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The map label for this gene is glpA [H]

Identifier: 159899141

GI number: 159899141

Start: 3364340

End: 3365884

Strand: Direct

Name: glpA [H]

Synonym: Haur_2622

Alternate gene names: 159899141

Gene position: 3364340-3365884 (Clockwise)

Preceding gene: 159899140

Following gene: 159899142

Centisome position: 53.01

GC content: 53.92

Gene sequence:

>1545_bases
ATGCTTGATTCGATTGATGTTTTGGTAATTGGTGGTGGCGCAACGGGCACGGGAGTTTTGCGCGATTTGGCGATGCGCGG
CTTGAGTTGCGTTTTGGTCGAGCGCCGCGATCTGGCCGATGGCACAACTGGCCGCTACCACGGCTTGCTGCATTCTGGCG
CACGCTACATTGGCCGCGACCGCGAAGCAGCCCGCGATTGTGCAATTGAAAATCAGATTTTGCGCCGCATCATTCCGCAT
TGCATCGAGGATACCAGCGGCTACTTTGTGTCCACGCCCCAAGATCCCAAACGCTACGCCGAAGAATTTTTAGGTTTGTG
CTTTGCGGCAGGCGTGCCAGCCCAACAAGTGCGGGTTAGCAGCCTTTTGCAACGTGAGCCAGCGCTCAATCGCGGCATTT
CGCATGCCTTCGAGGTTGCCGATGGTTCGGCTGATGCCTTTTTGACAGTTGAAGCCAATGTACGTTCGGCTCGTGAGTAT
GGCGGGCAGACCTTACTCTATCACGAAGTGATCAATTTAATCGTTGAGGCTGGCACAGTCGTTGGCGCTCGCTTGCGCAA
TACCCTGACTGGCGAGGAATTTAATCTCGCCTGCCACTACGTAGTCAATGCTGCTGGAGCGTGGGCTGGCCGGATCGCCG
CCATGGCTGGAATCGCCGTTGATATTGTGGCGGGCAAAGGTGTGATGGTGGCCTTTAATCATCGCTTGGTTAATAGCGTG
ATCAATCGCTGCAAGCAGCCAGGTGATGGCGATATTATCGTGCCTGTGCGCACGGTTTGCGTGGCTGGAACCACCGATGA
AAGTGTGCCCGACCCCGATGATCGTTCGATGTTGGCCCATGAAATTGCCACAGTTTTGGATGAAGGTGAGATTCTAATTC
CTGGTTTGTCTCAAGCCCGCATGCTGCGAGCATGGGCTGGCGTGCGCCCACTCTATCGCGAGCAAGCCACCACCGAAGAT
CGCGATCTTAGCCGCGATTTTAAAGTGCTTGATCATGCCCAACGCGATGGGTTAGACGGCATTGTTTCAATTGTAGGCGG
CAAATACACAACCTATCGCATGATGGCCGAACGTACAGTCGATCTGGTTGCCAAATATGTGCAAAACACCAGCGCCTGTC
GCACCGCTGAGGAAGCCATTCCAGCGCCCGATCAACGTCGTTTATTTACGGTTGGTGCACCATTGGCAACAATTGAGGCC
GAACAAAGCTATGGTGATTTAATTTGTGAATGCGAATTGGTTACCCGCCAACGTTTGCTCGATGCATGGCAAGCAGGCGC
AACCAGTATCGACGATTTGCGCCGCGACACGCGCATCGGCATGGGGCCGTGCCAAGGTGGTTTTTGCACGATGCGCACCG
CCGCTCTTGCTTACGAAGCCCAAGTTGCCGATCAACAACAAAGTATCGAGGCAATTGAGCACTTTTTGCAAGAACGTTGG
CGCGGTATTCAGCCAATTCTCTGGGGCGATCAGTTACGTCAGGCACGGCTCGACGAGCAAATTTACCTTAATTTGCTGAA
TGTAAACCCTGAGGATGCCCAATAA

Upstream 100 bases:

>100_bases
GCCGCTGGTAAATTAATACCCAAATAAGCACCATAACCCGAAGATTTAGCTAAACAGTGCGATCTTCGGGTTGTTTAATC
TGGCATAAGGATGTTTGGCG

Downstream 100 bases:

>100_bases
TGCGGCAGCAACTTGCCCGTTGGCAACAATTGGCTCGCCAGCTCAAACAACAACTACGGGTACTATTGTTGGCATGGCGT
GATCCGCGTGTGCCGTGGTA

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MLDSIDVLVIGGGATGTGVLRDLAMRGLSCVLVERRDLADGTTGRYHGLLHSGARYIGRDREAARDCAIENQILRRIIPH
CIEDTSGYFVSTPQDPKRYAEEFLGLCFAAGVPAQQVRVSSLLQREPALNRGISHAFEVADGSADAFLTVEANVRSAREY
GGQTLLYHEVINLIVEAGTVVGARLRNTLTGEEFNLACHYVVNAAGAWAGRIAAMAGIAVDIVAGKGVMVAFNHRLVNSV
INRCKQPGDGDIIVPVRTVCVAGTTDESVPDPDDRSMLAHEIATVLDEGEILIPGLSQARMLRAWAGVRPLYREQATTED
RDLSRDFKVLDHAQRDGLDGIVSIVGGKYTTYRMMAERTVDLVAKYVQNTSACRTAEEAIPAPDQRRLFTVGAPLATIEA
EQSYGDLICECELVTRQRLLDAWQAGATSIDDLRRDTRIGMGPCQGGFCTMRTAALAYEAQVADQQQSIEAIEHFLQERW
RGIQPILWGDQLRQARLDEQIYLNLLNVNPEDAQ

Sequences:

>Translated_514_residues
MLDSIDVLVIGGGATGTGVLRDLAMRGLSCVLVERRDLADGTTGRYHGLLHSGARYIGRDREAARDCAIENQILRRIIPH
CIEDTSGYFVSTPQDPKRYAEEFLGLCFAAGVPAQQVRVSSLLQREPALNRGISHAFEVADGSADAFLTVEANVRSAREY
GGQTLLYHEVINLIVEAGTVVGARLRNTLTGEEFNLACHYVVNAAGAWAGRIAAMAGIAVDIVAGKGVMVAFNHRLVNSV
INRCKQPGDGDIIVPVRTVCVAGTTDESVPDPDDRSMLAHEIATVLDEGEILIPGLSQARMLRAWAGVRPLYREQATTED
RDLSRDFKVLDHAQRDGLDGIVSIVGGKYTTYRMMAERTVDLVAKYVQNTSACRTAEEAIPAPDQRRLFTVGAPLATIEA
EQSYGDLICECELVTRQRLLDAWQAGATSIDDLRRDTRIGMGPCQGGFCTMRTAALAYEAQVADQQQSIEAIEHFLQERW
RGIQPILWGDQLRQARLDEQIYLNLLNVNPEDAQ
>Mature_514_residues
MLDSIDVLVIGGGATGTGVLRDLAMRGLSCVLVERRDLADGTTGRYHGLLHSGARYIGRDREAARDCAIENQILRRIIPH
CIEDTSGYFVSTPQDPKRYAEEFLGLCFAAGVPAQQVRVSSLLQREPALNRGISHAFEVADGSADAFLTVEANVRSAREY
GGQTLLYHEVINLIVEAGTVVGARLRNTLTGEEFNLACHYVVNAAGAWAGRIAAMAGIAVDIVAGKGVMVAFNHRLVNSV
INRCKQPGDGDIIVPVRTVCVAGTTDESVPDPDDRSMLAHEIATVLDEGEILIPGLSQARMLRAWAGVRPLYREQATTED
RDLSRDFKVLDHAQRDGLDGIVSIVGGKYTTYRMMAERTVDLVAKYVQNTSACRTAEEAIPAPDQRRLFTVGAPLATIEA
EQSYGDLICECELVTRQRLLDAWQAGATSIDDLRRDTRIGMGPCQGGFCTMRTAALAYEAQVADQQQSIEAIEHFLQERW
RGIQPILWGDQLRQARLDEQIYLNLLNVNPEDAQ

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=398, Percent_Identity=28.894472361809, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI285002231, Length=398, Percent_Identity=28.894472361809, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1788574, Length=513, Percent_Identity=42.1052631578947, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI2367226, Length=373, Percent_Identity=23.3243967828418, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509253, Length=396, Percent_Identity=30.8080808080808, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322036, Length=432, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI161077125, Length=392, Percent_Identity=28.0612244897959, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653942, Length=392, Percent_Identity=28.0612244897959, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653944, Length=392, Percent_Identity=28.0612244897959, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130025, Length=392, Percent_Identity=28.0612244897959, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586295, Length=387, Percent_Identity=25.8397932816537, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921278, Length=402, Percent_Identity=24.3781094527363, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 56264; Mature: 56264

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSIDVLVIGGGATGTGVLRDLAMRGLSCVLVERRDLADGTTGRYHGLLHSGARYIGRD
CCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
REAARDCAIENQILRRIIPHCIEDTSGYFVSTPQDPKRYAEEFLGLCFAAGVPAQQVRVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SLLQREPALNRGISHAFEVADGSADAFLTVEANVRSAREYGGQTLLYHEVINLIVEAGTV
HHHHHCCHHHHCHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCEEHHHHHHHHHHHHHHH
VGARLRNTLTGEEFNLACHYVVNAAGAWAGRIAAMAGIAVDIVAGKGVMVAFNHRLVNSV
HHHHHHHCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHEEEEEECCCEEEEEHHHHHHHH
INRCKQPGDGDIIVPVRTVCVAGTTDESVPDPDDRSMLAHEIATVLDEGEILIPGLSQAR
HHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
MLRAWAGVRPLYREQATTEDRDLSRDFKVLDHAQRDGLDGIVSIVGGKYTTYRMMAERTV
HHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHH
DLVAKYVQNTSACRTAEEAIPAPDQRRLFTVGAPLATIEAEQSYGDLICECELVTRQRLL
HHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCEEEEHHHHHHHHHH
DAWQAGATSIDDLRRDTRIGMGPCQGGFCTMRTAALAYEAQVADQQQSIEAIEHFLQERW
HHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGIQPILWGDQLRQARLDEQIYLNLLNVNPEDAQ
CCCCCCCCHHHHHHHHCCHHHEEEEECCCCCCCC
>Mature Secondary Structure
MLDSIDVLVIGGGATGTGVLRDLAMRGLSCVLVERRDLADGTTGRYHGLLHSGARYIGRD
CCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
REAARDCAIENQILRRIIPHCIEDTSGYFVSTPQDPKRYAEEFLGLCFAAGVPAQQVRVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHH
SLLQREPALNRGISHAFEVADGSADAFLTVEANVRSAREYGGQTLLYHEVINLIVEAGTV
HHHHHCCHHHHCHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCEEHHHHHHHHHHHHHHH
VGARLRNTLTGEEFNLACHYVVNAAGAWAGRIAAMAGIAVDIVAGKGVMVAFNHRLVNSV
HHHHHHHCCCCCCCCEEEEEEHHCCCHHHHHHHHHHHHEEEEEECCCEEEEEHHHHHHHH
INRCKQPGDGDIIVPVRTVCVAGTTDESVPDPDDRSMLAHEIATVLDEGEILIPGLSQAR
HHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
MLRAWAGVRPLYREQATTEDRDLSRDFKVLDHAQRDGLDGIVSIVGGKYTTYRMMAERTV
HHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHH
DLVAKYVQNTSACRTAEEAIPAPDQRRLFTVGAPLATIEAEQSYGDLICECELVTRQRLL
HHHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCEEEEHHHHHHHHHH
DAWQAGATSIDDLRRDTRIGMGPCQGGFCTMRTAALAYEAQVADQQQSIEAIEHFLQERW
HHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGIQPILWGDQLRQARLDEQIYLNLLNVNPEDAQ
CCCCCCCCHHHHHHHHCCHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]