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The map label for this gene is cbs [H]

Identifier: 159900235

GI number: 159900235

Start: 4677120

End: 4678511

Strand: Reverse

Name: cbs [H]

Synonym: Haur_3718

Alternate gene names: 159900235

Gene position: 4678511-4677120 (Counterclockwise)

Preceding gene: 159900236

Following gene: 159900234

Centisome position: 73.72

GC content: 50.93

Gene sequence:

>1392_bases
ATGACAGAGACGGCAACAATGGCGATGCCGCAAATTCACGACACCATTTTGGACGCGATCGGCAACACGCCCTTGGTTCG
CTTGAATCGGGTTAATCGGGGGGTTCGCGCTCAAGTGCTGGCCAAAGTCGAATACATGAATCCAGGTGGTTCGGTCAAAG
ACCGCATCGGGATTGCCATGATCGAGGATGCCGAGCGCTCAGGCCGACTCAAACCAGGTGGCACGATTGTCGAACCAACC
AGCGGGAATACTGGCGCGGGCTTAGCAATTGCCGCAGCAATCCGTGGTTACAAAACGATTTTTGTGATGCCCGACAAAAT
GAGTGACGAAAAAATTCGTTATTTGCGTGCTTTAGGAGCCAAAGTCGTAATTACCCCAACTGCTGTCGAGCCAGACGATC
CACGCTCGTATTATTCGGTTTCCAAGCGCTTGGCCGAAGAAACTCCTAATGCAATTTTAGCTGGTCAATATTGGAACCAA
GCCAATCCTGAGGCCCACTACCGTACCACTGGCCCTGAAATCTGGCGACAAACTGCTGGCAAAATCGATGCCTTTATCGC
AGGCATGGGCACTGGCGGTACAATCAGCGGTACGGCTAAATTCTTGAAAGAGCAAAATCCCAATATTCAAGTCGTCGGGA
TTGACCCAGTTGGTTCGTTGTATACCGAATATTTCCGCACTGGCCAGCTTGGCCCAGCCTTTGGCTATAAAGTTGAAGGG
GTTGGCGAAGATTTCTTGCCCACCACGATGCACTTCCAATATGTTGATGATGTGGTGCAGGTTGGTGATAAAGAATCGTT
CGTGATGACTCGCCGCATGGTGCGCGAAGAAGGCTTGTTTGTCGGCGGTTCGTGTGGCATGGCCGTGGCAGGTGCGATGC
GCTGGTTGCGTGCTCAAAATTGGGACGAAAGCAAAACTGCTGTGATCCTGCTGCCCGATTCGGGCGTGCGCTACATCAGC
AAAATCTTCTCAGACGATTGGATGCGCGAAAATGGTTTCTTGGAAAGCGAACCAATTAGCCAATTGCTTGATATTCGGCC
ACGCTCGGTCATTTCAGCCAAAGCAACCCACACCGTGGCCCAAGTTATCCAAGATATGAAAGCCAACGATATTTCGCAAA
TGCCAGTCGTGCGCGATGATGGCACCTTGGTTGGCTTGATTACTGAAGTTGATTTGTTGGATTATCTGCTTTCGGGCGCT
GGTCAGATGGATCACCAAATTAGCGATATTGTCAGTAGCGCCGTGGCAACCGTCGGCCCCGACACGAGTATCGACGCGTT
GACCGAAGTATTTAGCCGTGGTCAAGTCGGGGTGGTGGTCGATGAATCCGACGTTGTACGCGGGATCATCACCAAAATTG
ACATGATTGATTATTTAGCCAATAAGGCATAA

Upstream 100 bases:

>100_bases
TTGCTTTGTGCTACCATGAGGCCAAGCCTTGCGCTTGCGACATTGAATTTTTGCGATTAGGATAGAAAGCATGACAGATC
AATCAACTCAGGAGCACCCA

Downstream 100 bases:

>100_bases
GATCTAGCCAATCGCTTCGTGCGTTGGCTTGCAAGATCGGCTGTGGCTCATTCGACAAGCAGCATCCAATCCCGCTATTG
GGTGCTGTTTGGTCTATACC

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTETATMAMPQIHDTILDAIGNTPLVRLNRVNRGVRAQVLAKVEYMNPGGSVKDRIGIAMIEDAERSGRLKPGGTIVEPT
SGNTGAGLAIAAAIRGYKTIFVMPDKMSDEKIRYLRALGAKVVITPTAVEPDDPRSYYSVSKRLAEETPNAILAGQYWNQ
ANPEAHYRTTGPEIWRQTAGKIDAFIAGMGTGGTISGTAKFLKEQNPNIQVVGIDPVGSLYTEYFRTGQLGPAFGYKVEG
VGEDFLPTTMHFQYVDDVVQVGDKESFVMTRRMVREEGLFVGGSCGMAVAGAMRWLRAQNWDESKTAVILLPDSGVRYIS
KIFSDDWMRENGFLESEPISQLLDIRPRSVISAKATHTVAQVIQDMKANDISQMPVVRDDGTLVGLITEVDLLDYLLSGA
GQMDHQISDIVSSAVATVGPDTSIDALTEVFSRGQVGVVVDESDVVRGIITKIDMIDYLANKA

Sequences:

>Translated_463_residues
MTETATMAMPQIHDTILDAIGNTPLVRLNRVNRGVRAQVLAKVEYMNPGGSVKDRIGIAMIEDAERSGRLKPGGTIVEPT
SGNTGAGLAIAAAIRGYKTIFVMPDKMSDEKIRYLRALGAKVVITPTAVEPDDPRSYYSVSKRLAEETPNAILAGQYWNQ
ANPEAHYRTTGPEIWRQTAGKIDAFIAGMGTGGTISGTAKFLKEQNPNIQVVGIDPVGSLYTEYFRTGQLGPAFGYKVEG
VGEDFLPTTMHFQYVDDVVQVGDKESFVMTRRMVREEGLFVGGSCGMAVAGAMRWLRAQNWDESKTAVILLPDSGVRYIS
KIFSDDWMRENGFLESEPISQLLDIRPRSVISAKATHTVAQVIQDMKANDISQMPVVRDDGTLVGLITEVDLLDYLLSGA
GQMDHQISDIVSSAVATVGPDTSIDALTEVFSRGQVGVVVDESDVVRGIITKIDMIDYLANKA
>Mature_462_residues
TETATMAMPQIHDTILDAIGNTPLVRLNRVNRGVRAQVLAKVEYMNPGGSVKDRIGIAMIEDAERSGRLKPGGTIVEPTS
GNTGAGLAIAAAIRGYKTIFVMPDKMSDEKIRYLRALGAKVVITPTAVEPDDPRSYYSVSKRLAEETPNAILAGQYWNQA
NPEAHYRTTGPEIWRQTAGKIDAFIAGMGTGGTISGTAKFLKEQNPNIQVVGIDPVGSLYTEYFRTGQLGPAFGYKVEGV
GEDFLPTTMHFQYVDDVVQVGDKESFVMTRRMVREEGLFVGGSCGMAVAGAMRWLRAQNWDESKTAVILLPDSGVRYISK
IFSDDWMRENGFLESEPISQLLDIRPRSVISAKATHTVAQVIQDMKANDISQMPVVRDDGTLVGLITEVDLLDYLLSGAG
QMDHQISDIVSSAVATVGPDTSIDALTEVFSRGQVGVVVDESDVVRGIITKIDMIDYLANKA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=481, Percent_Identity=39.7089397089397, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI295821200, Length=481, Percent_Identity=39.7089397089397, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI4557415, Length=481, Percent_Identity=39.7089397089397, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI11345492, Length=337, Percent_Identity=25.8160237388724, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788754, Length=325, Percent_Identity=40.6153846153846, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI2367138, Length=319, Percent_Identity=38.2445141065831, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=337, Percent_Identity=45.4005934718101, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25147552, Length=337, Percent_Identity=44.213649851632, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535051, Length=319, Percent_Identity=38.871473354232, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI115535073, Length=316, Percent_Identity=42.4050632911392, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17562970, Length=317, Percent_Identity=38.801261829653, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=39.5424836601307, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=290, Percent_Identity=39.3103448275862, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=231, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6321594, Length=497, Percent_Identity=36.6197183098592, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6321449, Length=346, Percent_Identity=34.971098265896, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24643623, Length=413, Percent_Identity=42.8571428571429, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI20129101, Length=413, Percent_Identity=42.8571428571429, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 50316; Mature: 50185

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2 ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETATMAMPQIHDTILDAIGNTPLVRLNRVNRGVRAQVLAKVEYMNPGGSVKDRIGIAM
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCHHHCCEEE
IEDAERSGRLKPGGTIVEPTSGNTGAGLAIAAAIRGYKTIFVMPDKMSDEKIRYLRALGA
EECCHHCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCC
KVVITPTAVEPDDPRSYYSVSKRLAEETPNAILAGQYWNQANPEAHYRTTGPEIWRQTAG
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHC
KIDAFIAGMGTGGTISGTAKFLKEQNPNIQVVGIDPVGSLYTEYFRTGQLGPAFGYKVEG
CHHHHEEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCEEECC
VGEDFLPTTMHFQYVDDVVQVGDKESFVMTRRMVREEGLFVGGSCGMAVAGAMRWLRAQN
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCC
WDESKTAVILLPDSGVRYISKIFSDDWMRENGFLESEPISQLLDIRPRSVISAKATHTVA
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
QVIQDMKANDISQMPVVRDDGTLVGLITEVDLLDYLLSGAGQMDHQISDIVSSAVATVGP
HHHHHHCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
DTSIDALTEVFSRGQVGVVVDESDVVRGIITKIDMIDYLANKA
CCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TETATMAMPQIHDTILDAIGNTPLVRLNRVNRGVRAQVLAKVEYMNPGGSVKDRIGIAM
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHEEEEEECCCCCCHHHCCEEE
IEDAERSGRLKPGGTIVEPTSGNTGAGLAIAAAIRGYKTIFVMPDKMSDEKIRYLRALGA
EECCHHCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCC
KVVITPTAVEPDDPRSYYSVSKRLAEETPNAILAGQYWNQANPEAHYRTTGPEIWRQTAG
EEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHC
KIDAFIAGMGTGGTISGTAKFLKEQNPNIQVVGIDPVGSLYTEYFRTGQLGPAFGYKVEG
CHHHHEEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCEEECC
VGEDFLPTTMHFQYVDDVVQVGDKESFVMTRRMVREEGLFVGGSCGMAVAGAMRWLRAQN
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCC
WDESKTAVILLPDSGVRYISKIFSDDWMRENGFLESEPISQLLDIRPRSVISAKATHTVA
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
QVIQDMKANDISQMPVVRDDGTLVGLITEVDLLDYLLSGAGQMDHQISDIVSSAVATVGP
HHHHHHCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
DTSIDALTEVFSRGQVGVVVDESDVVRGIITKIDMIDYLANKA
CCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]