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The map label for this gene is nprS [H]

Identifier: 159900162

GI number: 159900162

Start: 4583875

End: 4585473

Strand: Reverse

Name: nprS [H]

Synonym: Haur_3645

Alternate gene names: 159900162

Gene position: 4585473-4583875 (Counterclockwise)

Preceding gene: 159900166

Following gene: 159900161

Centisome position: 72.25

GC content: 53.22

Gene sequence:

>1599_bases
ATGGTTCGCAAACGTTTAATCACTGTGGCTGCATTGCTCGGTTTAGTTGGGGCTGTCTTTGGTTCTGCTGTTAGCACTGG
TGCTCAAGATTACGACAAAGTTCGCGGGCAGTTGATCCGCACTTATCGCGAAGCCGAAGCCAAAGGCGTGCGCCCAGATT
GGGTCACCGCAGCGGTTGATACCAGCTTGAATCACTTCGCTGGCAAGGGTGCCAATAGCGCCAATTTGCAAGTGCGTGGC
GTTGATCAAGATGATCTGGGCATCAACGTGCGCCTTGACCAAACCTATGCTGGCTTGCCAGTCTTTGGCGGCCAAGTCAT
TGCGCACCTCGACAATAAAGGCAATGTGACCCAAGAAAGTGGTGAACTCTTCGCGGTTGATGGGATTGATACCAGCGCTA
GCTTAAGCTCGGCCGAGGCGATCAAAATTGCTCAAAGCCAAGTCAAGTATGATTTCAACGCCAAAAACGCGAGCGGTACA
GAAGTCAGTAGCGAACTCAAAATCTTGCCACGCGAAGGCAAAGATTCGGTGATCGTCTTCCAAGTAAGCTTGCACATTGA
AGATGGCAGCGAAGCAACCGCTCACCACGAGTTCTTCATCAACGCCAAAACTGGCGAAACTGAGTTGTACTACAACGACA
TGGATGGAGTCAACGCGACTGGGACTGGCAAGAGCTTATACAGCGGCAATGTCTCAATTACCACCGACTTGGTGAGTGGG
GTTTACTATCTGCGCGATAACTCACGCGGCGGGATGTACACCACCAACATGAACAACCGCACCACTGGCGGTAGCACCTT
CACCGATGCTGATAATGTTTGGGGAACCAACACGACTGCCAACGTTCAAAGCGCTGGCGTTGATGCCCACTATGGCGCTC
AATTGACCTGGGACTACTACTTGAGCAGCTTTGGCCGCCGTGGCATCGATGGCAATGGCTTCCGCGTATTGAGCCGCGTG
CACTATGGCAATCGCTATAACAACGCCTTCTGGAACGGCTCAAGCATGACCTATGGTGATGGCGATGGCACAACCTTCCG
TCCATTGGTTTCGCTCGATGTTGCAGGCCACGAAATTACCCACGGTCTGACCGAAAAAACCGCTGGCTTGATCTATAGCA
ACGAATCAGGTGCTGCTAATGAATCATTCTCGGATATTTTCGGCACAATGGTCGAATATAGCAGCGGCACAGGCGATTAT
CTGATTGGCGAAGACATCTACACCCCAGCCACCGCTGGCGATGCGTTGCGCAATATGTCGAACCCAGCCGCCGAAGGCGA
CCCCGACCACTACAGCAAGCGCTACACTGGCACTGGCGATAATGGCGGCGTGCACATCAACAGTGGGATTCAAAACCAAG
TCTTCTATCTGTTGGCTCAAGGTGGAACCAACCGCACCTCTGGCTTAGCAGTAACTGGCATTGGCCGACCAAAAGCCGCT
GCGATCTTCTATCGTGCCTTGACGGTCTACTTGACCCCAAGCTCAAACTTCAAGGCCGTGCGCACCGCAACCCTCAACGC
CGCCCGCGACCTCTATGGCGCAAGCAGCGCTGAATACAACGCAACTGCTCAAGCCTGGACGGCTTGTGGCGTACAATAA

Upstream 100 bases:

>100_bases
ATTTTCGTCAATTTTGAATAAGCTGCTGTTTTATGTGGTGGCTTGCTGATGAGCTAGTTGTTCTCGAAATCCCTACAAAT
TGCGGAGGTTATAATTCTTT

Downstream 100 bases:

>100_bases
GCACTAGCTAAATCTCGTTTCCAAGCACACGCTCCATGTGGGGCGTGTGTTTTTGTGTATTGTGAGAATGATTACCAATG
CTCATGCACGTTTAAAGCGC

Product: thermolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MVRKRLITVAALLGLVGAVFGSAVSTGAQDYDKVRGQLIRTYREAEAKGVRPDWVTAAVDTSLNHFAGKGANSANLQVRG
VDQDDLGINVRLDQTYAGLPVFGGQVIAHLDNKGNVTQESGELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGT
EVSSELKILPREGKDSVIVFQVSLHIEDGSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSG
VYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVDAHYGAQLTWDYYLSSFGRRGIDGNGFRVLSRV
HYGNRYNNAFWNGSSMTYGDGDGTTFRPLVSLDVAGHEITHGLTEKTAGLIYSNESGAANESFSDIFGTMVEYSSGTGDY
LIGEDIYTPATAGDALRNMSNPAAEGDPDHYSKRYTGTGDNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPKAA
AIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGVQ

Sequences:

>Translated_532_residues
MVRKRLITVAALLGLVGAVFGSAVSTGAQDYDKVRGQLIRTYREAEAKGVRPDWVTAAVDTSLNHFAGKGANSANLQVRG
VDQDDLGINVRLDQTYAGLPVFGGQVIAHLDNKGNVTQESGELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGT
EVSSELKILPREGKDSVIVFQVSLHIEDGSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSG
VYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVDAHYGAQLTWDYYLSSFGRRGIDGNGFRVLSRV
HYGNRYNNAFWNGSSMTYGDGDGTTFRPLVSLDVAGHEITHGLTEKTAGLIYSNESGAANESFSDIFGTMVEYSSGTGDY
LIGEDIYTPATAGDALRNMSNPAAEGDPDHYSKRYTGTGDNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPKAA
AIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGVQ
>Mature_532_residues
MVRKRLITVAALLGLVGAVFGSAVSTGAQDYDKVRGQLIRTYREAEAKGVRPDWVTAAVDTSLNHFAGKGANSANLQVRG
VDQDDLGINVRLDQTYAGLPVFGGQVIAHLDNKGNVTQESGELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGT
EVSSELKILPREGKDSVIVFQVSLHIEDGSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSG
VYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVDAHYGAQLTWDYYLSSFGRRGIDGNGFRVLSRV
HYGNRYNNAFWNGSSMTYGDGDGTTFRPLVSLDVAGHEITHGLTEKTAGLIYSNESGAANESFSDIFGTMVEYSSGTGDY
LIGEDIYTPATAGDALRNMSNPAAEGDPDHYSKRYTGTGDNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPKAA
AIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGVQ

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 56661; Mature: 56661

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKRLITVAALLGLVGAVFGSAVSTGAQDYDKVRGQLIRTYREAEAKGVRPDWVTAAVD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TSLNHFAGKGANSANLQVRGVDQDDLGINVRLDQTYAGLPVFGGQVIAHLDNKGNVTQES
CCHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEECCEEEEEECCCCCEECCC
GELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGTEVSSELKILPREGKDSVIVF
CCEEEEECCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEE
QVSLHIEDGSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSG
EEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEECCCEEEEEHHHCC
VYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVDAHYGAQLTWDYY
EEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEHHHH
LSSFGRRGIDGNGFRVLSRVHYGNRYNNAFWNGSSMTYGDGDGTTFRPLVSLDVAGHEIT
HHHHCCCCCCCCCCEEEEEHHCCCCCCCCEECCCEEEECCCCCCEEEEEEEEECCCCHHH
HGLTEKTAGLIYSNESGAANESFSDIFGTMVEYSSGTGDYLIGEDIYTPATAGDALRNMS
CCHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHCC
NPAAEGDPDHYSKRYTGTGDNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPKAA
CCCCCCCCCHHCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCCHHH
AIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGVQ
HHEEEEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MVRKRLITVAALLGLVGAVFGSAVSTGAQDYDKVRGQLIRTYREAEAKGVRPDWVTAAVD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TSLNHFAGKGANSANLQVRGVDQDDLGINVRLDQTYAGLPVFGGQVIAHLDNKGNVTQES
CCHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEECCEEEEEECCCCCEECCC
GELFAVDGIDTSASLSSAEAIKIAQSQVKYDFNAKNASGTEVSSELKILPREGKDSVIVF
CCEEEEECCCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEECCCCCCEEEE
QVSLHIEDGSEATAHHEFFINAKTGETELYYNDMDGVNATGTGKSLYSGNVSITTDLVSG
EEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEECCCEEEEEHHHCC
VYYLRDNSRGGMYTTNMNNRTTGGSTFTDADNVWGTNTTANVQSAGVDAHYGAQLTWDYY
EEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEHHHH
LSSFGRRGIDGNGFRVLSRVHYGNRYNNAFWNGSSMTYGDGDGTTFRPLVSLDVAGHEIT
HHHHCCCCCCCCCCEEEEEHHCCCCCCCCEECCCEEEECCCCCCEEEEEEEEECCCCHHH
HGLTEKTAGLIYSNESGAANESFSDIFGTMVEYSSGTGDYLIGEDIYTPATAGDALRNMS
CCHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHCC
NPAAEGDPDHYSKRYTGTGDNGGVHINSGIQNQVFYLLAQGGTNRTSGLAVTGIGRPKAA
CCCCCCCCCHHCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCCHHH
AIFYRALTVYLTPSSNFKAVRTATLNAARDLYGASSAEYNATAQAWTACGVQ
HHEEEEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2203733; 3149972 [H]