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The map label for this gene is gluP [H]

Identifier: 159900030

GI number: 159900030

Start: 4423509

End: 4424369

Strand: Reverse

Name: gluP [H]

Synonym: Haur_3513

Alternate gene names: 159900030

Gene position: 4424369-4423509 (Counterclockwise)

Preceding gene: 159900031

Following gene: 159900029

Centisome position: 69.71

GC content: 51.45

Gene sequence:

>861_bases
ATGCAAGATCCCTATTCAGGCTATCAACCTGAGCGTGTTGAATATTCGCCCAGCCAACCTGTGATGGTGCAACTGCCCAA
TGCACCAGTACGGGCTACTTGGGTGTTTATGGCGATCAACGTCGTTATGTTTGTGATCTGTATTCTTCAGGGCATGAGTG
TGATGGGCAATACCGAAGGCGATGCCTTTGTCTTGATCGAACTTGGAGCCAAGTGGTCGCCTTTGATGGATATCGGCGGC
GAATGGTGGCGCTTATTCACGGCGACCGTGCTGCACGGCGGGATTGTGCATATTGGCTTTAATATGTATGCCCTGTATGC
GCTTGGCCCAACCGTTGAGCGCTTCTATGGTAGCCTGCGGTTTAGCGTGATCTACCTGATTGCGGGGATTGGCGGGGCTT
GGGCTTCGTATAGTTTTGGCAGTTTGACTGGCCCTTCAATTGGCGCATCGGGGGCAATCTTCGGCCTGATTGGCTGCTTG
ATTGGCTTTTTCCTTTCGGCTCGCAGTGTCTTGGGTGATTTTGCTCGCCAAAACTTGCGCCAAATGGTCGGTACAGCCGC
GATTAACTTGATCATTGGCTTATCGTTTTCGTCGGTGATCGACAATTATGCTCACATTGGCGGGATGCTGATGGGCTTGG
CGGTGGGCTATGGTTTGGCTCCACGCTTAGTCTATATTGCCGATTGGTTTAAGCCGCGGATTGAGGCTAAAGCACCATCA
GCATTGCTCTGGCTGAGCGTGGTTGGCGCGATTGGCTTTATTCTGGTTGCGACGTGGTTTGTGCATAACCAACGCATGAA
CGATGCTACAAGCGTTGCGCTCTTAGAAGAACTTTATCAAGCTTGGTTAAATGCCCGTTAG

Upstream 100 bases:

>100_bases
AGTGAAGGTTCTGCGATTGAAGGTTATTGCCAAAAGCCTAAGTTCTTGTTTCGTCGCTATTGAGCTTGATTGCTGCAATT
GGCTCAGAAATTGGCAACCC

Downstream 100 bases:

>100_bases
ACGGTTGGAGGTCGCATGAACGATCGAGTTCCGCGAAAACCTGATGGAATGTTGCTAGCCCTGGTGGGCGGCTTGGTTGC
GTTTGGGCTAGTGATGGTCT

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQDPYSGYQPERVEYSPSQPVMVQLPNAPVRATWVFMAINVVMFVICILQGMSVMGNTEGDAFVLIELGAKWSPLMDIGG
EWWRLFTATVLHGGIVHIGFNMYALYALGPTVERFYGSLRFSVIYLIAGIGGAWASYSFGSLTGPSIGASGAIFGLIGCL
IGFFLSARSVLGDFARQNLRQMVGTAAINLIIGLSFSSVIDNYAHIGGMLMGLAVGYGLAPRLVYIADWFKPRIEAKAPS
ALLWLSVVGAIGFILVATWFVHNQRMNDATSVALLEELYQAWLNAR

Sequences:

>Translated_286_residues
MQDPYSGYQPERVEYSPSQPVMVQLPNAPVRATWVFMAINVVMFVICILQGMSVMGNTEGDAFVLIELGAKWSPLMDIGG
EWWRLFTATVLHGGIVHIGFNMYALYALGPTVERFYGSLRFSVIYLIAGIGGAWASYSFGSLTGPSIGASGAIFGLIGCL
IGFFLSARSVLGDFARQNLRQMVGTAAINLIIGLSFSSVIDNYAHIGGMLMGLAVGYGLAPRLVYIADWFKPRIEAKAPS
ALLWLSVVGAIGFILVATWFVHNQRMNDATSVALLEELYQAWLNAR
>Mature_286_residues
MQDPYSGYQPERVEYSPSQPVMVQLPNAPVRATWVFMAINVVMFVICILQGMSVMGNTEGDAFVLIELGAKWSPLMDIGG
EWWRLFTATVLHGGIVHIGFNMYALYALGPTVERFYGSLRFSVIYLIAGIGGAWASYSFGSLTGPSIGASGAIFGLIGCL
IGFFLSARSVLGDFARQNLRQMVGTAAINLIIGLSFSSVIDNYAHIGGMLMGLAVGYGLAPRLVYIADWFKPRIEAKAPS
ALLWLSVVGAIGFILVATWFVHNQRMNDATSVALLEELYQAWLNAR

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901888, Length=148, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532986, Length=152, Percent_Identity=26.9736842105263, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 31122; Mature: 31122

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDPYSGYQPERVEYSPSQPVMVQLPNAPVRATWVFMAINVVMFVICILQGMSVMGNTEG
CCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC
DAFVLIELGAKWSPLMDIGGEWWRLFTATVLHGGIVHIGFNMYALYALGPTVERFYGSLR
CEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCHHHHHHHHHHH
FSVIYLIAGIGGAWASYSFGSLTGPSIGASGAIFGLIGCLIGFFLSARSVLGDFARQNLR
HHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMVGTAAINLIIGLSFSSVIDNYAHIGGMLMGLAVGYGLAPRLVYIADWFKPRIEAKAPS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCH
ALLWLSVVGAIGFILVATWFVHNQRMNDATSVALLEELYQAWLNAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDPYSGYQPERVEYSPSQPVMVQLPNAPVRATWVFMAINVVMFVICILQGMSVMGNTEG
CCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC
DAFVLIELGAKWSPLMDIGGEWWRLFTATVLHGGIVHIGFNMYALYALGPTVERFYGSLR
CEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCHHHHHHHHHHH
FSVIYLIAGIGGAWASYSFGSLTGPSIGASGAIFGLIGCLIGFFLSARSVLGDFARQNLR
HHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMVGTAAINLIIGLSFSSVIDNYAHIGGMLMGLAVGYGLAPRLVYIADWFKPRIEAKAPS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCH
ALLWLSVVGAIGFILVATWFVHNQRMNDATSVALLEELYQAWLNAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]