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The map label for this gene is cdr [H]

Identifier: 159898867

GI number: 159898867

Start: 2993349

End: 2994998

Strand: Direct

Name: cdr [H]

Synonym: Haur_2346

Alternate gene names: 159898867

Gene position: 2993349-2994998 (Clockwise)

Preceding gene: 159898866

Following gene: 159898868

Centisome position: 47.16

GC content: 54.18

Gene sequence:

>1650_bases
ATGAAAATTATGATTATCGGCGGGGTCGCTGCTGGCATGAGTGCCGCCACCCGCCTCCGTCGGCTCGACGAACATGCCGA
GATTGTGGTGTTGGAACGCGGCGAGTATGTTTCGTATGCCAATTGTGGTTTGCCCTACCATATCGCTGGCACAATCGCTG
AGCGCGAAAAGCTCTTAGTTGCCAGCCCTGAATATCTGCGCCAAACCTTTAATCTCGACCTACGCTTACAACACGAGGTG
ATCGCCATCGATCCTCAGCAAAAAACTGTGACGATCAAAACACCCCAACAGCCCACGCCAATCCAAGAGCGCTACGATAA
ATTGTTGATTGCGGTCGGCAGTCAAGCCTTACAATTGCCGATTCCTGGCAGCGATTTACCCCAAATTCACACAGTTCGCA
CAATCCCCGATGTTGATCAGATCAATCAATTATTGGCTGATGGCGCAGGCCATGCGGTGGTCATCGGCGCTGGCTATATT
GGCCTCGAAACGATTGAAGCCTTGCAACAGCGTGGCCTAACCGTCGAGCTAGTTGAGCTGGCCAAGCAAGTGTTGCCCTT
GTTCGATCATGAGATGGTTAGCGAAGTTGCTGATTTGCTGCAACAACATGGGGTTAAATTGCATCTTGGGGCCAGCGCTC
AACGCTTTGTACCAACCAACCAGCAAATCGCTGTACATCTCAGCGATGGGCGGCAGATCAAAACCGATCTGGTGATTATG
GCGGTTGGGGTGCGGCCAGCCAGCCAATTAGCCCAAACCGCTGGCCTGACGCTTGGCGAACGTGGCGGCATCGCCGTCAA
CCAGCATCTACAAACCTCCGACCCAGCGATTTATGCTGCTGGCGATGTGATTGAAGTGCAAGATACGGTGTTGCAACAAC
CAGCCTTGATTGCGCTGGCGGGGCCGGCTAACCGCCAAGGCCGCATCGTGGCGGAGCATATGCTTGGGCGCAGCAGTCGC
TATCATTCCAGCCAAGGCACGGCGATCGTCAAAGTGCATACAACCACTTGTGCCATGACCGGAGCCTCGGAAAAGAGCCT
GCAACGCGCCCAACGCGCCTATCACAAAATCTATTTGCACCCCAATGATCACGCTGGCTACTACCCTGATGCTCAACCAA
TGCATCTCAAGCTCTTATTTGCCCCTGCCGATGGGAGAATTCTAGGGGCGCAAATCGTTGGTGGCGCTGGCGTGGATAAA
CGCATCGATGTCTTGGCGACGGCAATTCGCGCCAAAATGAGCGTCCACGACTTGACTGAGCTTGAGTTGGCCTATGCGCC
GCCCTATGGCTCGGCCAAAGATCCCATTAACATGGCTGGATTTTTGGCCAGCAACCTGCTCGATGGCACGGTGAAATTCT
GGTATGCCGAGGAATATCCCGCGATCACTGAGCATGCGCTGATCGTTGATGTGCGCAACCCTGATGAATATGCAGCGTGG
CACATTCCAGAAGCGATAAATCTGCCGCTGGCTGAACTACGCACCGCGATTCCAAGCCTCAAAGCCCAAGCCGAAGGGCG
ACCAATTCGCTTACACTGTATGGTTGGCATGCGCAGCTACATCGCCTACCGGATTTTGCGCCAAAGCGGCTTCACGAATG
TGGCAACGCTAGCTGGTGGCGCATTGACCTTGAAGGCATTTGGTCATTAA

Upstream 100 bases:

>100_bases
ATCCGCTGCCCAAACCCTGTTGTGAAGAATGTAACAAAATCGCTGCAAGCTGCATCAATTAAGTAGCAATCGATGTTGCC
ATTTAAATTTGAGGCTTGTG

Downstream 100 bases:

>100_bases
TCATTTTTAGCACCATAACCTTTTCGTTGCAAAACCCTGTTGCAGTGCAGCAGGGTTTTGTCTATCTCAAAATCCAGCAA
ACAATCATCCAAGATCCATT

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKIMIIGGVAAGMSAATRLRRLDEHAEIVVLERGEYVSYANCGLPYHIAGTIAEREKLLVASPEYLRQTFNLDLRLQHEV
IAIDPQQKTVTIKTPQQPTPIQERYDKLLIAVGSQALQLPIPGSDLPQIHTVRTIPDVDQINQLLADGAGHAVVIGAGYI
GLETIEALQQRGLTVELVELAKQVLPLFDHEMVSEVADLLQQHGVKLHLGASAQRFVPTNQQIAVHLSDGRQIKTDLVIM
AVGVRPASQLAQTAGLTLGERGGIAVNQHLQTSDPAIYAAGDVIEVQDTVLQQPALIALAGPANRQGRIVAEHMLGRSSR
YHSSQGTAIVKVHTTTCAMTGASEKSLQRAQRAYHKIYLHPNDHAGYYPDAQPMHLKLLFAPADGRILGAQIVGGAGVDK
RIDVLATAIRAKMSVHDLTELELAYAPPYGSAKDPINMAGFLASNLLDGTVKFWYAEEYPAITEHALIVDVRNPDEYAAW
HIPEAINLPLAELRTAIPSLKAQAEGRPIRLHCMVGMRSYIAYRILRQSGFTNVATLAGGALTLKAFGH

Sequences:

>Translated_549_residues
MKIMIIGGVAAGMSAATRLRRLDEHAEIVVLERGEYVSYANCGLPYHIAGTIAEREKLLVASPEYLRQTFNLDLRLQHEV
IAIDPQQKTVTIKTPQQPTPIQERYDKLLIAVGSQALQLPIPGSDLPQIHTVRTIPDVDQINQLLADGAGHAVVIGAGYI
GLETIEALQQRGLTVELVELAKQVLPLFDHEMVSEVADLLQQHGVKLHLGASAQRFVPTNQQIAVHLSDGRQIKTDLVIM
AVGVRPASQLAQTAGLTLGERGGIAVNQHLQTSDPAIYAAGDVIEVQDTVLQQPALIALAGPANRQGRIVAEHMLGRSSR
YHSSQGTAIVKVHTTTCAMTGASEKSLQRAQRAYHKIYLHPNDHAGYYPDAQPMHLKLLFAPADGRILGAQIVGGAGVDK
RIDVLATAIRAKMSVHDLTELELAYAPPYGSAKDPINMAGFLASNLLDGTVKFWYAEEYPAITEHALIVDVRNPDEYAAW
HIPEAINLPLAELRTAIPSLKAQAEGRPIRLHCMVGMRSYIAYRILRQSGFTNVATLAGGALTLKAFGH
>Mature_549_residues
MKIMIIGGVAAGMSAATRLRRLDEHAEIVVLERGEYVSYANCGLPYHIAGTIAEREKLLVASPEYLRQTFNLDLRLQHEV
IAIDPQQKTVTIKTPQQPTPIQERYDKLLIAVGSQALQLPIPGSDLPQIHTVRTIPDVDQINQLLADGAGHAVVIGAGYI
GLETIEALQQRGLTVELVELAKQVLPLFDHEMVSEVADLLQQHGVKLHLGASAQRFVPTNQQIAVHLSDGRQIKTDLVIM
AVGVRPASQLAQTAGLTLGERGGIAVNQHLQTSDPAIYAAGDVIEVQDTVLQQPALIALAGPANRQGRIVAEHMLGRSSR
YHSSQGTAIVKVHTTTCAMTGASEKSLQRAQRAYHKIYLHPNDHAGYYPDAQPMHLKLLFAPADGRILGAQIVGGAGVDK
RIDVLATAIRAKMSVHDLTELELAYAPPYGSAKDPINMAGFLASNLLDGTVKFWYAEEYPAITEHALIVDVRNPDEYAAW
HIPEAINLPLAELRTAIPSLKAQAEGRPIRLHCMVGMRSYIAYRILRQSGFTNVATLAGGALTLKAFGH

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=320, Percent_Identity=25.625, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI21389617, Length=320, Percent_Identity=25.625, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI65787454, Length=320, Percent_Identity=25.625, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI91199540, Length=351, Percent_Identity=26.7806267806268, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI22202629, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4757732, Length=257, Percent_Identity=26.8482490272374, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789065, Length=318, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789765, Length=293, Percent_Identity=26.6211604095563, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788892, Length=182, Percent_Identity=32.4175824175824, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082354, Length=212, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081717, Length=219, Percent_Identity=31.9634703196347, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=305, Percent_Identity=25.2459016393443, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789915, Length=324, Percent_Identity=22.5308641975309, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787352, Length=259, Percent_Identity=26.6409266409266, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=216, Percent_Identity=28.7037037037037, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32565766, Length=298, Percent_Identity=27.8523489932886, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585130, Length=288, Percent_Identity=26.0416666666667, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358499, Length=305, Percent_Identity=28.1967213114754, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281359715, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281359713, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639250, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI18543267, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639252, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24639257, Length=288, Percent_Identity=23.2638888888889, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 59568; Mature: 59568

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMIIGGVAAGMSAATRLRRLDEHAEIVVLERGEYVSYANCGLPYHIAGTIAEREKLLV
CEEEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEEEEEHHCCCEEEE
ASPEYLRQTFNLDLRLQHEVIAIDPQQKTVTIKTPQQPTPIQERYDKLLIAVGSQALQLP
ECHHHHHHHHCCCEEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHEEEEECCCEEEEC
IPGSDLPQIHTVRTIPDVDQINQLLADGAGHAVVIGAGYIGLETIEALQQRGLTVELVEL
CCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEHHHHH
AKQVLPLFDHEMVSEVADLLQQHGVKLHLGASAQRFVPTNQQIAVHLSDGRQIKTDLVIM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEEE
AVGVRPASQLAQTAGLTLGERGGIAVNQHLQTSDPAIYAAGDVIEVQDTVLQQPALIALA
EECCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEHHHHHCCCCEEEEE
GPANRQGRIVAEHMLGRSSRYHSSQGTAIVKVHTTTCAMTGASEKSLQRAQRAYHKIYLH
CCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHEEEEEE
PNDHAGYYPDAQPMHLKLLFAPADGRILGAQIVGGAGVDKRIDVLATAIRAKMSVHDLTE
CCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCE
LELAYAPPYGSAKDPINMAGFLASNLLDGTVKFWYAEEYPAITEHALIVDVRNPDEYAAW
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCEEE
HIPEAINLPLAELRTAIPSLKAQAEGRPIRLHCMVGMRSYIAYRILRQSGFTNVATLAGG
ECCHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHCCC
ALTLKAFGH
EEEEEECCC
>Mature Secondary Structure
MKIMIIGGVAAGMSAATRLRRLDEHAEIVVLERGEYVSYANCGLPYHIAGTIAEREKLLV
CEEEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEEEEEHHCCCEEEE
ASPEYLRQTFNLDLRLQHEVIAIDPQQKTVTIKTPQQPTPIQERYDKLLIAVGSQALQLP
ECHHHHHHHHCCCEEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHEEEEECCCEEEEC
IPGSDLPQIHTVRTIPDVDQINQLLADGAGHAVVIGAGYIGLETIEALQQRGLTVELVEL
CCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEHHHHH
AKQVLPLFDHEMVSEVADLLQQHGVKLHLGASAQRFVPTNQQIAVHLSDGRQIKTDLVIM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEEE
AVGVRPASQLAQTAGLTLGERGGIAVNQHLQTSDPAIYAAGDVIEVQDTVLQQPALIALA
EECCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEECCCEEEEHHHHHCCCCEEEEE
GPANRQGRIVAEHMLGRSSRYHSSQGTAIVKVHTTTCAMTGASEKSLQRAQRAYHKIYLH
CCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHEEEEEE
PNDHAGYYPDAQPMHLKLLFAPADGRILGAQIVGGAGVDKRIDVLATAIRAKMSVHDLTE
CCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCE
LELAYAPPYGSAKDPINMAGFLASNLLDGTVKFWYAEEYPAITEHALIVDVRNPDEYAAW
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCEEE
HIPEAINLPLAELRTAIPSLKAQAEGRPIRLHCMVGMRSYIAYRILRQSGFTNVATLAGG
ECCHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHCCC
ALTLKAFGH
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA