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The map label for this gene is yhcR [H]

Identifier: 159898670

GI number: 159898670

Start: 2706061

End: 2708229

Strand: Direct

Name: yhcR [H]

Synonym: Haur_2149

Alternate gene names: 159898670

Gene position: 2706061-2708229 (Clockwise)

Preceding gene: 159898669

Following gene: 159898675

Centisome position: 42.64

GC content: 50.21

Gene sequence:

>2169_bases
ATGGATTTTGCAATGTGGCATAACGTGAAAAGCAAAGTGGGCATCCTACTTGGCTTCACGCTGTTGGTCGGCTCGCTTGG
CCAAGCTGCACCAACGAAGGCCGCCGAAAAGCTGTGTTTCAACCAGCCCGGCGTTGTTGAATGTATTGCTCCCGAGTTCC
GCGATTACTGGGAAAAGAACGGTGGGCTGCCCGTTTTTGGCTATCCCCAAACCGCAGCCTATGAAGAAGCCACTCCTGAA
GGTAAGTTCTTGGTGCAATATTTCGAGCGCCAACGGCTTGAATATCACCCCGAGAAACCAGCTCCATTTACGATTTTGCT
TGGCCGGATTAATGATGAAGTGCTGTTGCGCGAAAACCGTGTATGGCGCGATTTCCCCACTGCTCCCCAAGCGACTGGCT
GCCAATTGTTCAGCGAAACTGGCCATAGCGTTTGTGGTGAGTTCTTGAAATATTGGAACTCGCAAGGTTTGGATTTGGGC
GAAAATGGCATTACCTACGGCGAATCATTAGCCTTGTGGGGCTTGCCACTCTCTGATCCGCAAGAAGAAATTAACATCGA
TGGAGATAAAGTGTTGACCCAACACTTTGAGCGTGCTCGCATGGAATGGCACACCAAAGATGGCAAGAACCAAATCTTGC
TGACCCGCCTTGGCGTGACCTTGGTGCCAATGCAGCTCAAAATGTTGGCAATCAACGACTTCCACGGCCAAATTTCAACG
GGCCGCAAGGTGAGCAATAAAGATGTTGGTGGCGCTGCCTACTTGAGCAGCTACATCAAACAAGCTCGCGCCAAAGCTCG
CTACTCGTTGACCGTGCAAGCTGGCGATATGGTCGGCGCAAGCCCACCAAGCTCAGCTTTGTTGCAAGATCAGCCAACCA
TGGAATTCCTCAATATGTTGGGAGTTAATGTTGGCACAATCGGCAACCACGAATTCGATGAAGGCTTCGATGAAATGATG
CGCTTGATCGATGGTGGCTGTCACCCAACCGCTGGCTGCTGGGAAGGTGCAAACTATCCCTATGTTGTGGCCAACGTGAT
CGACAAACGCACCAATAAGACAATTTTGCCAGCCTATCATGTGATGAACATCGATGGGGCACGCATTGGCTTTATTGGCG
TAGTATTAGAAAATACCCCTGAAATCGTGATTCCATCAGGTGTGACCAACCTTGAGTTTATCGATGAAGTTACGGCGATC
AACCAAGCAGTAACCGAGTTGAACGGCCAAGGTGTGCATGCAATCATTGTTTTGGCCCACGAAGGTGGTACGCAAAACGC
CACAACTGGCGCAATCACTGGCCCAATTGCTGAAATTGCCAATGGCATTAATGATGATGTTGATGTGATCGTTAGCGCTC
ACACCCACACCTCAATCAGCGGCGAAGTTGATGGCAAGTTGATCACCCAAGCGCTTTCGTATAGCACCGCATTTGCTGAT
ATCGATTTGACAATCGACCGCGCCAAACGCGATATTGTCGCCAAAAAAGCGACGATCGTCACGACCTTCCACGAAGACAT
GACCCCTGATGCTGATGTTGCGGCAATGGTCAAGAAATATGAAGACCAAGTAGCACCCCAAGTCAACCGCAAGGTTGGTA
CTGCTGCTAGTGCGATCACCAACACGGCCAATGCGGCTGGCGAATCGGCCTTAGGTAACCTGATTGCCGATGCTCAACGT
AACACCATGAGCACTCAATTTGCCTTTATGAACCCAGGTGGCATTCGTGCACCACTCGATGCTGGCGAAATTACCTGGGG
CGAGTTGTATTCAATTCAGCCATTCAGCAACGATTTGGTCAAGATGACCGTAACTGGGGCTGATATTTACACCTTGCTCA
ACCAACAATGGCAAAACCAAAGCGATGGGACAGTTCGCGCTCGTATCCTGCAAATTTCAGGTTTGAGCTACACCTGGACT
GATGCCAATCCTGTTGGTCAAAAGGTTGTCGAGGTGCTCGATGGTAACGGCAAGGCTTTGGATAAAGCTGCGAGCTACAC
GATCACCGTCAATAGCTTCTTGGCTGATGGTGGCGATGGCTTCGTTGTGCTCAAACAAGGCACCAATCGCGAAGTTGGCC
CAACCGATCTCGATGGCTTCGTGCGCTACATCGAAAAGTTAGCTCAGCCAATCAGCGCCAACATCGAAAACCGTATCGTC
AAACAATAA

Upstream 100 bases:

>100_bases
TGTGAATAAAATACAACCAAAATTTGAACTAAATTTAACCAAAAATATTATTTTATGACGTATAATACTAGTTGATCTGT
GTGTCCAGGAGAAACAATTC

Downstream 100 bases:

>100_bases
TTACACGACAACACACGATCACCAATGCAGCAGGCCAAACCTGCTGCATTGTGTTTTAGGGCAACCAGCGCGGCCAAATC
GCATCATCAGCAAATTGGCT

Product: 5'-nucleotidase domain-containing protein

Products: Phosphate; Uridine [C]

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MDFAMWHNVKSKVGILLGFTLLVGSLGQAAPTKAAEKLCFNQPGVVECIAPEFRDYWEKNGGLPVFGYPQTAAYEEATPE
GKFLVQYFERQRLEYHPEKPAPFTILLGRINDEVLLRENRVWRDFPTAPQATGCQLFSETGHSVCGEFLKYWNSQGLDLG
ENGITYGESLALWGLPLSDPQEEINIDGDKVLTQHFERARMEWHTKDGKNQILLTRLGVTLVPMQLKMLAINDFHGQIST
GRKVSNKDVGGAAYLSSYIKQARAKARYSLTVQAGDMVGASPPSSALLQDQPTMEFLNMLGVNVGTIGNHEFDEGFDEMM
RLIDGGCHPTAGCWEGANYPYVVANVIDKRTNKTILPAYHVMNIDGARIGFIGVVLENTPEIVIPSGVTNLEFIDEVTAI
NQAVTELNGQGVHAIIVLAHEGGTQNATTGAITGPIAEIANGINDDVDVIVSAHTHTSISGEVDGKLITQALSYSTAFAD
IDLTIDRAKRDIVAKKATIVTTFHEDMTPDADVAAMVKKYEDQVAPQVNRKVGTAASAITNTANAAGESALGNLIADAQR
NTMSTQFAFMNPGGIRAPLDAGEITWGELYSIQPFSNDLVKMTVTGADIYTLLNQQWQNQSDGTVRARILQISGLSYTWT
DANPVGQKVVEVLDGNGKALDKAASYTITVNSFLADGGDGFVVLKQGTNREVGPTDLDGFVRYIEKLAQPISANIENRIV
KQ

Sequences:

