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The map label for this gene is sdhA [H]

Identifier: 159900302

GI number: 159900302

Start: 4753131

End: 4754630

Strand: Direct

Name: sdhA [H]

Synonym: Haur_3785

Alternate gene names: 159900302

Gene position: 4753131-4754630 (Clockwise)

Preceding gene: 159900301

Following gene: 159900303

Centisome position: 74.89

GC content: 53.07

Gene sequence:

>1500_bases
GTGATTCAGCATGATGTAATTGTGGTTGGCAGTGGCATCGCTGGGATGCGCTGCGCCCTTGAGATTAAACGTAACGCGCC
CAAAGCCGATGTGGCGATTGTGACCAAACAATATCCAGTTCGGGCGGCTTCGGTCGTCGAACGCACAGGCATTGCCGCCG
CCTTAGGGAATAGCAGCAGTGATAGCGTTGAAGCGCATATCAGCGATACCTTGGCCTATGGCAAAAGCAATAATGCCGCT
GCGGTCAAGGCGCTGTGCGAGCAAGCTCCTGCCGCTGTGTATGAGCTAGAGCACATGGGCTTGCCATTTAGCCGCTTGAA
GAGTGGCCGGATCGCCCAACAAGTTGGCTATGGCCATAGTCAACCACGCTTGGCTAACGCTGGCGACCAAACTGGCCACG
CAATTGTCACGACCTTGTATGGCGAAGTCGTGCGCTTTGGTATCAAAGTGTATCCTGAGTGGTTTATGTTGGGTTTGGTG
GTTGAAGGCAAAAACGTGCGTGGTGTGAGTGTGCTCGATATTCGCAGCAGCGAAATCGAAGTTATCAATGCCAAAGTAAC
GGTGCTGGCAACTGGCAGCTATGGTCAACTCTATGCCACTTCCAGCGATTCATATGCCTCAACTGGCGATGGCCATGCCG
CTGCTTTGCGAGCTGGCATCAACCTAATCGGCATGGATTTGGTCAATTTCCACCCCTTGGGTGTGGCCAATACTGGCTTG
ATTATCAACGAACAAGTGCTAGCCGATGGCGCACACCTGCTTAACGCCAGCGAAAAACGCTTTACCAACGAACAAGCTAG
CTTGGCTGAGGTAACTGCTGCGGTTAACGCTGAAATTGCTGCTGGCAGAGGCGTTGATGGTCATGTTTGGCTCGATGTGC
GGCATCTGCCAACCAGCCAAATTCGTGAGCGCTACCCACACCTATTGGATTATGCCGAAGATTTTGCTGGTGTTAATCCC
AACCATGATTTTATTCCAGTCAAGCCGACCCAACAATCGAGCCTTGGTGGTTTGCCAACCGACCTCAATGGTAGCGTGGC
AGGCTTTGAAGGTTTGTATGCAGTTGGCGCTTGCGCCAATAACGGCGTGCACGGCGAGCAAGCCTTGCCTGGCAACGAAT
TGGCGGCTGCCGTAGTGTTTGCCAAACTGGCAGGCGCGGCAATTGCCGACAAACTGGGCGCGGCTAGCTATGGCAACGTG
CCAAGCTACGCTACCAGCAACGCCAGCGACGAAATCGAAGGCTTGTTCGGCCAAAAAGGTAGCCACAAATTGGGTCTTGT
GCGCAAAAACCTGCGTCAAGCCTTCAATAGCCAAGCCCATACTGCGGCCAGCGATGAACAACACGTTGGTTTAGTACATA
GCTTGCGCGAACAATTTGGCCAAATTGCCCTGCACGATAAAAATCGGCGCTTTAATACTGAATTGCTCGAAGCCCTAGAG
CTTGATCGGCTACTGGATGTGGCAGATGCTGTGGCAAAAGCAAGCGTGGCTGCGCTCTAA

Upstream 100 bases:

>100_bases
TGTGCGCCATACGGTCAACTTTTTGTTGATTGTCTTGGGTATCGCCGGGGCAATTTTGGGCTTCTGGACGTTGTGGGCTT
TGGCATAAGGAGTGTCGTCT

Downstream 100 bases:

>100_bases
GCGGATTGGTATGCCCTCATCCCCTAACCTTCCAAAGGGTTGGCTTCCGCTGCGAACTACCTGATGTTGTGGGATGTGTG
ATGTTCCCTGATTGCCCTTG

Product: succinate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MIQHDVIVVGSGIAGMRCALEIKRNAPKADVAIVTKQYPVRAASVVERTGIAAALGNSSSDSVEAHISDTLAYGKSNNAA
AVKALCEQAPAAVYELEHMGLPFSRLKSGRIAQQVGYGHSQPRLANAGDQTGHAIVTTLYGEVVRFGIKVYPEWFMLGLV
VEGKNVRGVSVLDIRSSEIEVINAKVTVLATGSYGQLYATSSDSYASTGDGHAAALRAGINLIGMDLVNFHPLGVANTGL
IINEQVLADGAHLLNASEKRFTNEQASLAEVTAAVNAEIAAGRGVDGHVWLDVRHLPTSQIRERYPHLLDYAEDFAGVNP
NHDFIPVKPTQQSSLGGLPTDLNGSVAGFEGLYAVGACANNGVHGEQALPGNELAAAVVFAKLAGAAIADKLGAASYGNV
PSYATSNASDEIEGLFGQKGSHKLGLVRKNLRQAFNSQAHTAASDEQHVGLVHSLREQFGQIALHDKNRRFNTELLEALE
LDRLLDVADAVAKASVAAL

Sequences:

>Translated_499_residues
MIQHDVIVVGSGIAGMRCALEIKRNAPKADVAIVTKQYPVRAASVVERTGIAAALGNSSSDSVEAHISDTLAYGKSNNAA
AVKALCEQAPAAVYELEHMGLPFSRLKSGRIAQQVGYGHSQPRLANAGDQTGHAIVTTLYGEVVRFGIKVYPEWFMLGLV
VEGKNVRGVSVLDIRSSEIEVINAKVTVLATGSYGQLYATSSDSYASTGDGHAAALRAGINLIGMDLVNFHPLGVANTGL
IINEQVLADGAHLLNASEKRFTNEQASLAEVTAAVNAEIAAGRGVDGHVWLDVRHLPTSQIRERYPHLLDYAEDFAGVNP
NHDFIPVKPTQQSSLGGLPTDLNGSVAGFEGLYAVGACANNGVHGEQALPGNELAAAVVFAKLAGAAIADKLGAASYGNV
PSYATSNASDEIEGLFGQKGSHKLGLVRKNLRQAFNSQAHTAASDEQHVGLVHSLREQFGQIALHDKNRRFNTELLEALE
LDRLLDVADAVAKASVAAL
>Mature_499_residues
MIQHDVIVVGSGIAGMRCALEIKRNAPKADVAIVTKQYPVRAASVVERTGIAAALGNSSSDSVEAHISDTLAYGKSNNAA
AVKALCEQAPAAVYELEHMGLPFSRLKSGRIAQQVGYGHSQPRLANAGDQTGHAIVTTLYGEVVRFGIKVYPEWFMLGLV
VEGKNVRGVSVLDIRSSEIEVINAKVTVLATGSYGQLYATSSDSYASTGDGHAAALRAGINLIGMDLVNFHPLGVANTGL
IINEQVLADGAHLLNASEKRFTNEQASLAEVTAAVNAEIAAGRGVDGHVWLDVRHLPTSQIRERYPHLLDYAEDFAGVNP
NHDFIPVKPTQQSSLGGLPTDLNGSVAGFEGLYAVGACANNGVHGEQALPGNELAAAVVFAKLAGAAIADKLGAASYGNV
PSYATSNASDEIEGLFGQKGSHKLGLVRKNLRQAFNSQAHTAASDEQHVGLVHSLREQFGQIALHDKNRRFNTELLEALE
LDRLLDVADAVAKASVAAL

