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The map label for this gene is cobB [H]

Identifier: 159900601

GI number: 159900601

Start: 5220619

End: 5221353

Strand: Reverse

Name: cobB [H]

Synonym: Haur_4088

Alternate gene names: 159900601

Gene position: 5221353-5220619 (Counterclockwise)

Preceding gene: 159900605

Following gene: 159900597

Centisome position: 82.27

GC content: 55.37

Gene sequence:

>735_bases
ATGGTGTTATCACTTGATCTACGGCGCTATCGCAATATCGTCGTATTGACGGGGGCGGGAATTTCGGTCGCTTCAGGGGT
GCGACCGTTTCGCGGCCCGAATGGAGTCTGGAACGAGTGGGATATTGAACGCTGCGCCACCCGCACAGCACTGGAGCAAT
CTCCCCAGTTGGTTTGGCAAGCTTTTGGGCCACTACGCAGCCAGCTACAAACGACTCAGCCCAACGCCGCCCATCGAGCT
TTGGCTCGCTTTGAACAATCGTTGGGTAAGCATCAACGTTTTACCCTCATCACCCAAAATATTGATGGCTTGCACCAACT
CGCTGGCAGCCGCAATTTGGTCGAGTTTCATGGTAGCCTGCGCCAAAGCCGCTGTAGTGACGAGCAATGTGACCAGCCAA
GTTTTGTTGATCAGCGGGCGCACACCCAAACGCTGCCGCTCTGCCCAACCTGTGGCAAGCCTTTACGCCCAGATATTGTG
CTGTTTGAAGAGGCGATTCCAGTTTGGGCCGAAACCCAAGCCAAACGCAGCCTGCGCGAATGCGATTTCTTTTTGGCGGT
GGGCACGTCGGGTACGGTGTTTCCTGCGGCAGCCTTTGCGCGTACTGCTCAAATGTTGGGTGCACGCACAATGTTGGTCA
ATTTGGAGCCACATGCTGCCGACGATTCAGCCTTTGAAGAACAGCAGATCGGGCGAGCTGAAGAGCTATTGCCCACGCTG
CTAGGAGTTGCTTAG

Upstream 100 bases:

>100_bases
TCGGTACAGAACGCGGTACAATAGAGTTGAAGGTGTCGTGATGATATCTGGATGTTAACCCGCACCATGCTGGTGCTAAC
TTCACTGCGGAAGAATAATC

Downstream 100 bases:

>100_bases
CTGAATTGTGACTGGCAATTGTTCGACCGACGAGGTACAGTAACCTTTGCTGCTACAGAGCATAAACGTCAGCAAAATTT
GCTGATTTGGCTGTTGCAAA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MVLSLDLRRYRNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQTTQPNAAHRA
LARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIV
LFEEAIPVWAETQAKRSLRECDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTL
LGVA

Sequences:

>Translated_244_residues
MVLSLDLRRYRNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQTTQPNAAHRA
LARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIV
LFEEAIPVWAETQAKRSLRECDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTL
LGVA
>Mature_244_residues
MVLSLDLRRYRNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQTTQPNAAHRA
LARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIV
LFEEAIPVWAETQAKRSLRECDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTL
LGVA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=232, Percent_Identity=37.0689655172414, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI13787215, Length=236, Percent_Identity=36.864406779661, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI6912664, Length=236, Percent_Identity=36.864406779661, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI6912662, Length=261, Percent_Identity=28.735632183908, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI300797577, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI6912660, Length=216, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7657575, Length=231, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI308199517, Length=233, Percent_Identity=40.7725321888412, Blast_Score=157, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17567771, Length=259, Percent_Identity=25.8687258687259, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571445, Length=194, Percent_Identity=30.9278350515464, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648389, Length=205, Percent_Identity=29.7560975609756, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27031; Mature: 27031

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSLDLRRYRNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQ
CEEECCHHHHCCEEEEECCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AFGPLRSQLQTTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHH
RQSRCSDEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIVLFEEAIPVWAETQAKRSLRE
HHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
CDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTL
CCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHH
LGVA
HCCC
>Mature Secondary Structure
MVLSLDLRRYRNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQ
CEEECCHHHHCCEEEEECCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AFGPLRSQLQTTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHH
RQSRCSDEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIVLFEEAIPVWAETQAKRSLRE
HHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
CDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTL
CCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHH
LGVA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]