>Translated_722_residues
MDFAMWHNVKSKVGILLGFTLLVGSLGQAAPTKAAEKLCFNQPGVVECIAPEFRDYWEKNGGLPVFGYPQTAAYEEATPE
GKFLVQYFERQRLEYHPEKPAPFTILLGRINDEVLLRENRVWRDFPTAPQATGCQLFSETGHSVCGEFLKYWNSQGLDLG
ENGITYGESLALWGLPLSDPQEEINIDGDKVLTQHFERARMEWHTKDGKNQILLTRLGVTLVPMQLKMLAINDFHGQIST
GRKVSNKDVGGAAYLSSYIKQARAKARYSLTVQAGDMVGASPPSSALLQDQPTMEFLNMLGVNVGTIGNHEFDEGFDEMM
RLIDGGCHPTAGCWEGANYPYVVANVIDKRTNKTILPAYHVMNIDGARIGFIGVVLENTPEIVIPSGVTNLEFIDEVTAI
NQAVTELNGQGVHAIIVLAHEGGTQNATTGAITGPIAEIANGINDDVDVIVSAHTHTSISGEVDGKLITQALSYSTAFAD
IDLTIDRAKRDIVAKKATIVTTFHEDMTPDADVAAMVKKYEDQVAPQVNRKVGTAASAITNTANAAGESALGNLIADAQR
NTMSTQFAFMNPGGIRAPLDAGEITWGELYSIQPFSNDLVKMTVTGADIYTLLNQQWQNQSDGTVRARILQISGLSYTWT
DANPVGQKVVEVLDGNGKALDKAASYTITVNSFLADGGDGFVVLKQGTNREVGPTDLDGFVRYIEKLAQPISANIENRIV
KQ
>Mature_722_residues
MDFAMWHNVKSKVGILLGFTLLVGSLGQAAPTKAAEKLCFNQPGVVECIAPEFRDYWEKNGGLPVFGYPQTAAYEEATPE
GKFLVQYFERQRLEYHPEKPAPFTILLGRINDEVLLRENRVWRDFPTAPQATGCQLFSETGHSVCGEFLKYWNSQGLDLG
ENGITYGESLALWGLPLSDPQEEINIDGDKVLTQHFERARMEWHTKDGKNQILLTRLGVTLVPMQLKMLAINDFHGQIST
GRKVSNKDVGGAAYLSSYIKQARAKARYSLTVQAGDMVGASPPSSALLQDQPTMEFLNMLGVNVGTIGNHEFDEGFDEMM
RLIDGGCHPTAGCWEGANYPYVVANVIDKRTNKTILPAYHVMNIDGARIGFIGVVLENTPEIVIPSGVTNLEFIDEVTAI
NQAVTELNGQGVHAIIVLAHEGGTQNATTGAITGPIAEIANGINDDVDVIVSAHTHTSISGEVDGKLITQALSYSTAFAD
IDLTIDRAKRDIVAKKATIVTTFHEDMTPDADVAAMVKKYEDQVAPQVNRKVGTAASAITNTANAAGESALGNLIADAQR
NTMSTQFAFMNPGGIRAPLDAGEITWGELYSIQPFSNDLVKMTVTGADIYTLLNQQWQNQSDGTVRARILQISGLSYTWT
DANPVGQKVVEVLDGNGKALDKAASYTITVNSFLADGGDGFVVLKQGTNREVGPTDLDGFVRYIEKLAQPISANIENRIV
KQ

Specific function: Sugar-nonspecific endonuclease that yields nucleotide 3'-monophosphate products. No 5'-nucleotidase activity was detected, using 5'-AMP as the substrate, in the presence of diverse divalent metals and with various pH values [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TNase-like domain [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=566, Percent_Identity=24.2049469964664, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI1786687, Length=530, Percent_Identity=21.3207547169811, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790658, Length=230, Percent_Identity=27.8260869565217, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641187, Length=478, Percent_Identity=26.3598326359833, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221329836, Length=480, Percent_Identity=27.2916666666667, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28573524, Length=518, Percent_Identity=24.7104247104247, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24652512, Length=462, Percent_Identity=25.7575757575758, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19921980, Length=462, Percent_Identity=25.7575757575758, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161076508, Length=462, Percent_Identity=25.7575757575758, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19922446, Length=532, Percent_Identity=23.6842105263158, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654424, Length=532, Percent_Identity=23.6842105263158, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922444, Length=568, Percent_Identity=23.0633802816901, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019948
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR016071
- InterPro:   IPR006021 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00746 Gram_pos_anchor; PF00149 Metallophos; PF00565 SNase; PF01336 tRNA_anti [H]

EC number: 3.6.1.45; 3.1.3.5 [C]

Molecular weight: Translated: 78451; Mature: 78451

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00283 SOYBEAN_KUNITZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAMWHNVKSKVGILLGFTLLVGSLGQAAPTKAAEKLCFNQPGVVECIAPEFRDYWEKN
CCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHCC
GGLPVFGYPQTAAYEEATPEGKFLVQYFERQRLEYHPEKPAPFTILLGRINDEVLLRENR
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCC
VWRDFPTAPQATGCQLFSETGHSVCGEFLKYWNSQGLDLGENGITYGESLALWGLPLSDP
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
QEEINIDGDKVLTQHFERARMEWHTKDGKNQILLTRLGVTLVPMQLKMLAINDFHGQIST
HHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCEEECEEEEEEEEECCCCCCCC
GRKVSNKDVGGAAYLSSYIKQARAKARYSLTVQAGDMVGASPPSSALLQDQPTMEFLNML
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
GVNVGTIGNHEFDEGFDEMMRLIDGGCHPTAGCWEGANYPYVVANVIDKRTNKTILPAYH
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCEEECEEE
VMNIDGARIGFIGVVLENTPEIVIPSGVTNLEFIDEVTAINQAVTELNGQGVHAIIVLAH
EEECCCCEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
EGGTQNATTGAITGPIAEIANGINDDVDVIVSAHTHTSISGEVDGKLITQALSYSTAFAD
CCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEEE
IDLTIDRAKRDIVAKKATIVTTFHEDMTPDADVAAMVKKYEDQVAPQVNRKVGTAASAIT
EEEEHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
NTANAAGESALGNLIADAQRNTMSTQFAFMNPGGIRAPLDAGEITWGELYSIQPFSNDLV
HCHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCEE
KMTVTGADIYTLLNQQWQNQSDGTVRARILQISGLSYTWTDANPVGQKVVEVLDGNGKAL
EEEECCHHHHHHHHHHHCCCCCCEEEEEEEEEECCEEEECCCCHHHHHHHHHHCCCCCEE
DKAASYTITVNSFLADGGDGFVVLKQGTNREVGPTDLDGFVRYIEKLAQPISANIENRIV
CCCCEEEEEEEHEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHC
KQ
CC
>Mature Secondary Structure
MDFAMWHNVKSKVGILLGFTLLVGSLGQAAPTKAAEKLCFNQPGVVECIAPEFRDYWEKN
CCCHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHCC
GGLPVFGYPQTAAYEEATPEGKFLVQYFERQRLEYHPEKPAPFTILLGRINDEVLLRENR
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCC
VWRDFPTAPQATGCQLFSETGHSVCGEFLKYWNSQGLDLGENGITYGESLALWGLPLSDP
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
QEEINIDGDKVLTQHFERARMEWHTKDGKNQILLTRLGVTLVPMQLKMLAINDFHGQIST
HHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCEEECEEEEEEEEECCCCCCCC
GRKVSNKDVGGAAYLSSYIKQARAKARYSLTVQAGDMVGASPPSSALLQDQPTMEFLNML
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
GVNVGTIGNHEFDEGFDEMMRLIDGGCHPTAGCWEGANYPYVVANVIDKRTNKTILPAYH
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCEEECEEE
VMNIDGARIGFIGVVLENTPEIVIPSGVTNLEFIDEVTAINQAVTELNGQGVHAIIVLAH
EEECCCCEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
EGGTQNATTGAITGPIAEIANGINDDVDVIVSAHTHTSISGEVDGKLITQALSYSTAFAD
CCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEEE
IDLTIDRAKRDIVAKKATIVTTFHEDMTPDADVAAMVKKYEDQVAPQVNRKVGTAASAIT
EEEEHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
NTANAAGESALGNLIADAQRNTMSTQFAFMNPGGIRAPLDAGEITWGELYSIQPFSNDLV
HCHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCEE
KMTVTGADIYTLLNQQWQNQSDGTVRARILQISGLSYTWTDANPVGQKVVEVLDGNGKAL
EEEECCHHHHHHHHHHHCCCCCCEEEEEEEEEECCEEEECCCCHHHHHHHHHHCCCCCEE
DKAASYTITVNSFLADGGDGFVVLKQGTNREVGPTDLDGFVRYIEKLAQPISANIENRIV
CCCCEEEEEEEHEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHC
KQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UMP [C]

Specific reaction: H2O + UMP --> Phosphate + Uridine [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Inhibitor from Salmonella typhimurium cytoplasm [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]