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The map label for this gene is ltrA [H]

Identifier: 159898445

GI number: 159898445

Start: 2317173

End: 2318960

Strand: Direct

Name: ltrA [H]

Synonym: Haur_1921

Alternate gene names: 159898445

Gene position: 2317173-2318960 (Clockwise)

Preceding gene: 159898444

Following gene: 159898446

Centisome position: 36.51

GC content: 49.72

Gene sequence:

>1788_bases
ATGCGCACAGCCGACACTATTTTGGCAGTCATTCGTGATCGTGGGCAACGAGGATTGCCCTTAGCGCGTGTCTATCGCAT
ATTGTTCAATGAGGATCTCTATTTGCGTGCCTATGGGCGGCTAGCAACCAAACAAGGCGCACTCACCAAAGGAAGTACAG
ACGAAACTATTGATGGAATGTCAATGGCGAAAATTCATCGTATCATCGCCGATCTTCGCCGCGAGACCTATCGCTGGACT
CCAGTACGACGGGTCTACATCCCAAAAGCAACGGGAAAAACCCGACCTTTAGGGGTTCCTACATGGTCAGATAAGTTGGT
TCAGGAAGTCTTACGCTCCATTCTCGACGCGTATTACGACCCCCAAATGAGCGACCATTCACATGGTTTTCGTCCGAACC
GTGGATGCCATACGGCTCTTAAAGCCATTCAGCGTTGCTGGACGGGCACACGGTGGTTTATTGAGGGTGATATTGCACAA
TATTTTGACACGATCAATCACACGACACTCCTCACAATATTGGCGAAACGCATCCACGATGGCCGTTTTCTTCGGTTGAT
CCAGACACTCTTGCAGGCAGGATATCTTCACGATTGGGTGTATCATCCGACGCTGAGTGGAACACCACAAGGCGGGGTAA
TCTCCCCACTCTTGGCAAACATTTACCTGCATGAATTTGACCAGTTTGTCGAACATACGCTGATACCTGCCTATACCAAA
GGGCAGAGACGGAAAGTCAATCCGGCCTATGCACAGATGGAACAACGAATCAGCAAATTACGTCGTCAACGGGAGTACGC
AAGCGTTACCCCGCTCCTGAAGGAGCTTCGCACCCTGCCCTCCCGTGATGTGCATGATCCTGATTACCGACGGTTACGCT
ATGTGCGGTATGCCGATGACTTTCTCCTTGGGTTTGCGGGAACAAAAGTGGAAGCAGAGGCGATCAAACAGCAGATTAAT
GTATGGCTGTATGATCATCTCCAATTAAAACTGTCCACTCAGAAAACGCTGATCACGCACGCAAGTAGTGATCCAGCCCA
TTTTCTTGGCTATGACATCGTGACGCAACAGGCAAATAGCAAACAGACGGGAAACCGACGCATTGTGAATGGCCGGATCG
CGTTACGCGTAGCCCGCGCAACGATTACTGCGAAATGCAACCGCTATATGAAAAACGGGAAGGCTACCCACCGACCCGAA
CTGCTGAGCGAAACCGACTTTACTATTATTGCAACGTATCAGCAGGAATATCGTGGCATTGTGCAATATTACATGCTTGC
CCACAATGTATCGCATTTGCACCGCCTGCATTGGGTTATGAAGCAATCCTTGCTCAAAACACTGGCTGCCAAACACAAAA
CAACTAGTGCCGTGATGCGAAGGAAATATCTGGCAACACAGCAGTTGCCTGACGGGCGCAGAATGCTCTGCATTCGCGTA
TTCGTCGAGCAACCAGCACGACCGCCACTCATAGCTCAATTTGGTGGGATTTCTTTGCGCCGCAATCCAATGGCAATCCT
CAATGAACGTCCACCCCAACTATGGAATGTGGGAACCGAAATTATCCAACGCTTGAAAGCGCAAGAATGCGAGCTATGTG
GAAGCCATGAAGATGTGGAAGTCCACCATATCCGCAGGCTTGCCAACCTAAAGCGATCGGGACGAACGGAAAAACCACAA
TGGATGCAACGCATGATTACGCGGCAACGAAAAACGCTCGTAGTCTGTTCTCAATGTCACCACCGCATCCATGCTGGAAA
AACACTACCACAGCAAATCACGAAATAA

Upstream 100 bases:

>100_bases
AGTCGTGGGCGTAACGACCCATTGCGGCGTATAGGAAAGCTATACACAGGGCGAAGGGGAGTAGGTGATTTTTGACTGTT
CTGGTAGAAAGGAGCGCGAG

Downstream 100 bases:

>100_bases
ATCACTGGAGAGCCGGGTGCGGTGAAAGTCGCATGCCCGGTTCGGAGGGGGGCGGATGGAAAAGGACGCAAAGCGTACCT
CGCCAGCCGCCTACCCTACG

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MRTADTILAVIRDRGQRGLPLARVYRILFNEDLYLRAYGRLATKQGALTKGSTDETIDGMSMAKIHRIIADLRRETYRWT
PVRRVYIPKATGKTRPLGVPTWSDKLVQEVLRSILDAYYDPQMSDHSHGFRPNRGCHTALKAIQRCWTGTRWFIEGDIAQ
YFDTINHTTLLTILAKRIHDGRFLRLIQTLLQAGYLHDWVYHPTLSGTPQGGVISPLLANIYLHEFDQFVEHTLIPAYTK
GQRRKVNPAYAQMEQRISKLRRQREYASVTPLLKELRTLPSRDVHDPDYRRLRYVRYADDFLLGFAGTKVEAEAIKQQIN
VWLYDHLQLKLSTQKTLITHASSDPAHFLGYDIVTQQANSKQTGNRRIVNGRIALRVARATITAKCNRYMKNGKATHRPE
LLSETDFTIIATYQQEYRGIVQYYMLAHNVSHLHRLHWVMKQSLLKTLAAKHKTTSAVMRRKYLATQQLPDGRRMLCIRV
FVEQPARPPLIAQFGGISLRRNPMAILNERPPQLWNVGTEIIQRLKAQECELCGSHEDVEVHHIRRLANLKRSGRTEKPQ
WMQRMITRQRKTLVVCSQCHHRIHAGKTLPQQITK

Sequences:

>Translated_595_residues
MRTADTILAVIRDRGQRGLPLARVYRILFNEDLYLRAYGRLATKQGALTKGSTDETIDGMSMAKIHRIIADLRRETYRWT
PVRRVYIPKATGKTRPLGVPTWSDKLVQEVLRSILDAYYDPQMSDHSHGFRPNRGCHTALKAIQRCWTGTRWFIEGDIAQ
YFDTINHTTLLTILAKRIHDGRFLRLIQTLLQAGYLHDWVYHPTLSGTPQGGVISPLLANIYLHEFDQFVEHTLIPAYTK
GQRRKVNPAYAQMEQRISKLRRQREYASVTPLLKELRTLPSRDVHDPDYRRLRYVRYADDFLLGFAGTKVEAEAIKQQIN
VWLYDHLQLKLSTQKTLITHASSDPAHFLGYDIVTQQANSKQTGNRRIVNGRIALRVARATITAKCNRYMKNGKATHRPE
LLSETDFTIIATYQQEYRGIVQYYMLAHNVSHLHRLHWVMKQSLLKTLAAKHKTTSAVMRRKYLATQQLPDGRRMLCIRV
FVEQPARPPLIAQFGGISLRRNPMAILNERPPQLWNVGTEIIQRLKAQECELCGSHEDVEVHHIRRLANLKRSGRTEKPQ
WMQRMITRQRKTLVVCSQCHHRIHAGKTLPQQITK
>Mature_595_residues
MRTADTILAVIRDRGQRGLPLARVYRILFNEDLYLRAYGRLATKQGALTKGSTDETIDGMSMAKIHRIIADLRRETYRWT
PVRRVYIPKATGKTRPLGVPTWSDKLVQEVLRSILDAYYDPQMSDHSHGFRPNRGCHTALKAIQRCWTGTRWFIEGDIAQ
YFDTINHTTLLTILAKRIHDGRFLRLIQTLLQAGYLHDWVYHPTLSGTPQGGVISPLLANIYLHEFDQFVEHTLIPAYTK
GQRRKVNPAYAQMEQRISKLRRQREYASVTPLLKELRTLPSRDVHDPDYRRLRYVRYADDFLLGFAGTKVEAEAIKQQIN
VWLYDHLQLKLSTQKTLITHASSDPAHFLGYDIVTQQANSKQTGNRRIVNGRIALRVARATITAKCNRYMKNGKATHRPE
LLSETDFTIIATYQQEYRGIVQYYMLAHNVSHLHRLHWVMKQSLLKTLAAKHKTTSAVMRRKYLATQQLPDGRRMLCIRV
FVEQPARPPLIAQFGGISLRRNPMAILNERPPQLWNVGTEIIQRLKAQECELCGSHEDVEVHHIRRLANLKRSGRTEKPQ
WMQRMITRQRKTLVVCSQCHHRIHAGKTLPQQITK

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=585, Percent_Identity=33.8461538461538, Blast_Score=306, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6226521, Length=589, Percent_Identity=31.0696095076401, Blast_Score=276, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 68960; Mature: 68960

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTADTILAVIRDRGQRGLPLARVYRILFNEDLYLRAYGRLATKQGALTKGSTDETIDGM
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCCCCCCH
SMAKIHRIIADLRRETYRWTPVRRVYIPKATGKTRPLGVPTWSDKLVQEVLRSILDAYYD
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PQMSDHSHGFRPNRGCHTALKAIQRCWTGTRWFIEGDIAQYFDTINHTTLLTILAKRIHD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCHHHHHHHHHHHHCC
GRFLRLIQTLLQAGYLHDWVYHPTLSGTPQGGVISPLLANIYLHEFDQFVEHTLIPAYTK
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GQRRKVNPAYAQMEQRISKLRRQREYASVTPLLKELRTLPSRDVHDPDYRRLRYVRYADD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
FLLGFAGTKVEAEAIKQQINVWLYDHLQLKLSTQKTLITHASSDPAHFLGYDIVTQQANS
HHHCCCCCCHHHHHHHHHHCEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCC
KQTGNRRIVNGRIALRVARATITAKCNRYMKNGKATHRPELLSETDFTIIATYQQEYRGI
CCCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEEEHHHHHHHH
VQYYMLAHNVSHLHRLHWVMKQSLLKTLAAKHKTTSAVMRRKYLATQQLPDGRRMLCIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHEE
FVEQPARPPLIAQFGGISLRRNPMAILNERPPQLWNVGTEIIQRLKAQECELCGSHEDVE
EHHCCCCCCCEECCCCCEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
VHHIRRLANLKRSGRTEKPQWMQRMITRQRKTLVVCSQCHHRIHAGKTLPQQITK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MRTADTILAVIRDRGQRGLPLARVYRILFNEDLYLRAYGRLATKQGALTKGSTDETIDGM
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCCCCCCH
SMAKIHRIIADLRRETYRWTPVRRVYIPKATGKTRPLGVPTWSDKLVQEVLRSILDAYYD
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PQMSDHSHGFRPNRGCHTALKAIQRCWTGTRWFIEGDIAQYFDTINHTTLLTILAKRIHD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCHHHHHHHHHHHHCC
GRFLRLIQTLLQAGYLHDWVYHPTLSGTPQGGVISPLLANIYLHEFDQFVEHTLIPAYTK
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GQRRKVNPAYAQMEQRISKLRRQREYASVTPLLKELRTLPSRDVHDPDYRRLRYVRYADD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
FLLGFAGTKVEAEAIKQQINVWLYDHLQLKLSTQKTLITHASSDPAHFLGYDIVTQQANS
HHHCCCCCCHHHHHHHHHHCEEEEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCC
KQTGNRRIVNGRIALRVARATITAKCNRYMKNGKATHRPELLSETDFTIIATYQQEYRGI
CCCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEEEHHHHHHHH
VQYYMLAHNVSHLHRLHWVMKQSLLKTLAAKHKTTSAVMRRKYLATQQLPDGRRMLCIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHEE
FVEQPARPPLIAQFGGISLRRNPMAILNERPPQLWNVGTEIIQRLKAQECELCGSHEDVE
EHHCCCCCCCEECCCCCEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
VHHIRRLANLKRSGRTEKPQWMQRMITRQRKTLVVCSQCHHRIHAGKTLPQQITK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]