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The map label for this gene is hisG [H]

Identifier: 159899153

GI number: 159899153

Start: 3380313

End: 3381314

Strand: Reverse

Name: hisG [H]

Synonym: Haur_2634

Alternate gene names: 159899153

Gene position: 3381314-3380313 (Counterclockwise)

Preceding gene: 159899154

Following gene: 159899152

Centisome position: 53.28

GC content: 53.29

Gene sequence:

>1002_bases
ATGCTACGTTTTGCTGTGCCTTCCAAAGGTGCTCTTGCTGATGATACGTTTCGCTTTTTTGAAAGCTGTGGCCTGAAAGT
CTCGCGACCCAATCCGCGCCGCTACACGGCTTCGATCAAAGCGCTGCCCGAAGTTGAAGTCTTGCTGCATCGTGCACCCG
ATATTGTCGAGAAAGTCGCCGATGGCTCGATTGATTTGGGCGTAAGTGGCTATGATTTGGTCGAAGAACTGGGCGGCGAG
AGCGATGATCTAGTCGTGGTCTATAAAGATTTGGGCTTTGGCTACTGCGATTTGGTGCTGGCCGTGCCCGATCATTGGAT
TGACGTAACCTCGTGGCGTGATGTGGCCGATTTGGCGGCGGAGTATGCCCGGGCTGGCCGCCAATTGCGCATCGCCACCA
AGTTTCCCAATTTGGTGCGCCAATGGTGTCATCAGCAAGGCATCAATGTTTTTGCGCTGATCGACTCGCAAGGTGCAACC
GAGGCCGCGCCTTCGTTGGGATATGCCGATATCATCGCCGATTTGACAGCCACTGGGACAACCCTACGCGATAATCATCT
CAAAATGATTCAAGGAGGCACAATTCTGCAAGCGCAAGCTGCATTAATCGCCAACCGACGGTCGCTACGGGAAAGTTCGC
AAAAACAACGGGTTGTCCAATCGATTTTAGAGCTGATCGAAGCTCGCCATCGCGCCAAAACCTATGTTTCGTTGATTGCC
AACGTGCCAGGCTCGGATGTTGCCGATGTTGGGGCAAGAGTGGTAGCCCATGCCGCCTTGGCAGGATTGCAAGGCCCAAC
TGTTTCGCCAGTTTGGAGTCGCGATGGTGGTGAAGGCTGGTACGCGGTGTCGTTGGTCGTCGATAGCGCCAACATTTTGC
CAGCGATCGATCATTTGCGTTCGATTGGCTCGACAGGCATTACGGTTCTGCCAGTCCACTATGTTTTTGCCGAACGTTCT
CAAAGTTTTGCCGCATTGAGCGAGTTGATGCACAAAAGCTAG

Upstream 100 bases:

>100_bases
GAGCGCTAAGCTTGGTTGGGCGCTGGAAGATCGAAATGCAGGTGCGTCGTTTGAATTTGCCCGACGTAACTGCTGAATGG
ACTGTGGAGATAACGCGCTA

Downstream 100 bases:

>100_bases
CAGAAGGTGCTCCACGCTGGAGGCACTGATGTTAACTGCAAGTGAACAATTGGTAACTGCGATTAAATTGCGCGAGCTGG
GCTTGCAACGTGAGCAAGCC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MLRFAVPSKGALADDTFRFFESCGLKVSRPNPRRYTASIKALPEVEVLLHRAPDIVEKVADGSIDLGVSGYDLVEELGGE
SDDLVVVYKDLGFGYCDLVLAVPDHWIDVTSWRDVADLAAEYARAGRQLRIATKFPNLVRQWCHQQGINVFALIDSQGAT
EAAPSLGYADIIADLTATGTTLRDNHLKMIQGGTILQAQAALIANRRSLRESSQKQRVVQSILELIEARHRAKTYVSLIA
NVPGSDVADVGARVVAHAALAGLQGPTVSPVWSRDGGEGWYAVSLVVDSANILPAIDHLRSIGSTGITVLPVHYVFAERS
QSFAALSELMHKS

Sequences:

>Translated_333_residues
MLRFAVPSKGALADDTFRFFESCGLKVSRPNPRRYTASIKALPEVEVLLHRAPDIVEKVADGSIDLGVSGYDLVEELGGE
SDDLVVVYKDLGFGYCDLVLAVPDHWIDVTSWRDVADLAAEYARAGRQLRIATKFPNLVRQWCHQQGINVFALIDSQGAT
EAAPSLGYADIIADLTATGTTLRDNHLKMIQGGTILQAQAALIANRRSLRESSQKQRVVQSILELIEARHRAKTYVSLIA
NVPGSDVADVGARVVAHAALAGLQGPTVSPVWSRDGGEGWYAVSLVVDSANILPAIDHLRSIGSTGITVLPVHYVFAERS
QSFAALSELMHKS
>Mature_333_residues
MLRFAVPSKGALADDTFRFFESCGLKVSRPNPRRYTASIKALPEVEVLLHRAPDIVEKVADGSIDLGVSGYDLVEELGGE
SDDLVVVYKDLGFGYCDLVLAVPDHWIDVTSWRDVADLAAEYARAGRQLRIATKFPNLVRQWCHQQGINVFALIDSQGAT
EAAPSLGYADIIADLTATGTTLRDNHLKMIQGGTILQAQAALIANRRSLRESSQKQRVVQSILELIEARHRAKTYVSLIA
NVPGSDVADVGARVVAHAALAGLQGPTVSPVWSRDGGEGWYAVSLVVDSANILPAIDHLRSIGSTGITVLPVHYVFAERS
QSFAALSELMHKS

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=321, Percent_Identity=29.2834890965732, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320896, Length=318, Percent_Identity=27.0440251572327, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 36039; Mature: 36039

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFAVPSKGALADDTFRFFESCGLKVSRPNPRRYTASIKALPEVEVLLHRAPDIVEKVA
CCEECCCCCCCCCHHHHHHHHHCCCEECCCCCCEEEEHHHCCCHHHHHHHCCHHHHHHHC
DGSIDLGVSGYDLVEELGGESDDLVVVYKDLGFGYCDLVLAVPDHWIDVTSWRDVADLAA
CCCEECCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHEEECCCCCEECCCHHHHHHHHH
EYARAGRQLRIATKFPNLVRQWCHQQGINVFALIDSQGATEAAPSLGYADIIADLTATGT
HHHHCCCEEEEEHHCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCC
TLRDNHLKMIQGGTILQAQAALIANRRSLRESSQKQRVVQSILELIEARHRAKTYVSLIA
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVPGSDVADVGARVVAHAALAGLQGPTVSPVWSRDGGEGWYAVSLVVDSANILPAIDHLR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHH
SIGSTGITVLPVHYVFAERSQSFAALSELMHKS
HCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLRFAVPSKGALADDTFRFFESCGLKVSRPNPRRYTASIKALPEVEVLLHRAPDIVEKVA
CCEECCCCCCCCCHHHHHHHHHCCCEECCCCCCEEEEHHHCCCHHHHHHHCCHHHHHHHC
DGSIDLGVSGYDLVEELGGESDDLVVVYKDLGFGYCDLVLAVPDHWIDVTSWRDVADLAA
CCCEECCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHEEECCCCCEECCCHHHHHHHHH
EYARAGRQLRIATKFPNLVRQWCHQQGINVFALIDSQGATEAAPSLGYADIIADLTATGT
HHHHCCCEEEEEHHCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCC
TLRDNHLKMIQGGTILQAQAALIANRRSLRESSQKQRVVQSILELIEARHRAKTYVSLIA
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVPGSDVADVGARVVAHAALAGLQGPTVSPVWSRDGGEGWYAVSLVVDSANILPAIDHLR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHH
SIGSTGITVLPVHYVFAERSQSFAALSELMHKS
HCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA