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The map label for this gene is galK [H]

Identifier: 159900234

GI number: 159900234

Start: 4675809

End: 4676939

Strand: Reverse

Name: galK [H]

Synonym: Haur_3717

Alternate gene names: 159900234

Gene position: 4676939-4675809 (Counterclockwise)

Preceding gene: 159900235

Following gene: 159900233

Centisome position: 73.69

GC content: 52.17

Gene sequence:

>1131_bases
ATGACCGAGGTTAAAGCTGCATTTTTTGTTCGTTCTCCAGGTCGGGTAAATTTAATTGGCGAGCATACCGATTACAACGC
TGGGTTTGTTATGCCACTGGCGCTTGAACGTGGTACGACGTTTCAGGTTCAACCCCGTGATGATCAGCAGTTGATTGTGC
ATGCCCTACGTTTCAACGCACATGATCAAGCCGATTTGGCTAATTTGGCGGCTGGCACGCACGGCGATTGGCGTGATTAT
GTGCGCGGAACAGCCCAATCCTTGCTTGATGCTGGCTACGCGTTGCAAGGCGCTGAGATTAATATTGATGGTGATTTGCC
GCTGAGTGGCGGATTAAGCTCGTCAGCATCATTAGAAGTTGGCTTGGCTTTTAGCTTACTCTACGCCCAAGGCATCACGA
TTGCTCCCGCTGAATTAGCTAAAATTGCCCAACGCGCCGAAATTGAATATGCCCATGTTAATTGTGGAATTATGGATCAG
CTTGCGATTGCCGCAGGCGTTGCCGGCCATGCCACATTAATCGATTGCCGCTCGTTGGAAATTGAGGCCGTGCCGATTCC
GGCTGAAGTGGCAGTTTTGGTGATTGATAGTGGCGTGCCACGCACCTTGGCTGGCTCGGCTTATAATCAACGCCGCGCCG
AATGTGAACAAGCTGTAGCAATCTTGCGTCAACTCGACCCAAACATCAACGATTTGCGCGATGTTAACAGCGATTTGCTG
GCCCAAGCCGTTGAACAAGATCGCTTTGAAGAAGTGATTTATCGACGTGCCCGCCATGTTGTCAGCGAAAATGAGCGGGT
GCATAAAGCCGCCGCCGCGTTTCGGGCAGGCGATTTTGGCTACGTTGGCGAGTTGATGAACGAATCGCATTGGAGCCTGC
GCGATGATTATGAAGTTAGCGGCCCTGAGCTTGATCAACTAACTGAGTTGTTGCGCGATATGCCTGGGGTTTGGGGTGCT
CGCCTAACTGGCGCTGGCTTTGGTGGCTGCTGCGTGGCCTTGGTCGAAGCCAGCCACGTTGATGCGGTGATTGTGGCCTT
AAGTCCAGCCTATCATGCCGCAACTGGCCGCACCTGCGAAGCCTTTAGCACCAAAGCCTCAGCATTAACCATTGAAGAAC
CTAGAGCATAG

Upstream 100 bases:

>100_bases
GGTGCTGTTTGGTCTATACCCTCTGCTGTATTCCACTGAACTTGGCAGTGCTCCTTCGCTCGCTAACGTACCCATTTGAT
AGATTTTGGAGCATTTGGCT

Downstream 100 bases:

>100_bases
ATGTAATCGTTCATTGTATTAACAACCGCCAGCGTTCCCTCACCCCCAACCCCTCTCCCACGGCGGCGGGCGAGGGGAGA
ACTCCCAGAGCGGTTCCCCT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTEVKAAFFVRSPGRVNLIGEHTDYNAGFVMPLALERGTTFQVQPRDDQQLIVHALRFNAHDQADLANLAAGTHGDWRDY
VRGTAQSLLDAGYALQGAEINIDGDLPLSGGLSSSASLEVGLAFSLLYAQGITIAPAELAKIAQRAEIEYAHVNCGIMDQ
LAIAAGVAGHATLIDCRSLEIEAVPIPAEVAVLVIDSGVPRTLAGSAYNQRRAECEQAVAILRQLDPNINDLRDVNSDLL
AQAVEQDRFEEVIYRRARHVVSENERVHKAAAAFRAGDFGYVGELMNESHWSLRDDYEVSGPELDQLTELLRDMPGVWGA
RLTGAGFGGCCVALVEASHVDAVIVALSPAYHAATGRTCEAFSTKASALTIEEPRA

Sequences:

>Translated_376_residues
MTEVKAAFFVRSPGRVNLIGEHTDYNAGFVMPLALERGTTFQVQPRDDQQLIVHALRFNAHDQADLANLAAGTHGDWRDY
VRGTAQSLLDAGYALQGAEINIDGDLPLSGGLSSSASLEVGLAFSLLYAQGITIAPAELAKIAQRAEIEYAHVNCGIMDQ
LAIAAGVAGHATLIDCRSLEIEAVPIPAEVAVLVIDSGVPRTLAGSAYNQRRAECEQAVAILRQLDPNINDLRDVNSDLL
AQAVEQDRFEEVIYRRARHVVSENERVHKAAAAFRAGDFGYVGELMNESHWSLRDDYEVSGPELDQLTELLRDMPGVWGA
RLTGAGFGGCCVALVEASHVDAVIVALSPAYHAATGRTCEAFSTKASALTIEEPRA
>Mature_375_residues
TEVKAAFFVRSPGRVNLIGEHTDYNAGFVMPLALERGTTFQVQPRDDQQLIVHALRFNAHDQADLANLAAGTHGDWRDYV
RGTAQSLLDAGYALQGAEINIDGDLPLSGGLSSSASLEVGLAFSLLYAQGITIAPAELAKIAQRAEIEYAHVNCGIMDQL
AIAAGVAGHATLIDCRSLEIEAVPIPAEVAVLVIDSGVPRTLAGSAYNQRRAECEQAVAILRQLDPNINDLRDVNSDLLA
QAVEQDRFEEVIYRRARHVVSENERVHKAAAAFRAGDFGYVGELMNESHWSLRDDYEVSGPELDQLTELLRDMPGVWGAR
LTGAGFGGCCVALVEASHVDAVIVALSPAYHAATGRTCEAFSTKASALTIEEPRA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=340, Percent_Identity=45.8823529411765, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4503897, Length=398, Percent_Identity=30.1507537688442, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI48527957, Length=398, Percent_Identity=30.1507537688442, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786972, Length=354, Percent_Identity=42.090395480226, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71989053, Length=395, Percent_Identity=29.1139240506329, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319494, Length=369, Percent_Identity=25.7452574525745, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24661292, Length=413, Percent_Identity=30.5084745762712, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21355577, Length=413, Percent_Identity=30.5084745762712, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24661285, Length=413, Percent_Identity=30.5084745762712, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 40404; Mature: 40273

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVKAAFFVRSPGRVNLIGEHTDYNAGFVMPLALERGTTFQVQPRDDQQLIVHALRFNA
CCCCEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCC
HDQADLANLAAGTHGDWRDYVRGTAQSLLDAGYALQGAEINIDGDLPLSGGLSSSASLEV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCCCCCEEH
GLAFSLLYAQGITIAPAELAKIAQRAEIEYAHVNCGIMDQLAIAAGVAGHATLIDCRSLE
HHHHHHHHHCCCEECHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEEEECCCE
IEAVPIPAEVAVLVIDSGVPRTLAGSAYNQRRAECEQAVAILRQLDPNINDLRDVNSDLL
EEEECCCCEEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHH
AQAVEQDRFEEVIYRRARHVVSENERVHKAAAAFRAGDFGYVGELMNESHWSLRDDYEVS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCC
GPELDQLTELLRDMPGVWGARLTGAGFGGCCVALVEASHVDAVIVALSPAYHAATGRTCE
CCCHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHCCCCCCHH
AFSTKASALTIEEPRA
HHCCCCCEEEECCCCC
>Mature Secondary Structure 
TEVKAAFFVRSPGRVNLIGEHTDYNAGFVMPLALERGTTFQVQPRDDQQLIVHALRFNA
CCCEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCC
HDQADLANLAAGTHGDWRDYVRGTAQSLLDAGYALQGAEINIDGDLPLSGGLSSSASLEV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCCCCCEEH
GLAFSLLYAQGITIAPAELAKIAQRAEIEYAHVNCGIMDQLAIAAGVAGHATLIDCRSLE
HHHHHHHHHCCCEECHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEEEECCCE
IEAVPIPAEVAVLVIDSGVPRTLAGSAYNQRRAECEQAVAILRQLDPNINDLRDVNSDLL
EEEECCCCEEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHH
AQAVEQDRFEEVIYRRARHVVSENERVHKAAAAFRAGDFGYVGELMNESHWSLRDDYEVS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCC
GPELDQLTELLRDMPGVWGARLTGAGFGGCCVALVEASHVDAVIVALSPAYHAATGRTCE
CCCHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHCCCCCCHH
AFSTKASALTIEEPRA
HHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA