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The map label for this gene is merA [H]

Identifier: 159899568

GI number: 159899568

Start: 3850970

End: 3852388

Strand: Reverse

Name: merA [H]

Synonym: Haur_3049

Alternate gene names: 159899568

Gene position: 3852388-3850970 (Counterclockwise)

Preceding gene: 159899576

Following gene: 159899566

Centisome position: 60.7

GC content: 52.08

Gene sequence:

>1419_bases
ATGGACGATTTACTGGTAATTGGTGGCGGCTCGGCGGGGATTACCTTTGCAAAATTTGGCGCTTCGTTGGGGGCAAAAAT
TACCGTAATCGAGGCCAACAAGCTCGGTGGCGATTGTACTTGGACGGGCTGTGTGCCAAGTAAAAGCTTAATTCACGCTG
CCAAAATTGCTCATACCACGGCAACTGCTGCCCGTTATGGGATCAGCGCCCAGCCAAGCATCGATTTTGCCGCAGTGATG
GGCTATGTGCATTCTGTGCAGCAGCAAATTTATCAACACGATGATGCGCCTGAGGTGCTGCGTCAAGCGGGTGCACGGGT
AATCGAAGGGCGTGCGCGTTTTTATGATGATCAAACGGTGGAAGTTAATGGCGAGTTACTACGAGCCAAGCACTTTTGCA
TCGCGACTGGCTCGCATCCCAAAATTCCGACGATCCCTGGTTTGGCCGAGGCGGGCTACCTCACCAACGAAGATGTTTTT
TTACTAGAAGCATTGCCCAAGCGAATTGTTGTGCTTGGTGGTGGGCCGATTGGCTGTGAGCTAGGCCAAGCACTATTTCG
CTTGGGAGCTGAAGTGACGATTATTCAACAAGGCCCACGCCTGTTGCCCAAAGATGACCATGCCATGGGTGCGGCTTTGG
CTCAAGCACTTAAATCCGAGGGCTTACAGCTTTACCTCAACACCAAAACCCTCAAGGTCGAGTTGCAGGCTGGTGCAAAA
CAGCTCACGATTCAAACTGCCAATAACCAACCCCAAACCATCGTTGCTGATGCAATTTTAGTGGCAGCGGGTCGTACCCC
GAATCTACATAATTTGGGTTTGGATGCAGCAGGCATTTTGTATGACCCTGAACAGCGCATTCATGTTGACCACTATTTGC
GCACCAGTAATCCACGAGTGTTTGCCTGTGGCGATGTGATTGGGCGCTATCAATTTACCCATGTGGCGGCACAAGAAGCA
GGCTTGGTGCTACGCAATGCACTTTTTCCAGGCCAAAGCGCCATGAAATACGAATTAGTGCCGTGGGCAACCTTTACCGA
CCCCGAAGTTGGCCATGTTGGCTTGAATGAAGACCAAGCGCGGGCCAAGTATGGCAGCAGCTTGCGGGTGTATGAATTGC
CGTGGAGCGCCAACGACCGTGCTCGCACCGAGGATGCAACTCAGGGCTTTACCAAAATTTTGGCGGTTGGCCGCAAAGAA
CAAATTGTCGGCGTGCATATTATCGGCCAAGGCGCTGGCGATATGATCAATGCCGCAGTGCTAGCGATGGGCACGGGTGT
CAGTGCCTCAAAACTCGGTGGCTTAATTAATGTTTATCCAACCCGCTCGCAAGGTCTCAAAATGACCGCCCAACGCTCGT
TTACCCGCTGGCTCGAAAAACCATGGCTGCAACGAGCGTTACGCTGGTATTTTCGCTAA

Upstream 100 bases:

>100_bases
TGAATATTTAGCGATCTTCGCGTTTTTCGCGGTTTCAAGCTTCGCGATCTTCGTGGCCTTCGTGGATCATAACCCTAGCC
CCTCGATATAAGGAGCATGC

Downstream 100 bases:

>100_bases
ACCTGTTCTTTCAAGAGCCATATCAGTTTTATCATCGGCCTTCTACGAATCCTTTCCTTTGGCCCACTGCGGCGGTTGAT
GGGCAGGTTCCCCCTCACCT

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation subunit

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDDLLVIGGGSAGITFAKFGASLGAKITVIEANKLGGDCTWTGCVPSKSLIHAAKIAHTTATAARYGISAQPSIDFAAVM
GYVHSVQQQIYQHDDAPEVLRQAGARVIEGRARFYDDQTVEVNGELLRAKHFCIATGSHPKIPTIPGLAEAGYLTNEDVF
LLEALPKRIVVLGGGPIGCELGQALFRLGAEVTIIQQGPRLLPKDDHAMGAALAQALKSEGLQLYLNTKTLKVELQAGAK
QLTIQTANNQPQTIVADAILVAAGRTPNLHNLGLDAAGILYDPEQRIHVDHYLRTSNPRVFACGDVIGRYQFTHVAAQEA
GLVLRNALFPGQSAMKYELVPWATFTDPEVGHVGLNEDQARAKYGSSLRVYELPWSANDRARTEDATQGFTKILAVGRKE
QIVGVHIIGQGAGDMINAAVLAMGTGVSASKLGGLINVYPTRSQGLKMTAQRSFTRWLEKPWLQRALRWYFR

Sequences:

>Translated_472_residues
MDDLLVIGGGSAGITFAKFGASLGAKITVIEANKLGGDCTWTGCVPSKSLIHAAKIAHTTATAARYGISAQPSIDFAAVM
GYVHSVQQQIYQHDDAPEVLRQAGARVIEGRARFYDDQTVEVNGELLRAKHFCIATGSHPKIPTIPGLAEAGYLTNEDVF
LLEALPKRIVVLGGGPIGCELGQALFRLGAEVTIIQQGPRLLPKDDHAMGAALAQALKSEGLQLYLNTKTLKVELQAGAK
QLTIQTANNQPQTIVADAILVAAGRTPNLHNLGLDAAGILYDPEQRIHVDHYLRTSNPRVFACGDVIGRYQFTHVAAQEA
GLVLRNALFPGQSAMKYELVPWATFTDPEVGHVGLNEDQARAKYGSSLRVYELPWSANDRARTEDATQGFTKILAVGRKE
QIVGVHIIGQGAGDMINAAVLAMGTGVSASKLGGLINVYPTRSQGLKMTAQRSFTRWLEKPWLQRALRWYFR
>Mature_472_residues
MDDLLVIGGGSAGITFAKFGASLGAKITVIEANKLGGDCTWTGCVPSKSLIHAAKIAHTTATAARYGISAQPSIDFAAVM
GYVHSVQQQIYQHDDAPEVLRQAGARVIEGRARFYDDQTVEVNGELLRAKHFCIATGSHPKIPTIPGLAEAGYLTNEDVF
LLEALPKRIVVLGGGPIGCELGQALFRLGAEVTIIQQGPRLLPKDDHAMGAALAQALKSEGLQLYLNTKTLKVELQAGAK
QLTIQTANNQPQTIVADAILVAAGRTPNLHNLGLDAAGILYDPEQRIHVDHYLRTSNPRVFACGDVIGRYQFTHVAAQEA
GLVLRNALFPGQSAMKYELVPWATFTDPEVGHVGLNEDQARAKYGSSLRVYELPWSANDRARTEDATQGFTKILAVGRKE
QIVGVHIIGQGAGDMINAAVLAMGTGVSASKLGGLINVYPTRSQGLKMTAQRSFTRWLEKPWLQRALRWYFR

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=473, Percent_Identity=30.8668076109937, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=31.6017316017316, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI22035672, Length=455, Percent_Identity=30.5494505494506, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=25.0544662309368, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=25.0544662309368, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=25.0544662309368, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=25.0544662309368, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=25.2747252747253, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI291045266, Length=453, Percent_Identity=23.841059602649, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI291045268, Length=447, Percent_Identity=22.1476510067114, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=30.1969365426696, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=32.6340326340326, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=28.0701754385965, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=27.1762208067941, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=32.3275862068966, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=27.7185501066098, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=32.2222222222222, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=32.2222222222222, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=27.0833333333333, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=31.6916488222698, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=29.6842105263158, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=25.9414225941423, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=32.6797385620915, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17737741, Length=466, Percent_Identity=30.0429184549356, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=29.637526652452, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=29.637526652452, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=29.637526652452, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50895; Mature: 50895

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDLLVIGGGSAGITFAKFGASLGAKITVIEANKLGGDCTWTGCVPSKSLIHAAKIAHTT
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHH
ATAARYGISAQPSIDFAAVMGYVHSVQQQIYQHDDAPEVLRQAGARVIEGRARFYDDQTV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCHHHHCCCCEE
EVNGELLRAKHFCIATGSHPKIPTIPGLAEAGYLTNEDVFLLEALPKRIVVLGGGPIGCE
EECCEEEEEEEEEEEECCCCCCCCCCCCHHCCCCCCCCEEEEEECCCEEEEECCCCCCHH
LGQALFRLGAEVTIIQQGPRLLPKDDHAMGAALAQALKSEGLQLYLNTKTLKVELQAGAK
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECEEEEEEEECCCE
QLTIQTANNQPQTIVADAILVAAGRTPNLHNLGLDAAGILYDPEQRIHVDHYLRTSNPRV
EEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCHHEEEEHEEECCCCCE
FACGDVIGRYQFTHVAAQEAGLVLRNALFPGQSAMKYELVPWATFTDPEVGHVGLNEDQA
EEECCHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCEECCCCCCCCCCCCCHHH
RAKYGSSLRVYELPWSANDRARTEDATQGFTKILAVGRKEQIVGVHIIGQGAGDMINAAV
HHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHH
LAMGTGVSASKLGGLINVYPTRSQGLKMTAQRSFTRWLEKPWLQRALRWYFR
HHCCCCCCHHHHCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDLLVIGGGSAGITFAKFGASLGAKITVIEANKLGGDCTWTGCVPSKSLIHAAKIAHTT
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHH
ATAARYGISAQPSIDFAAVMGYVHSVQQQIYQHDDAPEVLRQAGARVIEGRARFYDDQTV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCHHHHCCCCEE
EVNGELLRAKHFCIATGSHPKIPTIPGLAEAGYLTNEDVFLLEALPKRIVVLGGGPIGCE
EECCEEEEEEEEEEEECCCCCCCCCCCCHHCCCCCCCCEEEEEECCCEEEEECCCCCCHH
LGQALFRLGAEVTIIQQGPRLLPKDDHAMGAALAQALKSEGLQLYLNTKTLKVELQAGAK
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECEEEEEEEECCCE
QLTIQTANNQPQTIVADAILVAAGRTPNLHNLGLDAAGILYDPEQRIHVDHYLRTSNPRV
EEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCHHEEEEHEEECCCCCE
FACGDVIGRYQFTHVAAQEAGLVLRNALFPGQSAMKYELVPWATFTDPEVGHVGLNEDQA
EEECCHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCEECCCCCCCCCCCCCHHH
RAKYGSSLRVYELPWSANDRARTEDATQGFTKILAVGRKEQIVGVHIIGQGAGDMINAAV
HHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHH
LAMGTGVSASKLGGLINVYPTRSQGLKMTAQRSFTRWLEKPWLQRALRWYFR
HHCCCCCCHHHHCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]