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=493, Percent_Identity=33.2657200811359, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1786942, Length=529, Percent_Identity=33.0812854442344, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1790597, Length=504, Percent_Identity=29.3650793650794, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788928, Length=515, Percent_Identity=26.0194174757282, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17505833, Length=490, Percent_Identity=33.0612244897959, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17550100, Length=490, Percent_Identity=32.0408163265306, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322701, Length=495, Percent_Identity=31.3131313131313, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6322416, Length=495, Percent_Identity=31.9191919191919, Blast_Score=237, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17137288, Length=488, Percent_Identity=31.9672131147541, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24655642, Length=488, Percent_Identity=31.9672131147541, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24655647, Length=488, Percent_Identity=31.9672131147541, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24663005, Length=494, Percent_Identity=29.9595141700405, Blast_Score=208, Evalue=7e-54,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 52531; Mature: 52531

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQHDVIVVGSGIAGMRCALEIKRNAPKADVAIVTKQYPVRAASVVERTGIAAALGNSSS
CCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCEEECCCCCC
DSVEAHISDTLAYGKSNNAAAVKALCEQAPAAVYELEHMGLPFSRLKSGRIAQQVGYGHS
CCEEHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCHHHHHCCCCC
QPRLANAGDQTGHAIVTTLYGEVVRFGIKVYPEWFMLGLVVEGKNVRGVSVLDIRSSEIE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCEE
VINAKVTVLATGSYGQLYATSSDSYASTGDGHAAALRAGINLIGMDLVNFHPLGVANTGL
EEEEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEEEHHHCCCCCCCCCCCE
IINEQVLADGAHLLNASEKRFTNEQASLAEVTAAVNAEIAAGRGVDGHVWLDVRHLPTSQ
EEEHHHHHCCHHHHCCHHHHHCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCHHH
IRERYPHLLDYAEDFAGVNPNHDFIPVKPTQQSSLGGLPTDLNGSVAGFEGLYAVGACAN
HHHHCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHCC
NGVHGEQALPGNELAAAVVFAKLAGAAIADKLGAASYGNVPSYATSNASDEIEGLFGQKG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCC
SHKLGLVRKNLRQAFNSQAHTAASDEQHVGLVHSLREQFGQIALHDKNRRFNTELLEALE
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHH
LDRLLDVADAVAKASVAAL
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQHDVIVVGSGIAGMRCALEIKRNAPKADVAIVTKQYPVRAASVVERTGIAAALGNSSS
CCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCEEECCCCCC
DSVEAHISDTLAYGKSNNAAAVKALCEQAPAAVYELEHMGLPFSRLKSGRIAQQVGYGHS
CCEEHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCHHHHHCCCCC
QPRLANAGDQTGHAIVTTLYGEVVRFGIKVYPEWFMLGLVVEGKNVRGVSVLDIRSSEIE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCEE
VINAKVTVLATGSYGQLYATSSDSYASTGDGHAAALRAGINLIGMDLVNFHPLGVANTGL
EEEEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHCCCEEEEHHHCCCCCCCCCCCE
IINEQVLADGAHLLNASEKRFTNEQASLAEVTAAVNAEIAAGRGVDGHVWLDVRHLPTSQ
EEEHHHHHCCHHHHCCHHHHHCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCHHH
IRERYPHLLDYAEDFAGVNPNHDFIPVKPTQQSSLGGLPTDLNGSVAGFEGLYAVGACAN
HHHHCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHCC
NGVHGEQALPGNELAAAVVFAKLAGAAIADKLGAASYGNVPSYATSNASDEIEGLFGQKG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCC
SHKLGLVRKNLRQAFNSQAHTAASDEQHVGLVHSLREQFGQIALHDKNRRFNTELLEALE
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHH
LDRLLDVADAVAKASVAAL
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]