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The map label for this gene is hepT [H]

Identifier: 159898866

GI number: 159898866

Start: 2992099

End: 2993079

Strand: Direct

Name: hepT [H]

Synonym: Haur_2345

Alternate gene names: 159898866

Gene position: 2992099-2993079 (Clockwise)

Preceding gene: 159898863

Following gene: 159898867

Centisome position: 47.15

GC content: 51.68

Gene sequence:

>981_bases
ATGACGCACACATTAAAACAATTGGAAATCCCAAGCACGTTACGCCATGATCTGCAAGCCGTCGAAGATCGCATTATGCA
GCGAGTCGAATCGCAATCGGCGCTGATCACGGCTGCTGGTCAACACATTGTTAGCTCTGGTGGCAAGCGTTTACGAGCCA
TGATGGTTCTGCTTGCATCACAATTAGGGCGCTACCGTTTGAGCGATAGCTTGCATGCGGCAACTGCTGTCGAGTTGATT
CATGCAGCCAGTTTGGTTCACGACGATTTAGTCGATGATGCCGACCGCCGCCGCGGCAAAGTTACCGTCCATGCCAAATG
GGATCAAGGCGTAGCATTGATGGTTGGTGATTACCTGTTTGCGGTGGCTGCTGGCGAAATGGCACTAGCTCCCGATCCAC
GCGTAATTCAGATTTTCGCCGAATCGGTTATGACGATTTCAGCCTCTGAATTACACCCCGTCATGGCCACGCTCCCAACG
GCAACAGCCCTCGAACAATATTACGCCAAAATTGGTGGCAAAACTGCCGCTTTATTTGAAGCCGCTGCCGCCGCTGGGGT
GGTTTGTGGTGGTGGCAGCCCTGAAGAAATTGAGGCCGCCGCCCGTTATGGCTATGATATTGGCTTAGCCTTCCAAATTG
TCGATGATATTCTCGATTTCGTCAGCACCGAGGAAACCCTCGGCAAGCCTGCTGGCAACGATTTACGCGAAGGCACCATC
ACCTTGCCTTTGATCTTGGCAGTCAAAGATCATCATGAGCATCCGTTGGTCAACTTGCTTGATCAATATGAACAGCTTAG
TGATGAGCAAGTTACCCAAGCAATTAGCCAAGTGAAGCAGCTTGGTGGGATCGATCAAGCCATCGCTCAAGCCCGTGAGA
TTACCCAACGTGGCTTAGCAGCACTCGATATCTTCCCGCCATCAGATGCCAAAGAGCTGCTGCGCGAAATCGCCGACTAC
GTACTCGACCGTAACTTCTAA

Upstream 100 bases:

>100_bases
TAAAGCCAGCGGCAAATCCGTTGACGCTAGGATCGTTTTCGGGTATGCTTTGCTGTACGCGATAACTTTCACAAAGACCG
AATTTATTAGGAAGCGTGCT

Downstream 100 bases:

>100_bases
ATTCAACCAATCATTACTTGTTAAGCAAAACCCTGTTGCAATGCAGCAGGGTTTTTAAATATGTCAGTTAGTCTTCATCT
AAGTAGCGAATTGGTACGCT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTHTLKQLEIPSTLRHDLQAVEDRIMQRVESQSALITAAGQHIVSSGGKRLRAMMVLLASQLGRYRLSDSLHAATAVELI
HAASLVHDDLVDDADRRRGKVTVHAKWDQGVALMVGDYLFAVAAGEMALAPDPRVIQIFAESVMTISASELHPVMATLPT
ATALEQYYAKIGGKTAALFEAAAAAGVVCGGGSPEEIEAAARYGYDIGLAFQIVDDILDFVSTEETLGKPAGNDLREGTI
TLPLILAVKDHHEHPLVNLLDQYEQLSDEQVTQAISQVKQLGGIDQAIAQAREITQRGLAALDIFPPSDAKELLREIADY
VLDRNF

Sequences:

>Translated_326_residues
MTHTLKQLEIPSTLRHDLQAVEDRIMQRVESQSALITAAGQHIVSSGGKRLRAMMVLLASQLGRYRLSDSLHAATAVELI
HAASLVHDDLVDDADRRRGKVTVHAKWDQGVALMVGDYLFAVAAGEMALAPDPRVIQIFAESVMTISASELHPVMATLPT
ATALEQYYAKIGGKTAALFEAAAAAGVVCGGGSPEEIEAAARYGYDIGLAFQIVDDILDFVSTEETLGKPAGNDLREGTI
TLPLILAVKDHHEHPLVNLLDQYEQLSDEQVTQAISQVKQLGGIDQAIAQAREITQRGLAALDIFPPSDAKELLREIADY
VLDRNF
>Mature_325_residues
THTLKQLEIPSTLRHDLQAVEDRIMQRVESQSALITAAGQHIVSSGGKRLRAMMVLLASQLGRYRLSDSLHAATAVELIH
AASLVHDDLVDDADRRRGKVTVHAKWDQGVALMVGDYLFAVAAGEMALAPDPRVIQIFAESVMTISASELHPVMATLPTA
TALEQYYAKIGGKTAALFEAAAAAGVVCGGGSPEEIEAAARYGYDIGLAFQIVDDILDFVSTEETLGKPAGNDLREGTIT
LPLILAVKDHHEHPLVNLLDQYEQLSDEQVTQAISQVKQLGGIDQAIAQAREITQRGLAALDIFPPSDAKELLREIADYV
LDRNF

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=334, Percent_Identity=27.8443113772455, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI1789578, Length=313, Percent_Identity=33.2268370607029, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1786623, Length=219, Percent_Identity=33.7899543378995, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17505681, Length=257, Percent_Identity=31.9066147859922, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319475, Length=297, Percent_Identity=28.956228956229, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24651612, Length=303, Percent_Identity=31.023102310231, Blast_Score=134, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35237; Mature: 35105

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTLKQLEIPSTLRHDLQAVEDRIMQRVESQSALITAAGQHIVSSGGKRLRAMMVLLAS
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QLGRYRLSDSLHAATAVELIHAASLVHDDLVDDADRRRGKVTVHAKWDQGVALMVGDYLF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCHHHHHHHHHH
AVAAGEMALAPDPRVIQIFAESVMTISASELHPVMATLPTATALEQYYAKIGGKTAALFE
HHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
AAAAAGVVCGGGSPEEIEAAARYGYDIGLAFQIVDDILDFVSTEETLGKPAGNDLREGTI
HHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCE
TLPLILAVKDHHEHPLVNLLDQYEQLSDEQVTQAISQVKQLGGIDQAIAQAREITQRGLA
EEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
ALDIFPPSDAKELLREIADYVLDRNF
EEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THTLKQLEIPSTLRHDLQAVEDRIMQRVESQSALITAAGQHIVSSGGKRLRAMMVLLAS
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QLGRYRLSDSLHAATAVELIHAASLVHDDLVDDADRRRGKVTVHAKWDQGVALMVGDYLF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEECCCCHHHHHHHHHH
AVAAGEMALAPDPRVIQIFAESVMTISASELHPVMATLPTATALEQYYAKIGGKTAALFE
HHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
AAAAAGVVCGGGSPEEIEAAARYGYDIGLAFQIVDDILDFVSTEETLGKPAGNDLREGTI
HHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCE
TLPLILAVKDHHEHPLVNLLDQYEQLSDEQVTQAISQVKQLGGIDQAIAQAREITQRGLA
EEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
ALDIFPPSDAKELLREIADYVLDRNF
EEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]