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The map label for this gene is rsbRA [H]

Identifier: 159898945

GI number: 159898945

Start: 3107769

End: 3108722

Strand: Direct

Name: rsbRA [H]

Synonym: Haur_2424

Alternate gene names: 159898945

Gene position: 3107769-3108722 (Clockwise)

Preceding gene: 159898944

Following gene: 159898949

Centisome position: 48.97

GC content: 51.68

Gene sequence:

>954_bases
ATGCGTCTGAGTCAACGTTTCGCCTTGTTAAGCTTGTTGCTATTTGAATCGGTCATGAGTATTTTGGGCTTACTCTTCTT
AGCATTCAATGATGGTGCACCTGAAGTGTTAATCGGCCTTGGCATTTTGCCAATTTTGACGCTCGGCTTGGCCTTTGGGG
CTTGGCGAAATTGGCCTTGGGTGCCAATTGCCAGCGTGGTGGTGGCAACTGCAATCACTGTGTTATTGCTGATCGATCCT
GCCAAAGATATTTACTTCTCACCAGTGTTGTTGGCTCCGATGGCAGTGGCTTTTGTGGTCACCGATTCGCGTACCACAAT
CGTCACAGCTCTGGTGGCAATTGTCGTGACATGGTTGCGGGCCGATAGCGATACGCCCTATCTTAAAGTTGATTATGCGA
TTTGCTATGCCTTTATTGCTGGTTGCTTGTGGTTGGGGCGTTTGATTTTGGAACAAACCCAACAGGCCAATACCGAGGCG
CTTGATTTGGCTCAAACTGAGCGCGGCATGGCGCAACGTTACGCCCAAGAGGCCGAAGATCGCGCCAGCAGCTTGCAGAC
CCAATCCGAGGAGCAACAACGCTTGTTGGCAACCGTCGCCGCCTTGGAAACGCCGATTGTTGAGGTTGCCGAGCAAGTCT
TGCTAGCGCCAATCATTGGCTATGTTGATGATCAACGGGCGGCCCAATTGACTGATCGAATTTTGGCGGCAGTTAATCAG
CGCCGCGCTAATGCGATTATTTTGGATATTACCAGCCTCAGTAACGTCAATGCCCAAACTGCCCAACAATTGCTGCGCCT
TGCCAGCGCGATTCGTTTATTGGGCAGTTCGGTGATTTTGAGTGGCATCAGCCCTGATTTGGCTACAACCTTAGTTCGCC
AGCGCATCGATTTGGGCATGGTTCGCACCGCCCCAACGCCGTATGCCGCCTTGCAGCTTGCCGCTACCCTTTAA

Upstream 100 bases:

>100_bases
ATGTTCACCTTGCGGGGGCTGAAAAATCACCCTGAGAACGCTTGCAATCCTGTTAGAATAGACAAGGCATCGCCCTGCAC
ACGATAAAGGAACCGCCATC

Downstream 100 bases:

>100_bases
AGTTTGCCAAGCTGCAACAAATCGCGTAAGCGCAAACTTTGACGATAGCGCAACAAGCCAATTCGGACAATCCGCCCCGC
AAAACGAGTGATCAAGCCAG

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MRLSQRFALLSLLLFESVMSILGLLFLAFNDGAPEVLIGLGILPILTLGLAFGAWRNWPWVPIASVVVATAITVLLLIDP
AKDIYFSPVLLAPMAVAFVVTDSRTTIVTALVAIVVTWLRADSDTPYLKVDYAICYAFIAGCLWLGRLILEQTQQANTEA
LDLAQTERGMAQRYAQEAEDRASSLQTQSEEQQRLLATVAALETPIVEVAEQVLLAPIIGYVDDQRAAQLTDRILAAVNQ
RRANAIILDITSLSNVNAQTAQQLLRLASAIRLLGSSVILSGISPDLATTLVRQRIDLGMVRTAPTPYAALQLAATL

Sequences:

>Translated_317_residues
MRLSQRFALLSLLLFESVMSILGLLFLAFNDGAPEVLIGLGILPILTLGLAFGAWRNWPWVPIASVVVATAITVLLLIDP
AKDIYFSPVLLAPMAVAFVVTDSRTTIVTALVAIVVTWLRADSDTPYLKVDYAICYAFIAGCLWLGRLILEQTQQANTEA
LDLAQTERGMAQRYAQEAEDRASSLQTQSEEQQRLLATVAALETPIVEVAEQVLLAPIIGYVDDQRAAQLTDRILAAVNQ
RRANAIILDITSLSNVNAQTAQQLLRLASAIRLLGSSVILSGISPDLATTLVRQRIDLGMVRTAPTPYAALQLAATL
>Mature_317_residues
MRLSQRFALLSLLLFESVMSILGLLFLAFNDGAPEVLIGLGILPILTLGLAFGAWRNWPWVPIASVVVATAITVLLLIDP
AKDIYFSPVLLAPMAVAFVVTDSRTTIVTALVAIVVTWLRADSDTPYLKVDYAICYAFIAGCLWLGRLILEQTQQANTEA
LDLAQTERGMAQRYAQEAEDRASSLQTQSEEQQRLLATVAALETPIVEVAEQVLLAPIIGYVDDQRAAQLTDRILAAVNQ
RRANAIILDITSLSNVNAQTAQQLLRLASAIRLLGSSVILSGISPDLATTLVRQRIDLGMVRTAPTPYAALQLAATL

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 34337; Mature: 34337

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSQRFALLSLLLFESVMSILGLLFLAFNDGAPEVLIGLGILPILTLGLAFGAWRNWPW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VPIASVVVATAITVLLLIDPAKDIYFSPVLLAPMAVAFVVTDSRTTIVTALVAIVVTWLR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHH
ADSDTPYLKVDYAICYAFIAGCLWLGRLILEQTQQANTEALDLAQTERGMAQRYAQEAED
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RASSLQTQSEEQQRLLATVAALETPIVEVAEQVLLAPIIGYVDDQRAAQLTDRILAAVNQ
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RRANAIILDITSLSNVNAQTAQQLLRLASAIRLLGSSVILSGISPDLATTLVRQRIDLGM
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCH
VRTAPTPYAALQLAATL
HCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRLSQRFALLSLLLFESVMSILGLLFLAFNDGAPEVLIGLGILPILTLGLAFGAWRNWPW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VPIASVVVATAITVLLLIDPAKDIYFSPVLLAPMAVAFVVTDSRTTIVTALVAIVVTWLR
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHH
ADSDTPYLKVDYAICYAFIAGCLWLGRLILEQTQQANTEALDLAQTERGMAQRYAQEAED
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RASSLQTQSEEQQRLLATVAALETPIVEVAEQVLLAPIIGYVDDQRAAQLTDRILAAVNQ
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RRANAIILDITSLSNVNAQTAQQLLRLASAIRLLGSSVILSGISPDLATTLVRQRIDLGM
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCH
VRTAPTPYAALQLAATL
HCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]