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The map label for this gene is tpm [H]

Identifier: 159899576

GI number: 159899576

Start: 3863017

End: 3863667

Strand: Reverse

Name: tpm [H]

Synonym: Haur_3057

Alternate gene names: 159899576

Gene position: 3863667-3863017 (Counterclockwise)

Preceding gene: 159899583

Following gene: 159899568

Centisome position: 60.88

GC content: 47.62

Gene sequence:

>651_bases
ATGGAAGCGACATTTTGGATCAATTCTTGGCAACAAGGCGGTAGTGCAACCAGCTTTCATCGGCGCGATATTCACCCGTA
TGTTGAGCATTTTGCTACGCCCGAATTTTTGCAGGGCAAACGGGTGTTGGTGCCTTTATGTGGTAAAACCAATGATTTGC
GTTGGTTTAGCCAATATGCCGAGGCCGTGATTGGGGTGGAGTTGGTAACCACTGCGATTGAGCAATTTTTTGCTGAGCAA
GAGCTTGATTACGTGCAACCCGACCCAACCACCTATGTTTCCGGCAATATTACGATTTTGAATCGTGATGTCTTGAGTTT
AACCACCGCTGATGTTGGCAACATCGATTTAGTCTATGATCGGGCGGCCTTGGTTGCCTTGCCCCACGAGATGCGCAACC
AGTATCGCGCGACGATCGATCAATTATTGCCTGTTGGCGGCCAGCAGATGATTATCACTTTAGAATATGCACCGCTGATG
GCCACCCCACCATTTAGCATTACGCCGACCGAGATTGAGTTTTACTATGGTGAGCGCTATTTTATCAGCCATTTTGCTGC
GCCCAGCCAGCCCGAACACCGCATGGTTGCTAAATTTAATTTGCAATTTCTCAAAGAGCATGGCTTTTTGATTACACGCT
ATCAGAAGTAG

Upstream 100 bases:

>100_bases
AATCACCATTGTGATGCGGTTAGCCTATGCGCCCCTTTTTCTCGCCAGCAATTTGCTTGGGGCATCGGTTGCACCTTTGT
GTGAGATTAAGGAGCCTACA

Downstream 100 bases:

>100_bases
CGACGAGAGCTCAGGGGCTAGAAGTCAGGTTTTTAACGTAGAGGTGCAGAGTAATTGATGGCTATAGTCTTTGGGCTTTG
GGCTATTGGAATAGGGTGTA

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MEATFWINSWQQGGSATSFHRRDIHPYVEHFATPEFLQGKRVLVPLCGKTNDLRWFSQYAEAVIGVELVTTAIEQFFAEQ
ELDYVQPDPTTYVSGNITILNRDVLSLTTADVGNIDLVYDRAALVALPHEMRNQYRATIDQLLPVGGQQMIITLEYAPLM
ATPPFSITPTEIEFYYGERYFISHFAAPSQPEHRMVAKFNLQFLKEHGFLITRYQK

Sequences:

>Translated_216_residues
MEATFWINSWQQGGSATSFHRRDIHPYVEHFATPEFLQGKRVLVPLCGKTNDLRWFSQYAEAVIGVELVTTAIEQFFAEQ
ELDYVQPDPTTYVSGNITILNRDVLSLTTADVGNIDLVYDRAALVALPHEMRNQYRATIDQLLPVGGQQMIITLEYAPLM
ATPPFSITPTEIEFYYGERYFISHFAAPSQPEHRMVAKFNLQFLKEHGFLITRYQK
>Mature_216_residues
MEATFWINSWQQGGSATSFHRRDIHPYVEHFATPEFLQGKRVLVPLCGKTNDLRWFSQYAEAVIGVELVTTAIEQFFAEQ
ELDYVQPDPTTYVSGNITILNRDVLSLTTADVGNIDLVYDRAALVALPHEMRNQYRATIDQLLPVGGQQMIITLEYAPLM
ATPPFSITPTEIEFYYGERYFISHFAAPSQPEHRMVAKFNLQFLKEHGFLITRYQK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=187, Percent_Identity=34.2245989304813, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 24798; Mature: 24798

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEATFWINSWQQGGSATSFHRRDIHPYVEHFATPEFLQGKRVLVPLCGKTNDLRWFSQYA
CCEEEEECCCCCCCCCCCCHHCCCCHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHH
EAVIGVELVTTAIEQFFAEQELDYVQPDPTTYVSGNITILNRDVLSLTTADVGNIDLVYD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEECCEEEEEECCCCCEEEEEC
RAALVALPHEMRNQYRATIDQLLPVGGQQMIITLEYAPLMATPPFSITPTEIEFYYGERY
CHHEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEECCCCCCCCCEEEEEECCEE
FISHFAAPSQPEHRMVAKFNLQFLKEHGFLITRYQK
EEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECC
>Mature Secondary Structure
MEATFWINSWQQGGSATSFHRRDIHPYVEHFATPEFLQGKRVLVPLCGKTNDLRWFSQYA
CCEEEEECCCCCCCCCCCCHHCCCCHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHH
EAVIGVELVTTAIEQFFAEQELDYVQPDPTTYVSGNITILNRDVLSLTTADVGNIDLVYD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEECCEEEEEECCCCCEEEEEC
RAALVALPHEMRNQYRATIDQLLPVGGQQMIITLEYAPLMATPPFSITPTEIEFYYGERY
CHHEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEECCCCCCCCCEEEEEECCEE
FISHFAAPSQPEHRMVAKFNLQFLKEHGFLITRYQK
EEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA