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The map label for this gene is panC

Identifier: 159899977

GI number: 159899977

Start: 4353435

End: 4354265

Strand: Reverse

Name: panC

Synonym: Haur_3460

Alternate gene names: 159899977

Gene position: 4354265-4353435 (Counterclockwise)

Preceding gene: 159899992

Following gene: 159899976

Centisome position: 68.61

GC content: 52.47

Gene sequence:

>831_bases
ATGCAGGTTGTAACAACGATTGAAGAAGTTCGGGCGGCGCGTCGCCAGTGGGCTGAGGTTGGTTTTGTGCCAACCATGGG
CTTTTTGCATGCTGGGCATTTAAGCTTAGTTCAACAATCCAAAGCCGAAAACGGGGTAGCCATCGCCTCGATTTTTGTCA
ATCCCACGCAGTTTGGCCCCAACGAAGATTTTGCCAGCTATCCACGGGATACGCCGCGCGACCTCGCCTTGTTGGAAGCA
GCTGGTTGCGATTTGGTCTGGATGCCTAGCGTCGAGGAAATTTATCCAGCGGGATTTAGCAGTTATGTGGAAGTTGAGGG
GGTTACGGCTCCGCTTGAGGGTGCTCGCCGACCTGGCCATTTTCGCGGTGTAGCCACGGTTGTGACCAAACTATTTAATG
TCGTTCAGCCAACCAAAGCCTATTTTGGCCAAAAAGATGCCCAGCAAACTGTGGTAATTCGCCAATTTGTGCGCGATTTA
GCCATGCCTGTAGAAGTAGTCATCGCCCCGACGATTCGTGAGGCCGATGGTTTGGCGATGAGCAGCCGCAATAGTTACCT
GAATGCTGAGCAACGTGCCGCAGCTCCAGTGCTATATCGAGCGTTAACAGCCGCTCAAACCGCCTATGCCGCAGGTCAAA
CCGATGCTGAGGCTATTCGCCAATTGATGTTGGAAACGCTGGCCCAAGAGCCACTAGCCCAAGTCGATTATGTTAGCATC
GCCGATCCGCGCAGTTTACAAGAACTAACCACGATCGATCAACAGGGCGTGTTGGTATCGCTAGCCGTGCGCATCGGCAA
AACCCGCTTGATCGATAATTTAGTGATGTAA

Upstream 100 bases:

>100_bases
AAATTAATATTTCCCGTTACAAAACTGCCAATTTGGCGCTTTCGCCTAGATTGAATTAAGATATTTGTTAGCAAGCGTTT
TTGTGGATAAGGAACGAACC

Downstream 100 bases:

>100_bases
CTTGGGGATCGGGGAAAGAAGCCACACAGATTTTAACCACGAAGCACACGAAGCACACTAAGGCTTTTTATCCTATAAGC
TTAGTGCTCTTCGTGTTCCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQVVTTIEEVRAARRQWAEVGFVPTMGFLHAGHLSLVQQSKAENGVAIASIFVNPTQFGPNEDFASYPRDTPRDLALLEA
AGCDLVWMPSVEEIYPAGFSSYVEVEGVTAPLEGARRPGHFRGVATVVTKLFNVVQPTKAYFGQKDAQQTVVIRQFVRDL
AMPVEVVIAPTIREADGLAMSSRNSYLNAEQRAAAPVLYRALTAAQTAYAAGQTDAEAIRQLMLETLAQEPLAQVDYVSI
ADPRSLQELTTIDQQGVLVSLAVRIGKTRLIDNLVM

Sequences:

>Translated_276_residues
MQVVTTIEEVRAARRQWAEVGFVPTMGFLHAGHLSLVQQSKAENGVAIASIFVNPTQFGPNEDFASYPRDTPRDLALLEA
AGCDLVWMPSVEEIYPAGFSSYVEVEGVTAPLEGARRPGHFRGVATVVTKLFNVVQPTKAYFGQKDAQQTVVIRQFVRDL
AMPVEVVIAPTIREADGLAMSSRNSYLNAEQRAAAPVLYRALTAAQTAYAAGQTDAEAIRQLMLETLAQEPLAQVDYVSI
ADPRSLQELTTIDQQGVLVSLAVRIGKTRLIDNLVM
>Mature_276_residues
MQVVTTIEEVRAARRQWAEVGFVPTMGFLHAGHLSLVQQSKAENGVAIASIFVNPTQFGPNEDFASYPRDTPRDLALLEA
AGCDLVWMPSVEEIYPAGFSSYVEVEGVTAPLEGARRPGHFRGVATVVTKLFNVVQPTKAYFGQKDAQQTVVIRQFVRDL
AMPVEVVIAPTIREADGLAMSSRNSYLNAEQRAAAPVLYRALTAAQTAYAAGQTDAEAIRQLMLETLAQEPLAQVDYVSI
ADPRSLQELTTIDQQGVLVSLAVRIGKTRLIDNLVM

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=268, Percent_Identity=45.1492537313433, Blast_Score=231, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=40.7766990291262, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_HERA2 (A9B3W0)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546224.1
- ProteinModelPortal:   A9B3W0
- SMR:   A9B3W0
- GeneID:   5735321
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_3460
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   HAUR316274:HAUR_3460-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30090; Mature: 30090

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 149-149 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVVTTIEEVRAARRQWAEVGFVPTMGFLHAGHLSLVQQSKAENGVAIASIFVNPTQFGP
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
NEDFASYPRDTPRDLALLEAAGCDLVWMPSVEEIYPAGFSSYVEVEGVTAPLEGARRPGH
CCCHHHCCCCCCHHHHHHHHCCCCEEECCCHHHHCCCCCCCEEEECCCCCCHHCCCCCCH
FRGVATVVTKLFNVVQPTKAYFGQKDAQQTVVIRQFVRDLAMPVEVVIAPTIREADGLAM
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHCCCCCEE
SSRNSYLNAEQRAAAPVLYRALTAAQTAYAAGQTDAEAIRQLMLETLAQEPLAQVDYVSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHCCEEEC
ADPRSLQELTTIDQQGVLVSLAVRIGKTRLIDNLVM
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQVVTTIEEVRAARRQWAEVGFVPTMGFLHAGHLSLVQQSKAENGVAIASIFVNPTQFGP
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
NEDFASYPRDTPRDLALLEAAGCDLVWMPSVEEIYPAGFSSYVEVEGVTAPLEGARRPGH
CCCHHHCCCCCCHHHHHHHHCCCCEEECCCHHHHCCCCCCCEEEECCCCCCHHCCCCCCH
FRGVATVVTKLFNVVQPTKAYFGQKDAQQTVVIRQFVRDLAMPVEVVIAPTIREADGLAM
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHCCCCCEE
SSRNSYLNAEQRAAAPVLYRALTAAQTAYAAGQTDAEAIRQLMLETLAQEPLAQVDYVSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHCCEEEC
ADPRSLQELTTIDQQGVLVSLAVRIGKTRLIDNLVM
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA