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The map label for this gene is lysN [H]

Identifier: 159899881

GI number: 159899881

Start: 4242088

End: 4243584

Strand: Reverse

Name: lysN [H]

Synonym: Haur_3364

Alternate gene names: 159899881

Gene position: 4243584-4242088 (Counterclockwise)

Preceding gene: 159899882

Following gene: 159899880

Centisome position: 66.86

GC content: 53.04

Gene sequence:

>1497_bases
ATGGAATTTCAGCTTGATCGTCAGCACGCCAAACCACTCTATATTCAATTATCCGAACAACTGCAAGAGCGGATTCGGAG
TGGCTCGTTGCCAGCTGGCACGAAACTGCCGCCAGTGCGCGATTTAGCTGAATCACTTGGTCTCACCCGTTTGACGGTTC
ACAATGCCTATAGCGAACTGCAAGCAAGTGGTTGGGTTGAGGCCTACGTTGGTCGCGGCACCTTCGTCGCCGAGCGGATC
AAGCCGATTATTCCAGCATATGAGATTCGCCAACGGGTAGTGGATGAGCTACAAACGCCATGGTTTAGCCAAGGCATGTT
GGCCGATATGCTACGCTTGGCCCAACAGCCAAATTTAATCTCCTTTGCCCAAGCCGCGCCAGCCGAAGAAACCTTTCCAG
TGCGTGAAATTGGCCGCGCAATTCAGCAAGCCCTGCGCGACCCCAGCGCCCTAGGCTATGGCCCAACCCAAGGCGAATTA
TGTTTGCGCGAAGCGATTGCCACATGGCTGCTCGACCGCAATGTTGTAACCTCGCCCGACCATGTGCTGGTGACAACTGG
TGCTCAGCAGGGCGTAGCCTTGGCATTAAAGGCCTTTGTTCGCCAAGGCGATGTGGTTTTGGTCGAGGAGCCAACCTATT
TGGGCTTTATCGAGCAGGCTACGGCCTTGGGTGTGCGCTTAATCGGCATTCCATTGGATGATCAAGGCTTGCGGTTGGAT
ATTTTGCAACGGGTATTGTGTGAATACAAACCACGGTTGCTCTATACCGTGCCAACCTTCCACAACCCAACCGGCGTTTG
CCTTTCGACCGAGCGCCAAGAAGCCCTATTGCAATTGGCCCAAGAACATAACTTAATTATTTTAGAAGATGATGTCTATG
GGCCGCTGAGCTACGATGCTCAAGCACCACACCCAATCAAAGCCCGCGATACTAATGGGCAGGTGGTCTATCTTGGCAGC
TTCTCCAAAATTCTAACTCCGGGCTTACGCCTAGGTTATTTGGTTGCCCGTGACGAATTTTTGCACCCGTTGCTGACTGC
CAAGCGTGGCAACGATCTCCACTGCTCGCCATTATTGCAACGAGCTTTGGCCGATTATCTTGGCCGTGGTCAGTTGGCGG
CGCATTTGCGCTATGTGCGTGAACTCTATCGTGAGCGTCGCGATGCCATGGAACGAGCGTTGAACCGCTATTGTCCCCGT
GATATTCAATGGACGCATCCACGTGGCGGGTTATGCTACTGGCTAACCTTGCCCTCTGGATTAAATGGCACCGATATTTA
TACCGAGGCGATTGAAGCAGGCGTTGGCGTGACCCTTGGCAATGTCTTTTTTCCACAACCGCCACGCAACGCCCACTTAC
GGCTCTGTTTTGCCACCCAATCACCAGAATTAATTGATCGTGGAATTCGCATCCTTGGCGATGTGCTAACCCGCCATGTC
TTGCGTTGTGGTCAACTTGCTGCCCGTGCTTGGCGCGAAACCACCCCACTGATGTAA

Upstream 100 bases:

>100_bases
CGATTGTCATGGCCTAGATGACAATAACGGCGTAGGACTGGTACAATAGTCTCCTACGCCGTTGTGTTTAATCGACAATT
CTGCTAGAGAAAGGCCAACC

Downstream 100 bases:

>100_bases
GTTGGTGAATGCCGAAACAAGGCCGTAACAGTGCTACTCAGCCTCGGTTGATCGATAGATTGCTGGCTTTCAAGGAAGGG
AATTTAGGTATGACACTGCG

Product: transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEFQLDRQHAKPLYIQLSEQLQERIRSGSLPAGTKLPPVRDLAESLGLTRLTVHNAYSELQASGWVEAYVGRGTFVAERI
KPIIPAYEIRQRVVDELQTPWFSQGMLADMLRLAQQPNLISFAQAAPAEETFPVREIGRAIQQALRDPSALGYGPTQGEL
CLREAIATWLLDRNVVTSPDHVLVTTGAQQGVALALKAFVRQGDVVLVEEPTYLGFIEQATALGVRLIGIPLDDQGLRLD
ILQRVLCEYKPRLLYTVPTFHNPTGVCLSTERQEALLQLAQEHNLIILEDDVYGPLSYDAQAPHPIKARDTNGQVVYLGS
FSKILTPGLRLGYLVARDEFLHPLLTAKRGNDLHCSPLLQRALADYLGRGQLAAHLRYVRELYRERRDAMERALNRYCPR
DIQWTHPRGGLCYWLTLPSGLNGTDIYTEAIEAGVGVTLGNVFFPQPPRNAHLRLCFATQSPELIDRGIRILGDVLTRHV
LRCGQLAARAWRETTPLM

Sequences:

>Translated_498_residues
MEFQLDRQHAKPLYIQLSEQLQERIRSGSLPAGTKLPPVRDLAESLGLTRLTVHNAYSELQASGWVEAYVGRGTFVAERI
KPIIPAYEIRQRVVDELQTPWFSQGMLADMLRLAQQPNLISFAQAAPAEETFPVREIGRAIQQALRDPSALGYGPTQGEL
CLREAIATWLLDRNVVTSPDHVLVTTGAQQGVALALKAFVRQGDVVLVEEPTYLGFIEQATALGVRLIGIPLDDQGLRLD
ILQRVLCEYKPRLLYTVPTFHNPTGVCLSTERQEALLQLAQEHNLIILEDDVYGPLSYDAQAPHPIKARDTNGQVVYLGS
FSKILTPGLRLGYLVARDEFLHPLLTAKRGNDLHCSPLLQRALADYLGRGQLAAHLRYVRELYRERRDAMERALNRYCPR
DIQWTHPRGGLCYWLTLPSGLNGTDIYTEAIEAGVGVTLGNVFFPQPPRNAHLRLCFATQSPELIDRGIRILGDVLTRHV
LRCGQLAARAWRETTPLM
>Mature_498_residues
MEFQLDRQHAKPLYIQLSEQLQERIRSGSLPAGTKLPPVRDLAESLGLTRLTVHNAYSELQASGWVEAYVGRGTFVAERI
KPIIPAYEIRQRVVDELQTPWFSQGMLADMLRLAQQPNLISFAQAAPAEETFPVREIGRAIQQALRDPSALGYGPTQGEL
CLREAIATWLLDRNVVTSPDHVLVTTGAQQGVALALKAFVRQGDVVLVEEPTYLGFIEQATALGVRLIGIPLDDQGLRLD
ILQRVLCEYKPRLLYTVPTFHNPTGVCLSTERQEALLQLAQEHNLIILEDDVYGPLSYDAQAPHPIKARDTNGQVVYLGS
FSKILTPGLRLGYLVARDEFLHPLLTAKRGNDLHCSPLLQRALADYLGRGQLAAHLRYVRELYRERRDAMERALNRYCPR
DIQWTHPRGGLCYWLTLPSGLNGTDIYTEAIEAGVGVTLGNVFFPQPPRNAHLRLCFATQSPELIDRGIRILGDVLTRHV
LRCGQLAARAWRETTPLM

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=359, Percent_Identity=28.133704735376, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI33469970, Length=359, Percent_Identity=28.133704735376, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4507369, Length=241, Percent_Identity=25.7261410788382, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790797, Length=472, Percent_Identity=30.5084745762712, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787710, Length=471, Percent_Identity=30.7855626326964, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1788722, Length=309, Percent_Identity=26.8608414239482, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786816, Length=403, Percent_Identity=26.5508684863524, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17567663, Length=215, Percent_Identity=24.6511627906977, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321236, Length=471, Percent_Identity=24.203821656051, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321000, Length=435, Percent_Identity=25.0574712643678, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321929, Length=203, Percent_Identity=29.5566502463054, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322401, Length=265, Percent_Identity=23.3962264150943, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356535, Length=349, Percent_Identity=26.3610315186246, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 55766; Mature: 55766

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQLDRQHAKPLYIQLSEQLQERIRSGSLPAGTKLPPVRDLAESLGLTRLTVHNAYSEL
CCCCCCHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHHHH
QASGWVEAYVGRGTFVAERIKPIIPAYEIRQRVVDELQTPWFSQGMLADMLRLAQQPNLI
HHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
SFAQAAPAEETFPVREIGRAIQQALRDPSALGYGPTQGELCLREAIATWLLDRNVVTSPD
EHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
HVLVTTGAQQGVALALKAFVRQGDVVLVEEPTYLGFIEQATALGVRLIGIPLDDQGLRLD
CEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCHHH
ILQRVLCEYKPRLLYTVPTFHNPTGVCLSTERQEALLQLAQEHNLIILEDDVYGPLSYDA
HHHHHHHHCCCCEEEECCCCCCCCCCEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
QAPHPIKARDTNGQVVYLGSFSKILTPGLRLGYLVARDEFLHPLLTAKRGNDLHCSPLLQ
CCCCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RALADYLGRGQLAAHLRYVRELYRERRDAMERALNRYCPRDIQWTHPRGGLCYWLTLPSG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCC
LNGTDIYTEAIEAGVGVTLGNVFFPQPPRNAHLRLCFATQSPELIDRGIRILGDVLTRHV
CCCCHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
LRCGQLAARAWRETTPLM
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFQLDRQHAKPLYIQLSEQLQERIRSGSLPAGTKLPPVRDLAESLGLTRLTVHNAYSEL
CCCCCCHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCEEEEHHHHHHHH
QASGWVEAYVGRGTFVAERIKPIIPAYEIRQRVVDELQTPWFSQGMLADMLRLAQQPNLI
HHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
SFAQAAPAEETFPVREIGRAIQQALRDPSALGYGPTQGELCLREAIATWLLDRNVVTSPD
EHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
HVLVTTGAQQGVALALKAFVRQGDVVLVEEPTYLGFIEQATALGVRLIGIPLDDQGLRLD
CEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCHHH
ILQRVLCEYKPRLLYTVPTFHNPTGVCLSTERQEALLQLAQEHNLIILEDDVYGPLSYDA
HHHHHHHHCCCCEEEECCCCCCCCCCEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
QAPHPIKARDTNGQVVYLGSFSKILTPGLRLGYLVARDEFLHPLLTAKRGNDLHCSPLLQ
CCCCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RALADYLGRGQLAAHLRYVRELYRERRDAMERALNRYCPRDIQWTHPRGGLCYWLTLPSG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCC
LNGTDIYTEAIEAGVGVTLGNVFFPQPPRNAHLRLCFATQSPELIDRGIRILGDVLTRHV
CCCCHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHH
LRCGQLAARAWRETTPLM
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA