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The map label for this gene is cmlA [H]

Identifier: 159898636

GI number: 159898636

Start: 2657395

End: 2658033

Strand: Direct

Name: cmlA [H]

Synonym: Haur_2115

Alternate gene names: 159898636

Gene position: 2657395-2658033 (Clockwise)

Preceding gene: 159898635

Following gene: 159898637

Centisome position: 41.87

GC content: 49.61

Gene sequence:

>639_bases
ATGCGCACAATTGATCTTGCAACATGGCCGCGTCGTCAACATTTTAGCTTCTATCAAGGCATGACCTACCCACATTTTAG
TTTATGTGCCAATGTCGATATTCAAATTTGGTATCAAGCAATTAAGGCTCGCCAAGCGCGTTTAAGCACCAGCCTTACCT
ATGTATTTGCCCGCGCCGCCAACGAACAAGTGGCCTTTCGTTGGCGAATTCGGGGTGATAATGTGGTTGAGCATGATCGG
GTTGATCCTTCGCCAACCGTCTTGCTCGACGACGATCTCTTTAGCTTTTGTGTGATTCCCTATCGGGCGGATTATCATGC
ATTTTCAGCCTTAGCCGAAGCCAAAGTCGCTGAAGTCAAAGCCAACCCAACCATCACCGACGAGCCAGGCCAAGATAATT
TGTTGTATATGACCAGCATTCCGTGGGTCAGCTTCACTAGCATGATGCACCCGATCCATCTCAACCCAATCGATTCAGTT
CCGCGCATTTCGTGGGGCAAACACACGCTTGAAGGCCAGCGCCGCTTGATGCCGGTGGCGGTACAAGTCCATCATGGCCT
GATGGATGGCTTGCATATTGGGCGTTTCTATGAGCGAGTTCAGGCAATTCTCGATCATCCTGAGGATTTTTTGGGCTAA

Upstream 100 bases:

>100_bases
TTTGGCGCTGGCCAATTGATCCACGGCCTACATCAAAAGGGGGATTGACGCGACCATGCAGTTGGCTATACTAGGCCACA
GCTTCGTTTAGAGGAACCAT

Downstream 100 bases:

>100_bases
GTTTGTACACCAAGCAGCTAAAATAGTGCTTAATCATCCTTTTTACATCCATTTCGATCGATTAGAATCAATAGGTGTGT
AGATAGGTGCAACGCTTGCA

Product: chloramphenicol O-acetyltransferase

Products: NA

Alternate protein names: Chloramphenicol acetyltransferase II; CAT-II [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRTIDLATWPRRQHFSFYQGMTYPHFSLCANVDIQIWYQAIKARQARLSTSLTYVFARAANEQVAFRWRIRGDNVVEHDR
VDPSPTVLLDDDLFSFCVIPYRADYHAFSALAEAKVAEVKANPTITDEPGQDNLLYMTSIPWVSFTSMMHPIHLNPIDSV
PRISWGKHTLEGQRRLMPVAVQVHHGLMDGLHIGRFYERVQAILDHPEDFLG

Sequences:

>Translated_212_residues
MRTIDLATWPRRQHFSFYQGMTYPHFSLCANVDIQIWYQAIKARQARLSTSLTYVFARAANEQVAFRWRIRGDNVVEHDR
VDPSPTVLLDDDLFSFCVIPYRADYHAFSALAEAKVAEVKANPTITDEPGQDNLLYMTSIPWVSFTSMMHPIHLNPIDSV
PRISWGKHTLEGQRRLMPVAVQVHHGLMDGLHIGRFYERVQAILDHPEDFLG
>Mature_212_residues
MRTIDLATWPRRQHFSFYQGMTYPHFSLCANVDIQIWYQAIKARQARLSTSLTYVFARAANEQVAFRWRIRGDNVVEHDR
VDPSPTVLLDDDLFSFCVIPYRADYHAFSALAEAKVAEVKANPTITDEPGQDNLLYMTSIPWVSFTSMMHPIHLNPIDSV
PRISWGKHTLEGQRRLMPVAVQVHHGLMDGLHIGRFYERVQAILDHPEDFLG

Specific function: This enzyme is an effector of chloramphenicol resistance in bacteria [H]

COG id: COG4845

COG function: function code V; Chloramphenicol O-acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloramphenicol acetyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023213
- InterPro:   IPR018372
- InterPro:   IPR001707
- ProDom:   PD002660 [H]

Pfam domain/function: PF00302 CAT [H]

EC number: =2.3.1.28 [H]

Molecular weight: Translated: 24437; Mature: 24437

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTIDLATWPRRQHFSFYQGMTYPHFSLCANVDIQIWYQAIKARQARLSTSLTYVFARAA
CCEECCCCCCCCCCCHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCC
NEQVAFRWRIRGDNVVEHDRVDPSPTVLLDDDLFSFCVIPYRADYHAFSALAEAKVAEVK
CCEEEEEEEECCCCEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHEEE
ANPTITDEPGQDNLLYMTSIPWVSFTSMMHPIHLNPIDSVPRISWGKHTLEGQRRLMPVA
CCCCCCCCCCCCCEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEHHH
VQVHHGLMDGLHIGRFYERVQAILDHPEDFLG
EEHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MRTIDLATWPRRQHFSFYQGMTYPHFSLCANVDIQIWYQAIKARQARLSTSLTYVFARAA
CCEECCCCCCCCCCCHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCC
NEQVAFRWRIRGDNVVEHDRVDPSPTVLLDDDLFSFCVIPYRADYHAFSALAEAKVAEVK
CCEEEEEEEECCCCEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHEEE
ANPTITDEPGQDNLLYMTSIPWVSFTSMMHPIHLNPIDSVPRISWGKHTLEGQRRLMPVA
CCCCCCCCCCCCCEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEHHH
VQVHHGLMDGLHIGRFYERVQAILDHPEDFLG
EEHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2268278 [H]