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The map label for this gene is dnaX [H]

Identifier: 159900437

GI number: 159900437

Start: 4915366

End: 4917093

Strand: Direct

Name: dnaX [H]

Synonym: Haur_3922

Alternate gene names: 159900437

Gene position: 4915366-4917093 (Clockwise)

Preceding gene: 159900432

Following gene: 159900438

Centisome position: 77.45

GC content: 55.44

Gene sequence:

>1728_bases
ATGTCGTCGCAAGCGTTATATCGAAAATGGCGGTCGCAGACCTTCGATGATTTGGTGGGCCAAAGCCATATTGTGCAAGC
CTTGCGCAATGCTATTGCCGCCAATCGCATTGGCCATGCCTATTTATTTACTGGGCCGCGTGGGGTTGGCAAAACCAGTG
CTGCACGGATTCTCTCCAAGGCGGTCAATTGCGAGCAAAGCGATCCGCGTTTGCGGCCTTGTGGCGAGTGCAGCACCTGC
CGCGCAATTGCCGAAGGTCGGGCCGTCGATGTGATTGAGATGGACGCTGCCTCGCATACCAGCGTTGATGATGCCCGCGA
AATTATCGAAAAAGTGCAATTTCGCCCAACCCAATTTCGCAAAAAAGTCTATGTGATCGACGAAGTGCATATGCTGAGCA
CCGCTGCCTTCAATGCGTTGCTCAAAACCCTCGAAGAACCACCTGACCATGCCATGTTTATTTTGGCGACGACTGAATTT
CACAAAGTGCCAGCGACGATTCTTTCGCGCTGTCAGCGCTTTGTGTTCAATCGCCATACGATTGCTAACACAATTGCCCA
CCTCGAATGGGTCGCTGGCGAAGAAGGCGTTTTCCTTGAGCCTGGCGTGGCTGAGGCGGTGGCACGCGCAGCAACTGGCT
CGATGCGCGATGCCATGAGCATCCTTGACCAGTTAATGGGCTATGGCGAACCGCAAATTCCATTGACTCGGGTGCAAAGT
TTGCTGGGGGCAACCGCCTCGCGCGAGGTCGAAACCTTAGTCGCCGCCTTTGCCGCCGAAGATGTGGCCGCGGCATTAAG
CGTGATCAACACGATTGCCGACCAAGGCGCTGATTTACGTCAATTCACCCGCGATGTGGTGAGCTACTTACGCGGCCTGA
TGTTGCTTAAATCGGGCGGAGCCGCCGATTTGCTTGATGTTGGGCACGACGTGTTGGCTACCATGCAAAGCCATAGCCAA
CAACTGGCCTTGGCAGCGATTTTGGCGTGGCTCAAAATTTTCAGCGGACTCGATCATCAACTACGCACTACGCCCTATGG
TCAATTGCCCTTAGAAATGGCGGTTGTTGAAGCCTTGGTTGTGCCAGTGCCAGCTGCGGTGGCTGCACCAAGCCCAGTTC
GCGGCACGGTGGCTCCGATAACGCGCCCGAATCCGGCGGTTGCACGCCCAGCTGAGCCAGCACCTGTCCAACGCCAAACC
CCAACGCCAAGTGTGGTTACGCCACGCCCAGTCGAGCAACCAGTCGTTGAGCAACCACCACAGGCCGAACCAACGCCAGT
GCCAGTTGCTGCTGTAGCAGCTCAACCAATGCCCGAAGCCGAGCAACATATCGTTTTGGCTGAATCGGAAATTTTGTTGG
CCGAGGTCGAGGCGGTTTGGCTGCAAGTGATCGAAGATCTCAAGCCCTACAATCCGCGCTTGCAAGCGGTGCTCAAAAGC
TGCGAACCATTGGCGCTTGAAGACAACACCTTGGTGATCGGCACACCCTCGCCATTCCATACCAAACAACTCGACGACCA
AACCCAACGCCGGTTGATCGAAGATTTACTGGCCAAAGCGGTGAATCGGCAGATGTTTGTGCGCGGCGAAGAAGCCAACC
GCGATCAGCAAAATCGTGCCCGTGATGCTCGTCGCCAGCGCGAAGAGATCATGAAAGATCATGTGGTCAAGGCTGCCCGT
AATATTTTCGATGCCCGCATTGTCGGCGTGCAAGAGGATGGCAGCTAA

Upstream 100 bases:

>100_bases
ATGTTCTTATTTGCCTTCATAATTCATCCCTCATCCTTCATCGTTCATATTGGTGAGCATGCTATAATTGAGACTGATGT
TTCAAAAGGGTTGAGTATAG

Downstream 100 bases:

>100_bases
ATTTTAGGGCTTTATTTTGAATCGAGTTCGATGCGTATCCACTAATCGAACTTTTCTAGGGTACAGGGGGAAACCCAAGA
TCATAGGTTTTCCGCTGTGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSSQALYRKWRSQTFDDLVGQSHIVQALRNAIAANRIGHAYLFTGPRGVGKTSAARILSKAVNCEQSDPRLRPCGECSTC
RAIAEGRAVDVIEMDAASHTSVDDAREIIEKVQFRPTQFRKKVYVIDEVHMLSTAAFNALLKTLEEPPDHAMFILATTEF
HKVPATILSRCQRFVFNRHTIANTIAHLEWVAGEEGVFLEPGVAEAVARAATGSMRDAMSILDQLMGYGEPQIPLTRVQS
LLGATASREVETLVAAFAAEDVAAALSVINTIADQGADLRQFTRDVVSYLRGLMLLKSGGAADLLDVGHDVLATMQSHSQ
QLALAAILAWLKIFSGLDHQLRTTPYGQLPLEMAVVEALVVPVPAAVAAPSPVRGTVAPITRPNPAVARPAEPAPVQRQT
PTPSVVTPRPVEQPVVEQPPQAEPTPVPVAAVAAQPMPEAEQHIVLAESEILLAEVEAVWLQVIEDLKPYNPRLQAVLKS
CEPLALEDNTLVIGTPSPFHTKQLDDQTQRRLIEDLLAKAVNRQMFVRGEEANRDQQNRARDARRQREEIMKDHVVKAAR
NIFDARIVGVQEDGS

Sequences:

>Translated_575_residues
MSSQALYRKWRSQTFDDLVGQSHIVQALRNAIAANRIGHAYLFTGPRGVGKTSAARILSKAVNCEQSDPRLRPCGECSTC
RAIAEGRAVDVIEMDAASHTSVDDAREIIEKVQFRPTQFRKKVYVIDEVHMLSTAAFNALLKTLEEPPDHAMFILATTEF
HKVPATILSRCQRFVFNRHTIANTIAHLEWVAGEEGVFLEPGVAEAVARAATGSMRDAMSILDQLMGYGEPQIPLTRVQS
LLGATASREVETLVAAFAAEDVAAALSVINTIADQGADLRQFTRDVVSYLRGLMLLKSGGAADLLDVGHDVLATMQSHSQ
QLALAAILAWLKIFSGLDHQLRTTPYGQLPLEMAVVEALVVPVPAAVAAPSPVRGTVAPITRPNPAVARPAEPAPVQRQT
PTPSVVTPRPVEQPVVEQPPQAEPTPVPVAAVAAQPMPEAEQHIVLAESEILLAEVEAVWLQVIEDLKPYNPRLQAVLKS
CEPLALEDNTLVIGTPSPFHTKQLDDQTQRRLIEDLLAKAVNRQMFVRGEEANRDQQNRARDARRQREEIMKDHVVKAAR
NIFDARIVGVQEDGS
>Mature_574_residues
SSQALYRKWRSQTFDDLVGQSHIVQALRNAIAANRIGHAYLFTGPRGVGKTSAARILSKAVNCEQSDPRLRPCGECSTCR
AIAEGRAVDVIEMDAASHTSVDDAREIIEKVQFRPTQFRKKVYVIDEVHMLSTAAFNALLKTLEEPPDHAMFILATTEFH
KVPATILSRCQRFVFNRHTIANTIAHLEWVAGEEGVFLEPGVAEAVARAATGSMRDAMSILDQLMGYGEPQIPLTRVQSL
LGATASREVETLVAAFAAEDVAAALSVINTIADQGADLRQFTRDVVSYLRGLMLLKSGGAADLLDVGHDVLATMQSHSQQ
LALAAILAWLKIFSGLDHQLRTTPYGQLPLEMAVVEALVVPVPAAVAAPSPVRGTVAPITRPNPAVARPAEPAPVQRQTP
TPSVVTPRPVEQPVVEQPPQAEPTPVPVAAVAAQPMPEAEQHIVLAESEILLAEVEAVWLQVIEDLKPYNPRLQAVLKSC
EPLALEDNTLVIGTPSPFHTKQLDDQTQRRLIEDLLAKAVNRQMFVRGEEANRDQQNRARDARRQREEIMKDHVVKAARN
IFDARIVGVQEDGS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=225, Percent_Identity=28.4444444444444, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194306571, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI194306567, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786676, Length=383, Percent_Identity=39.686684073107, Blast_Score=272, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6324039, Length=277, Percent_Identity=23.4657039711191, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=294, Percent_Identity=22.7891156462585, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=223, Percent_Identity=23.7668161434978, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62793; Mature: 62661

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQALYRKWRSQTFDDLVGQSHIVQALRNAIAANRIGHAYLFTGPRGVGKTSAARILSK
CCCHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
AVNCEQSDPRLRPCGECSTCRAIAEGRAVDVIEMDAASHTSVDDAREIIEKVQFRPTQFR
HHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHH
KKVYVIDEVHMLSTAAFNALLKTLEEPPDHAMFILATTEFHKVPATILSRCQRFVFNRHT
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IANTIAHLEWVAGEEGVFLEPGVAEAVARAATGSMRDAMSILDQLMGYGEPQIPLTRVQS
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
LLGATASREVETLVAAFAAEDVAAALSVINTIADQGADLRQFTRDVVSYLRGLMLLKSGG
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
AADLLDVGHDVLATMQSHSQQLALAAILAWLKIFSGLDHQLRTTPYGQLPLEMAVVEALV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHH
VPVPAAVAAPSPVRGTVAPITRPNPAVARPAEPAPVQRQTPTPSVVTPRPVEQPVVEQPP
HCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QAEPTPVPVAAVAAQPMPEAEQHIVLAESEILLAEVEAVWLQVIEDLKPYNPRLQAVLKS
CCCCCCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
CEPLALEDNTLVIGTPSPFHTKQLDDQTQRRLIEDLLAKAVNRQMFVRGEEANRDQQNRA
CCCCEECCCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHCHHHEEECCCCCCCHHHHH
RDARRQREEIMKDHVVKAARNIFDARIVGVQEDGS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC
>Mature Secondary Structure 
SSQALYRKWRSQTFDDLVGQSHIVQALRNAIAANRIGHAYLFTGPRGVGKTSAARILSK
CCHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
AVNCEQSDPRLRPCGECSTCRAIAEGRAVDVIEMDAASHTSVDDAREIIEKVQFRPTQFR
HHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHH
KKVYVIDEVHMLSTAAFNALLKTLEEPPDHAMFILATTEFHKVPATILSRCQRFVFNRHT
CEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IANTIAHLEWVAGEEGVFLEPGVAEAVARAATGSMRDAMSILDQLMGYGEPQIPLTRVQS
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
LLGATASREVETLVAAFAAEDVAAALSVINTIADQGADLRQFTRDVVSYLRGLMLLKSGG
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
AADLLDVGHDVLATMQSHSQQLALAAILAWLKIFSGLDHQLRTTPYGQLPLEMAVVEALV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHH
VPVPAAVAAPSPVRGTVAPITRPNPAVARPAEPAPVQRQTPTPSVVTPRPVEQPVVEQPP
HCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QAEPTPVPVAAVAAQPMPEAEQHIVLAESEILLAEVEAVWLQVIEDLKPYNPRLQAVLKS
CCCCCCCCHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
CEPLALEDNTLVIGTPSPFHTKQLDDQTQRRLIEDLLAKAVNRQMFVRGEEANRDQQNRA
CCCCEECCCEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHCHHHEEECCCCCCCHHHHH
RDARRQREEIMKDHVVKAARNIFDARIVGVQEDGS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]