Click here to switch to the map view.

The map label for this gene is rsbRA [H]

Identifier: 159898942

GI number: 159898942

Start: 3103059

End: 3104630

Strand: Reverse

Name: rsbRA [H]

Synonym: Haur_2421

Alternate gene names: 159898942

Gene position: 3104630-3103059 (Counterclockwise)

Preceding gene: 159898943

Following gene: 159898932

Centisome position: 48.92

GC content: 49.55

Gene sequence:

>1572_bases
ATGCGAGCACGTGTTCGTCGTCGAGTTACGTGGATCATCACACTCTCTGCATTGCTGCCATTGCTTAGTGTTTGGATATT
AGTTTTATATATCAGTTATCGCGCCGAGGAGCAATCGGCTGAGCGCCAACAAGTGGCCTTAACTGATTTGGCTGCCGAAG
ATTTTCGCCGATTTTTATTCAATACCACGATTGAACTGCAAGATGTTGCCGAGAATATTGCCCGTGAAACTGATCCGCAA
ACAATTACGGCTCAACAACTATCAACATTAGGGCTATTTCGTTCAAGTTTTGCCGAGGTAGCGATTTATAGCGCTGATGG
TCAGCGTCAGGTTGCTAGCTCGCGCTTTGGTGATCCGACCTTGCCAATGTCCTTAACTGGCGCACAGTTGTTGGCAGATC
TTAGTACGCGTCGCGTTTCATTCGCCGACCCACCCTCATTTACTGGCACCATTTCACGCAAATTAGCACCGCAAGAGATT
CCACGCTTTCGGGTTGCGACCCAACTGCTTAGCTCAAACAATCAAGCACTCTTTTTGGTAGCCGATGTCAGCATGCAACG
GATTTGGACGAGCACGACCCGAATTGAAACCGCTGCTGAAATGCGCGTGTTAATTCTGACTGAGCAAGGCGATCTGATTA
GCGCCGCCAAAATTGAATCGTTGCTAGAACACCCTGAGATGCGCGGAATACCGTTGCTTGGTTCTGAAGCAACCGTCGCA
ACTTATGAGAGTGTCTTTGGTGAAGAAGTTTTAGGCGTGCGCACCTCAATCGAGCCTGTCGATTGGATTTTAGTGGTTGA
ACGACCGCTAGAAGTGATTTATGGCAATGTTGGGCGCTTAGCCGTCAGTTTGCTGATGATTATTTTTATTGCAACCCCCA
TTGTGATTGGCGTTGGTTGGTATGTTGGGCGGCGGATCGCTGGCCCAATTCAAACCTTGTATGCAGGCGTAACCCGATTT
AGCGAAAACCCCAACAATTTCGAGCCAGTGTTGCTTGATACCCGCGATGAACTGGCCAGCCTCGCTGGGGCTTTCAATAC
CATGGCTAGCGGCCTGAATGCCTCACAAAAGCGGTTGGCTAACCTCAACGAAGAGCTTGAGGCCCAAGTTGTTGGTCGTA
CCAGCGAATTACACAATGCCTTGGCCGAGGTTCAAGCCCAAAATCTCGCCCAAGAACGCTTGCTTGATACGGTGCGCCGC
CTGAGCATGCCCAGCATTCCGATCACCAAACATATGGTGGTGATGCCCTTGGTCGGCGAATTTAGCGCTGATCGCGCCAA
TGATATTAGCACTACCTTGTTACTGACGATTGAGCAAGAACGCGCCAAAATTGTGATTTTGGATATTACTGGGGTTCCAG
TGGTTGATAATATCGTGGCGCGGGCGATTCTTGATGCGGCTCAGGCTGCTCGCTTGTTGGGTGCGCAAGTCATTTTGGCA
GGCATTCGTCCAGACATGGCCGAAACCTTGGTTAACTTGCACATCAATTTAGGTATGATCGAAAGCGCTGCTACCTTGGA
ACAAGCCTTCAAACGGGGCATGGAATATTTGCGGGTTAATCGACTTTCCTAA

Upstream 100 bases:

>100_bases
CACGGATCGAACTGGGTTGCTTGGTCCAAGGCAGCGCATGGTGTTTGGTAAATCAGCCATGAATTCTACGTCGTCCATGG
TCTGATGGATAGGAAACACT

Downstream 100 bases:

>100_bases
AACCACAAACGGCTCAATTGAGCCGCTTGTAGAAGAGAAAGAGTGTGTGTGAGGAGGAAGGATTTGTTTGTAGTATCCAA
TTACGAACTTACGAACATAT

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MRARVRRRVTWIITLSALLPLLSVWILVLYISYRAEEQSAERQQVALTDLAAEDFRRFLFNTTIELQDVAENIARETDPQ
TITAQQLSTLGLFRSSFAEVAIYSADGQRQVASSRFGDPTLPMSLTGAQLLADLSTRRVSFADPPSFTGTISRKLAPQEI
PRFRVATQLLSSNNQALFLVADVSMQRIWTSTTRIETAAEMRVLILTEQGDLISAAKIESLLEHPEMRGIPLLGSEATVA
TYESVFGEEVLGVRTSIEPVDWILVVERPLEVIYGNVGRLAVSLLMIIFIATPIVIGVGWYVGRRIAGPIQTLYAGVTRF
SENPNNFEPVLLDTRDELASLAGAFNTMASGLNASQKRLANLNEELEAQVVGRTSELHNALAEVQAQNLAQERLLDTVRR
LSMPSIPITKHMVVMPLVGEFSADRANDISTTLLLTIEQERAKIVILDITGVPVVDNIVARAILDAAQAARLLGAQVILA
GIRPDMAETLVNLHINLGMIESAATLEQAFKRGMEYLRVNRLS

Sequences:

>Translated_523_residues
MRARVRRRVTWIITLSALLPLLSVWILVLYISYRAEEQSAERQQVALTDLAAEDFRRFLFNTTIELQDVAENIARETDPQ
TITAQQLSTLGLFRSSFAEVAIYSADGQRQVASSRFGDPTLPMSLTGAQLLADLSTRRVSFADPPSFTGTISRKLAPQEI
PRFRVATQLLSSNNQALFLVADVSMQRIWTSTTRIETAAEMRVLILTEQGDLISAAKIESLLEHPEMRGIPLLGSEATVA
TYESVFGEEVLGVRTSIEPVDWILVVERPLEVIYGNVGRLAVSLLMIIFIATPIVIGVGWYVGRRIAGPIQTLYAGVTRF
SENPNNFEPVLLDTRDELASLAGAFNTMASGLNASQKRLANLNEELEAQVVGRTSELHNALAEVQAQNLAQERLLDTVRR
LSMPSIPITKHMVVMPLVGEFSADRANDISTTLLLTIEQERAKIVILDITGVPVVDNIVARAILDAAQAARLLGAQVILA
GIRPDMAETLVNLHINLGMIESAATLEQAFKRGMEYLRVNRLS
>Mature_523_residues
MRARVRRRVTWIITLSALLPLLSVWILVLYISYRAEEQSAERQQVALTDLAAEDFRRFLFNTTIELQDVAENIARETDPQ
TITAQQLSTLGLFRSSFAEVAIYSADGQRQVASSRFGDPTLPMSLTGAQLLADLSTRRVSFADPPSFTGTISRKLAPQEI
PRFRVATQLLSSNNQALFLVADVSMQRIWTSTTRIETAAEMRVLILTEQGDLISAAKIESLLEHPEMRGIPLLGSEATVA
TYESVFGEEVLGVRTSIEPVDWILVVERPLEVIYGNVGRLAVSLLMIIFIATPIVIGVGWYVGRRIAGPIQTLYAGVTRF
SENPNNFEPVLLDTRDELASLAGAFNTMASGLNASQKRLANLNEELEAQVVGRTSELHNALAEVQAQNLAQERLLDTVRR
LSMPSIPITKHMVVMPLVGEFSADRANDISTTLLLTIEQERAKIVILDITGVPVVDNIVARAILDAAQAARLLGAQVILA
GIRPDMAETLVNLHINLGMIESAATLEQAFKRGMEYLRVNRLS

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 57627; Mature: 57627

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50885 HAMP ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARVRRRVTWIITLSALLPLLSVWILVLYISYRAEEQSAERQQVALTDLAAEDFRRFLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
NTTIELQDVAENIARETDPQTITAQQLSTLGLFRSSFAEVAIYSADGQRQVASSRFGDPT
HCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCC
LPMSLTGAQLLADLSTRRVSFADPPSFTGTISRKLAPQEIPRFRVATQLLSSNNQALFLV
CCCCHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCHHHCHHHHHHHHHHHCCCCEEEEE
ADVSMQRIWTSTTRIETAAEMRVLILTEQGDLISAAKIESLLEHPEMRGIPLLGSEATVA
ECCHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCCHHH
TYESVFGEEVLGVRTSIEPVDWILVVERPLEVIYGNVGRLAVSLLMIIFIATPIVIGVGW
HHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YVGRRIAGPIQTLYAGVTRFSENPNNFEPVLLDTRDELASLAGAFNTMASGLNASQKRLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHH
NLNEELEAQVVGRTSELHNALAEVQAQNLAQERLLDTVRRLSMPSIPITKHMVVMPLVGE
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCC
FSADRANDISTTLLLTIEQERAKIVILDITGVPVVDNIVARAILDAAQAARLLGAQVILA
CCCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIRPDMAETLVNLHINLGMIESAATLEQAFKRGMEYLRVNRLS
CCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRARVRRRVTWIITLSALLPLLSVWILVLYISYRAEEQSAERQQVALTDLAAEDFRRFLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
NTTIELQDVAENIARETDPQTITAQQLSTLGLFRSSFAEVAIYSADGQRQVASSRFGDPT
HCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCC
LPMSLTGAQLLADLSTRRVSFADPPSFTGTISRKLAPQEIPRFRVATQLLSSNNQALFLV
CCCCHHHHHHHHHHHHCCEECCCCCCCCCHHHHCCCHHHCHHHHHHHHHHHCCCCEEEEE
ADVSMQRIWTSTTRIETAAEMRVLILTEQGDLISAAKIESLLEHPEMRGIPLLGSEATVA
ECCHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEECCCCHHH
TYESVFGEEVLGVRTSIEPVDWILVVERPLEVIYGNVGRLAVSLLMIIFIATPIVIGVGW
HHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
YVGRRIAGPIQTLYAGVTRFSENPNNFEPVLLDTRDELASLAGAFNTMASGLNASQKRLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHH
NLNEELEAQVVGRTSELHNALAEVQAQNLAQERLLDTVRRLSMPSIPITKHMVVMPLVGE
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCC
FSADRANDISTTLLLTIEQERAKIVILDITGVPVVDNIVARAILDAAQAARLLGAQVILA
CCCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIRPDMAETLVNLHINLGMIESAATLEQAFKRGMEYLRVNRLS
CCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]