAACTAGCCCTTCAGGTCACTCCAGAGTTGCTGGTTC
TTGATATTAAAATGCCACGGATGACTGGCTACGAAGCATGTCGTGAGTTGCGCAAGTATCCACAGTTTGCTTCGACACCA
ATTATTTTGCTATCGGCTAAAGGGCAAAAAACCGAAATTGAGGAAGGCTGGGAATCAGGCGCGACTGAGTATATGCTCAA
GCCCTATGCCCCAGCAACACTCATTGGTCGGGTGCGCGAATTGTTGAGTACGCGGGCATGA

Upstream 100 bases:

>100_bases
TGAGGGCAGTACATTCAGCTTCTCGCTACCAGAAGTGCAACCACGCCCCGACTTAGGCGAACGTGATGAGGTCTAGCATC
GGCAGAACACAGGAGCTTCG

Downstream 100 bases:

>100_bases
GTGCAATTTTTATCGAAAATCGGGTCGTGCATTACGAGGTTTTTGGCCGTGGTCAGCCAATTATCTTCTTGCATAGTTGG
CTTGGCTCTTGGCGCTATTG

Product: response regulator receiver protein

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 126; Mature: 125

Protein sequence:

>126_residues
MGMIKILVADDEPDVLFMTSFSLRSLGGFEVIEAHNGAEAVELALQVTPELLVLDIKMPRMTGYEACRELRKYPQFASTP
IILLSAKGQKTEIEEGWESGATEYMLKPYAPATLIGRVRELLSTRA

Sequences:

>Translated_126_residues
MGMIKILVADDEPDVLFMTSFSLRSLGGFEVIEAHNGAEAVELALQVTPELLVLDIKMPRMTGYEACRELRKYPQFASTP
IILLSAKGQKTEIEEGWESGATEYMLKPYAPATLIGRVRELLSTRA
>Mature_125_residues
GMIKILVADDEPDVLFMTSFSLRSLGGFEVIEAHNGAEAVELALQVTPELLVLDIKMPRMTGYEACRELRKYPQFASTPI
ILLSAKGQKTEIEEGWESGATEYMLKPYAPATLIGRVRELLSTRA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=36.1904761904762, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=29.6610169491525, Blast_Score=71, Evalue=2e-14,
Organism=Escherichia coli, GI1788394, Length=118, Percent_Identity=31.3559322033898, Blast_Score=69, Evalue=9e-14,
Organism=Escherichia coli, GI1786784, Length=95, Percent_Identity=40, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=34.4262295081967, Blast_Score=66, Evalue=7e-13,
Organism=Escherichia coli, GI87082012, Length=98, Percent_Identity=33.6734693877551, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI1790860, Length=95, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=32.2314049586777, Blast_Score=61, Evalue=3e-11,
Organism=Escherichia coli, GI2367329, Length=120, Percent_Identity=34.1666666666667, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13976; Mature: 13845

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMIKILVADDEPDVLFMTSFSLRSLGGFEVIEAHNGAEAVELALQVTPELLVLDIKMPR
CCEEEEEEECCCCCEEEEECCCHHCCCCEEEEECCCCHHHHHHHEECCCEEEEEEEECCC
MTGYEACRELRKYPQFASTPIILLSAKGQKTEIEEGWESGATEYMLKPYAPATLIGRVRE
CCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCEEECCCCCHHHHHHHHH
LLSTRA
HHHCCC
>Mature Secondary Structure 
GMIKILVADDEPDVLFMTSFSLRSLGGFEVIEAHNGAEAVELALQVTPELLVLDIKMPR
CEEEEEEECCCCCEEEEECCCHHCCCCEEEEECCCCHHHHHHHEECCCEEEEEEEECCC
MTGYEACRELRKYPQFASTPIILLSAKGQKTEIEEGWESGATEYMLKPYAPATLIGRVRE
CCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCEEECCCCCHHHHHHHHH
LLSTRA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA